Patents by Inventor Silvia Chen

Silvia Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180155678
    Abstract: The invention relates to placenta-derived matrix, methods of preparing, and methods of use thereof. The invention also relates to methods of culturing cells, delivering cells, promoting differentiation of stem cells or tissue-specific progenitor cells, and repairing, replacing, regenerating, filling, reducing or inhibiting scarring of defects using the same. The invention further relates to methods of coating placenta-derived matrix on a surface or injecting the placenta-derived matrix into a site of interest.
    Type: Application
    Filed: May 27, 2016
    Publication date: June 7, 2018
    Applicant: LIFENET HEALTH
    Inventors: Michael FRANCIS, Silvia CHEN, Erick BREATHWAITE, Rudy RODRIGUEZ, Alan SMITH, Alexander HUBER, Jung Bok LEE
  • Patent number: 9951112
    Abstract: The invention relates to truncated BMP-4 growth factors and variants thereof. The invention also relates to methods of making and using the truncated BMP-4 growth factors.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: April 24, 2018
    Assignee: LifeNet Health
    Inventors: Xiaofei Qin, Silvia Chen, Jingsong Chen, James Clagett
  • Publication number: 20180085125
    Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site, especially when sealing an anastomosis between adjacent intestinal sections so as to improve tissue viability, prevent tissue infection, and to prevent leakage. The present invention further relates to circular stapling instruments and elongated tubular hollow sleeves deployed from such stapling instruments and establishing an enclosure around the stapled and resected tissues at the anastomotic joint.
    Type: Application
    Filed: September 27, 2016
    Publication date: March 29, 2018
    Inventors: Nir I. Nativ, Silvia Chen
  • Publication number: 20180085124
    Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site, especially when sealing an anastomosis between adjacent intestinal sections so as to improve tissue viability, prevent tissue infection, and to prevent leakage. The present invention further relates to circular stapling instruments and elongated tubular hollow sleeves deployed from such stapling instruments and establishing an isolated enclosure around the stapled and resected tissues at the anastomotic joint.
    Type: Application
    Filed: September 27, 2016
    Publication date: March 29, 2018
    Inventors: Nir I. Nativ, Silvia Chen, John P. Matonick, Leo B. Kriksunov, Robert J. Tannhauser
  • Patent number: 9926357
    Abstract: The invention relates to truncated BMP-7 growth factors and variants thereof. The invention also relates to methods of making and using the truncated BMP-7 growth factors.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: March 27, 2018
    Assignee: LifeNet Health
    Inventors: Xiaofei Qin, Silvia Chen, Jingsong Chen, James Clagett
  • Publication number: 20180044629
    Abstract: The invention relates to biologically functional scaffolds having a porous structure, methods of preparing, and methods of use thereof. The invention also relates to methods of repairing a defect, methods of culturing cells and promoting differentiation of stem cells using the same.
    Type: Application
    Filed: February 9, 2016
    Publication date: February 15, 2018
    Applicant: LifeNet Health
    Inventors: Xiaofei QIN, Silvia CHEN
  • Publication number: 20180009865
    Abstract: The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors.
    Type: Application
    Filed: September 14, 2017
    Publication date: January 11, 2018
    Applicant: LifeNet Health
    Inventors: Xiaofei Qin, Silvia Chen, Jingsong Chen, James A. Clagett
  • Publication number: 20170369546
    Abstract: The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors. The invention further relates to compositions including a protease and a growth factor comprising a bone morphogenic protein (BMP) or a variant thereof. The invention also relates to methods of using the composition.
    Type: Application
    Filed: August 30, 2017
    Publication date: December 28, 2017
    Applicant: LifeNet Health
    Inventors: Xiaofei Qin, Silvia Chen, Jingsong Chen, James Clagett
  • Patent number: 9809635
    Abstract: The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors.
    Type: Grant
    Filed: March 21, 2011
    Date of Patent: November 7, 2017
    Assignee: LifeNet Health
    Inventors: Xiaofei Qin, Silvia Chen, Jingsong Chen, James A. Clagett
  • Publication number: 20160000062
    Abstract: The invention is an improved packaging assembly for storing, distributing, treating, mixing, and dispensing tissue and/or cellular material and/or implantable material. The packaging assembly may include pouches, tubes, and a bag made of a sealable, flexible polymeric material that is open at one end and a needle-free swabable connector attached to the pouch at the other end and acting as a port to allow for the introduction or discharge of biological solutions, rinsing solution, and/or preservation solutions into the packaging assembly. The designed thickness of the wall of the packaging assembly facilitates efficient heat/cold transfer, which is useful for successful controlled rate freezing, quick thawing, and resuscitation of viable cells or tissue. The invention is also useful for combining additional biological fluids with the cellular material or tissue, and for efficient mixing of the biological fluids with the tissue and/or cellular material in the assembly.
    Type: Application
    Filed: February 24, 2014
    Publication date: January 7, 2016
    Inventors: Silvia CHEN, Austin JOHNSON, Roberto BRACONE
  • Publication number: 20150064163
    Abstract: The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors. The invention further relates to compositions including a protease and a growth factor comprising a bone morphogenic protein (BMP) or a variant thereof. The invention also relates to methods of using the composition.
    Type: Application
    Filed: September 2, 2012
    Publication date: March 5, 2015
    Applicant: LIFENET HEALTH
    Inventors: Xiaofei Qin, Silvia Chen, Jingsong Chen, James Clagett
  • Publication number: 20140017785
    Abstract: The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.
    Type: Application
    Filed: September 18, 2013
    Publication date: January 16, 2014
    Applicant: LifeNet Health
    Inventors: Roberto Bracone, Jingsong Chen, Silvia Chen, James A. Clagett, Marilyn Gatin, Daniel Osborne
  • Patent number: 8541233
    Abstract: The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.
    Type: Grant
    Filed: June 28, 2010
    Date of Patent: September 24, 2013
    Assignee: LifeNet Health
    Inventors: Roberto Bracone, Jingsong Chen, Silvia Chen, James A. Clagett, Marilyn Gatin, Daniel Osborne
  • Publication number: 20130196910
    Abstract: The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors.
    Type: Application
    Filed: March 24, 2011
    Publication date: August 1, 2013
    Applicant: LIFENET HEALTH
    Inventors: Xiaofei Qin, Silvia Chen, Jingsong Chen, James Clagett
  • Publication number: 20130196909
    Abstract: The invention relates to truncated growth factors and variants thereof. The invention also relate to methods of making and using the truncated growth factors.
    Type: Application
    Filed: March 24, 2011
    Publication date: August 1, 2013
    Applicant: LIFENET HEALTH
    Inventors: Xiaofei Qin, Silvia Chen, Jingsong Chen, James Clagett
  • Publication number: 20130090290
    Abstract: The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors.
    Type: Application
    Filed: March 21, 2011
    Publication date: April 11, 2013
    Applicant: LIFENET HEALTH
    Inventors: Xiaofei Qin, Silvia Chen, Jingsong Chen, James A. Clagett
  • Publication number: 20110160857
    Abstract: The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.
    Type: Application
    Filed: June 28, 2010
    Publication date: June 30, 2011
    Inventors: Roberto Bracone, Jingsong Chen, Silvia Chen, James A. Clagett, Marilyn Gatin, Daniel Osborne
  • Publication number: 20080077251
    Abstract: The invention is further directed to producing a cleaned, disinfected, and devitalized cartilage graft by optionally cleaning and disinfecting the cartilage graft; treating the cartilage graft in a pretreatment solution; treating the cartilage graft in an extracting solution; washing the extracted cartilage graft with a rinsing solution; and subsequently soaking the devitalized cartilage graft in a storage solution. The devitalized cartilage graft is essentially free from metabolically viable and/or reproductively viable cells and the rinsing solution is hypotonic solution or isotonic solution. The present invention is further directed to a cleaned, disinfected, and devitalized cartilage graft and a process for cleaning, disinfecting, and devitalizing cartilage grafts.
    Type: Application
    Filed: July 16, 2007
    Publication date: March 27, 2008
    Inventors: Silvia Chen, Xiaofei Qin, Jingsong Chen, Lloyd Wolfinbarger