Patents by Inventor Shoji Takeuchi

Shoji Takeuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220088272
    Abstract: A graft is provided having a shell part that comes into contact with a body fluid when the graft is transplanted into a living body; and a core part that is located inside the shell part and does not substantially come into contact with the body fluid, in which the core part contains a plurality of first hydrogel fibers containing cells, the shell part contains a second hydrogel functioning as a semipermeable membrane, and the graft has a size with an outer diameter of greater than 1.5 mm.
    Type: Application
    Filed: November 7, 2019
    Publication date: March 24, 2022
    Inventors: Shoji TAKEUCHI, Fumisato OZAWA, Shogo NAGATA
  • Publication number: 20210371792
    Abstract: An object of the present invention is to provide an artificial tissue perfusion device capable of analyzing the interaction between a vascular cell layer and a parenchymal cell layer with high accuracy. An artificial tissue perfusion device includes a co-culture system (C) in which a plurality of types of cell are cultured. The co-culture system has a tubular well part (10) having a culture space (11) inside; a base material (20) having a perfusion flow path (26) which extends in a predetermined direction and is perfused with a medium, and a holding part (23) which opens to the perfusion flow path and holds the well part attachably and detachably; and a gel membrane (30) having a form of a porous membrane and disposed at an end portion of the well part facing the perfusion flow path in a case where the well part is held by the holding part.
    Type: Application
    Filed: December 28, 2018
    Publication date: December 2, 2021
    Applicant: The University of Tokyo
    Inventors: Shoji TAKEUCHI, Yuya MORIMOTO, Shogo NAGATA
  • Publication number: 20210340481
    Abstract: Provided are an alginate gel fiber for antibody production wherein an antibody-producing cell (for example, an antibody-producing CHO cell) is comprised in a core layer, and an antibody production method using the alginate gel fiber. An antibody production method is thereby additionally provided.
    Type: Application
    Filed: August 9, 2019
    Publication date: November 4, 2021
    Applicants: MOCHIDA PHARMACEUTICAL CO., LTD., THE UNIVERSITY OF TOKYO
    Inventors: Shoji FURUSAKO, Shoji TAKEUCHI
  • Publication number: 20210239044
    Abstract: A heat insulating sheet member capable of enhancing a heat insulating performance of an exhaust gas introduction path by an easy operation, including such a path in a turbocharger. The heat insulating sheet member is a bendable member formed from an inorganic flexible material. The heat insulating sheet member includes a first region corresponding to an inlet of a bottom wall portion, a second region corresponding to at least a terminating end portion of the scroll portion, a third region provided between the first region and the second region and corresponding to a coupling wall portion, and a fourth region corresponding to an outer peripheral wall portion. The first region and the third region, the third region and the second region, and the first region and the fourth region are coupled to each other with the inorganic flexible material in a continuous state.
    Type: Application
    Filed: June 24, 2019
    Publication date: August 5, 2021
    Inventor: Shoji Takeuchi
  • Publication number: 20200392439
    Abstract: An array includes a plurality of tubes disposed in contact with each other such that axial directions are parallel to each other; and a target substance disposed inside at least one of the plurality of tubes, in which the plurality of tubes are made of anionic hydrogel, and surfaces on which the plurality of tubes are in contact with each other are bonded with an adhesive including nanoparticles having surfaces coated with a cationic water-soluble polymer.
    Type: Application
    Filed: November 9, 2018
    Publication date: December 17, 2020
    Applicant: The University of Tokyo
    Inventors: Shoji Takeuchi, Haruka Yoshie, Ai Shima, Shogo Nagata
  • Publication number: 20200383618
    Abstract: [Problem] The present invention addresses the problem of providing: a novel fluorescent gel for glucose monitoring, whereby a concentration of glucose in a living body can be continuously measured and fibrosis of the gel can be suppressed even when the gel is implanted for a long period of time; and continuous glucose monitoring using the fluorescent gel. [Solution] A fluorescent gel for glucose monitoring, having a three-dimensional mesh structure in which a plurality of four-armed polymers having a polyethylene glycol skeleton are crosslinked at terminal ends thereof, wherein a fluorescent dye unit exhibiting a fluorescence response by bonding with glucose is immobilized in the gel structure by covalent bonding.
    Type: Application
    Filed: January 17, 2018
    Publication date: December 10, 2020
    Inventors: Shoji TAKEUCHI, Jun SAWAYAMA
  • Patent number: 10624991
    Abstract: The method for producing a three-dimensional artificial tissue is a method in which a three-dimensional artificial tissue extending in a predetermined direction is produced. The method includes: preparing a device including a culture tank having a culturing space surrounded by sidewalls, and a flow channel-forming member that penetrates through the sidewalls that face each other and is suspended in the culturing space along a predetermined direction; culturing cells in the culturing space and thereby forming a three-dimensional artificial tissue through which the flow channel-forming member penetrates; and removing the flow channel-forming member from the three-dimensional artificial tissue and thereby forming a perfusion flow channel that penetrates through the three-dimensional artificial tissue.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: April 21, 2020
    Assignee: THE UNIVERSITY OF TOKYO
    Inventors: Shoji Takeuchi, Yuya Morimoto, Nobuhito Mori
  • Patent number: 10221382
    Abstract: The present invention relates to a hollow microfiber comprising (1) one or more cell-adhesive layers having a cell-adhesive hydrogel, (2) an outer shell layer having a high-strength hydrogel that covers the outer periphery of the cell-adhesive layer that is positioned farthest from the center axis among the one or more cell-adhesive layers, and (3) a cell layer that covers the inner periphery of the cell-adhesive layer that is positioned closest to the center axis among the one or more cell-adhesive layers. The present invention also relates to a method of manufacturing the hollow microfiber and a kit for carrying out the manufacturing method.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: March 5, 2019
    Assignee: THE UNIVERSITY OF TOKYO
    Inventors: Shoji Takeuchi, Hiroaki Onoe, Shigenori Miura
  • Patent number: 10047353
    Abstract: Recombinant collagenases with a stable specific activity and enzyme agents for cell and tissue dissociation such a recombinant are provided. The recombinant collagenase is derived from Grimontia hollisae-derived collagenase is characterized by having, from the N terminus to the C terminus, a collagenase catalytic domain, a linker region sequence, and a prepeptidase C terminal domain, which Grimontia hollisae-derived recombinant collagenase does not comprise at least the prepeptidase C terminal domain. The obtained recombinant collagenase has a high and stable specific activity.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: August 14, 2018
    Assignees: Nippi, Incorporated, The University of Tokyo
    Inventors: Naoko Teramura, Katsumasa Iijima, Osamu Hayashida, Keisuke Tanaka, Shunji Hattori, Teru Okitsu, Shoji Takeuchi
  • Publication number: 20170274121
    Abstract: The method for producing a three-dimensional artificial tissue is a method in which a three-dimensional artificial tissue extending in a predetermined direction is produced. The method includes: preparing a device including a culture tank having a culturing space surrounded by sidewalls, and a flow channel-forming member that penetrates through the sidewalls that face each other and is suspended in the culturing space along a predetermined direction; culturing cells in the culturing space and thereby forming a three-dimensional artificial tissue through which the flow channel-forming member penetrates; and removing the flow channel-forming member from the three-dimensional artificial tissue and thereby forming a perfusion flow channel that penetrates through the three-dimensional artificial tissue.
    Type: Application
    Filed: June 30, 2015
    Publication date: September 28, 2017
    Applicant: The University of Tokyo
    Inventors: Shoji TAKEUCHI, Yuya MORIMOTO, Nobuhito MORI
  • Publication number: 20170218352
    Abstract: Recombinant collagenases with a stable specific activity and enzyme agents for cell and tissue dissociation such a recombinant are provided. The recombinant collagenase is derived from Grimontia hollisae-derived collagenase is characterized by having, from the N terminus to the C terminus, a collagenase catalytic domain, a linker region sequence, and a prepeptidase C terminal domain, which Grimontia hollisae-derived recombinant collagenase does not comprise at least the prepeptidase C terminal domain. The obtained recombinant collagenase has a high and stable specific activity.
    Type: Application
    Filed: March 6, 2015
    Publication date: August 3, 2017
    Inventors: Naoko Teramura, Katsumasa Iijima, Osamu Hayashida, Keisuke Tanaka, Shunji Hattori, Teru Okitsu, Shoji Takeuchi
  • Publication number: 20170130184
    Abstract: The present invention relates to a hollow microfiber comprising (1) one or more cell-adhesive layers having a cell-adhesive hydrogel, (2) an outer shell layer having a high-strength hydrogel that covers the outer periphery of the cell-adhesive layer that is positioned farthest from the center axis among the one or more cell-adhesive layers, and (3) a cell layer that covers the inner periphery of the cell-adhesive layer that is positioned closest to the center axis among the one or more cell-adhesive layers. The present invention also relates to a method of manufacturing the hollow microfiber and a kit for carrying out the manufacturing method.
    Type: Application
    Filed: May 20, 2015
    Publication date: May 11, 2017
    Inventors: Shoji TAKEUCHI, Hiroaki ONOE, Shigenori MIURA
  • Patent number: 9476834
    Abstract: A method for preparing a linearly extended supramolecular fiber or a plurality of linearly aligned supramolecular fibers, which comprises the step of allowing supramolecular monomers to be self-assembled in a microfluidic channel.
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: October 25, 2016
    Assignee: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Shoji Takeuchi, Hiroaki Onoe, Daisuke Kiriya, Itaru Hamachi, Masato Ikeda
  • Patent number: 9399789
    Abstract: Disclosed is a substrate (10A) for trapping a microorganism or cell (T), characterized by comprising a base (4) and having a space (2) into which a fluid (R) containing the microorganism or cell (T) is introduced and a microfine suction hole (1) through which the space (2) communicates with the outside of the base (4). The substrate is further characterized in that the space (2) has been formed in the base (4), and at least the portion of the base (4) which forms the microfine suction hole (1) is constituted of a single member.
    Type: Grant
    Filed: January 15, 2013
    Date of Patent: July 26, 2016
    Assignees: FUJIKURA LTD., THE UNIVERSITY OF TOKYO
    Inventors: Osamu Nukaga, Satoshi Yamamoto, Kazuhito Tabata, Masakazu Sugiyama, Shoji Takeuchi
  • Publication number: 20160120458
    Abstract: A skin gas measurement device includes a skin gas collecting unit that includes a skin gas collecting space having an opening that is to be attached to a skin surface, a porous material that is for adsorbing and concentrating a skin gas component that is emitted from the skin surface into the skin gas collecting space and that allows the adsorbed skin gas component to be desorbed at a relatively low temperature, and a heater for heating the porous material; and a skin gas measurement unit for measuring the skin gas component that is desorbed from the heated porous material.
    Type: Application
    Filed: May 26, 2014
    Publication date: May 5, 2016
    Applicants: NTT DOCOMO, INC., THE UNIVERSITY OF TOKYO
    Inventors: Yuuki YAMADA, Satoshi HIYAMA, Shoji TAKEUCHI, Tatsuya OKUBO, Keiji ITABASHI
  • Patent number: 8999443
    Abstract: A method for fabricating a microarray of plural soft materials includes: vapor-depositing a first layer poly(para-xylylene) resin on a substrate, forming a first micro pattern in the poly(para-xylylene) resin; obtaining a substrate including a first microarray formed by pouring a first soft material solution, freeze-drying the first soft material to obtain a micro-arrayed substrate of the freeze-dried first soft material; vapor-depositing a second layer poly(para-xylylene) resin on the micro-arrayed substrate of the freeze-dried first soft material, forming a second micro pattern placed differently from the first micro pattern by penetrating the poly(para-xylylene) resin of the first and second layers, forming a second microarray on the substrate by pouring a second soft material solution; and forming a microarray of the first and second soft materials on the substrate by peeling off the poly(para-xylylene) resin of the first and second layers.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: April 7, 2015
    Assignees: NTT DOCOMO, INC., The University of Tokyo
    Inventors: Satoshi Hiyama, Kaori Kuribayashi, Hiroaki Onoe, Shoji Takeuchi
  • Patent number: 8906644
    Abstract: A method for culturing hepatocytes, wherein hepatocytes embedded in an extracellular matrix is placed on a gas-permeable membrane and the hepatocytes are cultured while being supplied with oxygen from the gas-permeable membrane side. By this, the polarity in the hepatocytes can be induced and a bile canaliculus can be formed in a short period of time. Further, the formed polarity can be maintained for a longer period.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: December 9, 2014
    Assignees: The University of Tokyo, Mitsubishi Chemical Medience Corporation
    Inventors: Hitoshi Matsui, Yasuyuki Sakai, Teruo Fujii, Shoji Takeuchi, Yukiko Tsuda
  • Patent number: 8822722
    Abstract: To provide a fluorescent hydrogel having superior detectability of saccharides such as glucose and minimal invasiveness, a method for producing the same, and a sensor for measuring saccharides using the same. A florescent hydrogel having a structure represented by the following chemical formula 1, a method for producing the same, and a sensor for measuring saccharides using the same.
    Type: Grant
    Filed: September 7, 2011
    Date of Patent: September 2, 2014
    Assignees: Terumo Kabushiki Kaisha, The University of Tokyo
    Inventors: Yun-Jung Heo, Hideaki Shibata, Tetsuro Kawanishi, Shoji Takeuchi, Yukiko Matsunaga, Teru Okitsu
  • Patent number: 8785195
    Abstract: A microfiber showing improved mechanical strength, which comprises a micro gel fiber consisting of collagen gel or the like covered with high strength hydrogel such as alginate gel.
    Type: Grant
    Filed: October 12, 2010
    Date of Patent: July 22, 2014
    Assignee: The University of Tokyo
    Inventors: Shoji Takeuchi, Hiroaki Onoe, Yukiko Matsunaga, Daisuke Kiriya, Riho Gojo, Midori Negishi
  • Publication number: 20140010960
    Abstract: A method of producing a microstructured gel in a shape in accordance with a pattern comprises: dropping a polymerizable monomer aqueous solution containing a polymerizable monomer component onto a portion of a surface of a substrate having a pattern comprising a fine groove in the surface; moving by capillary action the polymerizable monomer aqueous solution along the groove constituting the pattern; and subjecting the polymerizable monomer aqueous solution in the groove to polymerization.
    Type: Application
    Filed: January 6, 2012
    Publication date: January 9, 2014
    Applicants: THE UNIVERSITY OF TOKYO, TERUMO KABUSHIKI KAISHA
    Inventors: Hideaki Shibata, Shoji Takeuchi, Yun-Jung Heo