Patents by Inventor Shlomo Margel

Shlomo Margel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090311192
    Abstract: Nanoparticles having an average particle size of less than 2000 nm, wherein said nanoparticles comprise a polymer having pendant cleavable iodine substituted groups are provided. Processes for preparing the nanoparticles and their use as a contrast agent for X-ray imaging are also described.
    Type: Application
    Filed: April 4, 2006
    Publication date: December 17, 2009
    Applicant: Bar-Ilan University
    Inventors: Shlomo Margel, Anna Galperin
  • Patent number: 7550282
    Abstract: Thrombin-conjugated nanoparticles, wherein said nanoparticles comprise one or more organic and/or inorganic compounds and process for preparing the same are provided. The thrombin-conjugated nanoparticles are suitable for use in the preparation of fibrin-based biological sealant.
    Type: Grant
    Filed: November 18, 2003
    Date of Patent: June 23, 2009
    Assignee: Bar-Ilan University
    Inventors: Shlomo Margel, Larisa Sheihet, Tamar Tennenbaum
  • Publication number: 20090110644
    Abstract: The invention provides nanoparticles consisting of a polymer which is a metal chelating agent coated with a magnetic metal oxide, wherein at least one active agent is covalently bound to the polymer, said nanoparticles may optionally further comprise at least one active agent physically or covalently bound to the outer surface of the magnetic metal oxide. Pharmaceutical compositions comprising these nanoparticles may be used, inter alia, for detection and treatment of tumors and inflammations.
    Type: Application
    Filed: September 24, 2008
    Publication date: April 30, 2009
    Inventors: Shlomo Margel, Benny Perlstein, Chaya Brodie, Tom Mikkelsen
  • Publication number: 20060104970
    Abstract: Thrombin-conjugated nanoparticles, wherein said nanoparticles comprise one or more organic and/or inorganic compounds and process for preparing the same are provided. The thrombin-conjugated nanoparticles are suitable for use in the preparation of fibrin-based biological sealant.
    Type: Application
    Filed: November 18, 2003
    Publication date: May 18, 2006
    Applicant: Bar-Ilan University
    Inventors: Shlomo Margel, Larisa Sheihet, Tamar Tennenbaum
  • Patent number: 6103379
    Abstract: A process for the preparation of a microsphere comprising a coating composed of one or more silica nanoparticles layers, comprises the steps of: a) providing a microsphere of polymeric material, the said microsphere having adsorbed on its surface one or more surfactants; and b) causing a layer of silica nanoparticles to coat the surface of the said microsphere by means of seeded polymerization of alkyl silicates onto the surface of said microsphere.
    Type: Grant
    Filed: April 3, 1997
    Date of Patent: August 15, 2000
    Assignee: Bar-Ilan University
    Inventors: Shlomo Margel, Hanna Bamnolker
  • Patent number: 5855987
    Abstract: Polymers containing a plurality of free hydroxy groups, such as cellulose, agarose or polyvinyl alcohol, are contacted in absence of reactants for hydroxy groups, with at least one N-heterocyclic compound, e.g. pyridine, pyrrole, pyridazine, their partially or fully hydrogenated analogs and any of these which may be substituted, in a pre-activation step prior to reaction with reactant for free hydroxy groups in the polymer, the polymer-bound residue of which reactant may be thereafter reacted in turn with amino compounds containing at least one unsubstituted N-attached hydrogen atom, e.g. proteins, thereby to form amine-polymer conjugates. The invention further relates to a powder, bandage, patch or like cover for application to wounds which has been manufactured from polymer containing a plurality of hydroxy groups by a process which includes the step of providing an amine conjugated to the polymer; the amine may be, e.g., trypsin, chymotrypsin, lysozyme, collagenase, albumin and hyaluronidase.
    Type: Grant
    Filed: April 4, 1995
    Date of Patent: January 5, 1999
    Assignee: Bar Ilan University
    Inventors: Shlomo Margel, Sophia Sturchak
  • Patent number: 5652059
    Abstract: A composition of matter includes a solid substrate having covalent bonds, provided by a connecting ligand, to at least one of (a) and (b), namely: (a) a single layer of at least one species of microspheres containing residual reactive functions; (b) a multiplicity of layers of at least one species of microspheres, wherein adjoining layers of multiplicity of layers are covalently linked together, the innermost layer of the multiplicity of layers having the covalent bonds to the solid substrate connected thereto, while at least the outermost layer of the multiplicity of layers contains residual reactive functions; the species of microspheres being selected from microspheres of silica, polyacrylic acid, polyglutaraldehyde, polyacrolein, poly(chloromethylated styrene) and albumin. At least some of the residual reactive functions may be used to immobilize drugs, prodrugs, proteins, biological cells and other controllably releasable substances.
    Type: Grant
    Filed: January 25, 1995
    Date of Patent: July 29, 1997
    Assignee: Bar Ilan University
    Inventor: Shlomo Margel
  • Patent number: 5516673
    Abstract: Polymers containing a plurality of free hydroxy groups, such as cellulose, agarose or polyvinyl alcohol, are contacted in absence of reactants for hydroxy groups, with at least one N-heterocyclic compound, e.g. pyridine, pyrrole, pyridazine, their partially or fully hydrogenated analogs and any of these which may be substituted, in a pre-activation step prior to reaction with reactant for free hydroxy groups in the polymer, the polymer-bound residue of which reactant may be thereafter reacted in turn with amino compounds containing at least one unsubstituted N-attached hydrogen atom, e.g. proteins, thereby to form amine-polymer conjugates. The invention further relates to a powder, bandage, patch or like cover for application to wounds which has been manufactured from polymer containing a plurality of hydroxy groups by a process which includes the step of providing an amine conjugated to the polymer; the amine may be, e.g., trypsin, chymotrypsin, lysozyme, collagenase, albumin and hyaluronidase.
    Type: Grant
    Filed: February 10, 1994
    Date of Patent: May 14, 1996
    Assignee: Bar Ilan University
    Inventors: Shlomo Margel, Sophia Sturchak
  • Patent number: 4861705
    Abstract: There are provided magnetic and non-magnetic agarose and agar polyaldehyde beads with diameters ranging from 40 microns up to 1 cm, and processes for the synthesis of such beads. The polyaldehyde compounds e.g. polyacrolein, polymethacrolein or polyglutaraldehyde, were used as microspheres or as powders. The agarose-polyaldehyde beads are capable of covalently binding in a single step, through their aldehyde groups, compounds containing primary amino groups or thiol groups, such as proteins, antibodies, enzymes and drugs. The beads are useful for various biological applications e.g. affinity chromatography, hemoperfusion, ion exchange resins, cell labeling, diagnostic purposes and cell separation.
    Type: Grant
    Filed: October 22, 1986
    Date of Patent: August 29, 1989
    Assignee: Yeda Research and Development Company, Ltd.
    Inventor: Shlomo Margel
  • Patent number: 4783336
    Abstract: Suspension polymerization of acrolein type compounds in the presence of appropriate surfactants results in the formation of microspheres in size ranging from 0.03 to 80 microns. Fluorescent and magnetic microspheres are obtained by carrying out the same polymerization in the presence of appropriate fluorochromic or ferrofluidic compounds, respectively. Hybrido-polyacrolein microspheres are obtained by grafting one type of such microspheres on another type. Immunomicrospheres were formed by binding covalently at physiological pH appropriate proteins to the microspheres. The immunomicrospheres can be used for various biological applications, such as specific markers for labeling cell surface receptors, for cell separation, for diagnostic purposes, etc.
    Type: Grant
    Filed: September 4, 1985
    Date of Patent: November 8, 1988
    Assignee: Yeda Research and Development Company, Ltd.
    Inventors: Shlomo Margel, Uzi Beitler
  • Patent number: 4732811
    Abstract: There are provided magnetic and non-magnetic agarose and agar polyaldehyde beads with diameters ranging from 40 microns up to 1 cm, and processes for the synthesis of such beads. The polyaldehyde compounds e.g. polyacrolein, polymethacrolein or polyglutaraldehyde, were used as microspheres or as powders. The agarose-polyaldehyde beads are capable of covalently binding in a single step, through their aldehyde groups, compounds containing primary amino groups of thiol groups, such as proteins, antibodies, enzymes and drugs. The beads are useful for various biological applications e.g. affinity chromatography, hemoperfusion, ion exchange resins, cell labeling, diagnostic purposes and cell separation.
    Type: Grant
    Filed: October 22, 1986
    Date of Patent: March 22, 1988
    Assignee: Yeda Research and Development Company, Ltd.
    Inventor: Shlomo Margel
  • Patent number: 4677138
    Abstract: Homopolymeric polyaldehyde microspheres can be prepared in yields of up to about 90% by preparing an aqueous solution consisting essentially of a suitable concentration of an .alpha.,.beta.-ethylenically unsaturated aldehyde and a suitable concentration of an appropriate surfactant under suitable conditions such that the surfactant has a net electrostatic charge. The solution, which may also contain a ferrofluidic material, fluorescent dye or additional solvent, is then irradiated under an inert atmosphere with a sufficient dose of .gamma.-radiation to effect polymerization and the monodisperse homopolymeric polyaldehyde microspheres so produced are recovered. Copolymeric polyaldehyde microspheres can be prepared by adding to the solution a suitable concentration of a copolymerizable comonomer before initiating polymerization.
    Type: Grant
    Filed: October 19, 1984
    Date of Patent: June 30, 1987
    Assignee: Yeda Research and Development Co., Ltd.
    Inventor: Shlomo Margel
  • Patent number: 4624923
    Abstract: A metal-containing polyaldehyde microsphere composed of a polyaldehyde microsphere to which a transition metal, e.g. Au, Ag, Pt, Pd, Tc, Fe, Ni or Co, is bound may be obtained in accordance with this invention. The polyaldehyde, e.g. polyacrolein or polyglutaraldehyde, may be encapsulated in agarose, and the microsphere may be radioactive or magnetic. The microphere may additionally have a compound having at least one amine group, e.g. a drug, antibody, antigen, enzyme or other protein, bound to its surface.In one embodiment a transition metal is bound to a polyaldehyde microsphere by contacting the polyaldehyde microsphere with a suitable amount of an appropriate salt or acid of the transition metal under suitable conditions so as to cause the salt or acid to be reduced to a lower valence state and to bind to the microsphere. Some salts or acids may thus be reduced to the elemental state; others are further reduced with an appropriate reducing agent.
    Type: Grant
    Filed: January 24, 1986
    Date of Patent: November 25, 1986
    Assignee: Yeda Research and Development Company Limited
    Inventor: Shlomo Margel
  • Patent number: 4552812
    Abstract: Suspension polymerization of acrolein type compounds in the presence of appropriate surfactants results in the formation of microspheres in size ranging from 0.03.mu. to 80.mu.. Fluorescent and magnetic microspheres are obtained by carrying out the same polymerization in the presence of appropriate fluorochromic or ferrofluidic compounds, respectively. Hybrido polyacrolein microspheres are obtained by grafting one type of such microspheres on another type. Immunomicrospheres were formed by binding covalently at physiological pH appropriate proteins to the microspheres. The immunomicrospheres can be used for various biological applications, such as specific markers for labelling cell surface receptors, for cell separation, for diagnostic purposes, etc.
    Type: Grant
    Filed: December 14, 1981
    Date of Patent: November 12, 1985
    Assignee: Yeda Research and Development Company
    Inventors: Shlomo Margel, Uzi Beitler
  • Patent number: 4267235
    Abstract: Suspension polymerization of aqueous glutaraldehyde in basic conditions in presence of surfactants such as isobutoxy acrylamide copolymers and/or cross-linking agents yield cross-linked, water insoluble glutaraldehyde polymer microspheres ranging in size from 200 A to 10.mu.. Addition of fluorochromes, e.g., FITC, during polymerization yields microspheres of high fluorescent intensity and addition of a suspension of metal containing particles such as Fe.sub.3 O.sub.4 during polymerization yields magnetic microspheres. Immunopolyglutaraldehyde microspheres can be obtained by interacting the polyglutaraldehyde microspheres with antibodies. The immunomicrospheres were used to label and separate cell subpopulations. The labeling specificity is considerably improved by increasing the amount of isobutoxy polyacrylamide incorporated in the microspheres.
    Type: Grant
    Filed: March 19, 1979
    Date of Patent: May 12, 1981
    Assignee: California Institute of Technology
    Inventors: Alan Rembaum, Shlomo Margel