Abstract: Disclosed herein is a process for producing a recombinant Candida cell, which involves genetically engineering a parent Candida cell using a Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas)(CRISPR/Cas) system. A recombinant Candida cell obtained using the process and a method for producing D-lactic acid from a biomass using the recombinant Candida cell are also disclosed.

Abstract: A system for image alignment includes an alignment mechanism (132) configured to permit user alignment of images. A first imaging modality (110) is configured to concurrently provide images in two imaging planes using an imaging mechanism (134) associated with the alignment mechanism (132). An image processing module (126) is configured to display first images collected with the first imaging modality and second images collected with a second imaging modality (130) to permit user alignment using the alignment mechanism between the first images and the second images in multiple planes. A registration module (115) is stored in memory and configured to register the first images with corresponding second images in the multiple planes when alignment in the multiple planes has been achieved.

Abstract: The present invention relates to a medical imaging apparatus. The apparatus comprises an ultrasound acquisition unit including an ultrasound probe for acquiring ultrasound image data of a patient. An image data interface is provided for receiving 3D medical image data of the patient and a position determining unit for determining a position of the ultrasound probe. A calibration unit determines a transfer function between the ultrasound image data and the 3D medical image data at a plurality of positions (C) of the ultrasound probe and provides a corresponding plurality of calibrated transfer functions and calibration positions. A computation unit synchronizes the ultrasound image data and the 3D medical image data on the basis of a position of the ultrasound probe and the plurality of calibrated transfer functions, said computation unit is further adapted to weight the calibrated transfer functions on the basis of a position of the ultrasound probe.

Abstract: The present invention relates to a medical imaging apparatus (10). The apparatus comprises an ultrasound acquisition unit including an ultrasound probe (14) for acquiring ultrasound image data of a patient (12). An image data interface (18) is provided for receiving 3D medical image data of the patient and a position determining unit (28) for determining a position of the ultrasound probe. A calibration unit (24) determines a transfer function between the ultrasound image data and the 3D medical image data at a plurality of positions (C) of the ultrasound probe and provides a corresponding plurality of calibrated transfer functions and calibration positions. A computation unit (26) synchronizes the ultrasound image data and the 3D medical image data on the basis of a position of the ultrasound probe and the plurality of calibrated transfer functions, said computation unit is further adapted to weight the calibrated transfer functions on the basis of a position of the ultrasound probe.

Abstract: A method and an apparatus for neural network computation using adaptive data representation, adapted for a processor to perform multiply-and-accumulate operations on a memory having a crossbar architecture, are provided. The memory comprises multiple input and output lines crossing each other, multiple cells respectively disposed at intersections of the input and output lines, and multiple sense amplifiers respectively connected to the output lines. In the method, an input cycle of kth bits respectively in an input data is adaptively divided into multiple sub-cycles, wherein a number of the divided sub-cycles is determined according to a value of k. The kth bits of the input data are inputted to the input lines with the sub-cycles and computation results of the output lines are sensed by the sense amplifiers. The computation results sensed in each sub-cycle are combined to obtain the output data corresponding to the kth bits of the input data.

Abstract: A method for producing lactic acid from a biomass-based material includes: cultivating a strain of Bacillus spp. or recombinant Candida spp. capable of yielding lactic acid by consumption of hexose and pentose in a seed medium containing molasses and corn steep liquor, so as to obtain a seed culture of the strain in the seed medium; and fermenting the biomass-based material with the seed culture of the strain. The biomass contains a fermentable sugar. Genomic DNA of the recombinant Candida spp. includes a gene encoding lactate dehydrogenase, and pdc gene in the genomic DNA of the recombinant Candida spp. is deleted, disrupted or disabled.

Abstract: A fusion imaging system co-registers and fuses real time ultrasound images with reference images such as those produced by MRI or CT imaging. In an illustrated implementation, previously acquired CT or MRI or ultrasound images are loaded into the system. An ultrasound system is operated in conjunction with a tracking system so that the ultrasound probe and images can be spatially tracked. A computerized image processor registers the probe position with a reference image of the anatomy being scanned by the probe and determines whether the probe appears to be inside the skin line of the subject. If that is the case it is due to probe compression of the subject, and the reference image is modified to locate the skin line in the reference image in front of the ultrasound probe. The modified reference images can then be readily co-registered and fused with the ultrasound images produced by the probe.

Abstract: Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.

Abstract: Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.

Abstract: The present disclosure describes ultrasound imaging systems and methods that may be used to image, for example, breast tissue. An ultrasound imaging system according to one embodiment may include a probe, a sensor attached to the probe and operatively associated with a position tracking system, a processor configured to receive probe position data from the position tracking system. The user interface may be configured to provide instructions for placement of the probe at a plurality of anatomical landmarks of a selected breast of the subject and receive user input to record the spatial location of the probe at each of the plurality of anatomical landmarks. The processor may be configured to determine a scan area based on the spatial location of the probe at each of the plurality of anatomical landmarks and generate a scan pattern for the selected breast. The processor may be further configured to monitor movement of the probe.

Abstract: The present invention relates to a medical imaging apparatus (10). The apparatus comprises an ultrasound acquisition unit including an ultrasound probe (14) for acquiring ultrasound image data of a patient (12). An image data interface (18) is provided for receiving 3D medical image data of the patient and a position determining unit (28) for determining a position of the ultrasound probe. A calibration unit (24) determines a transfer function between the ultrasound image data and the 3D medical image data at a plurality of positions (C) of the ultrasound probe and provides a corresponding plurality of calibrated transfer functions and calibration positions. A computation unit (26) synchronizes the ultrasound image data and the 3D medical image data on the basis of a position of the ultrasound probe and the plurality of calibrated transfer functions, said computation unit is further adapted to weight the calibrated transfer functions on the basis of a position of the ultrasound probe.

Abstract: The embodiments disclose a device, method and system for assisting in the determination of one or more ablation regions for covering a target region to be ablated. The device comprises a processor configured to receive vascular structure information of vessels inside the target region and derive a parametric map for the target region based on the received vascular structure information, each value in the parametric map indicating a metric of a corresponding voxel of the target region to be inside the one or more ablation regions. The parametric map serves to assist in the determination of the one or more ablation regions.

Abstract: A lampshade and a lamp are disclosed. The lampshade includes a base plate, an elastic cover, a support member, and a linking-up member. The base plate includes a container and a positioning member, and the container and the positioning member are configured on a surface of the base plate. The elastic cover covers the surface of the base plate. Two ends of the support member are bent to form two pivots which are pivotally connected to the base plate. The support member is capable of being received in the container. The linking-up member includes a fixing portion, a first end and a second end. The fixing portion is configured between the first end and the second end, and the fixing portion fixed to the support member. The linking-up member is movably disposed at the positioning member, and the linking-up member may allow the support member to move.

Abstract: Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.

Abstract: A system for image alignment includes an alignment mechanism (132) configured to permit user alignment of images. A first imaging modality (110) is configured to concurrently provide images in two imaging planes using an imaging mechanism (134) associated with the alignment mechanism (132). An image processing module (126) is configured to display first images collected with the first imaging modality and second images collected with a second imaging modality (130) to permit user alignment using the alignment mechanism between the first images and the second images in multiple planes. A registration module (115) is stored in memory and configured to register the first images with corresponding second images in the multiple planes when alignment in the multiple planes has been achieved.

Abstract: A lampshade and a lamp are disclosed. The lampshade includes a base plate, an elastic cover, a support member, and a linking-up member. The base plate includes a container and a positioning member, and the container and the positioning member are configured on a surface of the base plate. The elastic cover covers the surface of the base plate. Two ends of the support member are bent to form two pivots which are pivotally connected to the base plate. The support member is capable of being received in the container. The linking-up member includes a fixing portion, a first end and a second end. The fixing portion is configured between the first end and the second end, and the fixing portion fixed to the support member. The linking-up member is movably disposed at the positioning member, and the linking-up member may allow the support member to move.

Abstract: Disclosed herein is a process for producing a recombinant yeast cell, which includes providing a parent yeast cell that can produce ethanol by consuming a hexose and a pentose, and subjecting the parent yeast cell to a genetic modification treatment. The genetic modification treatment includes deleting, disrupting, or disabling the fps1 gene of the parent yeast cell, introducing a gene encoding xylitol dehydrogenase (XDH) into the genome of the parent yeast cell for over-production of XDH, and deleting, disrupting, or disabling the gpd1 and gpd2 genes of the parent yeast cell in a sequential order.

Abstract: An auxiliary lighting device includes two headlight units and two side light units located beside the headlight units respectively. Each of the side light units includes a housing arranged beside the respective headlight unit and located adjacent to a side corner of a head of a car, and an auxiliary light mounted in the housing. The housings of the side light units are arranged and directed outward so that the auxiliary lights of the side light units light in two directions. The auxiliary light of each of the side light units is connected to a turn signal switch of the car. Thus, the auxiliary light of one of the side light units is turned on to emit light beams toward and illuminate the zone to be turned.

Abstract: The present invention relates to the improvement of the maximum processing temperature of plastic substrates, in particular polymer films.

Abstract: A cover structure for an electronic device comprises a protective cover and a touch element. The protective cover is connected with the electronic device, and the protective cover is capable of being rotated with respect to the electronic device to a front side or a rear side of the electronic device. The touch element is disposed at the protective cover and can be exerted by an external force to touch the electronic device and activate corresponding functions of the electronic device.