Patents by Inventor Shulin Zeng
Shulin Zeng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9283563Abstract: In one aspect, the present invention provides a systems and methods for the real-time amplification and analysis of a sample of DNA.Type: GrantFiled: October 28, 2008Date of Patent: March 15, 2016Assignee: Canon U.S. Life Sciences, Inc.Inventors: Gregory H. Owen, Gregory A. Dale, Kenton C. Hasson, Shulin Zeng, Dwayne W. Warfield, Sarah Warfield
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Patent number: 9272282Abstract: The invention relates to systems and methods including a combination of thermal generating device technologies to achieve more efficiency and accuracy in PCR temperature cycling of nucleic samples undergoing amplification.Type: GrantFiled: August 13, 2013Date of Patent: March 1, 2016Assignee: Canon U.S. Life Sciences, Inc.Inventors: Gregory A. Dale, Shulin Zeng, Kenton C. Hasson
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Publication number: 20160051985Abstract: The present invention relates to systems and methods for the real time processing of nucleic acid during polymerase chain reaction (PCR) and thermal melt applications. According to an aspect of the invention, a system for the rapid serial processing of multiple nucleic acid assays is provided. In one embodiment, the system includes, but is not limited to: a microfluidic cartridge having microfluidic (flow-through) channels, a fluorescence imaging system, a temperature measurement and control system; a pressure measurement and control system for applying variable pneumatic pressures to the microfluidic cartridge; a storage device for holding multiple reagents (e.g., a well-plate); a liquid handling system comprising at least one robotic pipettor for aspirating, mixing, and dispensing reagent mixtures to the microfluidic cartridge; systems for data storage, processing, and output; and a system controller to coordinate the various devices and functions.Type: ApplicationFiled: August 24, 2015Publication date: February 25, 2016Applicant: Canon U.S. Life Sciences, Inc.Inventors: Ivor T. KNIGHT, Kenton C. Hasson, Johnathan S. Coursey, Hongye Liang, Sami Kanderian, Gregory H. Owen, Weidong Cao, Ying-Xin Wang, Scott Corey, Ben Lane, Conrad Laskowski, Alex Flamm, Brian Murphy, Eric Schneider, Takayoshi Hanagata, Hiroshi Inoue, Shulin Zeng, Brian Bean, Franklin Regan
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Publication number: 20150377875Abstract: This invention is in the field of medical devices. Specifically, the present invention provides fluidic systems having a plurality of reaction sites surrounded by optical barriers to reduce the amount of optical cross-talk between signals detected from various reaction sites. The invention also provides a method of manufacturing fluidic systems and methods of using the systems.Type: ApplicationFiled: June 1, 2015Publication date: December 31, 2015Inventors: Timothy M. Kemp, Chris Todd, Ron Oral, Shulin Zeng, John Howard, Jeff Fenton
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Publication number: 20150298122Abstract: A system and method for controlling fluid flow within a microchannel includes a fluid circuit comprising a fluid outlet well and one or more fluid inlet wells, all in communication with a microchannel. A negative pressure differential is applied to the outlet well and fluid flow from an inlet well into the microchannel is controlled by opening or closing the inlet well to atmospheric pressure. To stop fluid flow from the inlet well, a negative pressure differential may be applied to the inlet well to equalize pressure between the inlet and outlet wells. By sequentially opening and closing different inlet wells to atmosphere, controlled amounts of different reagents can be serially introduced into the microchannel.Type: ApplicationFiled: January 27, 2015Publication date: October 22, 2015Applicant: Canon U.S. Life Sciences, Inc.Inventors: Shulin Zeng, Gregory A. Dale
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Patent number: 9138744Abstract: An interface cartridge for a microfluidic chip, with microfluidic process channels and fluidic connection holes at opposed ends of the process channels, provides ancillary fluid structure, including fluid flow channels and input and/or waste wells, which mix and/or convey reaction fluids to the fluidic connection holes and into the process channels of the microfluidic chip.Type: GrantFiled: October 27, 2014Date of Patent: September 22, 2015Assignee: Canon U.S. Life Sciences, Inc.Inventors: Ray Tsao, Hiroshi Inoue, Shulin Zeng, Brian Murphy, Kenton C. Hasson
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Patent number: 9114399Abstract: The present invention relates to systems and methods for the real time processing of nucleic acid during polymerase chain reaction (PCR) and thermal melt applications. According to an aspect of the invention, a system for the rapid serial processing of multiple nucleic acid assays is provided. In one embodiment, the system includes, but is not limited to: a microfluidic cartridge having microfluidic (flow-through) channels, a fluorescence imaging system, a temperature measurement and control system; a pressure measurement and control system for applying variable pneumatic pressures to the microfluidic cartridge; a storage device for holding multiple reagents (e.g., a well-plate); a liquid handling system comprising at least one robotic pipettor for aspirating, mixing, and dispensing reagent mixtures to the microfluidic cartridge; systems for data storage, processing, and output; and a system controller to coordinate the various devices and functions.Type: GrantFiled: August 31, 2011Date of Patent: August 25, 2015Assignee: Canon U.S. Life Sciences, Inc.Inventors: Ivor T. Knight, Kenton C. Hasson, Johnathan S. Coursey, Hongye Liang, Sami Kanderian, Gregory H. Owen, Weidong Cao, Ying-Xin Wang, Scott Corey, Ben Lane, Conrad Laskowski, Alex Flamm, Brian Murphy, Eric Schneider, Takayoshi Hanagata, Hiroshi Inoue, Shulin Zeng, Brian Bean, Franklin Regan
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Patent number: 9075046Abstract: This invention is in the field of medical devices. Specifically, the present invention provides fluidic systems having a plurality of reaction sites surrounded by optical barriers to reduce the amount of optical cross-talk between signals detected from various reaction sites. The invention also provides a method of manufacturing fluidic systems and methods of using the systems.Type: GrantFiled: November 24, 2009Date of Patent: July 7, 2015Assignee: Theranos, Inc.Inventors: Timothy M. Kemp, Chris Todd, Ron Oral, Shulin Zeng, John Howard, Jeff Fenton
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Publication number: 20150111289Abstract: An interface cartridge for a microfluidic chip, with microfluidic process channels and fluidic connection holes at opposed ends of the process channels, provides ancillary fluid structure, including fluid flow channels and input and/or waste wells, which mix and/or convey reaction fluids to the fluidic connection holes and into the process channels of the microfluidic chip.Type: ApplicationFiled: October 27, 2014Publication date: April 23, 2015Applicant: Canon U.S. Life Sciences, Inc.Inventors: Ray Tsao, Hiroshi Inoue, Shulin Zeng, Brian Murphy, Kenton C. Hasson
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Patent number: 8939171Abstract: A system and method for controlling fluid flow within a microchannel includes a fluid circuit comprising a fluid outlet well and one or more fluid inlet wells, all in communication with a microchannel. A negative pressure differential is applied to the outlet well and fluid flow from an inlet well into the microchannel is controlled by opening or closing the inlet well to atmospheric pressure. To stop fluid flow from the inlet well, a negative pressure differential may be applied to the inlet well to equalize pressure between the inlet and outlet wells. By sequentially opening and closing different inlet wells to atmosphere, controlled amounts of different reagents can be serially introduced into the microchannel.Type: GrantFiled: February 15, 2012Date of Patent: January 27, 2015Assignee: Canon U.S. Life Sciences, Inc.Inventors: Shulin Zeng, Gregory A. Dale
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Patent number: 8871156Abstract: An interface cartridge for a microfluidic chip, with microfluidic process channels and fluidic connection holes at opposed ends of the process channels, provides ancillary fluid structure, including fluid flow channels and input and/or waste wells, which mix and/or convey reaction fluids to the fluidic connection holes and into the process channels of the microfluidic chip.Type: GrantFiled: November 15, 2012Date of Patent: October 28, 2014Assignee: Canon U.S. Life Sciences, Inc.Inventors: Ray Tsao, Hiroshi Inoue, Shulin Zeng, Brian Murphy, Kenton C. Hasson
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Publication number: 20140065703Abstract: The invention relates to systems and methods including a combination of thermal generating device technologies to achieve more efficiency and accuracy in PCR temperature cycling of nucleic samples undergoing amplification.Type: ApplicationFiled: August 13, 2013Publication date: March 6, 2014Applicant: Canon U.S. Life Sciences, Inc.Inventors: Gregory A. Dale, Shulin Zeng, Kenton C. Hasson
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Patent number: 8507257Abstract: The invention relates to systems and methods including a combination of thermal generating device technologies to achieve more efficiency and accuracy in PCR temperature cycling of nucleic samples undergoing amplification.Type: GrantFiled: December 13, 2010Date of Patent: August 13, 2013Assignee: Canon U.S. Life Sciences, Inc.Inventors: Gregory A. Dale, Shulin Zeng, Kenton C. Hasson
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Patent number: 8409848Abstract: At least one exemplary embodiment is directed to an apparatus that includes a microfluidic channel and at least one energy absorbing element, where the energy absorbing element is configured to absorb at least a portion of an incident electromagnetic radiation. The absorption of the radiation by the energy absorbing element varies the temperature of a sample in the microfluidic channel.Type: GrantFiled: June 29, 2007Date of Patent: April 2, 2013Inventors: Shulin Zeng, Kenton C. Hasson, Gregory A. Dale, John Keady
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Patent number: 8354080Abstract: An interface cartridge for a microfluidic chip, with microfluidic process channels and fluidic connection holes at opposed ends of the process channels, provides ancillary fluid structure, including fluid flow channels and input and/or waste wells, which mix and/or convey reaction fluids to the fluidic connection holes and into the process channels of the microfluidic chip.Type: GrantFiled: April 12, 2010Date of Patent: January 15, 2013Assignee: Canon U.S. Life Sciences, Inc.Inventors: Ray Tsao, Hiroshi Inoue, Shulin Zeng, Brian Murphy, Kenton C. Hasson
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Publication number: 20120145253Abstract: A system and method for controlling fluid flow within a microchannel includes a fluid circuit comprising a fluid outlet well and one or more fluid inlet wells, all in communication with a microchannel. A negative pressure differential is applied to the outlet well and fluid flow from an inlet well into the microchannel is controlled by opening or closing the inlet well to atmospheric pressure. To stop fluid flow from the inlet well, a negative pressure differential may be applied to the inlet well to equalize pressure between the inlet and outlet wells. By sequentially opening and closing different inlet wells to atmosphere, controlled amounts of different reagents can be serially introduced into the microchannel.Type: ApplicationFiled: February 15, 2012Publication date: June 14, 2012Applicant: Canon U.S. Life Sciences, Inc.Inventors: Shulin Zeng, Gregory A. Dale
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Publication number: 20120052560Abstract: The present invention relates generally to systems and methods for the rapid serial processing of multiple nucleic acid assays. More particularly, the present invention provides for the real time processing of nucleic acid during polymerase chain reaction (PCR) and thermal melt applications. According to an aspect of the invention, a system for the rapid serial processing of multiple nucleic acid assays is provided. In one embodiment, the system includes, but is not limited to: a microfluidic cartridge having microfluidic (flow-through) channels, a fluorescence imaging system, a temperature measurement and control system; a pressure measurement and control system for applying variable pneumatic pressures to the microfluidic cartridge; a storage device for holding multiple reagents (e.g.Type: ApplicationFiled: August 31, 2011Publication date: March 1, 2012Applicant: CANON U.S. LIFE SCIENCES, INC.Inventors: Ivor T. Knight, Kenton C. Hasson, Johnathan S. Coursey, Hongye Liang, Sami Kanderian, Gregory H. Owen, Weidong Cao, Ying-Xin Wang, Scott Corey, Ben Lane, Conrad Laskowski, Alex Flamm, Brian Murphy, Eric Schneider, Takayoshi Hanagata, Hiroshi Inoue, Shulin Zeng, Brian Bean, Franklin Regan
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Patent number: 8122901Abstract: A system and method for controlling fluid flow within a microchannel includes a fluid circuit comprising a fluid outlet well and one or more fluid inlet wells, all in communication with a microchannel. A negative pressure differential is applied to the outlet well and fluid flow from an inlet well into the microchannel is controlled by opening or closing the inlet well to atmospheric pressure. To stop fluid flow from the inlet well, a negative pressure differential may be applied to the inlet well to equalize pressure between the inlet and outlet wells. By sequentially opening and closing different inlet wells to atmosphere, controlled amounts of different reagents can be serially introduced into the microchannel.Type: GrantFiled: June 30, 2008Date of Patent: February 28, 2012Assignee: Canon U.S. Life Sciences, Inc.Inventors: Shulin Zeng, Gregory A. Dale
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Patent number: 8058054Abstract: In one aspect, the present invention provides a systems and methods for the real-time amplification and analysis of a sample of DNA.Type: GrantFiled: June 29, 2007Date of Patent: November 15, 2011Assignee: Canon U.S. Life Sciences, Inc.Inventors: Gregory H. Owen, Gregory A. Dale, Kenton C. Hasson, Shulin Zeng, Dwayne W. Warfield, Sarah Warfield, legal representative
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Publication number: 20110081136Abstract: The invention relates to systems and methods including a combination of thermal generating device technologies to achieve more efficiency and accuracy in PCR temperature cycling of nucleic samples undergoing amplification.Type: ApplicationFiled: December 13, 2010Publication date: April 7, 2011Applicant: Canon U.S. Life Sciences, Inc.Inventors: Gregory A. DALE, Shulin Zeng, Kenton C. Hasson