Abstract: What is described are pharmaceutical compositions, formulations, and uses thereof, for medicaments for intranasal delivery of insulin to a patient, comprising an aqueous mixture of human insulin, a solubilizing agent, and a surface active agent, wherein the human insulin may be rapid actin insulin.

Abstract: Compositions and methods are provided that include a biologically active agent and a permeabilizing agent effective to enhance mucosal delivery of the biologically active agent in a mammalian subject, in which the permeabilizing peptide is a tight junction modulating peptide (TJMP), a TJMP analogue, a conjugate of a TJMP, a conjugate of a TJMP analogue, or complexes thereof. The permeabilizing agent reversibly enhances mucosal epithelial paracellular transport, typically by modulating epithelial junctional structure and/or physiology at a mucosal epithelial surface in the subject.

Abstract: Compounds and components including sequences for mucosal epithelial transport of an active agent are given. Tight junction modulating peptide components are described for use in transport and delivery. Permeability can be enhanced with reversibility. Compounds and components for enhanced delivery may be peptide or protein variants, conjugates, or other analog types and structures.

Abstract: A double-stranded RNA, preferably a small, interfering (si)RNA or a siHybrid, to which cholesterol moieties are linked.

Abstract: A method of fabricating a circuit board includes the steps of: (a) defining a first jumper symbol and a second jumper symbol of a schematic circuit symbol library; (b) drawing the first jumper symbol and the second jumper symbol of the schematic circuit symbol library in a schematic circuit diagram for forming a three-terminal jumper symbol; (c) defining a first jumper pattern and a second jumper pattern of a PCB component pattern library; (d) calling the PCB component pattern library for drawing the first jumper pattern and the second jumper pattern in a PCB layout so as to define a three-terminal jumper pattern; (e) selecting a jumper symbol between the first jumper symbol and the second jumper symbol; and (f) mounting a jumper on the first jumper pattern or the second jumper pattern on the circuit board according to the PCB layout and a select result from step (e).

Abstract: A signal feeding structure of the invention includes a circuit board and a signal feeding component. The circuit board comprises a hole. The signal feeding component comprises a fixed portion electrically welded to the circuit board, a feeding portion extending from the fixed portion for feeding signal to the circuit board, and an extending portion extending from the fixed portion and welded in the hole of the circuit board. The fixed portion and the feeding portion forms an elastic structure.

Abstract: An antenna structure formed on a circuit board includes a first main body formed on the lateral side of the circuit board and a feed line connecting the circuit board and the first main body. The first main body is formed on the lateral side of the circuit board by edge-plating.

Abstract: A labeling method for a printed circuit board comprising a first layout face and a second layout face opposite to the first layout face. The labeling method comprises defining a track region in the first layout face, defining a first mapping region mapped by the track region on the second layout face; and defining a first corresponding region on the second layout face completely enclosing the first mapping region.

Abstract: Compositions and methods are provided that include a biologically active agent and a permeabilizing agent effective to enhance mucosal delivery of the biologically active agent in a mammalian subject, in which the permeabilizing peptide is PN159, PN159 analogues, conjugates of PN159, conjugates of PN159 analogues, or complexes thereof. The permeabilizing agent reversibly enhances mucosal epithelial paracellular transport, typically by modulating epithelial junctional structure and/or physiology at a mucosal epithelial surface in the subject.

Abstract: Cholesterol moieties are linked to specific ends of double-stranded RNA, preferably a small, interfering (si)RNA or to a dsHybrid. The dsHybrid has one strand comprised of DNA and one strand comprised of RNA. Preferably the sense strand is the DNA strand and the antisense strand is the RNA strand of the dsHybrid. The present invention is based upon the discovery that a cholesterol moiety, if linked to a specific end or ends of the sense or antisense strands of a siRNA, can enhance the delivery and silencing efficiency of the siRNA directed against its target message, in comparison with a corresponding, non-conjugated siRNA. Conjugated siRNAs and dsHybrids of the invention are optionally formulated with, or coordinately administered with, a secondary delivery-enhancing agent, such as a delivery-enhancing peptide, to enhance intracellular delivery and uptake of the conjugated siRNAs or dsHybrid.

Abstract: A printed circuit board (PCB) includes a plastic substrate, and a layout formed on the plastic substrate. The layout comprises a first layout and a second layout, the second layout is less dense than the first layout. The second layout comprises a pseudo-layout to prevent the PCB from being bent when heated.