Abstract: In some embodiments, a body cavity shape of a subject is reconstructed based on intrabody measurements of voltages by an intrabody probe (for example, a catheter probe) moving within a plurality of differently-oriented electromagnetic fields crossing the body cavity. In some embodiments, the method uses distances between electrodes as a spatially calibrated ruler. Positions of measurements made with the intrabody probe in different positions are optionally related by using spatial coherence of the measured electromagnetic fields as a constraint. Optionally, reconstruction is performed without using a detailed reference (image or simulation) describing the body cavity shape. Optionally, reconstruction uses further information to refine and/or constrain the reconstruction; for example: images, simulations, additional electromagnetic fields, and/or measurements characteristic of body cavity landmarks. Optionally, reconstruction accounts for time-dependent cavity shape changes, for example, phasic changes (e.g.

Abstract: Methods for creation and use (e.g., for navigation) of displays of flattened (e.g., curvature-straightened) 3-D reconstructions of tissue surfaces, optionally including reconstructions of the interior surfaces of hollow organs. In some embodiments, data comprising a 3-D representation of a tissue surface (for example an interior heart chamber surface) are subject to a geometrical transformation allowing the tissue surface to be presented substantially within a single view of a flattened reconstruction. In some embodiments, a catheter probe in use near the tissue surface is shown in positions that correspond to positions in 3-D space sufficiently to permit navigation; e.g., the probe is shown in flattened reconstruction views nearby view regions corresponding to regions it actually approaches. In some embodiments, automatic and/or easily triggered manual view switching between flattened reconstruction and source reconstruction views is implemented.

Abstract: A method of modifying tissue behavior, comprising: determining a desired modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation; selecting an electric field having an expected effect of modifying protein activity of at least one protein as an immediate response of a tissue to the field, said expected effect correlated with said desired modification; and applying said field to said tissue.

Abstract: A method of imaging nervous tissue, comprising acquiring functional imaging modality data from a functional imaging modality which images an intrabody volume of a patient having a body part, the patient having been injected with an imaging agent having a nervous tissue uptake by an autonomic nervous system (ANS); and locating the nervous tissue in the intrabody volume based on the functional imaging modality data.

Abstract: A method of performing dielectric-based imaging is disclosed comprising exciting at least one pair of electrodes according to an excitation scheme, the at least one pair of electrodes comprising at least one pair of in-body electrodes (also referred herein below intra-body electrode) located inside of the examined living body, measuring and recording voltages developing on the in-body electrodes during the excitation according to the excitation scheme, solving an inverse problem to achieve a 3D dielectric map from the recorded voltages and optionally providing a 3D image of the body tissues based on the 3D dielectric map.

Abstract: Methods and devices for tying management of an implantable medical device to the activities of a primary care physician are described, including access control, simplified parameter optimization, support for tuning a device in response to the effects of other treatments in parallel, and support for helping a primary physician and a patient work together to tune device configuration to the activity and performance needs of the patient. In some embodiments, a medical device is self-configuring in a device parameter domain, based on inputs provided in a patient performance domain. The self-configuring of the medical device is based, for example, on an automatically applied transformation of inputs derived from patient performance domain observations into changes in the configuration of the medical device which affect technical parameters of its operation.

Abstract: A method for selecting an implantation position of a pacing electrode of a pacing lead within an anatomical region of a body, comprising measuring values of at least one parameter of an anatomical region surrounding the pacing lead in at least one location. The method also comprises delivering an electric field to a tissue of the anatomical region, and measuring values of at least one parameter of the tissue surrounding the pacing lead in the at least one location after said delivering. The method further comprises determining changes in said measured values before and after said delivering and selecting an implantation position for the pacing electrode based on said determined changes.

Abstract: An N-M tomography system comprising: a carrier for the subject of an examination procedure; a plurality of detector heads; a carrier for the detector heads; and a detector positioning arrangement operable to position the detector heads during performance of a scan without interference or collision between adjacent detector heads to establish a variable bore size and configuration for the examination. Additionally, collimated detectors providing variable spatial resolution for SPECT imaging and which can also be used for PET imaging, whereby one set of detectors can be selectably used for either modality, or for both simultaneously.

Abstract: A tissue imaging method of imaging a target tissue including: providing a plurality of hardware electrodes; sending and receiving electrical signals using the plurality of hardware electrodes to produce measurement data; selecting a virtual electrode model, where each the virtual electrode includes two or more hardware electrodes; processing the measurement data using the virtual electrode model to provide a processed data output; and reconstructing an image using the processed data output.

Abstract: An N-M tomography system comprising: a carrier for the subject of an examination procedure; a plurality of detector heads; a carrier for the detector heads; and a detector positioning arrangement operable to position the detector heads during performance of a scan without interference or collision between adjacent detector heads to establish a variable bore size and configuration for the examination. Additionally, collimated detectors providing variable spatial resolution for SPECT imaging and which can also be used for PET imaging, whereby one set of detectors can be selectably used for either modality, or for both simultaneously.

Abstract: Devices and methods for RF heating of food, using techniques which allow uniformity and/or controlled non-uniformity.

Abstract: Methods and systems of computing parameter values of one or more model parameters are described. The model models structural and dielectric properties of a structure in a human or an animal body. An exemplary method includes: accessing voltage measurements made at different places in the vicinity of the structure by one or more in-body field sensing electrodes in response to currents applied to one or more field supplying electrodes; and computing the parameter values by adjusting the parameter values to fit predicted voltage values to the accessed voltage measurements, wherein the predicted voltage values are predicted from the model for the currents applied to the field supplying in-body electrodes.

Abstract: Methods and devices for tying management of an implantable medical device to the activities of a primary care physician are described, including access control, simplified parameter optimization, support for tuning a device in response to the effects of other treatments in parallel, and support for helping a primary physician and a patient work together to tune device configuration to the activity and performance needs of the patient. In some embodiments, a medical device is self-configuring in a device parameter domain, based on inputs provided in a patient performance domain. The self-configuring of the medical device is based, for example, on an automatically applied transformation of inputs derived from patient performance domain observations into changes in the configuration of the medical device which affect technical parameters of its operation.

Abstract: A method of performing conductivity-based imaging is disclosed comprising exciting at least one pair of electrodes according to an excitation scheme. The at least one pair of electrodes comprising a surface electrode located on the surface of an examined body and at least one in-body electrode located inside of the examined living body. Voltages developing on the surface electrodes and on the in-body electrodes during the excitation according to the excitation scheme arc measured, an inverse problem is solved to achieve a 3D conductivity map from the measured voltages, and a 3D image of the body tissues based on the 3D conductivity map is provided.

Abstract: A method of evaluating electrical impedance across a gap between a first catheter electrode and a second catheter electrode, both carried on a same catheter is provided. The method includes: receiving measurements of electrical voltages; and evaluating the electrical impedance across the gap based on the measurements of the electrical voltages. In some embodiments, the electrical voltages include: a first electrical voltage, which is a voltage measured between a reference electrode and the first catheter electrode measured under a first alternating electrical current having a first frequency and flowing through a conductor from an electrical source to the first catheter electrode, and a second electrical voltage, which is a voltage measured between the reference electrode and the second catheter electrode under the first alternating electrical current.

Abstract: Systems and method for remote field measurement-based mapping of anatomical structures (e.g., using impedance image of electrical fields) are described. In some embodiments, an image of features within a target region is produced by analysis of a spatial pattern of field measurements made in a measurement region remote from the target region features; for example, but not exclusively, by treating the spatial arrangement of field measurements in some portion of the measurement region as indicating the spatial (e.g., angular and/or distance) arrangement of features (e.g., anatomical structure of topography and/or tissue type) in the target region.