Patents by Inventor Shu Xiao

Shu Xiao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10363093
    Abstract: A method of inducing local cell death in patient tissue is provided. The method includes generating first and second radiation, conveying the radiation to a focusing element, and focusing the radiation on a target with the focusing element. A system for inducing local cell death in patient tissue is also provided. The system includes a power source for generating narrowband and/or ultra-wideband radiation, and a focusing element for focusing the radiation on a target.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: July 30, 2019
    Assignee: Old Dominion University Research Foundation
    Inventors: Karl H. Schoenbach, Shu Xiao
  • Patent number: 10328259
    Abstract: A system for treatment of biological tissues is provided. The system can deliver electric pulses to a targeted region within a biological tissue. The system includes an antenna assembly and a lens. The antenna assembly is configured to generate and direct electromagnetic radiation. The lens is configured to be positioned between a surface of the biological tissue and the antenna assembly. The lens can have a plurality of lossy portions. The lens can be configured to be adjustable to create a patient-specific desired electric field distribution by selective positioning of the plurality of lossy portions within the lens.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: June 25, 2019
    Assignee: Old Dominion University Research Foundation
    Inventors: Shu Xiao, Andrei Pakhomov, Karl H. Schoenbach
  • Publication number: 20190179703
    Abstract: The present inventions are related to systems and methods for accessing data from a flash memory, and more particularly to systems and methods for inter-cell interference handling in a flash memory. The systems and methods may include a soft information correction circuit that is operable to receive soft information corresponding to information accessed from a block of memory cells, and modify the soft information based upon a variance of the soft information and a median of the soft information to create corrected soft information, the corrected soft information being used to mitigate inter-cell interference in the block of memory cells.
    Type: Application
    Filed: February 12, 2019
    Publication date: June 13, 2019
    Applicant: SEAGATE TECHNOLOGY LLC
    Inventors: Fan Zhang, Shu Li, Jun Xiao, Haitao Xia
  • Publication number: 20190054294
    Abstract: Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.
    Type: Application
    Filed: August 16, 2018
    Publication date: February 21, 2019
    Inventors: Andrei G. PAKHOMOV, Olga N. PAKHOMOVA, Shu XIAO
  • Publication number: 20190038337
    Abstract: Systems and methods for treatment of a biological tissues including target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.
    Type: Application
    Filed: August 7, 2018
    Publication date: February 7, 2019
    Inventors: Karl H. SCHOENBACH, Richard HELLER, James CAMP, Stephen P. BEEBE, Shu XIAO, Amy DONATE
  • Patent number: 10143519
    Abstract: A method of treating a patient is described herein. The method can include the steps of identifying a target that contains biological tissue and directing one or more pulses of electromagnetic radiation at the target. The pulses of electromagnetic radiation can cause a temperature increase per unit of time in the biological tissue. Additionally, the temperature increase per unit of time can cause the change in the cell function in the biological tissue and can be within a range of approximately one degree Celsius per second to approximately one degree Celsius per microsecond.
    Type: Grant
    Filed: April 29, 2010
    Date of Patent: December 4, 2018
    Assignee: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
    Inventors: Karl H. Schoenbach, Shu Xiao
  • Publication number: 20180296837
    Abstract: A system for treatment of biological tissues is provided. The system can deliver electric pulses to a targeted region within a biological tissue. The system includes an antenna assembly and a lens. The antenna assembly is configured to generate and direct electromagnetic radiation. The lens is configured to be positioned between a surface of the biological tissue and the antenna assembly. The lens can have a plurality of lossy portions. The lens can be configured to be adjustable to create a patient-specific desired electric field distribution by selective positioning of the plurality of lossy portions within the lens.
    Type: Application
    Filed: June 21, 2018
    Publication date: October 18, 2018
    Inventors: Shu XIAO, Andrei PAKHOMOV, Karl H. SCHOENBACH
  • Patent number: 10070914
    Abstract: Systems and methods for treatment of a biological tissues comprising target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: September 11, 2018
    Assignee: Old Dominion University Research Foundation
    Inventors: Karl H. Schoenbach, Richard Heller, James Camp, Stephen P. Beebe, Shu Xiao, Amy Donate
  • Publication number: 20180243558
    Abstract: A pulse generation system is disclosed. The pulse generation system includes a controller, an output terminal, and a plurality of pulse generator circuits. The controller is configured to cause a driving signal pulse to be transmitted to any selected one or more of the pulse generator circuits, and to cause the driving signal pulse to not be transmitted to any selected one or more other pulse generator circuits. Each of the pulse generator circuits is configured to generate an output voltage pulse at the output terminal in response to the driving signal pulse being transmitted thereto.
    Type: Application
    Filed: February 28, 2017
    Publication date: August 30, 2018
    Applicant: Pulse Biosciences, Inc.
    Inventors: Brian G. Athos, Shu Xiao, David J. Danitz, Mark P. Kreis, Darrin R. Uecker
  • Patent number: 10029093
    Abstract: A system for treatment of biological tissues is provided. The system includes a lens having a hollow, substantially hemispherical shape with an outer surface and an inner surface, the inner surface defining a substantially hemispherical cavity for inserting the biological tissues. The system further includes an antenna assembly for generating and directing electromagnetic radiation towards the outer surface. In the system, the lens is configured to direct the electromagnetic energy to an area in the cavity, a dielectric constant of the lens at the inner surface substantially matches a dielectric constant of the biological tissues, the dielectric constant monotonically increases from the outer surface to the inner surface, and the electromagnetic energy is generated via a series of pulses having a transient of less than about 1 nanosecond.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: July 24, 2018
    Assignee: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
    Inventors: Shu Xiao, Andrei Pakhomov, Karl H. Schoenbach
  • Patent number: 9762921
    Abstract: An apparatus configured to filter video information according to certain aspects includes a memory unit and a processor in communication with the memory unit. The memory unit stores video information comprising at least two adjacent video blocks, each video block comprising a plurality of video samples, and each video sample having a bit depth. The processor determines a filtered video sample based at least in part on a video sample and an adjustment value. The processor determines the adjustment value at least in part from an input with a limited bit depth. The input is determined from a set of one or more video samples, and its bit depth is limited such that it is less than the bit depth of the one or more video samples.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: September 12, 2017
    Assignee: QUALCOMM Incorporated
    Inventors: Sanjeev Kumar, Geert Van der Auwera, Kai Wang, Shu Xiao, Marta Karczewicz
  • Publication number: 20170246455
    Abstract: A pulse generator discharge circuit is disclosed. The circuit includes one or more discharge stages, each discharge stage including a plurality of control input terminals. The circuit also includes first and second discharge terminals, and a plurality of serially connected switches electrically connected between the first and second discharge terminals, where a conductive state of each of the switches is controlled by a control signal. The circuit also includes a plurality of inductive elements configured to generate the control signals for the serially connected switches, where each inductive element is configured to generate a control signal for one of the serially connected switches in response to one or more input signals at one or more of the control input terminals, and where each of the serially connected switches is configured to receive a control signal from a respective one of the inductive elements.
    Type: Application
    Filed: November 9, 2016
    Publication date: August 31, 2017
    Applicant: Pulse Biosciences, Inc.
    Inventors: Brian G. Athos, Darrin R. Uecker, Shu Xiao
  • Publication number: 20170245928
    Abstract: A sub-microsecond pulsed electric field generator is disclosed. The field generator includes a controller, which generates a power supply control signal and generates a pulse generator control signal, and a power supply, which receives the power supply control signal and generates one or more power voltages based on the received power supply control signal. The field generator also includes a pulse generator which receives the power voltages and the pulse generator control signal, and generates one or more pulses based on the power voltages and based on the pulse generator control signal. The controller receives feedback signals representing a value of a characteristic of or a result of the pulses and generates at least one of the power supply control signal and the pulse generator control signal based on the received feedback signals.
    Type: Application
    Filed: May 6, 2016
    Publication date: August 31, 2017
    Applicant: PULSE BIOSCIENCES, INC.
    Inventors: Shu Xiao, Brian G. Athos, Mark P. Kreis, David J. Danitz, Darrin R. Uecker
  • Patent number: 9724011
    Abstract: An imaging and recordation system is provided. The system includes a high-power, focusing antenna for illuminating biological tissue. The system further includes a power source for powering the antenna. The system further includes a data acquisition module, for recording the dielectric properties of tissues illuminated by the high-power, focusing antenna. The system illuminates the tissues using ultrashort electrical pulses.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: August 8, 2017
    Assignee: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
    Inventors: Karl H. Schoenbach, Shu Xiao
  • Publication number: 20170165003
    Abstract: A method of inducing local cell death in patient tissue is provided. The method includes generating first and second radiation, conveying the radiation to a focusing element, and focusing the radiation on a target with the focusing element. A system for inducing local cell death in patient tissue is also provided. The system includes a power source for generating narrowband and/or ultra-wideband radiation, and a focusing element for focusing the radiation on a target.
    Type: Application
    Filed: May 31, 2016
    Publication date: June 15, 2017
    Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
    Inventors: Karl H. Schoenbach, Shu Xiao
  • Publication number: 20170095664
    Abstract: A system for treatment of biological tissues is provided. The system includes a lens having a hollow, substantially hemispherical shape with an outer surface and an inner surface, the inner surface defining a substantially hemispherical cavity for inserting the biological tissues. The system further includes an antenna assembly for generating and directing electromagnetic radiation towards the outer surface. In the system, the lens is configured to direct the electromagnetic energy to an area in the cavity, a dielectric constant of the lens at the inner surface substantially matches a dielectric constant of the biological tissues, the dielectric constant monotonically increases from the outer surface to the inner surface, and the electromagnetic energy is generated via a series of pulses having a transient of less than about 1 nanosecond.
    Type: Application
    Filed: May 10, 2016
    Publication date: April 6, 2017
    Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
    Inventors: Shu Xiao, Andrei Pakhomov, Karl H. Schoenbach
  • Patent number: 9455743
    Abstract: A method includes executing, at a processor, a dedicated arithmetic encoding instruction. The dedicated arithmetic encoding instruction accepts a plurality of inputs including a first range, a first offset, and a first state and produces one or more outputs based on the plurality of inputs. The method also includes storing a second state, realigning the first range to produce a second range, and realigning the first offset to produce a second offset based on the one or more outputs of the dedicated arithmetic encoding instruction.
    Type: Grant
    Filed: May 27, 2014
    Date of Patent: September 27, 2016
    Assignee: Qualcomm Incorporated
    Inventors: Bo Zhou, Mao Zeng, Erich James Plondke, Lucian Codrescu, Shu Xiao, Junchen Du, Suhail Jalil
  • Patent number: 9351791
    Abstract: A method of inducing local cell death in patient tissue is provided. The method includes generating first and second radiation, conveying the radiation to a focusing element, and focusing the radiation on a target with the focusing element. A system for inducing local cell death in patient tissue is also provided. The system includes a power source for generating narrow-band and/or ultra-wideband radiation, and a focusing element for focusing the radiation on a target.
    Type: Grant
    Filed: January 20, 2010
    Date of Patent: May 31, 2016
    Assignee: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
    Inventors: Karl H. Schoenbach, Shu Xiao
  • Patent number: 9333368
    Abstract: A system for treatment of biological tissues is provided. The system includes a lens having a hollow, substantially hemispherical shape with an outer surface and an inner surface, the inner surface defining a substantially hemispherical cavity for inserting the biological tissues. The system further includes an antenna assembly for generating and directing electromagnetic radiation towards the outer surface. In the system, the lens is configured to direct the electromagnetic energy to an area in the cavity, a dielectric constant of the lens at the inner surface substantially matches a dielectric constant of the biological tissues, the dielectric constant monotonically increases from the outer surface to the inner surface, and the electromagnetic energy is generated via a series of pulses having a transient of less than about 1 nanosecond.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: May 10, 2016
    Assignee: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
    Inventors: Shu Xiao, Andrei Pakhomov, Karl H. Schoenbach
  • Publication number: 20160106335
    Abstract: An imaging and recordation system is provided. The system includes a high-power, focusing antenna for illuminating biological tissue. The system further includes a power source for powering the antenna. The system further includes a data acquisition module, for recording the dielectric properties of tissues illuminated by the high-power, focusing antenna. The system illuminates the tissues using ultrashort electrical pulses.
    Type: Application
    Filed: October 16, 2015
    Publication date: April 21, 2016
    Inventors: Karl H. Schoenbach, Shu Xiao