Abstract: Described herein are T cells engineered to express a chimeric antigen receptor (CAR), such as an anti-mesothelin CAR alone or in combination with a follicle-stimulating hormone receptor (FSHR) binding domain and/or a dominant negative transforming growth factor-? receptor II (dnTGF?RII) for the treatment of diseases associated with mesothelin expression. Also described are T cells engineered to express a modified T cell receptor (TCR).

Abstract: Disclosed is a microfluidic detection device including a circuit substrate and a transparent substrate. The circuit substrate is provided with at least one first light-emitting device used to emit a detection beam, a photodetector used to receive the detection beam and send out a sensing signal, and a control circuit electrically connected to the first light-emitting device and the photodetector. The transparent substrate overlaps the circuit substrate and is provided with a microfluidic channel and a light guide structure. The light guide structure has a light incident surface disposed corresponding to the first light-emitting device and a light exiting surface disposed corresponding to the photodetector. The light guide structure extends from each of the light incident surface and the light exiting surface to the microfluidic channel and is adapted to transmit the detection beam into and out of the microfluidic channel.

Abstract: Embodiments of the invention are provided to automatically generate corner simulation scenarios. In an embodiment, an exemplary method includes performing the following operations for a predetermined number of iterations for each set of predefined parameters. The operations include generating a set of parameter values for the set of predefined parameters; determining whether the set of parameter values is valid or invalid based on a set of predefined metrics; and if the set of parameter values is valid, performing a simulation task to simulate a trajectory planner of the ADV in a simulation scenario configured by the set of parameter values. The method further includes calculating a performance score for the simulation task; and if the performance score of the simulation task is below a predetermined threshold, saving the set of parameter values in a storage, wherein the set of parameter values is used for re-tuning the trajectory planner.

Abstract: In an embodiment, an autonomous driving system (ADS) determines that a corresponding autonomous driving vehicle (ADV) has stopped on a gradient. The ADS determines a first brake hold pressure based on a first gradient value of the ADV measured at a first point in time. The ADS then applies the first brake hold pressure to a brake system in the ADV. Then, the ADS determines a second brake hold pressure based on a second gradient value of the ADV measured at a second point in time. The ADS then applies the second brake hold pressure to the brake system accordingly.

Abstract: A system perceives an environment of an autonomous driving vehicle (ADV) based on a plurality of sensors and map data. The system determines an obstacle in the perceived environment to be a moving vehicle and the moving vehicle is to a left lane, to a right lane, or in front of the ADV. The system performs an inference on the obstacle using a neural network model to determine whether a behavior of the obstacle is anomalous. The system determines the obstacle is anomalous based on the performed inference.

Abstract: According to some embodiments, systems, methods and media for operating an autonomous driving vehicles (ADV) in an unforeseen scenario are disclosed. In one embodiment, an exemplary method includes determining that the ADV has entered an unforeseen scenario; and identifying one or more surrounding vehicles that are navigating the unforeseen scenario. The method further includes generating a trajectory by mimicking driving behaviors of one or more of the one or more surrounding vehicles; and operating the ADV to follow the trajectory to navigate the unforeseen scenario.

Abstract: Among the various aspects of the present disclosure are the provision of an image alignment and registration system and a breast cancer risk prediction system.

Abstract: A trajectory of an obstacle is predicted by a prediction module of the ADV. A trajectory of the ADV is determined based on the trajectory of the obstacle by a planning module of the ADV. A loss function of an analysis model of the prediction module is decomposed to multiple components with multiple weightings to generate a weighted loss function based on the trajectory of the ADV. A performance of the prediction module is evaluated based on the weighted loss function to improve the performance of the prediction module to increase a safety and comfort of the ADV.

Abstract: According to various embodiments, the disclosure discloses systems, methods and media for formulating training datasets for learning-based components in an autonomous driving vehicle (ADV). In an embodiment, an exemplary method includes allocating training datasets for training a learning-based model in the ADV, each training dataset being allocated to one of multiple predefined driving scenarios; determining a weight of each training dataset out of the training datasets; and optimizing the weight of each training dataset in one or more iterations according to a predetermined algorithm until a performance of the learning-based model reaches a predetermined threshold. The predetermined algorithm is one of a random search algorithm, a grid search algorithm, or a Bayesian algorithm.

Abstract: A plurality of trajectories of a plurality of obstacles are predicted, at an autonomous driving simulation platform, by a prediction module of an autonomous driving vehicle (ADV). A trajectory of the ADV is planned, at the autonomous driving simulation platform, by a planning module of the ADV based on the plurality of trajectories of the plurality of obstacles. A performance of the planning module is determined based on one or more evaluation metrics regarding the trajectory of the ADV. A performance of the prediction module is evaluated based on the performance of the planning module to improve the performance of the prediction module to deploy the prediction module to the ADV to drive autonomously.

Abstract: The present disclosure provides methods and techniques for evaluating and improving algorithms for autonomous driving planning and control (PNC), using one or more metrics (e.g., similarity scores) computed based on expert demonstrations. For example, the one or more metrics allow for improving PNC based on human, as opposed to or in addition to optimizing certain oversimplified properties, such as the least distance or time, as an objective. When driving in certain scenarios, such as taking a turn, people may drive in a distributed probability pattern instead of in a uniform line (e.g., different speeds and different curvatures at the same corner). As such, there can be more than one “correct” control trajectory for an autonomous vehicle to perform in the same turn. Safety, comfort, speeds, and other criteria may lead to different preferences and judgment as to how well the controlled trajectory has been computed.

Abstract: According to some embodiments, systems, methods and media for dynamically generating scenario parameters for an autonomous driving vehicles (ADV) are described. In one embodiment, when an ADV enters a driving scenario, the ADV can invoke a map-based scenario checker to determine the type of scenario, and invokes a corresponding neural network model to generate a set of parameters for the scenario based on real-time environmental conditions (e.g., traffics) and vehicle status information (e.g., speed). The set of scenario parameters can be a set of extra constraints for configuring the ADV to drive in a driving mode corresponding to the scenario.

Abstract: In one embodiment, a control command is generated with an MPC controller, the MPC controller including a cost function with weights associated with cost terms of the cost function. The control command is applied to a dynamic model of an autonomous driving vehicle (ADV) to simulate behavior of the ADV. One or more of the weights are based on evaluation of the dynamic model in response to the control command, resulting in an adjusted cost function of the MPC controller. Another control command is generated with the MPC controller having the adjusted cost function. This second control command can be used to effect movement of the ADV.

Abstract: A method of navigating an autonomous driving vehicle (ADV) includes determining a target function for an open space model based on one or more obstacles and map information within a proximity of the ADV, then iteratively performing first and second quadratic programming (QP) optimizations on the target function. Then, generating a second trajectory based on results of the first and second QP optimizations to control the ADV autonomously using the second trajectory. The first QP optimization is based on fixing a first set of variables of the target function. The second QP optimization is based on maximizing a sum of the distances from the ADV to each of the obstacles over a plurality of points of the first trajectory, and minimizing a difference between a target end-state of the ADV and a determined final state of the ADV using the first trajectory.

Abstract: A simulation of an autonomous driving vehicle (ADV) includes capturing first data that includes a control command output by an autonomous vehicle controller of the ADV, and capturing second data that includes the control command being implemented at a control unit of the ADV. The control command, for example, a steering command, a braking command, or a throttle command, is implemented by the ADV to affect movement of the ADV. A latency model is determined based on comparing the first data with the second data, where the latency model defines time delay and/or amplitude difference between the first data and the second data. The latency model is applied in a virtual driving environment.

Abstract: In one embodiment, control of an autonomous driving vehicle (ADV) includes determining a current scenario of the ADV. Based on the scenario, a control algorithm is selected among a plurality of distinct control algorithms as the active control algorithm. One or more control commands are generated using the active control algorithm, based one or more target inputs. The control commands are applied to effect movement of the ADV.

Abstract: In one embodiment, a computer-implemented method of operating an autonomous driving vehicle (ADV) includes perceiving a driving environment surrounding the ADV based on sensor data obtained from one or more sensors mounted on the ADV, determining a driving scenario, in response to a driving decision based on the driving environment, applying a predetermined machine-learning model to data representing the driving environment and the driving scenario to generate a set of one or more driving parameters, and planning a trajectory to navigate the ADV using the set of the driving parameters according to the driving scenario through the driving environment.

Abstract: Systems and methods are disclosed for optimizing values of a set of tunable parameters of an autonomous driving vehicle (ADV). The controllers can be a linear quadratic regular, a “bicycle model,” a model-reference adaptive controller (MRAC) that reduces actuation latency in control subsystems such as steering, braking, and throttle, or other controller (“controllers”). An optimizer selects a set tunable parameters for the controllers. A task distribution system pairs each set of parameters with each of a plurality of simulated driving scenarios, and dispatches a task to the simulator to perform the simulation with the set of parameters. Each simulation is scored. A weighted score is generated from the simulation. The optimizer uses the weighted score as a target objective for a next iteration of the optimizer, for a fixed number of iterations. A physical real-world ADV is navigated using the optimized set of parameters for the controllers in the ADV.

Abstract: In one embodiment, a method of training dynamic models for autonomous driving vehicles includes the operations of receiving a first set of training data from a training data source, the first set of training data representing driving statistics for a first set of features; training a dynamic model based on the first set of training data for the first set of features; determining a second set of features as a subset of the first set of features based on evaluating the dynamic model, each of the second set of features representing a feature whose performance score is below a predetermined threshold. The method further includes the following operations for each of the second set of features: retrieving a second set of training data associated with the corresponding feature of the second set of features, and retraining the dynamic model using the second set of training data.