Abstract: In an embodiment, a method includes: forming a fin extending from a substrate; forming a first gate mask over the fin, the first gate mask having a first width; forming a second gate mask over the fin, the second gate mask having a second width, the second width being greater than the first width; depositing a first filling layer over the first gate mask and the second gate mask; depositing a second filling layer over the first filling layer; planarizing the second filling layer with a chemical mechanical polish (CMP) process, the CMP process being performed until the first filling layer is exposed; and planarizing the first filling layer and remaining portions of the second filling layer with an etch-back process, the etch-back process etching materials of the first filling layer, the second filling layer, the first gate mask, and the second gate mask at the same rate.

Abstract: Methylation biomarker selection apparatuses and methods are provided. A methylation biomarker selection apparatus stores a plurality of first data sets and a plurality of second data sets, wherein each of the first data sets includes a plurality of methylation degrees corresponding to a plurality of methylation loci, and each of the second data sets includes at least one medical record. The methylation biomarker selection apparatus determines a plurality of primary biomarkers by identifying a plurality of differentiable loci from the methylation loci according to the methylation degrees, determines a plurality of secondary biomarkers by identifying a plurality of comorbidities of a target disease, and associated genes thereof based on the second data sets, and determines a plurality of candidate biomarkers based on a correlation analysis of the primary biomarkers and the secondary biomarkers.

Abstract: In an embodiment, a method includes: forming a fin extending from a substrate; forming a first gate mask over the fin, the first gate mask having a first width; forming a second gate mask over the fin, the second gate mask having a second width, the second width being greater than the first width; depositing a first filling layer over the first gate mask and the second gate mask; depositing a second filling layer over the first filling layer; planarizing the second filling layer with a chemical mechanical polish (CMP) process, the CMP process being performed until the first filling layer is exposed; and planarizing the first filling layer and remaining portions of the second filling layer with an etch-back process, the etch-back process etching materials of the first filling layer, the second filling layer, the first gate mask, and the second gate mask at the same rate.

Abstract: A magnetic tunneling junction (MTJ) element includes a reference layer, a tunnel barrier layer on the reference layer, a free layer on the tunnel barrier layer, and a composite capping layer on the free layer. The composite capping layer comprises a diffusion-stop layer on the free layer, a light-element sink layer on the diffusion-stop layer, and an amorphous layer on the light-element sink layer.

Abstract: An integrated circuit includes a first diffusion area for a first type transistor. The first type transistor includes a first drain region and a first source region. A second diffusion area for a second type transistor is separated from the first diffusion area. The second type transistor includes a second drain region and a second source region. A gate electrode continuously extends across the first diffusion area and the second diffusion area in a routing direction. A first metallic structure is electrically coupled with the first source region. A second metallic structure is electrically coupled with the second drain region. A third metallic structure is disposed over and electrically coupled with the first and second metallic structures. A width of the first metallic structure is substantially equal to or larger than a width of the third metallic structure.

Abstract: The present disclosure relates to the fields of a method a kit for molecular diagnostics and genomics. More particularly, this disclosure relates to a method and a kit fir detecting a DNA fragment joining event or distinguishing an alternative splicing event. The present disclosure also relates to a method for administering a subject with proper treatment by steps of determining the risk of a particular cancer type or genotype.

Abstract: The present disclosure provides a method, a system and a kit for assessing the homologous recombination deficiency (HRD) status of a subject. The present disclosure further provides a method, a system and a kit for identifying a treatment based on the HRD status for the human subject.

Abstract: The present application provides a method for determining a gene alteration, such as a gene fusion. The present application also provides a kit for determining a gene alteration. The present application further provides a method for treating a subject by determining whether a subject is at risk for a particular cancer type or genotype and administering proper treatment.

Abstract: A method and a system used to determine microsatellite instability (MSI) status utilizing Next-Generation Sequencing (NGS) and a machine learning model are disclosed. The present disclosure further provides a method and a system for identifying a treatment based on the computed MSI status data for the human subject.

Abstract: An apparatus, system and method of controlling the supply of DC current from a power source to an electrical load provides for a protective circuit that senses the characteristics of the connected load prior to permitting the enablement of a switch connecting the supply and the load. A voltage arising from applying a constant current to the load during a time period is compared with a predetermined threshold determined by the intended capacity of the switch so that, when closed, the current through the switch is compatible with the switch. The protective circuit may be used in conjunction with semiconductor switches, electromechanical contactors or relays. A plurality of such devices may be incorporated in an enclosure and controlled by logic so as to manage the supply of power from a power source to a plurality of electrical loads having differing power requirements.

Abstract: This disclosure relates to systems and methods that identify, predict, and rank immunogenic T-cell epitopes. In particular, this disclosure identifies epitopes that arose from disease-associated mutations, wherein the epitopes are predicted to elicit immune response from T cells. Specifically, this disclosure simultaneously considers peptide-level information, including MHC Class I and II presentation, helper and cytotoxic T cell response and sample-level information, including mutation clonality and MHC allele dosage. In some embodiment, the systems and methods are used for personalized treatment of cancers.

Abstract: Provided is a kit for detecting MET fusion, including MET gene fusion and MET exon 14 skipping. The kit includes a set of MET fusion-specific primer pairs and a set of MET fusion-specific probes. Also provided is a method for detecting MET fusion, including generating an amplified target cDNA to hybridize with the set of MET fusion-specific probes in a single reaction and detecting the probe-bound product to identify all possible MET fusions in a biological sample.

Abstract: This disclosure relates to systems and methods that identify, predict, and rank immunogenic T-cell epitopes. In particular, this disclosure identifies epitopes that arose from disease-associated mutations, wherein the epitopes are predicted to elicit immune response from T cells. Specifically, this disclosure simultaneously considers peptide-level information, including MHC Class I and II presentation, helper and cytotoxic T cell response and sample-level information, including mutation clonality and MHC allele dosage. In some embodiment, the systems and methods are used for personalized treatment of cancers.

Abstract: An apparatus, system and method of controlling the supply of DC current from a power source to an electrical load provides for a protective circuit that senses the characteristics of the connected load prior to permitting the enablement of a switch connecting the supply and the load. A voltage arising from applying a constant current to the load during a time period is compared with a predetermined threshold determined by the intended capacity of the switch so that, when closed, the current through the switch is compatible with the switch. The protective circuit may be used in conjunction with semiconductor switches, electromechanical contactors or relays. A plurality of such devices may be incorporated in an enclosure and controlled by logic so as to manage the supply of power from a power source to a plurality of electrical loads having differing power requirements.

Abstract: In control methods for a multi-function controller, which includes a sensor having a ring operation region, the position of an object on the sensor is detected for generating a position information, and the force applied to the sensor by the object is detected for generating a force information. When the sensor detects multiple successive position information, which indicate that the object is circling along the ring operation region, a rotation information may be generated additionally. The position information, the force information and the rotation information are used to perform operation in various functional modes.

Abstract: The present invention relates to gene therapy systems designed for the delivery of a therapeutic product to a subject using replication-defective virus composition(s) engineered with a built-in safety mechanism for ablating the therapeutic gene product, either permanently or temporarily, in response to a pharmacological agent—preferably an oral formulation, e.g., a pill. The invention is based, in part, on the applicants' development of an integrated approach, referred to herein as “PITA” (Pharmacologically Induced Transgene Ablation), for ablating a transgene or negatively regulating transgene expression. In this approach, replication-deficient viruses are used to deliver a transgene encoding a therapeutic product (an RNA or a protein) so that it is expressed in the subject, but can be reversibly or irreversibly turned off by administering the pharmacological agent; e.g., by administration of a small molecule that induces expression of an ablator specific for the transgene or its RNA transcript.

Abstract: This invention relates to a method of treating infection by methicillin-nonsusceptibale bacteria, vancomycin-nonsusceptibale bacteria, penicillin-nonsusceptibale bacteria, clarithromycin-nonsusceptibale bacteria, or metronidazole-nonsusceptibale bacteria by administering to a subject in need thereof an effective amount of a compound of the following formula:

Abstract: This invention relates to a method for treating inflammatory diseases or immune diseases, developmental or degenerative diseases, or tissue injuries. The method includes administering to a subject in need thereof an effective amount of one or more compounds of formula (I). Each variable in this formula is defined in the specification.

Abstract: In control methods for a multi-function controller, which includes a sensor having a ring operation region, the position of an object on the sensor is detected for generating a position information, and the force applied to the sensor by the object is detected for generating a force information. When the sensor detects multiple successive position information, which indicate that the object is circling along the ring operation region, a rotation information may be generated additionally. The position information, the force information and the rotation information are used to perform operation in various functional modes.