Abstract: A capacitive ultrasound transducer capable of operation in collapsed mode either with a reduced bias voltage, or with no bias voltage, is provided. The transducer includes a substrate that is contoured so that a middle region of the flexible membrane is collapsed against the substrate in the absence of a bias voltage. A non-collapsible gap may exists between the substrate and peripheral regions of the flexible membrane. The contour of the substrate may be such as to strain the flexible membrane past the point of collapse, or to mechanically interfere with the flexible membrane. The substrate may include a further membrane disposed beneath the flexible membrane, the further membrane being contoured so that the flexible membrane is collapsed against it. The substrate may a support disposed beneath the further membrane to deflect a corresponding portion of the further membrane upward toward the flexible membrane. The support may be a post.

Abstract: A method for preparation of iloperidone is provided which comprises reacting 6-fluoro-3-(4-piperidinyl)-1,2-benzoisoxazole hydrochloride with 1-[4-(3-chloropropoxyl)-3-methoxyphenyl]ethyl ketone in an inorganic alkaline aqueous solution. A crystallization method of iloperidone is also provided which comprises adding seed crystal to the iloperidone solution in ethyl acetate, and then iloperidone crystal is obtained with high purity by controlling the temperature and the stirring speed.

Abstract: Energy is transferred (336) to cause a mechanical property of biological tissue to change, as in ablation. An effect of the transferring is examined in more than one spatial dimension to, for example, make an ablation halting decision for a treatment region, i.e., line (312) or layer (314), or for a location (316) within the region. Halting decisions can be based on lesion-central and/or lesion-peripheral longitudinal displacement of treated tissue evaluated in real time against a characteristic curve. Steering in the azimuthal and/or elevation direction is afforded by, for example, linear, or 2D, multi-channel ultrasound arrays for therapy and imaging. Protocols includable are region-wide scanning (SI 010) and location-by-location completion for both (HIFU) therapy and tracking (acoustic-radiation-forced-based) displacement of treated tissue.

Abstract: An ultrasound power supply (100) adapted for supplying electrical power for driving an ultrasound transducer (202, 702) in contact with a subject (208), wherein the ultrasound power supply comprises:—a communications interface (102) adapted for receiving a first temperature measurement of a first volume (211, 318) of the subject and a second temperature measurement of a second volume (214, 320) of the subject;—a controller (108) adapted for modulating the output of electrical power for driving the ultrasound transducer such that via ultrasonic heating by the ultrasound transducer: a. the first temperature measurement is maintained above a first predetermined threshold, b. the first temperature measurement is maintained below a second predetermined threshold, and c. the second temperature measurement is maintained below a third predetermined threshold; and wherein the first predetermined threshold is above the third predetermined threshold.

Abstract: A method for preparation of iloperidone is provided which comprises reacting 6-fluoro-3-(4-piperidinyl)-1,2-benzoisoxazole hydrochloride with 1-[4-(3-chloropropoxyl)-3-methoxyphenyl]ethyl ketone in an inorganic alkaline aqueous solution. A crystallization method of iloperidone is also provided which comprises adding seed crystal to the iloperidone solution in ethyl acetate, and then iloperidone crystal is obtained with high purity by controlling the temperature and the stirring speed.

Abstract: An imaging system for imaging a viscoelastic medium is disclosed. The imaging system comprises a variable refractive lens (4) and a transducer system (5) for generating acoustic radiation. The imaging system is operated to alternate between first and second operating modes. While the variable refractive lens is operated to alternate between a first configuration and a second configuration, the transducer is operated to alternate between generating acoustic radiation for displacing the viscoelastic medium and acoustic radiation for imaging the displacement of the viscoelastic medium. In embodiments the variable refractive lens is a fluid focus lens. Moreover, in embodiments, the imaging system is integrated with a catheter-based interaction modality, such as a tissue ablation modality.

Abstract: An ablation control device (110) configured for halting, in real time, ablation of body tissue at a current ablation point to achieve a predetermined lesion size upon halting includes a control section (120) configured for registering, with a characteristic curve, one or more values and halting the ablation based on the registering. The value or values are obtained from monitoring (115), for the current ablation point, displacement caused by force applied to the body tissue. In one embodiment, halting is performed upon detecting, by the monitoring and after a peak value of the monitored displacement has occurred, an endpoint value of the monitored displacement. In another embodiment, the end-point value is determined prior to the detecting, and the determining is performed by the registering.

Abstract: A capacitive ultrasound transducer capable of operation in collapsed mode either with a reduced bias voltage, or with no bias voltage, is provided. The transducer includes a substrate that is contoured so that a middle region of the flexible membrane is collapsed against the substrate in the absence of a bias voltage. A non-collapsible gap may exists between the substrate and peripheral regions of the flexible membrane. The contour of the substrate may be such as to strain the flexible membrane past the point of collapse, or to mechanically interfere with the flexible membrane. The substrate may include a further membrane disposed beneath the flexible membrane, the further membrane being contoured so that the flexible membrane is collapsed against it. The substrate may a support disposed beneath the further membrane to deflect a corresponding portion of the further membrane upward toward the flexible membrane. The support may be a post.