Patents by Inventor Silvia Chen

Silvia Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11020121
    Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site, especially when sealing an anastomosis between adjacent intestinal sections so as to improve tissue viability, prevent tissue infection, and to prevent leakage. The present invention further relates to circular stapling instruments and elongated tubular hollow sleeves deployed from such stapling instruments and establishing an enclosure around the stapled and resected tissues at the anastomotic joint.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: June 1, 2021
    Assignee: Cilag GmbH International
    Inventors: Nir I. Nativ, Silvia Chen
  • Publication number: 20210153498
    Abstract: An improved packaging assembly for storing, distributing, treating, mixing, and dispensing tissue and/or cellular material and/or implantable material. The packaging assembly may include pouches, tubes, and a bag made of a sealable, flexible polymeric material that is open at one end and a needle-free swabable connector attached to the pouch at the other end and acting as a port to allow for the introduction or discharge of biological solutions, rinsing solution, and/or preservation solutions into the packaging assembly. The designed thickness of the wall of the packaging assembly facilitates efficient heat/cold transfer, which is useful for successful controlled rate freezing, quick thawing, and resuscitation of viable cells or tissue. The packaging assembly is also useful for combining additional biological fluids with the cellular material or tissue, and for efficient mixing of the biological fluids with the tissue and/or cellular material in the assembly.
    Type: Application
    Filed: January 6, 2021
    Publication date: May 27, 2021
    Inventors: Silvia Chen, Austin Johnson, Roberto Bracone
  • Patent number: 10993759
    Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site. The present invention further relates to hypothermic linear stapling instruments configured to pre-cool the tissues being joined by staples.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: May 4, 2021
    Assignee: Ethicon, Inc.
    Inventors: Nir I. Nativ, Leo B. Kriksunov, Robert J. Tannhauser, Silvia Chen
  • Publication number: 20210084890
    Abstract: The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.
    Type: Application
    Filed: November 23, 2020
    Publication date: March 25, 2021
    Inventors: Roberto Bracone, Jingsong Chen, Marilyn Gatin, Silvia Chen, James A. Clagett, Daniel Osborne
  • Patent number: 10932464
    Abstract: The invention is an improved packaging assembly for storing, distributing, treating, mixing, and dispensing tissue and/or cellular material and/or implantable material. The packaging assembly may include pouches, tubes, and a bag made of a sealable, flexible polymeric material that is open at one end and a needle-free swabable connector attached to the pouch at the other end and acting as a port to allow for the introduction or discharge of biological solutions, rinsing solution, and/or preservation solutions into the packaging assembly. The designed thickness of the wall of the packaging assembly facilitates efficient heat/cold transfer, which is useful for successful controlled rate freezing, quick thawing, and resuscitation of viable cells or tissue. The invention is also useful for combining additional biological fluids with the cellular material or tissue, and for efficient mixing of the biological fluids with the tissue and/or cellular material in the assembly.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: March 2, 2021
    Assignee: LifeNet Health
    Inventors: Silvia Chen, Austin Johnson, Roberto Bracone
  • Patent number: 10888320
    Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site, especially when sealing an anastomosis between adjacent intestinal sections to improve tissue viability under hypoxia conditions, prevent tissue inflammation, and to prevent leakage. The present invention further relates to hypothermic circular stapling instruments configured to pre-cool the tissues being joined by staples.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: January 12, 2021
    Assignee: Ethicon, Inc.
    Inventors: Nir I. Nativ, Leo B. Kriksunov, Robert J. Tannhauser, Silvia Chen
  • Patent number: 10856545
    Abstract: The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: December 8, 2020
    Assignee: LifeNet Health
    Inventors: Roberto Bracone, Jingsong Chen, Marilyn Gatin, Silvia Chen, James A. Clagett, Daniel Osborne
  • Publication number: 20200368391
    Abstract: The present disclosure relates to compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of preparing compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of using the bone compositions, bone implants and variants thereof.
    Type: Application
    Filed: August 7, 2020
    Publication date: November 26, 2020
    Inventors: Michael Francis, Rudy Rodriquez, Nathan Kemper, Silvia Chen
  • Patent number: 10780196
    Abstract: The present disclosure relates to compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of preparing compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of using the bone compositions, bone implants and variants thereof.
    Type: Grant
    Filed: October 9, 2014
    Date of Patent: September 22, 2020
    Assignee: LifeNet Health
    Inventors: Michael Francis, Rudy Rodriguez, Nathan Kemper, Silvia Chen
  • Publication number: 20200138012
    Abstract: The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.
    Type: Application
    Filed: June 20, 2019
    Publication date: May 7, 2020
    Inventors: Roberto BRACONE, Jingsong CHEN, Marilyn GATIN, Silvia CHEN, James A. CLAGETT, Daniel OSBORNE
  • Patent number: 10492791
    Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site, especially when sealing an anastomosis between adjacent intestinal sections so as to improve tissue viability, prevent tissue infection, and to prevent leakage. The present invention further relates to circular stapling instruments and elongated tubular hollow sleeves deployed from such stapling instruments and establishing an isolated enclosure around the stapled and resected tissues at the anastomotic joint.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: December 3, 2019
    Assignee: Ethicon LLC
    Inventors: Nir I. Nativ, Silvia Chen, John P. Matonick, Leo B. Kriksunov, Robert J. Tannhauser
  • Publication number: 20190328396
    Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site, especially when sealing an anastomosis between adjacent intestinal sections so as to improve tissue viability, prevent tissue infection, and to prevent leakage. The present invention further relates to circular stapling instruments and elongated tubular hollow sleeves deployed from such stapling instruments and establishing an enclosure around the stapled and resected tissues at the anastomotic joint.
    Type: Application
    Filed: July 12, 2019
    Publication date: October 31, 2019
    Inventors: Nir I. Nativ, Silvia Chen
  • Publication number: 20190314549
    Abstract: The present invention provides demineralized bone fibers exhibiting optimal handling properties (e.g., high moldability and low elastic modulus) and biological activities (e.g., osteoinductivity) as well as non-demineralized bone fibers useful for preparing the demineralized bone fibers. A well-controlled demineralization process for preparing the demineralized bone of fibers is also provided. Products comprising the demineralized bone fibers and uses thereof are further provided.
    Type: Application
    Filed: June 13, 2017
    Publication date: October 17, 2019
    Applicant: LifeNet Health
    Inventors: Silvia Chen, Grant Cleavenger, Dennis Phelps, Evans Wralstad, Breanne Gjurich, Austin Johnson, Alana Sampson, Adam Entsminger, Jingsong Chen
  • Patent number: 10390834
    Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site, especially when sealing an anastomosis between adjacent intestinal sections so as to improve tissue viability, prevent tissue infection, and to prevent leakage. The present invention further relates to circular stapling instruments and elongated tubular hollow sleeves deployed from such stapling instruments and establishing an enclosure around the stapled and resected tissues at the anastomotic joint.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: August 27, 2019
    Assignee: Ethicon LLC
    Inventors: Nir I. Nativ, Silvia Chen
  • Patent number: 10368542
    Abstract: The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.
    Type: Grant
    Filed: September 18, 2013
    Date of Patent: August 6, 2019
    Assignee: LifeNet Health
    Inventors: Roberto Bracone, Jingsong Chen, Silvia Chen, James A. Clagett, Marilyn Gatin, Daniel Osborne
  • Publication number: 20190153054
    Abstract: The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors. The invention further relates to compositions including a protease and a growth factor comprising a bone morphogenic protein (BMP) or a variant thereof. The invention also relates to methods of using the composition.
    Type: Application
    Filed: December 13, 2018
    Publication date: May 23, 2019
    Applicant: LifeNet Health
    Inventors: Xiaofei Qin, Silvia Chen, Jingsong Chen, James Clagett
  • Publication number: 20180361026
    Abstract: A method of preparing a decellularized placental membrane is provided. The method comprises removing cells from a pre-decellularized placental membrane comprising an amnion layer and a chorion layer to produce a decellularized placental membrane without separating the amnion layer from the chorion layer. The pre-decellularized placental membrane is obtained from an amniotic sac, and the decellularized placental membrane comprises the amnion layer and the chorion layer. Also provided is a decellularized placental membrane and a placenta-derived graft comprising the decellularized placental membrane. Further provided are the uses of the decellularized placental membrane or the placenta-derived graft.
    Type: Application
    Filed: December 23, 2016
    Publication date: December 20, 2018
    Applicant: LifeNet Health
    Inventors: Xiaofei QIN, Silvia Chen, Lindsey Aschenbach, Jiingsong Chen
  • Patent number: 10106591
    Abstract: The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors. The invention further relates to compositions including a protease and a growth factor comprising a bone morphogenic protein (BMP) or a variant thereof. The invention also relates to methods of using the composition.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: October 23, 2018
    Assignee: LifeNet Health
    Inventors: Xiaofei Qin, Silvia Chen, Jingsong Chen, James Clagett
  • Publication number: 20180201659
    Abstract: The invention relates to truncated BMP-4 growth factors and variants thereof. The invention also relates to methods of making and using the truncated BMP-4 growth factors.
    Type: Application
    Filed: March 12, 2018
    Publication date: July 19, 2018
    Applicant: LifeNet Health
    Inventors: Xiaofei QIN, Silvia Chen, Jingsong Chen, James Clagett
  • Publication number: 20180170988
    Abstract: The invention relates to truncated BMP-7 growth factors and variants thereof. The invention also relate to methods of making and using the truncated BMP-7 growth factors.
    Type: Application
    Filed: February 8, 2018
    Publication date: June 21, 2018
    Applicant: LifeNet Health
    Inventors: Xiaofei QIN, Silvia Chen, Jingsong Chen, James Clagett