Patents by Inventor Shu Xiao
Shu Xiao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11951307Abstract: Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.Type: GrantFiled: May 3, 2021Date of Patent: April 9, 2024Assignee: OLD DOMINION UNIVERSITY RESEARCH FOUNDATIONInventors: Andrei G. Pakhomov, Olga N. Pakhomova, Shu Xiao
-
Publication number: 20230329770Abstract: A pulse generator discharge circuit is disclosed. The circuit includes one or more discharge stages, each discharge stage including a plurality of control input terminals. The circuit also includes first and second discharge terminals, and a plurality of serially connected switches electrically connected between the first and second discharge terminals, where a conductive state of each of the switches is controlled by a control signal. The circuit also includes a plurality of inductive elements configured to generate the control signals for the serially connected switches, where each inductive element is configured to generate a control signal for one of the serially connected switches in response to one or more input signals at one or more of the control input terminals, and where each of the serially connected switches is configured to receive a control signal from a respective one of the inductive elements.Type: ApplicationFiled: June 21, 2023Publication date: October 19, 2023Inventors: Brian G. Athos, Darrin R. Uecker, Shu Xiao
-
Publication number: 20230293231Abstract: A sub-microsecond pulsed electric field generator is disclosed. The field generator includes a controller, which generates a power supply control signal and generates a pulse generator control signal, and a power supply, which receives the power supply control signal and generates one or more power voltages based on the received power supply control signal. The field generator also includes a pulse generator which receives the power voltages and the pulse generator control signal, and generates one or more pulses based on the power voltages and based on the pulse generator control signal. In some embodiments, the controller receives feedback signals representing a value of a characteristic of or a result of the pulses and generates at least one of the power supply control signal and the pulse generator control signal based on the received feedback signals.Type: ApplicationFiled: May 22, 2023Publication date: September 21, 2023Applicant: Pulse Biosciences, Inc.Inventors: Shu Xiao, Brian G. Athos, Mark P. Kreis, David J. Danitz, Darrin R. Uecker
-
Patent number: 11723712Abstract: A pulse generator discharge circuit is disclosed. The circuit includes one or more discharge stages, each discharge stage including a plurality of control input terminals. The circuit also includes first and second discharge terminals, and a plurality of serially connected switches electrically connected between the first and second discharge terminals, where a conductive state of each of the switches is controlled by a control signal. The circuit also includes a plurality of inductive elements configured to generate the control signals for the serially connected switches, where each inductive element is configured to generate a control signal for one of the serially connected switches in response to one or more input signals at one or more of the control input terminals, and where each of the serially connected switches is configured to receive a control signal from a respective one of the inductive elements.Type: GrantFiled: October 28, 2020Date of Patent: August 15, 2023Assignee: Pulse Biosciences, Inc.Inventors: Brian G. Athos, Darrin R. Uecker, Shu Xiao
-
Patent number: 11696800Abstract: A sub-microsecond pulsed electric field generator is disclosed. The field generator includes a controller, which generates a power supply control signal and generates a pulse generator control signal, and a power supply, which receives the power supply control signal and generates one or more power voltages based on the received power supply control signal. The field generator also includes a pulse generator which receives the power voltages and the pulse generator control signal, and generates one or more pulses based on the power voltages and based on the pulse generator control signal. In some embodiments, the controller receives feedback signals representing a value of a characteristic of or a result of the pulses and generates at least one of the power supply control signal and the pulse generator control signal based on the received feedback signals.Type: GrantFiled: March 9, 2021Date of Patent: July 11, 2023Assignee: Pulse Biosciences, Inc.Inventors: Shu Xiao, Brian G. Athos, Mark P. Kreis, David J. Danitz, Darrin R. Uecker
-
Patent number: 11351368Abstract: Methods and apparatuses (systems, devices, etc.) for treating biological tissue to evoke one or more desirable biological and/or physiological effects using pulsed electric fields in the sub-microsecond range at very low electric field strength (e.g., less than 1 kV/cm) but at high (e.g., megahertz) frequencies.Type: GrantFiled: October 30, 2019Date of Patent: June 7, 2022Assignee: Old Dominion University Research FoundationInventors: Andrei G. Pakhomov, Shu Xiao, Olga N. Pakhomova, Maura Casciola
-
Publication number: 20210268274Abstract: Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.Type: ApplicationFiled: May 3, 2021Publication date: September 2, 2021Inventors: Andrei G. PAKHOMOV, Olga N. PAKHOMOVA, Shu XIAO
-
Patent number: 11051882Abstract: A sub-microsecond pulsed electric field generator is disclosed. The field generator includes a controller, which generates a power supply control signal and generates a pulse generator control signal, and a power supply, which receives the power supply control signal and generates one or more power voltages based on the received power supply control signal. The field generator also includes a pulse generator which receives the power voltages and the pulse generator control signal, and generates one or more pulses based on the power voltages and based on the pulse generator control signal. In some embodiments, the controller receives feedback signals representing a value of a characteristic of or a result of the pulses and generates at least one of the power supply control signal and the pulse generator control signal based on the received feedback signals.Type: GrantFiled: November 22, 2019Date of Patent: July 6, 2021Assignee: Pulse Biosciences, Inc.Inventors: Shu Xiao, Brian G. Athos, Mark P. Kreis, David J. Danitz, Darrin R. Uecker
-
Publication number: 20210196375Abstract: A sub-microsecond pulsed electric field generator is disclosed. The field generator includes a controller, which generates a power supply control signal and generates a pulse generator control signal, and a power supply, which receives the power supply control signal and generates one or more power voltages based on the received power supply control signal. The field generator also includes a pulse generator which receives the power voltages and the pulse generator control signal, and generates one or more pulses based on the power voltages and based on the pulse generator control signal. In some embodiments, the controller receives feedback signals representing a value of a characteristic of or a result of the pulses and generates at least one of the power supply control signal and the pulse generator control signal based on the received feedback signals.Type: ApplicationFiled: March 9, 2021Publication date: July 1, 2021Applicant: Pulse Biosciences, Inc.Inventors: Shu Xiao, Brian G. Athos, Mark P. Kreis, David J. Danitz, Darrin R. Uecker
-
Patent number: 11043745Abstract: Resistively loaded dielectric biconical antenna apparatuses, including systems and devices, that may be used to transmit very short electrical pulses (e.g., nanosecond, sub-nanosecond, picosecond, etc.) into tissue non-invasively at energy levels sufficient to invoke biological changes in the tissue. These resistively loaded dielectric biconical antenna apparatuses may include a resistor ring reducing internal reflection and reducing energy loss, as well as delivering longer pulses (e.g. microsecond to millisecond) to tissue.Type: GrantFiled: February 11, 2019Date of Patent: June 22, 2021Assignee: OLD DOMINION UNIVERSITY RESEARCH FOUNDATIONInventors: Shu Xiao, Xianbing Zou
-
Patent number: 11020590Abstract: Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.Type: GrantFiled: August 16, 2018Date of Patent: June 1, 2021Assignee: OLD DOMINION UNIVERSITY RESEARCH FOUNDATIONInventors: Andrei G. Pakhomov, Olga N. Pakhomova, Shu Xiao
-
Publication number: 20210146129Abstract: A pulse generation system is disclosed. The pulse generation system includes a controller, an output terminal, and a plurality of pulse generator circuits. The controller is configured to cause a driving signal pulse to be transmitted to any selected one or more of the pulse generator circuits, and to cause the driving signal pulse to not be transmitted to any selected one or more other pulse generator circuits. Each of the pulse generator circuits is configured to generate an output voltage pulse at the output terminal in response to the driving signal pulse being transmitted thereto.Type: ApplicationFiled: January 26, 2021Publication date: May 20, 2021Applicant: Pulse Biosciences, Inc.Inventors: Brian G. Athos, Shu Xiao, David J. Danitz, Mark P. Kreis, Darrin R. Uecker
-
Patent number: 10946193Abstract: A pulse generation system is disclosed. The pulse generation system includes a controller, an output terminal, and a plurality of pulse generator circuits. The controller is configured to cause a driving signal pulse to be transmitted to any selected one or more of the pulse generator circuits, and to cause the driving signal pulse to not be transmitted to any selected one or more other pulse generator circuits. Each of the pulse generator circuits is configured to generate an output voltage pulse at the output terminal in response to the driving signal pulse being transmitted thereto.Type: GrantFiled: February 28, 2017Date of Patent: March 16, 2021Assignee: PULSE BIOSCIENCES, INC.Inventors: Brian G. Athos, Shu Xiao, David J. Danitz, Mark P. Kreis, Darrin R. Uecker
-
Publication number: 20210038282Abstract: A pulse generator discharge circuit is disclosed. The circuit includes one or more discharge stages, each discharge stage including a plurality of control input terminals. The circuit also includes first and second discharge terminals, and a plurality of serially connected switches electrically connected between the first and second discharge terminals, where a conductive state of each of the switches is controlled by a control signal. The circuit also includes a plurality of inductive elements configured to generate the control signals for the serially connected switches, where each inductive element is configured to generate a control signal for one of the serially connected switches in response to one or more input signals at one or more of the control input terminals, and where each of the serially connected switches is configured to receive a control signal from a respective one of the inductive elements.Type: ApplicationFiled: October 28, 2020Publication date: February 11, 2021Applicant: Pulse Biosciences, Inc.Inventors: Brian G. Athos, Darrin R. Uecker, Shu Xiao
-
Patent number: 10874451Abstract: A pulse generator discharge circuit is disclosed. The circuit includes one or more discharge stages, each discharge stage including a plurality of control input terminals. The circuit also includes first and second discharge terminals, and a plurality of serially connected switches electrically connected between the first and second discharge terminals, where a conductive state of each of the switches is controlled by a control signal. The circuit also includes a plurality of inductive elements configured to generate the control signals for the serially connected switches, where each inductive element is configured to generate a control signal for one of the serially connected switches in response to one or more input signals at one or more of the control input terminals, and where each of the serially connected switches is configured to receive a control signal from a respective one of the inductive elements.Type: GrantFiled: November 9, 2016Date of Patent: December 29, 2020Assignee: PULSE BIOSCIENCES, INC.Inventors: Brian G. Athos, Darrin R. Uecker, Shu Xiao
-
Publication number: 20200259261Abstract: Resistively loaded dielectric biconical antenna apparatuses, including systems and devices, that may be used to transmit very short electrical pulses (e.g., nanosecond, sub-nanosecond, picosecond, etc.) into tissue non-invasively at energy levels sufficient to invoke biological changes in the tissue. These resistively loaded dielectric biconical antenna apparatuses may include a resistor ring reducing internal reflection and reducing energy loss, as well as delivering longer pulses (e.g. microsecond to millisecond) to tissue.Type: ApplicationFiled: February 11, 2019Publication date: August 13, 2020Inventors: Shu XIAO, Xianbing ZOU
-
Patent number: 10660693Abstract: Systems and methods for treatment of a biological tissues including target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.Type: GrantFiled: August 7, 2018Date of Patent: May 26, 2020Assignee: Old Dominion University Research FoundationInventors: Karl H. Schoenbach, Richard Heller, James Camp, Stephen P. Beebe, Shu Xiao, Amy Donate
-
Publication number: 20200147371Abstract: Methods and apparatuses (systems, devices, etc.) for treating biological tissue to evoke one or more desirable biological and/or physiological effects using pulsed electric fields in the sub-microsecond range at very low electric field strength (e.g., less than 1 kV/cm) but at high (e.g., megahertz) frequencies.Type: ApplicationFiled: October 30, 2019Publication date: May 14, 2020Inventors: Andrei G. PAKHOMOV, Shu XIAO, Olga N. PAKHOMOVA, Maura CASCIOLA
-
Publication number: 20200085498Abstract: A sub-microsecond pulsed electric field generator is disclosed. The field generator includes a controller, which generates a power supply control signal and generates a pulse generator control signal, and a power supply, which receives the power supply control signal and generates one or more power voltages based on the received power supply control signal. The field generator also includes a pulse generator which receives the power voltages and the pulse generator control signal, and generates one or more pulses based on the power voltages and based on the pulse generator control signal. In some embodiments, the controller receives feedback signals representing a value of a characteristic of or a result of the pulses and generates at least one of the power supply control signal and the pulse generator control signal based on the received feedback signals.Type: ApplicationFiled: November 22, 2019Publication date: March 19, 2020Applicant: Pulse Biosciences, Inc.Inventors: Shu Xiao, Brian G. Athos, Mark P. Kreis, David J. Danitz, Darrin R. Uecker
-
Patent number: 10548665Abstract: A sub-microsecond pulsed electric field generator is disclosed. The field generator includes a controller, which generates a power supply control signal and generates a pulse generator control signal, and a power supply, which receives the power supply control signal and generates one or more power voltages based on the received power supply control signal. The field generator also includes a pulse generator which receives the power voltages and the pulse generator control signal, and generates one or more pulses based on the power voltages and based on the pulse generator control signal. The controller receives feedback signals representing a value of a characteristic of or a result of the pulses and generates at least one of the power supply control signal and the pulse generator control signal based on the received feedback signals.Type: GrantFiled: May 6, 2016Date of Patent: February 4, 2020Assignee: PULSE BIOSCIENCES, INC.Inventors: Shu Xiao, Brian G. Athos, Mark P. Kreis, David J. Danitz, Darrin R. Uecker