Patents by Inventor Shlomit Wizel

Shlomit Wizel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

Crystalline solid famciclovir forms I, II, III and preparation thereof

Publication number: 20040097528

Abstract: The present invention provides novel crystalline solid anhydrous forms of famciclovir, denominated form I, II and III, as well as their preparations thereof.

Type: Application

Filed: August 26, 2003

Publication date: May 20, 2004

Inventors: Ben-Zion Dolitzky, Shlomit Wizel, Ofer Reany, Jenny Shammai
Polymorphs of fexofenadine hydrochloride

Publication number: 20040058955

Abstract: The present invention provides novel crystal forms of fexofenadine hydrochloride Forms V, VI and VIII through XV and processes for their preparation and preparation of amorphous form and other crystalline forms of fexofenadine hydrochloride. Forms XIV and XV are solvates of ethyl acetate, while Form IX is anhydrous, but can be crystallized as a solvate of MTBE or cyclohexane. The forms are useful for administration to humans and animals to alleviate symptoms caused by histamine. The present invention further provides pharmaceutical compositions of the new crystalline forms.

Type: Application

Filed: September 12, 2003

Publication date: March 25, 2004

Inventors: Ben-Zon Dolitzky, Shlomit Wizel, Barnaba Krochmal, Dov Diller, Irwin Gross
Crystalline solids of carvedilol and processes for their preparation

Patent number: 6710184

Abstract: This invention relates to a novel crystalline solid of carvedilol or a solvate thereof, to processes for its preparation, to compositions containing it and to its use in medicine. This invention further relates to a novel process for preparing a crystalline solid of carvedilol Form II.

Type: Grant

Filed: January 15, 2003

Date of Patent: March 23, 2004

Assignee: Teva Pharmaceutical Industries Ltd.

Inventors: Ilan Kor, Shlomit Wizel
Polymorphic form XVI of fexofenadine hydrochloride

Publication number: 20040044038

Abstract: Provided is a crystalline (polymorphic) form of fexofenadine hydrochloride, denominated fexofenadine hydrochloride Form XVI.

Type: Application

Filed: June 10, 2003

Publication date: March 4, 2004

Inventors: Barnaba Krochmal, Dov Diller, Ben-Zion Dolitzky, Judith Aronhime, Shlomit Wizel, Boaz Gome, Igor Lifshitz
Novel crystalline forms of gatifloxacin

Publication number: 20040038988

Abstract: Provided are two novel crystalline forms of gatifloxacin, denominated form O and form V, and methods for their preparation.

Type: Application

Filed: June 16, 2003

Publication date: February 26, 2004

Inventors: Valerie Niddam-Hildesheim, Shlomit Wizel, Greta Sterimbaum, Ehud Amir
Novel crystalline forms of gatifloxacin

Publication number: 20040009989

Abstract: Provided are novel crystalline forms of gatifloxacin denominated forms A, B, C, D, E1, F, G, H, I, and J, and methods for their preparation. Also provided are methods for making known crystalline forms of gatifloxacin, in particular forms omega and T2RP.

Type: Application

Filed: May 12, 2003

Publication date: January 15, 2004

Inventors: Valerie Niddam-Hildesheim, Shlomit Wizel, Greta Sterimbaum, Ehud Amir
Amorphous and crystalline forms of losartan potassium and process for their preparation

Publication number: 20040006237

Abstract: This invention relates to novel amorphous losartan potassium, novel losartan potassium in a crystalline form that is a hydrate, novel crystalline losartan potassium Form IV and solvates thereof, novel crystalline losartan potassium Form V and solvates thereof, to processes for their preparation, to compositions containing them and to their use in medicine. This invention further relates to a novel process for preparing crystalline losartan potassium Form I and Form II.

Type: Application

Filed: November 13, 2002

Publication date: January 8, 2004

Applicant: Teva Pharmaceutical Industries Ltd.

Inventors: Ben Zion Dolitzky, Shlomit Wizel, Gennady Nisnevich, Igor Rukhman, Julia Kaftanov
Polymorphs of clopidogrel hydrogensulfate

Publication number: 20030225129

Abstract: Provided are new crystalline Forms III, IV, V and VI of clopidogrel hydrogensulfate and the amorphous form of clopidogrel hydrogensulfate, as well as their pharmaceutical compositions, and method of treatments with such compositions. Also provided are novel processes for preparation of clopidogrel hydrogensulfate Form I, Form II, Form III, Form IV, Form V, Form VI and amorphous form.

Type: Application

Filed: January 8, 2003

Publication date: December 4, 2003

Inventors: Revital Lifshitz-Liron, Eti Kovalevski-Ishai, Shlomit Wizel, Sharon Avhar-Maydan, Rami Lidor-Hadas
Crystalline forms of quetiapine hemifumarate

Publication number: 20030216376

Abstract: The present invention relates to novel crystalline forms of quetiapine hemifumarate, denominated quetiapine hemifumarate form II and quetiapine hemifumarate form III. These novel crystalline forms of quetiapine hemifumarate have been characterized by methods including x-ray powder diffraction (XRD), Fourier transform IR spectroscopy (FTIR), differential scanning calorimetry (DSC), and thermal gravimetric analysis (TGA). Methods for preparation of the novel crystalline quetiapine hemifumarate form II as its chloroform solvate and its dichloromethane solvate, form III as its chloroform solvate, and form I are provided.

Type: Application

Filed: March 20, 2003

Publication date: November 20, 2003

Inventors: Revital Lifshitz-Liron, Eti Kovalevski-ishai, Ben-Zion Dolitzky, Shlomit Wizel, Rami Lidor-Hadas
Crystalline solids of carvedilol and processes for their preparation

Publication number: 20030166702

Abstract: This invention relates to a novel crystalline solid of carvedilol or a solvate thereof, to processes for its preparation, to compositions containing it and to its use in medicine. This invention further relates to a novel process for preparing a crystalline solid of carvedilol Form II.

Type: Application

Filed: January 15, 2003

Publication date: September 4, 2003

Inventors: Ilan Kor, Shlomit Wizel
Polymorphs of fexofenadine base

Publication number: 20030158227

Abstract: The present invention provides novel crystal forms of fexofenadine base and processes for their preparation. The forms are useful for administration to humans and animals to alleviate symptoms caused by histamine. The present invention further provides pharmaceutical compositions of the new crystalline forms.

Type: Application

Filed: November 8, 2002

Publication date: August 21, 2003

Inventors: Barnaba Krochmal, Dov Diller, Ben-Zion Dolitzky, Judith Aronhime, Shlomit Wizel
Novel sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms

Publication number: 20030144527

Abstract: The present invention relates to a novel sulfonation of an intermediate of zonisamide. The sulfonation processes using chlorosulfonic acid as well as acetic anhydride and sulfuric acid in an organic solvent are disclosed. Crystalline forms of benzisoxazole methane sulfonic acid (BOS—H) and its salts (BOS—Na, BOS—Ca, and BOS—Ba) and their novel preparation processes are disclosed.

Type: Application

Filed: November 5, 2002

Publication date: July 31, 2003

Inventors: Tamar Nidam, Marioara Mendelovici, Edward Schwartz, Shlomit Wizel
Pioglitazone hydrochloride

Publication number: 20030139603

Abstract: Provided is a novel crystal form of pioglitazone hydrochloride and a method for making it. Also provided is a method for making a known crystal form of pioglitazone hydrochloride.

Type: Application

Filed: September 27, 2002

Publication date: July 24, 2003

Inventors: Shlomit Wizel, Serguei Finogueev, Jean Hildesheim
Preparation of levofloxacin and forms thereof

Publication number: 20030130507

Abstract: Levofloxacin was prepared by reacting (S)-(−)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid with N-methyl piperazine in a polar solvent or in a neat mixture to form levofloxacin. Further processing of the levofloxacin produced novel levofloxacin forms, including a hemihydrate and Forms A, B, C, F, G and H.

Type: Application

Filed: October 3, 2002

Publication date: July 10, 2003

Inventors: Valerie Niddam-Hildesheim, Neomi Gershon, Ehud Amir, Shlomit Wizel
Novel sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms

Publication number: 20030114682

Abstract: The present invention relates to a novel sulfonation of an intermediate of zonisamide. The sulfonation processes using chlorosulfonic acid as well as acetic anhydride and sulfuric acid in an organic solvent are disclosed. Crystalline forms of benzisoxazole methane sulfonic acid (BOS-H) and its salts (BOS-Na, BOS-Ca, and BOS-Ba) and their novel preparation processes are disclosed.

Type: Application

Filed: August 29, 2002

Publication date: June 19, 2003

Inventors: Tamar Nidam, Marioara Mendelovici, Eduard Schwartz, Shlomit Wizel
Novel crystal forms III, IV, V, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form I, compositions containing the new forms and methods of administering the new forms

Publication number: 20030114479

Abstract: The present invention provides new crystalline Forms III, IV and V of clopidogrel hydrogensulfate and the amorphous form of clopidogrel hydrogensulfate, as well as their pharmaceutical compositions, and method of treatments with such compositions. The present invention also provides novel processes for preparation of clopidogrel hydrogensulfate Form I, Form III, Form IV, Form V and the amorphous form. The present invention further provides a novel process where the amorphous form is converted to Form I by contacting Form I with an ether.

Type: Application

Filed: February 12, 2002

Publication date: June 19, 2003

Inventors: Revital Lifshitz-Liron, Eti Kovalevski-Ishai, Shlomit Wizel, Sharon Avhar Maydan, Rami Lidor-Hadas
Crystalline forms of valacyclovir hydrochloride

Publication number: 20030114470

Abstract: Provided are novel polymorphs and pseudopolymorphs of valacyclovir hydrochloride and pharmaceutical compositions containing these. Also provided are methods for making the novel polymorphs and pseudopolymorphs, which include valacyclovir hydrochloride monohydrate and valacyclovir hydrochloride dihydrate.

Type: Application

Filed: September 6, 2002

Publication date: June 19, 2003

Inventors: Shlomit Wizel, Judith Aronhime, Valerie Niddam-Hildesheim, Ben-Zion Dolitzky, Marina Yu Etinger, Michael Yuzefovich, Gennady A. Nisnevich, Boris Pertsikov, Boris Tishin, Dina Blasberger
Polymorphs of fexofenadine hydrochloride

Publication number: 20030021849

Abstract: The present invention provides novel crystal forms of fexofenadine hydrochloride Forms V, VI and VIII through XV and processes for their preparation and preparation of amorphous form and other crystalline forms of fexofenadine hydrochloride. Forms XIV and XV are solvates of ethyl acetate, while Form IX is a solvate of MTBE or cyclohexane. The forms are useful for administration to humans and animals to alleviate symptoms caused by histamine. The present invention further provides pharmaceutical compositions of the new crystalline forms.

Type: Application

Filed: April 26, 2002

Publication date: January 30, 2003

Inventors: Ben-Zion Dolitzky, Shlomit Wizel, Barnaba Krochmal, Dov Diller, Irwin Gross
Crystalline venlafaxine base and novel polymorphs of venlafaxine hydrochloride, processes for preparing thereof

Publication number: 20020183553

Abstract: The present invention relates to novel essentially pure venlafaxine and the process of preparation thereof. The present invention also relates to novel solvate forms of venlafaxine hydrochloride and the process of preparation thereof. Furthermore, the present invention provides a novel process for preparing venlafaxine hydrochloride from venlafaxine; the process comprises the steps of: i) preparing a mixture of venlafaxine with acetone; and ii) exposing the mixture in gaseous hydrochloric acid.

Type: Application

Filed: November 30, 2001

Publication date: December 5, 2002

Inventors: Ben-Zion Dolitzky, Judith Aronhime, Shlomit Wizel, Gennady A. Nisnevich
Polymorphs of fexofenadine hydrochloride

Publication number: 20020177608

Abstract: The present invention provides novel crystal forms of fexofenadine hydrochloride Forms V, VI and VIII through XV and processes for their preparation and preparation of amorphous form and other crystalline forms of fexofenadine hydrochloride. Forms XIV and XV are solvates of ethyl acetate, while Form IX is anhydrous, but can be crystallized as a solvate of MTBE or cyclohexane. The forms are useful for administration to humans and animals to alleviate symptoms caused by histamine. The present invention further provides pharmaceutical compositions of the new crystalline forms.

Type: Application

Filed: April 8, 2002

Publication date: November 28, 2002

Inventors: Ben-Zion Dolitzky, Shlomit Wizel, Barnaba Krochmal, Dov Diller, Irwin Gross

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