Patents by Inventor Shu Xiao
Shu Xiao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10363093Abstract: A method of inducing local cell death in patient tissue is provided. The method includes generating first and second radiation, conveying the radiation to a focusing element, and focusing the radiation on a target with the focusing element. A system for inducing local cell death in patient tissue is also provided. The system includes a power source for generating narrowband and/or ultra-wideband radiation, and a focusing element for focusing the radiation on a target.Type: GrantFiled: May 31, 2016Date of Patent: July 30, 2019Assignee: Old Dominion University Research FoundationInventors: Karl H. Schoenbach, Shu Xiao
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Patent number: 10328259Abstract: A system for treatment of biological tissues is provided. The system can deliver electric pulses to a targeted region within a biological tissue. The system includes an antenna assembly and a lens. The antenna assembly is configured to generate and direct electromagnetic radiation. The lens is configured to be positioned between a surface of the biological tissue and the antenna assembly. The lens can have a plurality of lossy portions. The lens can be configured to be adjustable to create a patient-specific desired electric field distribution by selective positioning of the plurality of lossy portions within the lens.Type: GrantFiled: June 21, 2018Date of Patent: June 25, 2019Assignee: Old Dominion University Research FoundationInventors: Shu Xiao, Andrei Pakhomov, Karl H. Schoenbach
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Publication number: 20190054294Abstract: Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.Type: ApplicationFiled: August 16, 2018Publication date: February 21, 2019Inventors: Andrei G. PAKHOMOV, Olga N. PAKHOMOVA, Shu XIAO
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Publication number: 20190038337Abstract: Systems and methods for treatment of a biological tissues including target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.Type: ApplicationFiled: August 7, 2018Publication date: February 7, 2019Inventors: Karl H. SCHOENBACH, Richard HELLER, James CAMP, Stephen P. BEEBE, Shu XIAO, Amy DONATE
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Patent number: 10143519Abstract: A method of treating a patient is described herein. The method can include the steps of identifying a target that contains biological tissue and directing one or more pulses of electromagnetic radiation at the target. The pulses of electromagnetic radiation can cause a temperature increase per unit of time in the biological tissue. Additionally, the temperature increase per unit of time can cause the change in the cell function in the biological tissue and can be within a range of approximately one degree Celsius per second to approximately one degree Celsius per microsecond.Type: GrantFiled: April 29, 2010Date of Patent: December 4, 2018Assignee: OLD DOMINION UNIVERSITY RESEARCH FOUNDATIONInventors: Karl H. Schoenbach, Shu Xiao
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Publication number: 20180296837Abstract: A system for treatment of biological tissues is provided. The system can deliver electric pulses to a targeted region within a biological tissue. The system includes an antenna assembly and a lens. The antenna assembly is configured to generate and direct electromagnetic radiation. The lens is configured to be positioned between a surface of the biological tissue and the antenna assembly. The lens can have a plurality of lossy portions. The lens can be configured to be adjustable to create a patient-specific desired electric field distribution by selective positioning of the plurality of lossy portions within the lens.Type: ApplicationFiled: June 21, 2018Publication date: October 18, 2018Inventors: Shu XIAO, Andrei PAKHOMOV, Karl H. SCHOENBACH
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Patent number: 10070914Abstract: Systems and methods for treatment of a biological tissues comprising target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.Type: GrantFiled: December 20, 2012Date of Patent: September 11, 2018Assignee: Old Dominion University Research FoundationInventors: Karl H. Schoenbach, Richard Heller, James Camp, Stephen P. Beebe, Shu Xiao, Amy Donate
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Publication number: 20180243558Abstract: A pulse generation system is disclosed. The pulse generation system includes a controller, an output terminal, and a plurality of pulse generator circuits. The controller is configured to cause a driving signal pulse to be transmitted to any selected one or more of the pulse generator circuits, and to cause the driving signal pulse to not be transmitted to any selected one or more other pulse generator circuits. Each of the pulse generator circuits is configured to generate an output voltage pulse at the output terminal in response to the driving signal pulse being transmitted thereto.Type: ApplicationFiled: February 28, 2017Publication date: August 30, 2018Applicant: Pulse Biosciences, Inc.Inventors: Brian G. Athos, Shu Xiao, David J. Danitz, Mark P. Kreis, Darrin R. Uecker
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Patent number: 10029093Abstract: A system for treatment of biological tissues is provided. The system includes a lens having a hollow, substantially hemispherical shape with an outer surface and an inner surface, the inner surface defining a substantially hemispherical cavity for inserting the biological tissues. The system further includes an antenna assembly for generating and directing electromagnetic radiation towards the outer surface. In the system, the lens is configured to direct the electromagnetic energy to an area in the cavity, a dielectric constant of the lens at the inner surface substantially matches a dielectric constant of the biological tissues, the dielectric constant monotonically increases from the outer surface to the inner surface, and the electromagnetic energy is generated via a series of pulses having a transient of less than about 1 nanosecond.Type: GrantFiled: May 10, 2016Date of Patent: July 24, 2018Assignee: OLD DOMINION UNIVERSITY RESEARCH FOUNDATIONInventors: Shu Xiao, Andrei Pakhomov, Karl H. Schoenbach
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Patent number: 9762921Abstract: An apparatus configured to filter video information according to certain aspects includes a memory unit and a processor in communication with the memory unit. The memory unit stores video information comprising at least two adjacent video blocks, each video block comprising a plurality of video samples, and each video sample having a bit depth. The processor determines a filtered video sample based at least in part on a video sample and an adjustment value. The processor determines the adjustment value at least in part from an input with a limited bit depth. The input is determined from a set of one or more video samples, and its bit depth is limited such that it is less than the bit depth of the one or more video samples.Type: GrantFiled: December 19, 2012Date of Patent: September 12, 2017Assignee: QUALCOMM IncorporatedInventors: Sanjeev Kumar, Geert Van der Auwera, Kai Wang, Shu Xiao, Marta Karczewicz
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Publication number: 20170245928Abstract: A sub-microsecond pulsed electric field generator is disclosed. The field generator includes a controller, which generates a power supply control signal and generates a pulse generator control signal, and a power supply, which receives the power supply control signal and generates one or more power voltages based on the received power supply control signal. The field generator also includes a pulse generator which receives the power voltages and the pulse generator control signal, and generates one or more pulses based on the power voltages and based on the pulse generator control signal. The controller receives feedback signals representing a value of a characteristic of or a result of the pulses and generates at least one of the power supply control signal and the pulse generator control signal based on the received feedback signals.Type: ApplicationFiled: May 6, 2016Publication date: August 31, 2017Applicant: PULSE BIOSCIENCES, INC.Inventors: Shu Xiao, Brian G. Athos, Mark P. Kreis, David J. Danitz, Darrin R. Uecker
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Publication number: 20170246455Abstract: A pulse generator discharge circuit is disclosed. The circuit includes one or more discharge stages, each discharge stage including a plurality of control input terminals. The circuit also includes first and second discharge terminals, and a plurality of serially connected switches electrically connected between the first and second discharge terminals, where a conductive state of each of the switches is controlled by a control signal. The circuit also includes a plurality of inductive elements configured to generate the control signals for the serially connected switches, where each inductive element is configured to generate a control signal for one of the serially connected switches in response to one or more input signals at one or more of the control input terminals, and where each of the serially connected switches is configured to receive a control signal from a respective one of the inductive elements.Type: ApplicationFiled: November 9, 2016Publication date: August 31, 2017Applicant: Pulse Biosciences, Inc.Inventors: Brian G. Athos, Darrin R. Uecker, Shu Xiao
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Patent number: 9724011Abstract: An imaging and recordation system is provided. The system includes a high-power, focusing antenna for illuminating biological tissue. The system further includes a power source for powering the antenna. The system further includes a data acquisition module, for recording the dielectric properties of tissues illuminated by the high-power, focusing antenna. The system illuminates the tissues using ultrashort electrical pulses.Type: GrantFiled: October 16, 2015Date of Patent: August 8, 2017Assignee: OLD DOMINION UNIVERSITY RESEARCH FOUNDATIONInventors: Karl H. Schoenbach, Shu Xiao
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Publication number: 20170165003Abstract: A method of inducing local cell death in patient tissue is provided. The method includes generating first and second radiation, conveying the radiation to a focusing element, and focusing the radiation on a target with the focusing element. A system for inducing local cell death in patient tissue is also provided. The system includes a power source for generating narrowband and/or ultra-wideband radiation, and a focusing element for focusing the radiation on a target.Type: ApplicationFiled: May 31, 2016Publication date: June 15, 2017Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATIONInventors: Karl H. Schoenbach, Shu Xiao
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Publication number: 20170095664Abstract: A system for treatment of biological tissues is provided. The system includes a lens having a hollow, substantially hemispherical shape with an outer surface and an inner surface, the inner surface defining a substantially hemispherical cavity for inserting the biological tissues. The system further includes an antenna assembly for generating and directing electromagnetic radiation towards the outer surface. In the system, the lens is configured to direct the electromagnetic energy to an area in the cavity, a dielectric constant of the lens at the inner surface substantially matches a dielectric constant of the biological tissues, the dielectric constant monotonically increases from the outer surface to the inner surface, and the electromagnetic energy is generated via a series of pulses having a transient of less than about 1 nanosecond.Type: ApplicationFiled: May 10, 2016Publication date: April 6, 2017Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATIONInventors: Shu Xiao, Andrei Pakhomov, Karl H. Schoenbach
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Patent number: 9455743Abstract: A method includes executing, at a processor, a dedicated arithmetic encoding instruction. The dedicated arithmetic encoding instruction accepts a plurality of inputs including a first range, a first offset, and a first state and produces one or more outputs based on the plurality of inputs. The method also includes storing a second state, realigning the first range to produce a second range, and realigning the first offset to produce a second offset based on the one or more outputs of the dedicated arithmetic encoding instruction.Type: GrantFiled: May 27, 2014Date of Patent: September 27, 2016Assignee: Qualcomm IncorporatedInventors: Bo Zhou, Mao Zeng, Erich James Plondke, Lucian Codrescu, Shu Xiao, Junchen Du, Suhail Jalil
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Patent number: 9351791Abstract: A method of inducing local cell death in patient tissue is provided. The method includes generating first and second radiation, conveying the radiation to a focusing element, and focusing the radiation on a target with the focusing element. A system for inducing local cell death in patient tissue is also provided. The system includes a power source for generating narrow-band and/or ultra-wideband radiation, and a focusing element for focusing the radiation on a target.Type: GrantFiled: January 20, 2010Date of Patent: May 31, 2016Assignee: OLD DOMINION UNIVERSITY RESEARCH FOUNDATIONInventors: Karl H. Schoenbach, Shu Xiao
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Patent number: 9333368Abstract: A system for treatment of biological tissues is provided. The system includes a lens having a hollow, substantially hemispherical shape with an outer surface and an inner surface, the inner surface defining a substantially hemispherical cavity for inserting the biological tissues. The system further includes an antenna assembly for generating and directing electromagnetic radiation towards the outer surface. In the system, the lens is configured to direct the electromagnetic energy to an area in the cavity, a dielectric constant of the lens at the inner surface substantially matches a dielectric constant of the biological tissues, the dielectric constant monotonically increases from the outer surface to the inner surface, and the electromagnetic energy is generated via a series of pulses having a transient of less than about 1 nanosecond.Type: GrantFiled: February 3, 2014Date of Patent: May 10, 2016Assignee: OLD DOMINION UNIVERSITY RESEARCH FOUNDATIONInventors: Shu Xiao, Andrei Pakhomov, Karl H. Schoenbach
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Publication number: 20160106335Abstract: An imaging and recordation system is provided. The system includes a high-power, focusing antenna for illuminating biological tissue. The system further includes a power source for powering the antenna. The system further includes a data acquisition module, for recording the dielectric properties of tissues illuminated by the high-power, focusing antenna. The system illuminates the tissues using ultrashort electrical pulses.Type: ApplicationFiled: October 16, 2015Publication date: April 21, 2016Inventors: Karl H. Schoenbach, Shu Xiao
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Publication number: 20150349796Abstract: A method includes executing, at a processor, a dedicated arithmetic encoding instruction. The dedicated arithmetic encoding instruction accepts a plurality of inputs including a first range, a first offset, and a first state and produces one or more outputs based on the plurality of inputs. The method also includes storing a second state, realigning the first range to produce a second range, and realigning the first offset to produce a second offset based on the one or more outputs of the dedicated arithmetic encoding instruction.Type: ApplicationFiled: May 27, 2014Publication date: December 3, 2015Applicant: QUALCOMM IncorporatedInventors: Bo Zhou, Mao Zeng, Erich James Plondke, Lucian Codrescu, Shu Xiao, Junchen Du, Suhail Jalil