Abstract: A liquid ejection head includes a nozzle, a pressure chamber configured to receive a pressure to eject liquid from the nozzle, a descender, and a communication channel. The descender has a first end and a second end opposite to each other. The first end is connected to the pressure chamber. The communication channel is connected to the second end and extends from a connection with the second end in an X direction. A first direction in which the descender extends from the second end toward the first end is inclined toward the communication channel relative to a Y direction orthogonal to the X direction.

Abstract: Disclosed herein are antibodies specific to a delta-1 chain of a ?? T cell receptor and methods of using such for modulating ?? T cell bioactivity. Such anti-Delta 1 antibodies may also be used to treat diseases associated with ?? T cell activation, such as solid tumors, or for detecting presence of ??1 T cells.

Abstract: A liquid discharge head includes: first and second common channels extending in a first direction; and individual channels including pressure chambers and nozzles. Each of the individual channels includes: a supply portion; a descender portion extending in a second direction; and a return portion extending in a third direction. The return portion includes: a throttle portion; and a wide portion. Each of the nozzles overlaps with the wide portion. A relationship of L2>L1 is satisfied, wherein L1 is a distance in the third direction from a center of each of the nozzles to a throttle starting position, and L2 is a distance in the third direction passing through a center in a cross section of the descender portion and ranging from a center line parallel to the second direction to the center of each of the nozzles.

Abstract: A liquid discharging head includes: a first member having a surface in which first openings are formed, the first openings arranged in a first direction and communicating with individual channels; a second member disposed at one side in a second direction with respect to the first member, the second member having: a space extending in the first direction and communicating with the first openings; and a second opening disposed at the first side in the second direction with respect to the space and communicating with the space; and a third member disposed between the first member and the second member in the second direction and having a communicating hole extending in the first direction and allowing the first openings to communicate with the space. The third member has a wall dividing the communicating hole into partial holes separated from each other in the first direction.

Abstract: There is provide a liquid discharge head including: a supply manifold; a feedback manifold; and a plurality of individual flow channels having: a supply portion, a descender portion, and a feedback portion. The supply manifold has a plurality of supply ports, and the feedback manifold has a plurality of feedback ports. At least part of the supply manifold overlaps with the feedback manifold in the second direction. The plurality of pressure chambers have first pressure chambers forming a first pressure chamber array and second pressure chambers forming a second pressure chamber array. The first pressure chamber array is arranged at one side, of the supply manifold, in a third direction and the second pressure chamber array is arranged at the other side, of the supply manifold, in the third direction. The first pressure chamber array and the second pressure chamber array are connected to the supply manifold.

Abstract: In a liquid ejection head, an ejection pressure is applied to a pressure chamber for liquid ejection from a nozzle. A descender extends in a first direction and includes a first end connected to the pressure chamber and a second end. A communication passage is connected to the second end, extends in a second direction crossing the first direction, and has a first dimension in the first direction. The nozzle is positioned at the communication passage such that a shortest distance between an outer periphery thereof and a center of the second end is greater than 0.5 times a second dimension of the second end in the second direction. When viewed in the first direction, the center of the second end and a center of a cross-section defined by the nozzle to be orthogonal to an extending direction of the nozzle intersect an axis of the communication passage.

Abstract: A liquid ejection head includes a supply manifold, a return manifold, a plurality of individual channels, and a connecting throttle channel. The supply manifold includes a supply port through which liquid is supplied from an exterior. The return manifold includes a return port through which liquid is discharged to the exterior. Each individual channel is connected, at an upstream end thereof, to the supply manifold and, at a downstream end thereof, to the return manifold. Each individual channel communicates with a corresponding one of nozzles and includes an individual throttle channel Through the connecting throttle channel, adjacent ones of the individual throttle channels communicate with each other. The connecting throttle channel has a channel resistance less than or equal to a channel resistance of each individual throttle channel.

Abstract: There is provide a liquid discharge head including: a supply manifold; a feedback manifold; and a plurality of individual flow channels having: a supply portion, a descender portion, and a feedback portion. The supply manifold has a plurality of supply ports, and the feedback manifold has a plurality of feedback ports. At least part of the supply manifold overlaps with the feedback manifold in the second direction. The plurality of pressure chambers have first pressure chambers forming a first pressure chamber array and second pressure chambers forming a second pressure chamber array. The first pressure chamber array is arranged at one side, of the supply manifold, in a third direction and the second pressure chamber array is arranged at the other side, of the supply manifold, in the third direction. The first pressure chamber array and the second pressure chamber array are connected to the supply manifold.

Abstract: A head module includes a pressure chamber, a piezoelectric member, a supply manifold, a return manifold, and a damper portion. The pressure chamber is configured to hold liquid therein and in fluid communication with a nozzle orifice. The piezoelectric member is configured to apply pressure to liquid held in the pressure chamber. The supply manifold is in fluid communication with the pressure chamber and configured to allow liquid to flow into the pressure chamber therefrom. The return manifold is in fluid communication with the pressure chamber and configured to allow liquid not ejected from the nozzle orifice to flow thereinto. The damper portion is positioned between the supply manifold and the return manifold when viewed in plan from a nozzle surface of the head module. The nozzle surface has the nozzle orifice defined therein. The damper portion includes a particular plate having a particular recessed portion.

Abstract: In a liquid ejection head, an ejection pressure is applied to a pressure chamber for liquid ejection from a nozzle. A descender extends in a first direction and includes a first end connected to the pressure chamber and a second end. A communication passage is connected to the second end, extends in a second direction crossing the first direction, and has a first dimension in the first direction. The nozzle is positioned at the communication passage such that a shortest distance between an outer periphery thereof and a center of the second end is greater than 0.5 times a second dimension of the second end in the second direction. When viewed in the first direction, the center of the second end and a center of a cross-section defined by the nozzle to be orthogonal to an extending direction of the nozzle intersect an axis of the communication passage.

Abstract: A liquid discharge head includes: a channel member having a nozzle surface and a back surface disposed separately from the nozzle surface, the channel member formed having nozzles arranged in the nozzle surface, individual channels connected to the nozzles, first and second common channels connected to the individual channels, a first opening that is opened in the back surface and communicates with an end of the first common channel, and a second opening that is opened in the back surface and communicates with an end of the second common channel, and a filter member disposed on the back surface and having a filter that covers the first opening. The second opening is not covered with the filter, and an area of the first opening is larger than an area of the second opening.

Abstract: A liquid ejection head includes a supply manifold, a return manifold, a plurality of individual channels, and a connecting throttle channel. The supply manifold includes a supply port through which liquid is supplied from an exterior. The return manifold includes a return port through which liquid is discharged to the exterior. Each individual channel is connected, at an upstream end thereof, to the supply manifold and, at a downstream end thereof, to the return manifold. Each individual channel communicates with a corresponding one of nozzles and includes an individual throttle channel. Through the connecting throttle channel, adjacent ones of the individual throttle channels communicate with each other. The connecting throttle channel has a channel resistance less than or equal to a channel resistance of each individual throttle channel.

Abstract: A liquid ejection head includes a supply manifold, a plurality of supply throttle channels, a plurality of pressure chambers, and a plurality of nozzles. The supply manifold includes a supply opening through which liquid is supplied from an exterior. The supply manifold extends in a first direction. Each of the supply throttle channels is connected, at one end thereof, to the supply manifold, and extends in a second direction. Each of the pressure chambers is connected to the other end of a corresponding one of the supply throttle channels, and extends in a third direction different from the first direction. Each of the nozzles communicates with a corresponding one of the pressure chambers. The second direction in which each of the supply throttle channels extends has a component of the first direction and a component of the third direction.

Abstract: A liquid ejection apparatus includes a supply manifold, a return manifold, and a plurality of individual channels. The supply manifold and the return manifold are elongate and vertically overlap each other, and liquid flows therein. Each individual channel connects the supply manifold and the return manifold and includes a supply throttle connected, at a supply-manifold-side opening thereof, to the supply manifold, a return throttle connected, at a return-manifold-side opening thereof, to the return manifold, a nozzle from which liquid is ejected, and a descender connecting the supply throttle and the return throttle, and connected to the nozzle. The supply-manifold-side opening of the supply throttle is positioned to vertically overlap a central area of the supply manifold in a width direction, and the return-manifold-side opening of the return throttle is positioned to vertically overlap a central area of the return manifold in the width direction.

Abstract: There is provided a liquid discharge apparatus configured to discharge a liquid, including a channel member for the liquid. The channel member is formed to include: a pressure chamber configured to contain the liquid; a nozzle configured to discharge the liquid; a connection channel connecting the pressure chamber and the nozzle; and a discharge channel which is connected to the connection channel so as to discharge the liquid in the connection channel or connected to the pressure chamber so as to discharge the liquid in the pressure chamber. An intersection line between an orthogonal plane orthogonal to an extending direction of the discharge channel and an upper surface of the discharge channel defining an upper portion of the discharge channel has an arc-like shape protruding upwardly.

Abstract: A platform technology provides particle and nucleic acid conjugates, and compositions thereof, with enhanced targeting to cells, tissues, organs. The particles and nucleic acids and other deliverables contain a synthetic binding protein such as a polypeptide monobody covalently conjugated to the surface of the particle or the nucleic acid, for linking a targeting agent to the particle's surface or the nucleic acid. The particles and nucleic acids and other deliverables optionally contain an antibody non-covalently conjugated to the binding protein, via an Fc domain of the antibody. The particles can include therapeutic agents, diagnostic agents, prophylactic agents, or a combination thereof, to be delivered to desired cells, tissues, and/or organs. The particles and nucleic acids and other deliverables can be used in a wide array of applications including, but not limited to, ex vivo perfusion of mammalian organs and in vivo disease treatment.

Abstract: A head module includes a pressure chamber, a piezoelectric member, a supply manifold, a return manifold, and a damper portion. The pressure chamber is configured to hold liquid therein and in fluid communication with a nozzle orifice. The piezoelectric member is configured to apply pressure to liquid held in the pressure chamber. The supply manifold is in fluid communication with the pressure chamber and configured to allow liquid to flow into the pressure chamber therefrom. The return manifold is in fluid communication with the pressure chamber and configured to allow liquid not ejected from the nozzle orifice to flow thereinto. The damper portion is positioned between the supply manifold and the return manifold when viewed in plan from a nozzle surface of the head module. The nozzle surface has the nozzle orifice defined therein. The damper portion includes a particular plate having a particular recessed portion.

Abstract: A liquid ejection head includes a stack structure including plates stacked and bonded with an adhesive agent, individual channels formed in the stack structure, dummy channels formed in the stack structure separately from the individual channels, and a first relief groove formed in the stack structure separately from the individual channels and configured to trap therein an excessive adhesive agent. Each individual channel includes a pressure chamber to which pressure is applied for liquid ejection form a nozzle, a supply throttle channel connected to the pressure chamber, and a return throttle channel communicating with the pressure chamber. The supply throttle channel and the return throttle channel each have a smaller cross-sectional area than the pressure chamber. The dummy channels include dummy chambers arranged laterally to an array of the pressure chambers arranged in an array direction. The first relief groove is connected to the dummy channels.

Abstract: A liquid discharge apparatus is provided, including a liquid discharge head including: an upper substrate, a plurality of piezoelectric elements, an intermediate substrate, a lower substrate and a plurality of individual traces arranged on the upper substrate and extending toward the contacts arranged on the one end side in the second direction from the plurality of piezoelectric elements respectively.

Abstract: The current application describes various compositions and methods for the production of FN3-based binding proteins with improved stability properties. Aspects of the disclosure relate to polypeptides comprising a variant fibronectin type III (FN3) domain from Sulfolobus tokodaii or Pyrococcus horikoshii comprising one or more amino acid substitutions or insertions in a loop region of FN3, in a non-loop region of FN3, or in both.