Abstract: A surface plasmon resonance sensor is provided, which comprises: a substrate; an adaptation layer disposed on the substrate and comprising a dielectric material; and a metal layer disposed on the adaptation layer, wherein the metal layer has a grating structure comprising plural metal lines. Furthermore, a surface plasmon resonance sensing instrument comprising the same and a method for detecting an analyte using the same are also provided.

Abstract: A memory apparatus and a data rearrangement method for computing in memory (CIM) are provided. The method includes determining whether first sequence data has two target bits that are both of a first value, inserting a non-target bit of a second value between the two target bits that are both of the first value and adjacent to each other to generate second sequence data, and receiving the second sequence data through memory cells in a memory to perform a multiply-accumulate (MAC) operation on the second sequence data. Each bit in the first sequence data is the first value or the second value. One of the two target bits is located adjacent to the other one of the two target bits in the first sequence data. The two target bits and the non-target bit are located in the first sequence data. Accordingly, the error rate is decreased.

Abstract: The invention relates to a suture thread material comprising at least one polymer and at least one eutectic mixture. The polymer can be a biocompatible polymer such as polycaprolactone or PLGA. The eutectic mixture may comprise maleic acid and an antibiotic such as metronidazole. Other eutectic mixtures can be used in suture thread materials to reduce SSis and/or to decrease pain and/or to increase lubricity of sutures. The invention also provides a method for the production of sutures with drug loadings, the method comprising the use of therapeutic deep eutectic solvent (THEDES) technology to significantly increase drug content in suture matrices.

Abstract: Anti-IL-12/IL-23p40 antibodies, such as ustekinumab, are used in methods and compositions for safe and effective treatment of psoriasis, particularly moderate to severe chronic plaque psoriasis, in pediatric patients. The methods and compositions address a clear unmet medical need in this patient population.

Abstract: The present invention relates to compositions of peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salt or solvate forms thereof, corresponding pharmaceutical compositions, methods and/or uses for treatment of autoimmune inflammation and related diseases and disorders.

Abstract: A receiver optical sub-assembly, a combo bi-directional optical sub-assembly, a combo optical module, an optical line terminal, and a passive optical network system, where the receiver optical sub-assembly includes a first transistor-outline can, where a light incident hole is disposed on the first transistor-outline can, and where a first demultiplexer, a first optical receiver, a second optical receiver, and an optical lens combination are packaged in the first transistor-outline can.

Abstract: Provided are a method and a device for real-time monitoring of tunnel deformation. The monitoring method includes: S1, erecting a plurality of structured light sources in an unstable area to be monitored of a tunnel structure, and erecting a monitoring terminal in a relatively stable region of the tunnel structure, where the monitoring terminal may communicate with the plurality of structured light sources; S2, observing all structured lights in the unstable area of the tunnel structure and obtaining structured light curves in real time by the monitoring terminal; S3, analyzing imaging changes of the structured lights, detecting deformation degrees and offset distances of the tunnel in real time, and monitoring the diseases such as settlement, convergence of a single-section of the tunnel and integral settlement of a multi-section of the tunnel by the data processing unit.

Abstract: The disclosure describes a transgenic dicot or monocot plant having bovine milk protein(s) (e.g., bovine casein) and methods of producing the transgenic dicot or monocot plant containing bovine milk protein(s). These transgenic dicot or monocot plants can express and produce bovine milk protein(s) (e.g., bovine casein). The methods involve introducing a recombinant DNA construct expressing a bovine milk protein into a dicot or monocot plant, obtaining the dicot or monocot plant containing the bovine milk protein(s) from a recombinant DNA construct, cultivating and harvesting the transgenic dicot or monocot plant, and extracting and purifying the bovine milk protein(s) (e.g., bovine casein) from transgenic dicot or monocotyledonous plants. The disclosure also describes food compositions comprising milk proteins produced using the transgenic dicot or monocot plants described herein.

Abstract: This application discloses an optical splitting apparatus, an optical splitting system, a passive optical network, and an optical fiber fault detection method. The optical splitting apparatus includes a first optical splitting unit, a plurality of first optical path processing units, and a second optical path processing unit. The first optical splitting unit includes a first port and a plurality of second ports, and the first port is separately connected to the plurality of second ports.

Abstract: Provided are a method and a device for real-time monitoring of tunnel deformation. The monitoring method includes: S1, erecting a plurality of structured light sources in an unstable area to be monitored of a tunnel structure, and erecting a monitoring terminal in a relatively stable region of the tunnel structure, where the monitoring terminal may communicate with the plurality of structured light sources; S2, observing all structured lights in the unstable area of the tunnel structure and obtaining structured light curves in real time by the monitoring terminal; S3, analyzing imaging changes of the structured lights, detecting deformation degrees and offset distances of the tunnel in real time, and monitoring the diseases such as settlement, convergence of a single-section of the tunnel and integral settlement of a multi-section of the tunnel by the data processing unit.

Abstract: One embodiment facilitates measurement of a performance of a storage device. During operation, the system determines a normalized cost for an I/O request, wherein the normalized cost is independent of an access pattern and a type of the I/O request, wherein the normalized cost is indicated by a first number of virtual I/O operations consumed by the I/O request, and wherein a virtual I/O operation is used as a logical unit of cost associated with physical I/O operations. The system identifies a performance metric for the storage device by calculating a second number of virtual I/O operations per second which can be executed by the storage device. The system allocates incoming I/O requests to the storage device based on the performance metric, e.g., to satisfy a Quality of Service requirement, thereby causing an enhanced measurement of the performance of the storage device.

Abstract: A receiver optical sub-assembly, a combo bi-directional optical sub-assembly, a combo optical module, an optical line terminal, and a passive optical network system, where the receiver optical sub-assembly includes a first transistor-outline can, where a light incident hole is disposed on the first transistor-outline can, and where a first demultiplexer, a first optical receiver, a second optical receiver, and an optical lens combination are packaged in the first transistor-outline can.

Abstract: The present disclosure relates to a system and a method for data protection. In some embodiments, an exemplary method for data encoding includes: receiving a data bulk; performing an erasure coding (EC) encoding on the data bulk to generate one or more EC codewords; distributing a plurality of portions of each EC codeword of the one or more EC codewords across a plurality of solid-state drives (SSDs); performing, at each SSD of the plurality of SSDs, an error correction coding (ECC) encoding on portions of the one or more EC codewords distributed to the SSD to generate an ECC codeword; and storing, in each SSD of the plurality of SSDs, the ECC codeword.

Abstract: A method of treating mild to moderate psoriasis in a patient administers an IL-23 specific antibody, e.g., guselkumab, at an initial dose and subsequent doses in order for the patient to respond to the antibody and meet one or more of the clinical endpoints.

Abstract: One embodiment described herein provides a distributed computing system. The distributed computing system can include a compute cluster comprising one or more compute nodes and a storage cluster comprising a plurality of storage nodes. A respective compute node can be configured to: receive a request for a computation task; obtain path information associated with data required by the computation task; identify at least one storage node based on the obtained path information; send at least one computation instruction associated with the computation task to the identified storage node; and receive computation results from the identified storage node subsequently to the identified storage node performing the computation task.

Abstract: The present disclosure provides methods, systems, and non-transitory computer readable media for optimizing data storing. An exemplary system comprises: a flash drive comprising a plurality of dies; and a memory configured to store a mapping associating a first virtual machine with a first set of dies of the plurality of dies and a second virtual machine with a second set of dies of the plurality of dies, wherein: the first set of dies are hibernated in response to the first virtual machine changing to an inactive state; and the first set of dies are activated in response to the first virtual machine changing to an active state.

Abstract: One embodiment provides a system which facilitates data management. During operation, the system processes, by a storage device, a write request and data associated with the write request, wherein the storage device comprises a plurality of channels over which to access a non-volatile memory of the storage device. The system writes the data to a first data buffer of the storage device while bypassing a first interface and a memory controller. The system sends the write request to the memory controller via the first interface. The system writes, via a first channel allocated for host write operations, the data from the first data buffer to the non-volatile memory. The system performs a garbage collection operation on the data, which comprises accessing the data via a second channel allocated for garbage collection operations.

Abstract: One embodiment provides a system which facilitates data management. The system receives, by a storage device via read requests from multiple streams, a first plurality of logical block addresses (LBAs) and corresponding stream identifiers. The system assigns a respective LBA to a first queue of a plurality of queues based on the stream identifier corresponding to the LBA. Responsive to determining that a second plurality of LBAs in the first queue are of a sequentially similar pattern: the system retrieves, from a non-volatile memory of the storage device, data associated with the second plurality of LBAs; and the system stores the retrieved data and the second plurality of LBAs in a volatile memory of the storage device while bypassing data-processing operations.

Abstract: The disclosure discloses a percussion and cutting composite drilling tool, which relates to the field of drilling equipment and is mainly used to solve the problems of low working efficiency and high wear rate of drill bit existed in breaking rocks only by cutting effect. The main structure comprises a PDC drill bit and a percussion drill bit, which is characterized by a percussion structure directly connected to the percussion drill bit. The disclosure provides a percussion and cutting composite drilling tool, which is suitable for strata under different geological conditions and has higher construction efficiency and lower bit wear.