Patents by Inventor Shunhai Wang

Shunhai Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR ANALYSIS OF VIRAL CAPSID PROTEIN COMPOSITION
    Publication number: 20220275398
    Abstract: Methods of determining the stoichiometry of a viral capsid and/or determining the heterogeneity of protein components in a viral capsid are disclosed.
    Type: Application
    Filed: May 17, 2022
    Publication date: September 1, 2022
    Inventor: Shunhai Wang
  • Anti-VEGF protein compositions and methods for producing the same
    Patent number: 11407813
    Abstract: The present disclosure pertains compositions comprising anti-VEGF proteins and methods for producing such compositions.
    Type: Grant
    Filed: October 1, 2021
    Date of Patent: August 9, 2022
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Andrew Tustian, Ankit Vartak, Thomas Daly, Erica Pyles, Nisha Palackal, Shunhai Wang, Ning Li, Matthew Franklin
  • METHOD AND SYSTEM OF IDENTIFYING AND QUANTIFYING A PROTEIN
    Publication number: 20220244270
    Abstract: Methods and system for identifying and/or quantifying a protein are provided herein.
    Type: Application
    Filed: April 20, 2022
    Publication date: August 4, 2022
    Inventors: Yuetian Yan, Shunhai Wang
  • ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME
    Publication number: 20220235116
    Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
    Type: Application
    Filed: April 1, 2022
    Publication date: July 28, 2022
    Inventors: Andrew Tustian, Ankit Vartak, Thomas Daly, Erica Pyles, Nisha Palackal, Shunhai Wang, Ning Li, Matthew Franklin
  • ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME
    Publication number: 20220227836
    Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
    Type: Application
    Filed: February 8, 2022
    Publication date: July 21, 2022
    Inventors: Shunhai Wang, Ning Li, Hunter Chen, Amardeep Singh Bhupender Bhalla
  • ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME
    Publication number: 20220227835
    Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
    Type: Application
    Filed: January 13, 2022
    Publication date: July 21, 2022
    Applicant: Regeneron Pharmaceuticals, Inc.
    Inventors: Shunhai Wang, Ning Li, Hunter Chen, Amardeep Singh Bhupender Bhalla
  • Method and system of identifying and quantifying a protein
    Patent number: 11385239
    Abstract: Methods and system for identifying and/or quantifying a protein are provided herein.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: July 12, 2022
    Assignee: Regeneran Pharmaceuticals, Inc.
    Inventors: Yuetian Yan, Shunhai Wang
  • Glucuronylation as a new acidic post-translational modification on therapeutic monoclonal antibodies
    Patent number: 11366123
    Abstract: Compositions and methods for identifying glucuronylated protein drug products are provided.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: June 21, 2022
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventor: Shunhai Wang
  • Methods for analysis of viral capsid protein composition
    Patent number: 11359213
    Abstract: Methods of determining the stoichiometry of a viral capsid and/or determining the heterogeneity of protein components in a viral capsid are disclosed.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: June 14, 2022
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventor: Shunhai Wang
  • SYSTEM AND METHOD FOR CHARACTERIZING DRUG PRODUCT IMPURITIES
    Publication number: 20220169704
    Abstract: Systems and methods for characterizing low molecular weight (LMW) protein drug product impurities are provided. One embodiment uses hydrophilic interaction chromatography (HILIC) coupled to mass spectrometry analysis. After removal of the N-linked glycans from the protein drug product, for example an antibody drug product, the elution of LMW impurities from the HILIC column was determined by the size of the molecular weight species. In some embodiments, the HILIC separation is performed under denaturing conditions, making the detection of LMW forms using this method highly comparable to both SDS-PAGE and CE-SDS methods. LMW drug product impurities include, but are not limited to light chain, half antibody, H2L, H2, HL, HC, peptide backbone-truncated species, and combinations thereof.
    Type: Application
    Filed: February 22, 2022
    Publication date: June 2, 2022
    Inventor: Shunhai Wang
  • Methods for analysis of viral capsid protein composition
    Patent number: 11345929
    Abstract: Methods of determining the stoichiometry of a viral capsid and/or determining the heterogeneity of protein components in a viral capsid are disclosed.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: May 31, 2022
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventor: Shunhai Wang
  • ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME
    Publication number: 20220162289
    Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
    Type: Application
    Filed: February 8, 2022
    Publication date: May 26, 2022
    Inventors: Andrew Tustian, Ankit Vartak, Thomas Daly, Erica Pyles, Nisha Palackal, Shunhai Wang, Ning Li
  • METHODS FOR PRODUCING AFLIBERCEPT IN CHEMICALLY DEFINED MEDIA HAVING REDUCED AFLIBERCEPT VARIANTS
    Publication number: 20220127331
    Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
    Type: Application
    Filed: December 21, 2021
    Publication date: April 28, 2022
    Inventors: Shawn Lawrence, Amy Johnson, Meghan Casey, Jaimie Mastrogiacomo, Shunhai Wang, Ning Li
  • Anti-VEGF protein compositions and methods for producing the same
    Patent number: 11306135
    Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
    Type: Grant
    Filed: August 30, 2021
    Date of Patent: April 19, 2022
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Shunhai Wang, Ning Li, Hunter Chen, Amardeep Singh Bhupender Bhalla
  • SYSTEM AND METHOD OF ANALYSIS OF A PROTEIN USING LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY
    Publication number: 20220113317
    Abstract: The present disclosure pertains to method and system of characterizing a protein using an electrospray ionization source.
    Type: Application
    Filed: December 23, 2021
    Publication date: April 14, 2022
    Inventor: Shunhai Wang
  • Anti-VEGF protein compositions and methods for producing the same
    Patent number: 11299532
    Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions in chemically defined media to reduce amounts of certain Aflibercept variants.
    Type: Grant
    Filed: September 29, 2021
    Date of Patent: April 12, 2022
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Andrew Tustian, Ankit Vartak, Thomas Daly, Erica Pyles, Nisha Palackal, Shunhai Wang, Ning Li
  • ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME
    Publication number: 20220098280
    Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
    Type: Application
    Filed: August 26, 2021
    Publication date: March 31, 2022
    Inventors: Shunhai Wang, Ning Li, Hunter Chen, Amardeep Singh Bhupender Bhalla
  • ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME
    Publication number: 20220048975
    Abstract: The present disclosure pertains compositions comprising anti-VEGF proteins and methods for producing such compositions.
    Type: Application
    Filed: October 13, 2021
    Publication date: February 17, 2022
    Inventors: Andrew Tustian, Ankit Vartak, Thomas Daly, Erica Pyles, Nisha Palackal, Shunhai Wang, Ning Li
  • System and method of analysis of a protein using liquid chromatography-mass spectrometry
    Patent number: 11249089
    Abstract: The present disclosure pertains to method and system of characterizing a protein using an electrospray ionization source.
    Type: Grant
    Filed: December 10, 2019
    Date of Patent: February 15, 2022
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventor: Shunhai Wang
  • Method and System of Identifying and Quantifying A Protein
    Publication number: 20220043002
    Abstract: Methods and system for identifying and/or quantifying a protein are provided herein.
    Type: Application
    Filed: October 30, 2019
    Publication date: February 10, 2022
    Inventors: Yuetian Yan, Shunhai Wang