Patents by Inventor Sidney Wallace
Sidney Wallace has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080153865Abstract: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.Type: ApplicationFiled: October 29, 2007Publication date: June 26, 2008Inventors: Chun Li, Sidney Wallace, Dong-Fang Yu, David Young
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Patent number: 7384977Abstract: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.Type: GrantFiled: August 31, 2006Date of Patent: June 10, 2008Assignee: PG-TXL Company, L.P.Inventors: Chun Li, Sidney Wallace, Dong-Fang Yu, David J. Yang
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Patent number: 7261875Abstract: The present invention concerns a design for dendritic poly(amino acid) polymer carriers, also known as nonlinear polymers, and their applications. These dendritic poly(amino acid) carriers have multiple functional groups at the polymer surface. In addition, they have heterofunctional groups on the poly(amino acid) side chains for drug or diagnostic agent attachment. They are designed to allow sufficient preservation of the binding affinity of the targeting ligand while conjugating therapeutic or diagnostic agents to the polymers. The present invention also describes methods of production of the polymer carriers and methods for the treatment or diagnosis of diseases employing the polymer carriers. The present invention also includes methods to introduce targeting moieties site-specifically to the end of polymer chains.Type: GrantFiled: December 20, 2002Date of Patent: August 28, 2007Assignee: Board of Regents, The University of Texas SystemInventors: Chun Li, Wayne Tansey, Chusilp Charnsangavej, Sidney Wallace
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Publication number: 20070196275Abstract: Conjugate molecules comprising a ligand bonded to a polymer are disclosed. One such conjugate molecule comprises a ligand bonded to a polymer, a chelating agent bonded to the polymer, and a radioisotope chelated to the chelating agent. The conjugate molecules may be useful in detecting and/or treating tumors or biological receptors. These conjugate molecules may be synthesized without the necessity of preactivation of the ligand using an SCN-polymer-chelating agent precursor. Conjugate molecules incorporating an annexin V ligand are particularly useful for visualizing apoptotic cells. Conjugate molecules incorporating a C225 ligand are particularly useful for targeting tumors expressing EGFR.Type: ApplicationFiled: February 9, 2007Publication date: August 23, 2007Inventors: Chun Li, Xiaoxia Wen, Qing-Ping Wu, Sidney Wallace, Lee Ellis
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Publication number: 20060287220Abstract: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.Type: ApplicationFiled: August 31, 2006Publication date: December 21, 2006Inventors: Chun Li, Sidney Wallace, Dong-Fang Yu, David Yang
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Patent number: 7135496Abstract: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.Type: GrantFiled: October 28, 2002Date of Patent: November 14, 2006Assignee: PG-TXL Company, L.P.Inventors: Chun Li, Sidney Wallace, Dong-Fang Yu, David Yang
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Publication number: 20060155303Abstract: An occlusion method and apparatus. The occluder includes a elastically deformable members and a jacket. The elastically deformable members are secured in spaced relation and extend in arcuate conformation therebetween. The jacket covers at least a portion of the elastically deformable members. The elastically deformable members are configured to become compressed upon application of a force and to recover the arcuate conformation upon removal of the force to occlude a site.Type: ApplicationFiled: February 6, 2006Publication date: July 13, 2006Inventors: Andras Konya, Sidney Wallace, Kenneth Wright
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Publication number: 20060135404Abstract: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.Type: ApplicationFiled: November 23, 2005Publication date: June 22, 2006Inventors: Chun Li, Sidney Wallace, Dong-Fang Yu, David Yang
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Patent number: 7060724Abstract: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.Type: GrantFiled: January 30, 2003Date of Patent: June 13, 2006Assignee: PG-TXL Company, L.P.Inventors: Chun Li, Sidney Wallace, Dong-Fang Yu, David J. Yang
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Publication number: 20060111273Abstract: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as polyglutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.Type: ApplicationFiled: October 20, 2005Publication date: May 25, 2006Inventors: Chun Li, Sidney Wallace, Dong-Fang Yu, David Yang
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Patent number: 6994717Abstract: An occlusion method and apparatus. The occluder includes elastically deformable members and a jacket. The elastically deformable members are secured in spaced relation and extend in arcuate conformation therebetween. The jacket covers at least a portion of the elastically deformable members. The elastically deformable members are configured to become compressed upon application of a force and to recover the arcuate conformation upon removal of the fore to occlude a site.Type: GrantFiled: April 9, 2002Date of Patent: February 7, 2006Assignee: Board of Regents, The University of Texas SystemsInventors: András Kónya, Sidney Wallace, Kenneth C. Wright
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Publication number: 20050152842Abstract: The present invention includes PG polymer complexes with paramagnetic materials, such as Gd, Mn and iron oxide. The complexes may also include chelating agents which may be covalently attached to the PG polymer backbone through linkers. PEG may also be attached to the PG polymer backbone. The complexes may include targeting molecules. The complexes are useful as MRI contrast agents, particularly as blood pool agents.Type: ApplicationFiled: December 22, 2004Publication date: July 14, 2005Inventors: Chun Li, Xiaoxia Wen, Edward Jackson, Sidney Wallace
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Patent number: 6884817Abstract: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.Type: GrantFiled: May 17, 2002Date of Patent: April 26, 2005Assignee: PG-TXL Company, L.P.Inventors: Chun Li, Sidney Wallace, Dong-Fang Yu, David J. Yang
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Publication number: 20040198638Abstract: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.Type: ApplicationFiled: April 19, 2004Publication date: October 7, 2004Applicant: PG-TXL Company, L.P.Inventors: Chun Li, Sidney Wallace, Dong-Fang Yu, David Yang
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Patent number: 6730699Abstract: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.Type: GrantFiled: November 20, 2002Date of Patent: May 4, 2004Assignee: PG-TXL Company, L.P.Inventors: Chun Li, Sidney Wallace, Dong-Fang Yu, David Yang
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Publication number: 20040018960Abstract: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.Type: ApplicationFiled: July 14, 2003Publication date: January 29, 2004Applicant: PG-TXL Company, L.P.Inventors: Chun Li, Sidney Wallace, Dong-Fang Yu, David J. Yang
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Publication number: 20030232968Abstract: The present invention concerns a design for dendritic poly(amino acid) polymer carriers, also known as nonlinear polymers, and their applications. These dendritic poly(amino acid) carriers have multiple functional groups at the polymer surface. In addition, they have heterofunctional groups on the poly(amino acid) side chains for drug or diagnostic agent attachment. They are designed to allow sufficient preservation of the binding affinity of the targeting ligand while conjugating therapeutic or diagnostic agents to the polymers. The present invention also describes methods of production of the polymer carriers and methods for the treatment or diagnosis of diseases employing the polymer carriers. The present invention also includes methods to introduce targeting moieties site-specifically to the end of polymer chains.Type: ApplicationFiled: December 20, 2002Publication date: December 18, 2003Inventors: Chun Li, Wayne Tansey, Chusilp Charnsangavej, Sidney Wallace
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Publication number: 20030216772Abstract: A coil-type vasoocclusion device (10) for establishing an embolus or vascular occlusion in a human or veterinary patient is adapted for introduction into the patient via a catheter (32). The device (10) first includes a coil (12) having proximal and distal coil ends (16,18) and a coil lumen (20). The device (10) also includes a core (22) disposed in at least part of the coil lumen (20), the core having proximal and distal core ends (24,26). Only one core end (24 or 26) is directly affixed to a respective end (16 or 18) of the coil (12); the other core end (26 or 24) is not directly connected to either end (16 or 18) of the coil (12). The core (22) is preferably nitinol in a superelastic state, being in other than its stress induced, martensitic condition. The device (10) can include a thrombogenic material (38) connected to or carried by the coil (12). The coil (12) is preferably adapted to achieve a suitable secondary shape (60) when deployed from the catheter (32).Type: ApplicationFiled: March 20, 2003Publication date: November 20, 2003Applicant: Board of Regents, University of Texas SystemInventors: Andras Konya, Sidney Wallace, Kenneth Carroll Wright
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Publication number: 20030176320Abstract: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.Type: ApplicationFiled: January 30, 2003Publication date: September 18, 2003Inventors: Chun Li, Sidney Wallace, Dong-Fang Yu, David J. Yang
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Publication number: 20030166507Abstract: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.Type: ApplicationFiled: November 20, 2002Publication date: September 4, 2003Applicant: PG-TXL Company, L.P.Inventors: Chun Li, Sidney Wallace, Dong-Fang Yu, David Yang