Patents by Inventor Simon A. Thomas

Simon A. Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHIMERIC ANTIGEN RECEPTOR
    Publication number: 20190177412
    Abstract: The present invention provides a chimeric antigen receptor (CAR) which binds human CD22, having an antigen-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: CDR1—NYWIH (SEQ ID No. 1); CDR2—GINPGNNYATYRRKFQG (SEQ ID No. 2) CDR3—EGYGNYGAWFAY (SEQ ID No. 3); and b) a light chain variable region (VL) having CDRs with the following sequences: CDR1—RSSQSLANSYGNTFLS (SEQ ID No. 4); CDR2—GISNRFS (SEQ ID No. 5) CDR3—LQGTHQPYT (SEQ ID No. 6). The present invention also provides a cell comprising such a CAR and the use of such a cell to treat cancer.
    Type: Application
    Filed: June 15, 2017
    Publication date: June 13, 2019
    Inventors: Shimobi Onuoha, Martin Pulé, Simon Thomas, Shaun Cordoba, Evangelia Kokalaki
  • Control of the generation and display of royalty administration and rights management data based on the user's rights of access
    Patent number: 10319040
    Abstract: A system and method provides a customizable user-centric web portal display of data subsets associated with a client. The RARM system controls the generation and display of royalty administration and rights management (RARM) data, including royalty data and other associated data and information based on the user's rights of access, calculated royalty data metrics and other criteria. The system provides an aggregated display of a base subset of a user's royalty data and other associated data based on the user's access rights and supplemental subsets of royalty data based on whether the metrics satisfy a predetermined threshold or criteria.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: June 11, 2019
    Assignee: KTech Services Limited
    Inventors: Willard Bengt Anders Ahdritz, Raphael Willy Robert Amselli, Simon Thomas Dennett, James Piers Fitzherbert-Brockholes, Richard Alwin Curtis Thompson
  • Cell
    Publication number: 20190161531
    Abstract: The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.
    Type: Application
    Filed: December 6, 2018
    Publication date: May 30, 2019
    Inventors: Martin Pulé, Shaun Cordoba, Shimobi Onuoha, Simon Thomas
  • CELL
    Publication number: 20190023761
    Abstract: The present invention relates to a cell which comprises a chimeric antigen receptor (CAR) and a signal transduction modifying protein, selected from one of the following: (i) a truncated protein which comprises an SH2 domain from a protein which binds a phosphorylated immunoreceptor tyrosine-based activation motif (ITAM), but lacks a kinase domain; (ii) a truncated protein which comprises an SH2 domain from a protein which binds a phosphorylated immunoreceptor tyrosine-based inhibition motif (ITIM) but lacks a phosphatase domain; (iii) a fusion protein which comprises (a) an SH2 domain from a protein which binds a phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) or from a protein which binds a phosphorylated immunoreceptor tyrosine-based inhibition motif (ITIM); and (ii) a heterologous domain.
    Type: Application
    Filed: May 31, 2016
    Publication date: January 24, 2019
    Inventors: Martin Pulé, Shaun Cordoba, Simon Thomas, Khai Kong
  • CHIMERIC CYTOKINE RECEPTOR
    Publication number: 20190016820
    Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.
    Type: Application
    Filed: August 27, 2018
    Publication date: January 17, 2019
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne, Shimobi Onuoha, Simon Thomas
  • Cell
    Patent number: 10174099
    Abstract: The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: January 8, 2019
    Assignees: UCL BUSINESS PLC, AUTOLUS LIMITED
    Inventors: Martin Pulé, Shaun Cordoba, Shimobi Onuoha, Simon Thomas
  • CELL
    Publication number: 20180371054
    Abstract: The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.
    Type: Application
    Filed: June 29, 2018
    Publication date: December 27, 2018
    Inventors: Martin Pulé, Shaun Cordoba, Shimobi Onuoha, Simon Thomas
  • DRIVE FOR A DOOR LEAF OR WINDOW LEAF
    Publication number: 20180313130
    Abstract: A drive for a leaf of a door, window, or the like, comprising at least one mechanical energy store, which is charged by an opening movement of the leaf and discharged by a closing movement of the leaf, at least one electric motor, which is operatively connected to the leaf via at least one motor shaft and can be operated as a generator in order to dampen the leaf movements, and a control and/or regulator electronics unit for controlling the electric motor. The control and/or regulator electronics unit comprises means via which the drive behaviour can be variably specified repeatedly by a respective user and/or via which the drive behaviour can be variably adjusted repeatedly in accordance with the behaviour of a respective user.
    Type: Application
    Filed: February 6, 2018
    Publication date: November 1, 2018
    Inventors: Matthias Hucker, Simon Burghard, Dirk Huber, Thomas Schüler, Jörg Evertz, Simon Thomas Hasenfratz, Remo Sommer
  • Cell
    Patent number: 10098926
    Abstract: The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: October 16, 2018
    Assignees: UCL BUSINESS PLC, AUTOLUS LIMITED
    Inventors: Martin Pulé, Shaun Cordoba, Shimobi Onuoha, Simon Thomas
  • CHIMERIC CYTOKINE RECEPTOR
    Publication number: 20180244797
    Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.
    Type: Application
    Filed: August 19, 2016
    Publication date: August 30, 2018
    Applicant: AUTOLUS LIMITED
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne, Shimobi Onuoha, Simon Thomas
  • DRIVE UNIT
    Publication number: 20180223575
    Abstract: A drive unit for closing a leaf of a door or a window comprises an energy accumulator for providing a closing force for closing the leaf, a damping device which counteracts the closing force and has an electric motor which can be operated as a generator and can be coupled to an actuating element of the drive unit, and a control device for controlling the electric motor. The control device is designed to determine a nominal path curve which indicates a position of the leaf or a closing speed of the leaf in dependence upon time, and to perform the control of the electric motor in order to damp the closing movement of the leaf on the basis of the established target path curve.
    Type: Application
    Filed: February 6, 2018
    Publication date: August 9, 2018
    Inventors: Matthias Hucker, Jörg Evertz, Oliver Baur, Simon Thomas Hasenfratz, Remo Sommer
  • Encoding and Decoding Variable Length Instructions
    Publication number: 20180143832
    Abstract: Methods of encoding and decoding are described which use a variable number of instruction words to encode instructions from an instruction set, such that different instructions within the instruction set may be encoded using different numbers of instruction words. To encode an instruction, the bits within the instruction are re-ordered and formed into instruction words based upon their variance as determined using empirical or simulation data. The bits in the instruction words are compared to corresponding predicted values and some or all of the instruction words that match the predicted values are omitted from the encoded instruction.
    Type: Application
    Filed: November 24, 2017
    Publication date: May 24, 2018
    Inventors: Simon Thomas Nield, James McCarthy
  • Cable spacer clamp arm liner
    Patent number: 9948080
    Abstract: A liner for use with a cable spacer clamp arm is provided. The liner includes a first portion formed in an arcuate configuration and made from a first elastomeric material. A second portion is formed in the arcuate configuration and is receivable within the first portion. The second portion is made from a second elastomeric material different from the first elastomeric material. The first portion attaches to the second portion.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: April 17, 2018
    Assignee: PREFORMED LINE PRODUCTS CO.
    Inventors: John Alexander Bentley, Simon Thomas Clinton
  • Cell
    Publication number: 20170369550
    Abstract: The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.
    Type: Application
    Filed: December 23, 2015
    Publication date: December 28, 2017
    Inventors: Martin Pulé, Shaun Cordoba, Shimobi Onuoha, Simon Thomas
  • Cell
    Publication number: 20170340704
    Abstract: The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.
    Type: Application
    Filed: June 23, 2017
    Publication date: November 30, 2017
    Inventors: Martin Pulé, Shaun Cordoba, Shimobi Onuoha, Simon Thomas
  • Cell
    Publication number: 20170340705
    Abstract: The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.
    Type: Application
    Filed: June 23, 2017
    Publication date: November 30, 2017
    Inventors: Martin Pulé, Shaun Cordoba, Shimobi Onuoha, Simon Thomas
  • METHOD FOR SEPARATING A CARBON STRUCTURE FROM A SEED STRUCTURE
    Publication number: 20170314122
    Abstract: A method is employed to separate a carbon structure, which is disposed on a seed structure, from the seed structure. In the method, a carbon structure is deposited on the seed structure in a process chamber of a CND reactor. The substrate comprising the seed structure (2) and the carbon structure (1) is heated to a process temperature. At least one etching gas is injected into the process chamber, the etching gas having the chemical formula AOmXn, AOmXnYp or AmXn, wherein A is selected from a group of elements that includes S, C and N, wherein O is oxygen, wherein X and Y are different halogens, and wherein m, n and p are natural numbers greater than zero. Through a chemical reaction with the etching gas, the seed structure is converted into a gaseous reaction product. A carrier gas flow is used to remove the gaseous reaction product from the process chamber.
    Type: Application
    Filed: October 12, 2015
    Publication date: November 2, 2017
    Applicant: AIXTRON SE
    Inventors: Kenneth B. K. TEO, Alexandre JOUVRAY, Jai MATHARU, Simon THOMAS
  • CABLE SPACER CLAMP ARM LINER
    Publication number: 20170194781
    Abstract: A liner for use with a cable spacer clamp arm is provided. The liner includes a first portion formed in an arcuate configuration and made from a first elastomeric material. A second portion is formed in the arcuate configuration and is receivable within the first portion. The second portion is made from a second elastomeric material different from the first elastomeric material. The first portion attaches to the second portion.
    Type: Application
    Filed: December 30, 2015
    Publication date: July 6, 2017
    Inventors: John Alexander Bentley, Simon Thomas Clinton
  • Self-filling modular barrier
    Patent number: 9677237
    Abstract: A flood barrier unit having a base and at least one side wall is provided. The walls of the unit are tapered such that it is capable of being stacked vertically with other such units when not in use. The unit preferably includes at least one connection slot on each wall, wherein each connection slot is adapted to sealingly accept a connection piece. A plurality of such units may be connected together to form a watertight flood barrier, where adjacent units are adapted to be connected together in a watertight manner using one connection piece. Additional connection pieces suitable for sealingly engaging a vertical structure such as the wall of a building are also provided.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: June 13, 2017
    Assignee: FLUVIAL INNOVATIONS LTD
    Inventor: Simon Thomas Phelps
  • Electrical harness connector
    Patent number: 9627788
    Abstract: An electrical assembly is disclosed in which two flexible printed circuits are electrically joined. This allows greater lengths of flexible printed circuits to be provided, for example for gas turbine engine harnesses. Each flexible printed circuit has a terminating region having electrically conductive through holes that are connected to respective electrical tracks of the flexible printed circuit. The terminating regions are adjacent each other in the electrical assembly, and an electrically conductive pin is passed through the aligned through holes, then permanently bonded in position, for example by welding. This results in a robust, reliable connection of two flexible printed circuits.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: April 18, 2017
    Assignee: ROLLS-ROYCE plc
    Inventors: Daniel Martin Armstrong, Simon Thomas Cort