Patents by Inventor Shulin Zeng
Shulin Zeng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240085338Abstract: This invention is in the field of medical devices. Specifically, the present invention provides fluidic systems having a plurality of reaction sites surrounded by optical barriers to reduce the amount of optical cross-talk between signals detected from various reaction sites. The invention also provides a method of manufacturing fluidic systems and methods of using the systems.Type: ApplicationFiled: April 17, 2023Publication date: March 14, 2024Inventors: Timothy Michael KEMP, Chris TODD, Ron ORAL, Shulin ZENG, John HOWARD, Jeff FENTON, Elizabeth A. HOLMES, Ian GIBBONS (deceased), Shaunak ROY
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Patent number: 11630069Abstract: This invention is in the field of medical devices. Specifically, the present invention provides fluidic systems having a plurality of reaction sites surrounded by optical barriers to reduce the amount of optical cross-talk between signals detected from various reaction sites. The invention also provides a method of manufacturing fluidic systems and methods of using the systems.Type: GrantFiled: August 29, 2017Date of Patent: April 18, 2023Assignee: Labrador Diagnostics LLCInventors: Timothy Michael Kemp, Chris Todd, Ron Oral, Shulin Zeng, John Howard, Jeff Fenton, Elizabeth A. Holmes, Ian Gibbons, Shaunak Roy
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Patent number: 11214823Abstract: The present invention relates to sample-to-answer systems, devices, cartridges, and method of using the same for detecting the presence of microorganisms in a sample, such as bacteria.Type: GrantFiled: December 22, 2016Date of Patent: January 4, 2022Assignee: Canon U.S.A., Inc.Inventors: Abhijit Dohale, Arvind Virmani, Brian Scrivens, Christopher Sneeder, Denis Alias, George Maltezos, Hanyoup Kim, Harini Shandilya, Hongye Liang, Jason Zsak, Johnathan Stuart Coursey, Kenton C. Hasson, Melissa Gosse, Shulin Zeng, Yasuyuki Numajiri, Makoto Ogusu, Yoichi Murakami, Kunihiro Sakai
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Patent number: 10632470Abstract: An apparatus for performing a thermocyclic process, such as amplifying DNA, includes a microfluidic chip with a channel formed therein and one or more thermal distribution elements disposed over portions of the chip. Each thermal distribution element is configured to distribute thermal energy from an external thermal energy source substantially uniformly over the portion of the chip covered by the thermal distribution element. The portion of the chip covered by the thermal distribution element thereby comprises a discrete temperature zone. Other temperature zones can be defined by other thermal distribution elements or by portions of the chip not covered by a thermal distribution element. The channel is configured so that a fluid flowing through the channel would enter and exit the different temperature zones a plurality of times, thereby alternately exposing the fluid to the temperature of each zone for a period of time required for the fluid to traverse the zone.Type: GrantFiled: August 7, 2017Date of Patent: April 28, 2020Assignee: Canon U.S.A., Inc.Inventors: Gregory A. Dale, Kenton C. Hasson, Shulin Zeng, Michele Stone
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Patent number: 10527554Abstract: This invention is in the field of medical devices. Specifically, the present invention provides fluidic systems having a plurality of reaction sites surrounded by optical barriers to reduce the amount of optical cross-talk between signals detected from various reaction sites. The invention also provides a method of manufacturing fluidic systems and methods of using the systems.Type: GrantFiled: August 29, 2017Date of Patent: January 7, 2020Assignee: Theranos IP Company, LLCInventors: Timothy Michael Kemp, Chris Todd, Ron Oral, Shulin Zeng, John Howard, Jeff Fenton, Elizabeth A. Holmes, Ian Gibbons, Shaunak Roy
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Patent number: 10363558Abstract: The present invention relates to systems and methods for the real time processing of nucleic acid during polymerase chain reaction (PCR) and thermal melt applications. According to an aspect of the invention, a system for the rapid serial processing of multiple nucleic acid assays is provided. In one embodiment, the system includes, but is not limited to: a microfluidic cartridge having microfluidic (flow-through) channels, a fluorescence imaging system, a temperature measurement and control system; a pressure measurement and control system for applying variable pneumatic pressures to the microfluidic cartridge; a storage device for holding multiple reagents (e.g., a well-plate); a liquid handling system comprising at least one robotic pipettor for aspirating, mixing, and dispensing reagent mixtures to the microfluidic cartridge; systems for data storage, processing, and output; and a system controller to coordinate the various devices and functions.Type: GrantFiled: August 24, 2015Date of Patent: July 30, 2019Assignee: Canon U.S. Life Sciences, Inc.Inventors: Ivor T. Knight, Kenton C. Hasson, Johnathan S. Coursey, Hongye Liang, Sami Kanderian, Gregory H. Owen, Weidong Cao, Ying-Xin Wang, Scott Corey, Ben Lane, Conrad Laskowski, Alex Flamm, Brian Murphy, Eric Schneider, Takayoshi Hanagata, Hiroshi Inoue, Shulin Zeng, Brian Bean, Franklin Regan
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Patent number: 10226772Abstract: The invention relates to systems and methods including a combination of thermal generating device technologies to achieve more efficiency and accuracy in PCR temperature cycling of nucleic samples undergoing amplification.Type: GrantFiled: February 29, 2016Date of Patent: March 12, 2019Assignee: Canon U.S. Life Sciences, Inc.Inventors: Gregory A. Dale, Shulin Zeng, Kenton C. Hasson
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Patent number: 10092902Abstract: An interface cartridge for a microfluidic chip, with microfluidic process channels and fluidic connection holes at opposed ends of the process channels, provides ancillary fluid structure, including fluid flow channels and input and/or waste wells, which mix and/or convey reaction fluids to the fluidic connection holes and into the process channels of the microfluidic chip.Type: GrantFiled: September 21, 2015Date of Patent: October 9, 2018Assignee: Canon U.S. Life Sciences, Inc.Inventors: Ray Tsao, Hiroshi Inoue, Shulin Zeng, Brian Murphy, Kenton C. Hasson
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Publication number: 20180056299Abstract: An apparatus for performing a thermocyclic process, such as amplifying DNA, includes a microfluidic chip with a channel formed therein and one or more thermal distribution elements disposed over portions of the chip. Each thermal distribution element is configured to distribute thermal energy from an external thermal energy source substantially uniformly over the portion of the chip covered by the thermal distribution element. The portion of the chip covered by the thermal distribution element thereby comprises a discrete temperature zone. Other temperature zones can be defined by other thermal distribution elements or by portions of the chip not covered by a thermal distribution element. The channel is configured so that a fluid flowing through the channel would enter and exit the different temperature zones a plurality of times, thereby alternately exposing the fluid to the temperature of each zone for a period of time required for the fluid to traverse the zone.Type: ApplicationFiled: August 7, 2017Publication date: March 1, 2018Applicant: Canon U.S. Life Sciences, Inc.Inventors: Gregory A. Dale, Kenton C. Hasson, Shulin Zeng, Michele Stone
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Publication number: 20180045649Abstract: This invention is in the field of medical devices. Specifically, the present invention provides fluidic systems having a plurality of reaction sites surrounded by optical barriers to reduce the amount of optical cross-talk between signals detected from various reaction sites. The invention also provides a method of manufacturing fluidic systems and methods of using the systems.Type: ApplicationFiled: August 29, 2017Publication date: February 15, 2018Inventors: Timothy Michael Kemp, Chris Todd, Ron Oral, Shulin Zeng, John Howard, Jeff Fenton
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Publication number: 20180015398Abstract: The present invention relates to systems and methods for preparing a fluidic cartridge for use in an analyzer device. In one non-limiting aspect, the present invention provides a method of preparing a fluidic cartridge for use in an analyzer device. The method may include controlling valves and a vacuum pump of a priming station to evacuate air from a fluidic cartridge loaded in the priming station. The method may include controlling the valves and the vacuum pump to draw priming fluid into sipper wells and channels of the loaded fluidic cartridge. In another non-limiting aspect, the present invention provides a priming station for preparing a fluidic cartridge for use in an analyzer device. The priming station may include a vacuum pump, a priming manifold assembly, and a controller. The priming manifold assembly may be configured to interface with a fluidic cartridge loaded in the priming station.Type: ApplicationFiled: July 10, 2017Publication date: January 18, 2018Applicant: Canon U.S. Life Sciences, Inc.Inventors: Joshua Mull, Owen Lu, Eric Schneider, Collin Grimes, Jamie Kendall, Franklin Francis Regan, IV, Ralph McCann, Scott Sundberg, Makoto Ogusu, Sean Ison, Jared Spaniol, Shulin Zeng, Ivor Knight
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Publication number: 20170327867Abstract: The present invention relates to sample-to-answer systems, devices, cartridges, and method of using the same for detecting the presence of microorganisms in a sample, such as bacteria.Type: ApplicationFiled: December 22, 2016Publication date: November 16, 2017Applicant: Canon U.S. Life Sciences, Inc.Inventors: Abhijit Dohale, Arvind Virmani, Brian Scrivens, Christopher Sneeder, Denis Alias, George Maltezos, Hanyoup Kim, Harini Shandilya, Hongye Liang, Jason Zsak, Johnathan Stuart Coursey, Kenton C. Hasson, Melissa Gosse, Shulin Zeng, Yasuyuki Numajiri, Makoto Ogusu, Yoichi Murakami, Kunihiro Sakai
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Patent number: 9772291Abstract: This invention is in the field of medical devices. Specifically, the present invention provides fluidic systems having a plurality of reaction sites surrounded by optical barriers to reduce the amount of optical cross-talk between signals detected from various reaction sites. The invention also provides a method of manufacturing fluidic systems and methods of using the systems.Type: GrantFiled: June 1, 2015Date of Patent: September 26, 2017Assignee: Theranos, Inc.Inventors: Timothy Michael Kemp, Chris Todd, Ron Oral, Shulin Zeng, John Howard, Jeff Fenton
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Patent number: 9724695Abstract: An apparatus for performing a thermocyclic process, such as amplifying DNA, includes a microfluidic chip with a channel formed therein and one or more thermal distribution elements disposed over portions of the chip. Each thermal distribution element is configured to distribute thermal energy from an external thermal energy source substantially uniformly over the portion of the chip covered by the thermal distribution element. The portion of the chip covered by the thermal distribution element thereby comprises a discrete temperature zone. Other temperature zones can be defined by other thermal distribution elements or by portions of the chip not covered by a thermal distribution element. The channel is configured so that a fluid flowing through the channel would enter and exit the different temperature zones a plurality of times, thereby alternately exposing the fluid to the temperature of each zone for a period of time required for the fluid to traverse the zone.Type: GrantFiled: June 23, 2008Date of Patent: August 8, 2017Assignee: Canon U.S. Life Sciences, Inc.Inventors: Gregory A. Dale, Kenton C. Hasson, Shulin Zeng, Michele Stone
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Publication number: 20170114380Abstract: A system for amplifying nucleic acids is disclosed which, in one embodiment, includes a fluidic device having a sample channel and a heat exchange channel disposed sufficiently close to the sample channel such that a heat exchange fluid in the heat exchange channel can cause a sample in the sample channel to gain or lose heat at desired levels. In one illustrative embodiment, the system further includes three reservoirs coupled to the heat exchange channel and a temperature control system configured to heat fluids stored in the respective reservoirs at different temperatures. One or more pumps and a controller are configured to cause fluid stored in the reservoirs to enter and flow through the heat exchange channel at different times.Type: ApplicationFiled: January 6, 2017Publication date: April 27, 2017Inventors: Shulin Zeng, Kenton C. Hasson, Gregory A. Dale
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Patent number: 9540686Abstract: A system for amplifying nucleic acids is disclosed which, in one embodiment, includes a fluidic device having a sample channel and a heat exchange channel disposed sufficiently close to the sample channel such that a heat exchange fluid in the heat exchange channel can cause a sample in the sample channel to gain or lose heat at desired levels. In one illustrative embodiment, the system further includes three reservoirs coupled to the heat exchange channel and a temperature control system configured to heat fluids stored in the respective reservoirs at different temperatures. One or more pumps and a controller are configured to cause fluid stored in the reservoirs to enter and flow through the heat exchange channel at different times.Type: GrantFiled: September 18, 2008Date of Patent: January 10, 2017Assignee: Canon U.S. Life Sciences, Inc.Inventors: Shulin Zeng, Kenton C. Hasson, Gregory A. Dale
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Publication number: 20160362722Abstract: In one aspect, the present invention provides a systems and methods for the real-time amplification and analysis of a sample of DNA.Type: ApplicationFiled: March 14, 2016Publication date: December 15, 2016Applicant: Canon U.S. Life sciences, Inc.Inventors: Gregory H. Owen, Gregory A. Dale, Kenton C. Hasson, Shulin Zeng, Dwayne Warren Warfield
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Publication number: 20160354785Abstract: The invention relates to systems and methods including a combination of thermal generating device technologies to achieve more efficiency and accuracy in PCR temperature cycling of nucleic samples undergoing amplification.Type: ApplicationFiled: February 29, 2016Publication date: December 8, 2016Applicant: Canon U.S. Life Sciences, Inc.Inventors: Gregory A. Dale, Shulin Zeng, Kenton C. Hasson
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Patent number: 9427736Abstract: A system and method for controlling fluid flow within a microchannel includes a fluid circuit comprising a fluid outlet well and one or more fluid inlet wells, all in communication with a microchannel. A negative pressure differential is applied to the outlet well and fluid flow from an inlet well into the microchannel is controlled by opening or closing the inlet well to atmospheric pressure. To stop fluid flow from the inlet well, a negative pressure differential may be applied to the inlet well to equalize pressure between the inlet and outlet wells. By sequentially opening and closing different inlet wells to atmosphere, controlled amounts of different reagents can be serially introduced into the microchannel.Type: GrantFiled: January 27, 2015Date of Patent: August 30, 2016Assignee: Canon U.S. Life Sciences, Inc.Inventors: Shulin Zeng, Gregory A. Dale
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Publication number: 20160074864Abstract: An interface cartridge for a microfluidic chip, with microfluidic process channels and fluidic connection holes at opposed ends of the process channels, provides ancillary fluid structure, including fluid flow channels and input and/or waste wells, which mix and/or convey reaction fluids to the fluidic connection holes and into the process channels of the microfluidic chip.Type: ApplicationFiled: September 21, 2015Publication date: March 17, 2016Applicant: Canon U.S. Life Sciences, Inc.Inventors: Ray Tsao, Hiroshi Inoue, Shulin Zeng, Brian Murphy, Kenton C. Hasson