Abstract: Aspects of this technical solution can include a plurality of SAR TC stages configured to convert an input time signal to a digital code including a plurality of output signals each corresponding to a SAR TDC stage among the plurality of SAR TDC stages connected to an input of a following SAR TDC stage among the plurality of SAR TDC stages, where the SAR stage is controlled by a clock signal based on a delayed clock signal from a previous SAR TDC stage among the plurality of SAR TDC stages.

Abstract: A long-endurance self-powered ocean buoy includes a buoy body, a power generation device and a gas bag base; the power generation device is mounted at a lower end of the gas bag base and includes a housing, a first power generation assembly, a second power generation assembly and a storage battery; the first power generation assembly includes a plurality of mutually-communicated gas chambers, hydraulic bags and control integration units. The lowest gas chamber is filled with a volatile working medium which can generate gas pressure by volatilization to drive power generation fans in turbines on a vent pipe communicating adjacent gas chambers for power generation. The second power generation assembly includes a plurality of temperature difference energy modules with one end surrounded by a phase change material and the other end in contact with the housing, so as to increase the power generation efficiency.

Abstract: A long-endurance self-powered ocean buoy includes a buoy body, a power generation device and a gas bag base; the power generation device is mounted at a lower end of the gas bag base and includes a housing, a first power generation assembly, a second power generation assembly and a storage battery; the first power generation assembly includes a plurality of mutually-communicated gas chambers, hydraulic bags and control integration units. The lowest gas chamber is filled with a volatile working medium which can generate gas pressure by volatilization to drive power generation fans in turbines on a vent pipe communicating adjacent gas chambers for power generation. The second power generation assembly includes a plurality of temperature difference energy modules with one end surrounded by a phase change material and the other end in contact with the housing, so as to increase the power generation efficiency.

Abstract: A compute in-memory architecture comprising multiple neurons is provided. Each neuron includes one or more storage compute cells, each of which includes a logic circuit configured to receive a multi-bit input and a weight. The weight is defined by one or more weight bits. The logic circuit is further configured to output a control voltage corresponding to logic ‘HIGH’ when XNOR operation between an input sign bit and a corresponding weight bit is 1 and a corresponding input magnitude bit is also 1. A first digital-to-analog converter is formed from a first MOSCAP group in electrical communication with the logic circuit. The first MOSCAP group includes a total number of MOSCAPs equal to input magnitude bit resolution times weight bit resolution. Characteristically, each MOSCAP in the first MOSCAP group has a first end that receives the control voltage, and a second end in electrical communication with a first summation line.

Abstract: A subharmonic switching power amplifier architecture includes a power amplifier core that includes at least one power amplifier that receives an input signal and is operable in a power back-off region. Characteristically, the at least one power amplifier is configured to be toggled at a carrier frequency (Fc) when the power level of the input signal is equal to or higher than a predetermined power level and at a subharmonic component of the carrier frequency when the power level of the input signal is less than the predetermined power level. Concurrent harmonic tuning and subharmonic tuning is implemented to enhance the efficiency at both peak power mode and power back-off mode. Characteristically, the power amplifier being configured to be operated by a voltage mode or current mode driver and in the current mode with zero-voltage-switching.

Abstract: A circuit arrangement includes an array of switches that represent a Boolean satisfiability expression that has a plurality of clauses each defined by a combination of Boolean variables Xi or ¬Xi, a first plane, and a constraints network operatively arranged with the first plane. The constraints network enforces each of the clauses such that values of different ones of the variables continue to randomly or pseudo randomly flip until the values of the variables Xi and ¬Xi stop changing or a predetermined condition occurs.

Abstract: An optical power prism that may be used in folded lens systems that consists of a glass prism and a glass lens attached to a surface of the prism using a thin layer of optical glue or by optical contact. The glass lens does not have a flange and thus the prism can be smaller than prisms used in conventional power prisms with the same lens effective area, thus reducing the Z-height of the power prism when compared to conventional power prisms. An optical glass may be used for the lens that has a higher refractive index than can be provided by optical plastic which allows the lens to be thinner than plastic lenses. The lenses may be formed by molding a glass wafer to form lens shapes on a first surface of the wafer; the molded wafer is then ground from a second surface to singulate the lenses.

Abstract: The invention provides monoclonal antibodies and antigen-binding fragments thereof specific for TNFR2, and methods of using the same to treat cancer or autoimmune disorder, including combination therapy with antagonists of the PD-1/PD-L1 immune checkpoint.

Abstract: A semiconductor device, includes: a first conductive type semiconductor region including a first semiconductor structure, wherein the first semiconductor structure includes one or more pairs of stack, the one or more pairs of stack respectively includes a first layer and a second layer, the first layer includes AlxGa1-xN, the second layer includes AlyGa1-yN, wherein 0?x<1, 0<y<1, x<y, wherein one of the one or more pairs of stack includes an interface region located between the first layer and the second layer adjacent to the first layer; a second conductive type semiconductor region located on the first conductive type semiconductor region; and an active region located between the first conductive type semiconductor region and the second conductive type semiconductor region; wherein the first semiconductor structure includes a first dopant having a first doping concentration with a peak value at the interface region.

Abstract: An optical power prism that may be used in folded lens systems that consists of a glass prism and a glass lens attached to a surface of the prism using a thin layer of optical glue or by optical contact. The glass lens does not have a flange and thus the prism can be smaller than prisms used in conventional power prisms with the same lens effective area, thus reducing the Z-height of the power prism when compared to conventional power prisms. An optical glass may be used for the lens that has a higher refractive index than can be provided by optical plastic which allows the lens to be thinner than plastic lenses. The lenses may be formed by molding a glass wafer to form lens shapes on a first surface of the wafer; the molded wafer is then ground from a second surface to singulate the lenses.

Abstract: An optical power prism that may be used in folded lens systems that consists of a glass prism and a glass lens attached to a surface of the prism using a thin layer of optical glue or by optical contact. The glass lens does not have a flange and thus the prism can be smaller than prisms used in conventional power prisms with the same lens effective area, thus reducing the Z-height of the power prism when compared to conventional power prisms. An optical glass may be used for the lens that has a higher refractive index than can be provided by optical plastic which allows the lens to be thinner than plastic lenses. The lenses may be formed by molding a glass wafer to form lens shapes on a first surface of the wafer; the molded wafer is then ground from a second surface to singulate the lenses.

Abstract: A subharmonic switching digital power amplifier system includes a power amplifier core that includes at least one power amplifier operable in a power back-off region and a power supply providing at least one operating voltage to the power amplifier. Characteristically, the power amplifier is toggled at a subharmonic component of a carrier frequency (Fc) to achieve power back-off wherein the power amplifier is operated in a voltage mode or current mode driver. Multi-subharmonics can be used to further enhance the power back-off efficiency. A switching digital power amplifier system employing phase interleaving is also provided.

Abstract: The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.

Abstract: A subharmonic switching digital power amplifier system includes a power amplifier core that includes at least one power amplifier operable in a power back-off region and a power supply providing at least one operating voltage to the power amplifier. Characteristically, the power amplifier is toggled at a subharmonic component of a carrier frequency (Fc) to achieve power back-off wherein the power amplifier is operated in a voltage mode or current mode driver. Multi-subharmonics can be used to further enhance the power back-off efficiency. A switching digital power amplifier system employing phase interleaving is also provided.

Abstract: The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.

Abstract: An optical power prism that may be used in folded lens systems that consists of a glass prism and a glass lens attached to a surface of the prism using a thin layer of optical glue or by optical contact. The glass lens does not have a flange and thus the prism can be smaller than prisms used in conventional power prisms with the same lens effective area, thus reducing the Z-height of the power prism when compared to conventional power prisms. An optical glass may be used for the lens that has a higher refractive index than can be provided by optical plastic which allows the lens to be thinner than plastic lenses. The lenses may be formed by molding a glass wafer to form lens shapes on a first surface of the wafer; the molded wafer is then ground from a second surface to singulate the lenses.

Abstract: The invention features all-trans retinoic acid (ATRA)-related compounds capable of associating with Pin1 and methods of treating a proliferative disorder characterized by elevated Pin1 marker levels, Pin1 degradation, and/or reduced Pin1 Ser71 phosphorylation in a subject by administering an ATRA-related compound. The invention also features methods of treating proliferative disorders, autoimmune diseases, and addiction conditions (e.g., diseases, disorders, and conditions characterized by elevated Pin1 marker levels) by administering an ATRA-related compound in combination with another therapeutic compound.

Abstract: The invention features methods of treating a proliferative disorder characterized by elevated Pin1 marker levels and/or reduced Pin1 Ser71 phosphorylation in a subject by administering a retinoic acid compound. Additionally, the invention features methods of treating proliferative disorders (e.g., proliferative disorders characterized by elevated Pin1 marker levels) by administering a retinoic acid compound in combination with another anti-proliferative compound. Finally, the invention also features methods including high-throughput screens for discovering and validating Pin1 inhibitors.

Abstract: The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.

Abstract: Biomarkers and driver mutations for diagnosis and prognosis of Pin 1-associated diseases are disclosed. In one embodiment, the methods for diagnosis of Pin 1-associated diseases may include detecting the level of Pin1 to stage abnormal cell growth, such as breast or prostate cancer. In another embodiment, the methods include evaluating the efficacy of a treatment of abnormal cell growth, such as cancer, by monitoring the levels of Pin1. In another embodiment, the methods include using driver mutations to determine the pharmacogenetics of abnormal cell growth, such as cancer. In the present disclosure, elevated active monomeric Pin1 levels may be detected by Pin1 biomarkers, which may include Pin1 Q33K or E100D driver mutations, Pin1 protein or transcript overexpression, dephosphorylation of Pin1 on Ser71, dephosphorylation of S16, phosphorylation of S65, phosphorylation of S138, deacetylation of Pin1 on K13 and deacetylation of K46, and/or desumoylation of Pin1 on K6 and desumolation of K63, among others.