Patents by Inventor Shmuel Bukshpan

Shmuel Bukshpan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210023143
    Abstract: The present invention relates to methods of using compositions comprising intact mitochondria and/or ruptured mitochondria for elevating lipid metabolism in cells. The present invention further provides methods for treating diseases which benefit from elevation of lipid and cholesterol metabolism and methods for inducing weight loss or reducing weight gain comprising administering compositions comprising intact mitochondria and/or ruptured mitochondria to a subject in need thereof.
    Type: Application
    Filed: March 26, 2019
    Publication date: January 28, 2021
    Inventors: Natalie Yivgi Ohana, Uriel Halavee, Shmuel Bukshpan
  • Patent number: 10702556
    Abstract: The present invention relates to compositions and methods of inducing angiogenesis and methods of treating a pathology that would benefit from angiogenesis by use of a composition comprising partially purified intact mitochondria and/or ruptured mitochondria derived therefrom.
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: July 7, 2020
    Assignee: Minovia Therpautices Ltd.
    Inventors: Natalie Yivgi-Ohana, Uriel Halavee, Shmuel Bukshpan
  • Publication number: 20200023005
    Abstract: The present invention relates to products and methods for treatment of hair loss. Specifically, the present application relates to compositions and methods for prevention and treatment of hair loss, comprising administration of a composition comprising intact mitochondria, ruptured mitochondria and/or mitochondrial constituents.
    Type: Application
    Filed: March 22, 2018
    Publication date: January 23, 2020
    Inventors: Natalie YIVGI-OHANA, Uriel HALAVEE, Shmuel BUKSHPAN
  • Patent number: 10325379
    Abstract: A biometric device that may include a sensor that reacts to a chemical element associated with a sweat gland; wherein when the sensor is contacted by an area of a skin of a person, an image that comprises information about locations of sweat glands within the area of the skin of the person is generated by the sensor; an image processor that is configured to generate an authentication result by comparing between (a) the information of the image generated by the sensor and (b) reference information of locations of sweat glands of a given person; wherein the authentication result indicates whether the person is the given person; and a communication module for communicating an authentication result indication.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: June 18, 2019
    Inventors: Shmuel Bukshpan, Uriel Halavee, Arie Heiman
  • Publication number: 20170116492
    Abstract: A biometric device that may include a sensor that reacts to a chemical element associated with a sweat gland; wherein when the sensor is contacted by an area of a skin of a person, an image that comprises information about locations of sweat glands within the area of the skin of the person is generated by the sensor; an image processor that is configured to generate an authentication result by comparing between (a) the information of the image generated by the sensor and (b) reference information of locations of sweat glands of a given person; wherein the authentication result indicates whether the person is the given person; and a communication module for communicating an authentication result indication
    Type: Application
    Filed: September 14, 2016
    Publication date: April 27, 2017
    Inventors: Shmuel Bukshpan, Uriel Halavee, Arie Heiman
  • Publication number: 20170027482
    Abstract: A wireless colorimetric sensor for detecting, quantifying, or both detecting and quantifying, at least one analyte in a sample, the sensor including a light transparent chemochromic layer applied onto the photoactive surface of an image sensor, or attached thereto via an optic coupler, wherein the chemochromic layer comprises a chemochromic material that is optically altered when contacted with the analyte. A method for detecting at least one analyte with a colorimetric sensor.
    Type: Application
    Filed: April 2, 2015
    Publication date: February 2, 2017
    Inventors: Gleb ZILBERSTEIN, Shmuel BUKSHPAN
  • Publication number: 20150260656
    Abstract: Disclosed is a method for detecting at least one analyte in a sample, which comprises applying a variable optical filter, comprising a chemochromic material that is sensitive to the analyte, to an optical lens of a camera, an optical lens of a multi-cell photosensor and/or to a multi-cell photosensor, contacting at least part of the chemochromic material with the sample, exposing at least part of the variable optical filter to electromagnetic radiation after at least part of the chemochromic material was exposed to the sample to obtain digital data regarding the chemochromic material that was contacted with the sample and processing the digital data and comparing said digital data with a reference.
    Type: Application
    Filed: October 22, 2013
    Publication date: September 17, 2015
    Applicant: SPECTROPHON LTD.
    Inventors: Gleb Zilberstein, Shmuel Bukshpan
  • Publication number: 20150079193
    Abstract: The present invention relates to compositions and methods of inducing angiogenesis and methods of treating a pathology that would benefit from angiogenesis by use of a composition comprising partially purified intact mitochondria and/or ruptured mitochondria derived therefrom.
    Type: Application
    Filed: May 16, 2013
    Publication date: March 19, 2015
    Inventors: Natalie Yivgi-Ohana, Uriel Halavee, Shmuel Bukshpan
  • Publication number: 20150024017
    Abstract: A solid buffer including one or more ion exchange materials, wherein said solid buffer has a volumetric buffering capacity greater than about 20 mM H+/(L·pH unit) and further wherein, when said material is in an environment capable of transporting H+ ions, said solid buffer is adapted to cause the death of at least one target cell within or in contact with said environment. A selectively permeable barrier layer may be provided covering the solid buffer.
    Type: Application
    Filed: April 11, 2014
    Publication date: January 22, 2015
    Applicant: OPLON PURE SCIENCE, LTD.
    Inventors: Shmuel BUKSHPAN, Gleb ZILBERSTEIN
  • Patent number: 8697102
    Abstract: A solid buffer including one or more ion exchange materials, wherein said solid buffer has a volumetric buffering capacity greater than about 20 mM H+/(L.pH unit) and further wherein, when said material is in an environment capable of transporting H+ ions, said solid buffer is adapted to cause the death of at least one target cell within or in contact with said environment. A selectively permeable barrier layer may be provided covering the solid buffer.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: April 15, 2014
    Assignee: Oplon B.V.
    Inventors: Shmuel Bukshpan, Gleb Zilberstein
  • Publication number: 20130040026
    Abstract: A method of producing a liquid substantially free of beverage spoiling microorganisms, characterized in that said method comprises steps of: (a) obtaining a liquid; (b) obtaining a bioactive material that does not affect a predetermined set of organoleptic parameters of said liquid upon contact with said concentrate for a predetermined length of time; and, (c) treating said liquid with said bioactive material until the concentration of beverage-spoiling microorganism falls below a predetermined threshold.
    Type: Application
    Filed: December 2, 2010
    Publication date: February 14, 2013
    Inventors: Shmuel Bukshpan, Gleb Zilberstein
  • Publication number: 20120135060
    Abstract: Provided herein are biocidic compositions including an ion exchange material, wherein when said material is in an environment capable of transporting H+, said ion exchange material is adapted to cause the death of at least one cell within or in contact with said environment. A selectively permeable barrier layer may be provided covering the ion exchange material. Also provided herein are methods of making the foregoing biocidic compositions. In addition, provided herein are methods of using the foregoing biocidic compositions to cause the death of at least one cell.
    Type: Application
    Filed: October 28, 2011
    Publication date: May 31, 2012
    Inventors: Shmuel BUKSHPAN, Avi SHANI, Gleb ZILBERSTEIN
  • Patent number: 8038792
    Abstract: The present invention relates to methods and apparatus for promoting rapid formation of biomolecule crystals from a solution of biomolecules, preferably proteins, wherein the protein solution undergoes rapid concentration according to its isoelectric point in an electric field. Protein crystallization according to the methods of the present invention takes place within a period of hours or less.
    Type: Grant
    Filed: November 4, 2008
    Date of Patent: October 18, 2011
    Inventor: Shmuel Bukshpan
  • Publication number: 20110112050
    Abstract: Methods and apparatus for the separation of polysaccharides, particular heparin products, and glycosylated molecules are provided. The separation is based on the molecular weight and charge, by application of an electric field across a low-friction matrix, modified with a charged separation agent comprising charged regions ordered in a monotonous sequence distributed throughout the matrix, to generate a charge density gradient formed when an external electric field is applied. Saccharides of different charges migrate differently across the porous matrix and immobilized by charge neutralization in different charge regions of the matrix.
    Type: Application
    Filed: May 20, 2009
    Publication date: May 12, 2011
    Applicant: CRYSTAL CLEAR PARTNERSHIP
    Inventors: Shmuel Bukshpan, Gleb Zilberstein
  • Patent number: 7914656
    Abstract: The present invention relates to matrixes, arrays, systems and methods for analyzing biomolecules by their isoelectric point, optionally, in combination with a second dimension analysis. The assortment of matrixes, arrays and systems provided herein are useful for causing a biomolecule under the influence of an electrical field to accumulate into an buffer that comprises a pH value that is the same as the isoelectric point of the biomolecule. The methods of this invention are useful for, e.g., research and diagnostic purposes.
    Type: Grant
    Filed: January 4, 2007
    Date of Patent: March 29, 2011
    Assignee: Protein Forest, Inc.
    Inventors: Shmuel Bukshpan, Gleb Zilbertstein
  • Publication number: 20100316697
    Abstract: The present invention provides methods and compositions for targeting a drug to a specific desired location, such as an intracellular location in a mammalian cell, by causing said drug to migrate along a pH gradient to the specific location, where the drug preferentially accumulates at a pH range of the specific location. Accordingly, the invention described herein is based on providing a drug which is “pH matched” with that of a particular location, such that the drug preferentially migrates to and accumulates at the pH or pH range at that location. The location may be a type of tissue, a type of cell, a sub-cellular location or an intracellular location, such as an organelle. Without being bound to any theory, the drug migrates along or across a pH gradient, and stops migrating and accumulates at a location of specific pH or range of pH at which the drug is energetically neutral, or where its diffusion potential is at a minimum.
    Type: Application
    Filed: May 7, 2008
    Publication date: December 16, 2010
    Applicant: CLEAR DIRECTION LTD.
    Inventors: Shmuel Bukshpan, Gleb Zilberstein
  • Publication number: 20100272768
    Abstract: A solid buffer including one or more ion exchange materials, wherein said solid buffer has a volumetric buffering capacity greater than about 20 mM H+/(L.pH unit) and further wherein, when said material is in an environment capable of transporting H+ ions, said solid buffer is adapted to cause the death of at least one target cell within or in contact with said environment. A selectively permeable barrier layer may be provided covering the solid buffer.
    Type: Application
    Filed: June 25, 2010
    Publication date: October 28, 2010
    Applicant: OPLON B.V.
    Inventors: Shmuel BUKSHPAN, Gleb ZILBERSTEIN
  • Patent number: 7794698
    Abstract: A method of generating a change in a cellular process of a target cell is disclosed. The method comprises contacting the target cell with a solid buffer, so as to alter an intracellular pH value in at least a portion of the cell, thereby generating the change in a cellular process of a target cell of a multicellular organism. The method may be used to kill either eukaryotic or prokaryotic cells. Pharmaceutical compositions and devices are also enclosed.
    Type: Grant
    Filed: November 1, 2006
    Date of Patent: September 14, 2010
    Assignee: Oplon B.V.
    Inventors: Shmuel Bukshpan, Gleb Zilberstein
  • Publication number: 20100178268
    Abstract: The present invention presents a biocidic packaging for cosmetics and/or foodstuffs, comprises at least one insoluble proton sink or source (PSS). The packaging is provided useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of said LTC upon contact. The PSS comprises, inter alia, (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of said LTCs' environment. The present invention also discloses a method for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of said LTC being in a packaging, especially cosmetic or foodstuffs' packaging.
    Type: Application
    Filed: April 3, 2008
    Publication date: July 15, 2010
    Applicant: OPLON B.V.
    Inventors: Shmuel Bukshpan, Gleb Zilberstein
  • Publication number: 20100133114
    Abstract: Means and methods for deterring biofilm in water supply systems, comprising at least one insoluble proton sink or source (PSS). The means and methods for deterring biofilm is provided useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact. The PSS comprises, inter alia, (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of the LTCs' environment.
    Type: Application
    Filed: April 3, 2008
    Publication date: June 3, 2010
    Applicant: OPLON B.V.
    Inventors: Shmuel Bukshpan, Gleb Zilberstein