Abstract: There is provided a liquid discharge head including: a plurality of individual channels arranged in a row in a first direction; an inflow channel extending in the first direction and connected to the plurality of individual channels; and an outflow channel extending in the first direction and connected to the plurality of individual channels, wherein first connecting parts connected respectively to the plurality of individual channels are provided on both end parts in a second direction of an upper surface of the outflow channel, the second direction being horizontal and orthogonal to the first direction; the upper surface of the outflow channel has a convex part having a shape which is, as projected in the first direction, convex upward; and a highest point of the convex part is located, in the second direction, between the both end parts in the second direction of the upper surface of the outflow channel.

Abstract: Disclosed herein are anti-Galectin-9 antibodies and methods of using such for inhibiting a signaling pathway mediated by Galectin-9 or eliminating pathologic cells expressing Galectin-9. Such anti-Galectin-9 antibodies may also be used to diagnose and/or to treat diseases associated with Galectin-9, such as autoimmune diseases and solid tumors.

Abstract: The present invention provides modified fibronectin type III (Fn3) molecules, and nucleic acid molecules encoding the modified Fn3 molecules. Also provided are methods of preparing these molecules, and kits to perform the methods.

Abstract: Disclosed herein are anti-Galectin-9 antibodies and methods of using such for inhibiting a signaling pathway mediated by Galectin-9 or eliminating pathologic cells expressing Galectin-9. Such anti-Galectin-9 antibodies may also be used to diagnose and/or to treat diseases associated with Galectin-9, such as autoimmune diseases and solid tumors.

Abstract: Disclosed herein are antibodies specific to a delta1 chain of a ?? T cell receptor and methods of using such for modulating ?? T cell bioactivity. Such anti-Delta1 antibodies may also be used to treat diseases associated with ?? T cell activation, such as solid tumors, or for detecting presence of ??1 T cells.

Abstract: Disclosed herein are anti-Galectin-9 antibodies and methods of using such for inhibiting a signaling pathway mediated by Galectin-9 or eliminating pathologic cells expressing Galectin-9. Such anti-Galectin-9 antibodies may also be used to diagnose and/or to treat diseases associated with Galectin-9, such as autoimmune diseases and solid tumors.

Abstract: There is provided a printer including first to fourth head chips, and first and second rollers. The first to fourth head chips are arranged at intervals in a second direction orthogonal to a first direction. A nozzle, of nozzles arranged in a second head chip N and used for printing, which is positioned closest to the one side in the second direction is referred to as a nozzle A. A nozzle, of nozzles arranged in a fourth head chip N and used for printing, which is positioned closest to the one side in the second direction is referred to as a nozzle B. The nozzle A is arranged closer to the one side in the second direction than the nozzle B and the first roller is arranged closer to the other side in the second direction than the second roller.

Abstract: Embodiments concern compositions and methods involving recombinant antibodies to histone post-translational modifications. The invention provides compositions and methods for histone methyltransferase assays. In certain embodiments, the compositions and methods involve a recombinant antibody that binds histone H3 fragment harboring biomarkers such as H3K9me3 mark, H3K4me3 mark, H3K36me3 mark, H3K27me3, H3K9me3 and H3S10phos or a recombinant antibody that binds histone H4 fragment harboring H4K20me3 mark.

Abstract: A liquid discharge apparatus is provided, including a liquid discharge head including: an upper substrate, a plurality of piezoelectric elements, an intermediate substrate, a lower substrate and a plurality of individual traces arranged on the upper substrate and extending toward the contacts arranged on the one end side in the second direction from the plurality of piezoelectric elements respectively.

Abstract: A liquid ejection apparatus is disclosed. One apparatus includes a nozzle through which fluid is ejected or purged, and a pressure regulating valve arranged upstream of the nozzle. The pressure regulating valve is configured to open in response to an open/close pressure differential of the fluid across the pressure regulating valve. The pressure regulating valve is configured to controllably regulate the open/close pressure differential. The apparatus further includes a controller configured to, when a suction pump is being operated to perform a first purging operation comprising creating a first negative pressure through suctioning by the suction pump to purge the fluid through the nozzle, control the pressure regulating valve to set the open/close pressure differential of the pressure regulating valve to a first value.

Abstract: The present invention provides a fibronectin type III (Fn3) molecule, wherein the Fn3 contains a stabilizing mutation. The present invention also provides Fn3 polypeptide monobodies, nucleic acid molecules encoding monobodies, and variegated nucleic acid libraries encoding such monobodies. Also provided are methods of preparing a Fn3 polypeptide monobody, and kits to perform the methods.

Abstract: A liquid discharge apparatus is provided, including a liquid discharge head including: an upper substrate, a plurality of piezoelectric elements, an intermediate substrate, a lower substrate and a plurality of individual traces arranged on the upper substrate and extending toward the contacts arranged on the one end side in the second direction from the plurality of piezoelectric elements respectively.

Abstract: Aspects of the disclosure relate to compositions of enzyme-binding polypeptides (EBPs) that modify the substrate specificity of an enzyme and a method for identifying an EBP that modifies substrate specificity of an enzyme binding at least one substrate, the method comprising: contacting the enzyme with a polypeptide library comprising a plurality of EBPs that bind different epitopes of the enzyme; identifying EBPs that bind to the enzyme to form an EBP-enzyme complex; assaying for the activity level and substrate specificity of the EBP-enzyme complex; and identifying EBPs that modify the substrate specificity of the enzyme by identifying EBPs that, when in an EBP-enzyme complex, have a different substrate specificity than un-complexed EBP; wherein the catalytic rate constant of the EBP-enzyme complex is ?50% of the un-complexed enzyme for at least one substrate and/or wherein the EBP-enzyme complex retains binding to a substrate.

Abstract: There is provided a printer including first to fourth head chips, and first and second rollers. The first to fourth head chips are arranged at intervals in a second direction orthogonal to a first direction. A nozzle, of nozzles arranged in a second head chip N and used for printing, which is positioned closest to the one side in the second direction is referred to as a nozzle A. A nozzle, of nozzles arranged in a fourth head chip N and used for printing, which is positioned closest to the one side in the second direction is referred to as a nozzle B. The nozzle A is arranged closer to the one side in the second direction than the nozzle B and the first roller is arranged closer to the other side in the second direction than the second roller.

Abstract: There is provided an ink jet printer including a carriage, and an ink jet head. The ink jet head has two first nozzle groups to jet a first ink, two second nozzle groups to jet a second ink, and two third nozzle groups to jet the second ink. Each of the first, second and third nozzle groups includes a plurality of nozzles arrayed at a pitch P along a second direction. The second nozzle groups accord respectively with the first nozzle groups in terms of nozzle position in the second direction, the third nozzle groups are dislocated respectively from the second nozzle groups in terms of nozzle position in the second direction, and any two groups selected from the first and second nozzle groups are arranged respectively on two opposite sides of each of the third nozzle groups in the first direction.

Abstract: A liquid ejecting head, including a flow-path unit that includes: first and second nozzle groups disposed alongside each other in a second direction orthogonal to a first direction in which nozzles are arranged; first and second common liquid chambers respectively communicating with the first and second nozzle groups, the first and second common liquid chambers being disposed alongside each other in the second direction; a liquid supply opening communicating with the first common liquid chamber and a liquid discharge opening communicating with the second common liquid chamber, on one side of the flow-path unit in the first direction; and a connecting path connecting the first and second common liquid chambers on the other side of the flow-path unit in the first direction, wherein the first common liquid chamber is disposed nearer to an outer periphery of the flow-path unit in the second direction than the second common liquid chamber.

Abstract: The invention provides a molecular affinity clamp. The architecture of the affinity clamp is modular with two biorecognition modules, each capable of binding a target motif. The first biorecognition module has a recognition domain that possesses inherent or natural specificity for the target motif. The second biorecognition module also has a recognition domain that binds the motif. The two biorecognition modules are tethered together either directly, e.g., via a peptide bond between the two modules, or indirectly, e.g., via a linker moiety or linker.

Abstract: A liquid discharge apparatus is provided, including a liquid discharge head including: an upper substrate, a plurality of piezoelectric elements, an intermediate substrate, a lower substrate and a plurality of individual traces arranged on the upper substrate and extending toward the contacts arranged on the one end side in the second direction from the plurality of piezoelectric elements respectively.

Abstract: There is provided a printer including first to fourth head chips, and first and second rollers. The first to fourth head chips are arranged at intervals in a second direction orthogonal to a first direction. A nozzle, of nozzles arranged in a second head chip N and used for printing, which is positioned closest to the one side in the second direction is referred to as a nozzle A. A nozzle, of nozzles arranged in a fourth head chip N and used for printing, which is positioned closest to the one side in the second direction is referred to as a nozzle B. The nozzle A is arranged closer to the one side in the second direction than the nozzle B and the first roller is arranged closer to the other side in the second direction than the second roller.

Abstract: The present invention provides a fibronectin type III (Fn3) molecule, wherein the Fn3 contains a stabilizing mutation. The present invention also provides Fn3 polypeptide monobodies, nucleic acid molecules encoding monobodies, and variegated nucleic acid libraries encoding such monobodies. Also provided are methods of preparing a Fn3 polypeptide monobody, and kits to perform the methods.