Abstract: The present disclosure relates to a system and a method for data protection. In some embodiments, an exemplary method for data encoding includes: receiving a data bulk; performing an erasure coding (EC) encoding on the data bulk to generate one or more EC codewords; distributing a plurality of portions of each EC codeword of the one or more EC codewords across a plurality of solid-state drives (SSDs); performing, at each SSD of the plurality of SSDs, an error correction coding (ECC) encoding on portions of the one or more EC codewords distributed to the SSD to generate an ECC codeword; and storing, in each SSD of the plurality of SSDs, the ECC codeword.

Abstract: A method of treating mild to moderate psoriasis in a patient administers an IL-23 specific antibody, e.g., guselkumab, at an initial dose and subsequent doses in order for the patient to respond to the antibody and meet one or more of the clinical endpoints.

Abstract: One embodiment described herein provides a distributed computing system. The distributed computing system can include a compute cluster comprising one or more compute nodes and a storage cluster comprising a plurality of storage nodes. A respective compute node can be configured to: receive a request for a computation task; obtain path information associated with data required by the computation task; identify at least one storage node based on the obtained path information; send at least one computation instruction associated with the computation task to the identified storage node; and receive computation results from the identified storage node subsequently to the identified storage node performing the computation task.

Abstract: The present disclosure provides methods, systems, and non-transitory computer readable media for optimizing data storing. An exemplary system comprises: a flash drive comprising a plurality of dies; and a memory configured to store a mapping associating a first virtual machine with a first set of dies of the plurality of dies and a second virtual machine with a second set of dies of the plurality of dies, wherein: the first set of dies are hibernated in response to the first virtual machine changing to an inactive state; and the first set of dies are activated in response to the first virtual machine changing to an active state.

Abstract: One embodiment provides a system which facilitates data management. During operation, the system processes, by a storage device, a write request and data associated with the write request, wherein the storage device comprises a plurality of channels over which to access a non-volatile memory of the storage device. The system writes the data to a first data buffer of the storage device while bypassing a first interface and a memory controller. The system sends the write request to the memory controller via the first interface. The system writes, via a first channel allocated for host write operations, the data from the first data buffer to the non-volatile memory. The system performs a garbage collection operation on the data, which comprises accessing the data via a second channel allocated for garbage collection operations.

Abstract: One embodiment provides a system which facilitates data management. The system receives, by a storage device via read requests from multiple streams, a first plurality of logical block addresses (LBAs) and corresponding stream identifiers. The system assigns a respective LBA to a first queue of a plurality of queues based on the stream identifier corresponding to the LBA. Responsive to determining that a second plurality of LBAs in the first queue are of a sequentially similar pattern: the system retrieves, from a non-volatile memory of the storage device, data associated with the second plurality of LBAs; and the system stores the retrieved data and the second plurality of LBAs in a volatile memory of the storage device while bypassing data-processing operations.

Abstract: The disclosure discloses a percussion and cutting composite drilling tool, which relates to the field of drilling equipment and is mainly used to solve the problems of low working efficiency and high wear rate of drill bit existed in breaking rocks only by cutting effect. The main structure comprises a PDC drill bit and a percussion drill bit, which is characterized by a percussion structure directly connected to the percussion drill bit. The disclosure provides a percussion and cutting composite drilling tool, which is suitable for strata under different geological conditions and has higher construction efficiency and lower bit wear.

Abstract: The present disclosure provides methods, systems, and non-transitory computer readable media for efficiently storing data. The methods include segmenting a parcel of data into one or more data chunks according to a physical block size of the secondary storage unit, wherein the one or more data chunks include a partial data chunk and zero or more full data chunks; sending each full data chunk of the zero or more full data chunks to the secondary storage unit to be written to a selected physical block of the secondary storage unit; collecting, in a collection buffer, the current partial data chunk and at least another partial data chunk; and sending a combination of the current partial data chunk and a subset of the plurality of other partial data chunks to the secondary storage unit to be written to a selected physical block of the secondary storage unit, wherein said combination fills substantially all of a physical-block-sized data chunk.

Abstract: One embodiment provides a system and method for reshaping the power budget of a cabinet to facilitate an improved deployment density of servers. A battery cabinet comprises: a plurality of sealed batteries; a power outlet; and a power management module coupled to the sealed batteries and the power outlet. The power management module comprises: a power monitoring module configured to monitor a first amount of power consumed by one or more computing devices via a main power supply; a detection module configured to detect that the first amount of power consumption exceeds a predetermined power consumption threshold; and a power provision module configured to provide, via the sealed batteries, power to the power outlet until the first amount of power consumption no longer exceeds the predetermined power consumption threshold.

Abstract: Embodiments of the disclosure provide systems and methods accessing a storage device of a host machine. The method can include: receiving, via a first guest flash translation layer (FTL) instance, a first request for accessing the storage device from a first virtual machine running on a host machine, wherein the first request comprises a first physical address of the storage device; transmitting, via the first FTL instance, the first request to a host FTL driver; converting, via the host FTL driver, the first request into a first hardware command; transmitting, via the host FTL driver, the first hardware command to the storage device; and executing, via the solid state drive, the first hardware command.

Abstract: The invention provides a device comprising: at least one biocompatible polymer, and an eutectic composition comprising a first agent and an agent capable of forming a eutectic composition with the first agent; or one or more fatty acids; or one or more fatty alcohols; or one or more fatty amines or combinations thereof. The device can be administered to a subject in need thereof an effective amount of one or more active agents. The at least one biocompatible polymer may be selected from the group comprising poly ethylene-vinyl-acetate, vinyl acetate, silicone, polycaprolactone, polylacticco-glycolic acid, polylactic acid or polyglycolic acid.

Abstract: Anti-IL-12/IL-23p40 antibodies, such as ustekinumab, are used in methods and compositions for safe and effective treatment of psoriasis, particularly moderate to severe chronic plaque psoriasis, in pediatric patients. The methods and compositions address a clear unmet medical need in this patient population.

Abstract: The present disclosure provides methods, systems, and non-transitory computer readable media for performing data transfers with improved error encoding. The methods include receiving a request for data transfer from a source medium in the data storage system to a destination medium in the data storage system, wherein the data storage system comprises a computer cluster and a storage cluster; determining whether the source medium and the destination medium are within the storage cluster; based on the determination of whether the source medium and the destination medium are within the storage cluster, transferring the data from the source medium to the destination medium, wherein: the data is transferred without performing error correcting code check when the data is transferred within the storage cluster, and the data is transferred with an error correcting code check when the data is transferred between the computer cluster and the storage cluster.

Abstract: During operation, a key-value storage system can receive a request to write data to a data region in a first non-volatile memory. The system can determine a key associated with the data and the key can correspond to an entry in a data structure maintained by a volatile memory the storage system. In response to determining the key, the system can write the data to the data region in the first non-volatile memory. The system can update in the volatile memory the data structure entry corresponding to the key with a physical location in the data region of the first non-volatile memory to which the data is written. The system can write the data structure update to a second non-volatile memory. The system can then store a snapshot of the data structure in a metadata region associated with the first non-volatile memory, thereby allowing persistent storage of the data structure.

Abstract: An optical fiber connector, a single-fiber bidirectional optical assembly, and an optical fiber transmission system are provided. The optical fiber connector is used in a single-fiber bidirectional optical assembly that includes a first optical module and a light filter. The optical fiber connector includes an optical path changing module, an optical fiber, a ferrule, and a tube. The optical fiber is disposed in the ferrule, the optical path changing module is in physical contact with the ferrule, the optical path changing module and the ferrule are fastened through the tube, and an optical path port is disposed at a location that is on the tube opposite from the first optical module. The optical path changing module is configured to change a transmission path of a first optical signal.

Abstract: A method of treating psoriasis in a patient by administering an IL-23 specific antibody, e.g., guselkumab, in a clinically proven safe and clinically proven effective amount and the patient achieves PASI90, PASI100 or IGA 0 or 1 score as measured 16, 24, 32, 40 and 48 weeks after initial treatment and the patient achieves higher efficacy than a patient treated with the secukinumab antibody.

Abstract: A system, apparatus, and method are provided for preventing the accumulation of particulate matter such as combustion soot on sensors positioned in exhaust gas conduits of internal combustion engines. In an embodiment, the apparatus includes a device for deflecting soot deposits from sensor surfaces. In an embodiment, the apparatus includes a device employing a surface acoustic wave generator for dislodging soot accumulation or measuring soot accumulations to trigger burn-off events. In an embodiment, an injector injects pressurized bursts of gas toward a sensor surface to dislodge particulate matter. In an embodiment, charged electrodes attract charged particles of soot from the exhaust gas flow to form deposits that are then subject to burn-off events.

Abstract: The present disclosure provides methods, systems, and non-transitory computer readable media for operating a cache drive in a data storage system. The methods include receiving, from an IO interface in the cache drive of the compute server, a write request to write data; caching the data corresponding to the write request in a cache storage of the cache drive of the compute server; performing one or more compute processes on the data; and in response to performing the one or more compute processes on the data, providing the processed data to a storage cluster for storing via the IO interface that is communicatively coupled to the storage cluster.