Patents by Inventor Simon Benita

Simon Benita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220202712
    Abstract: The present disclosure provides self-emulsifying drug delivery systems for delivery of lipophilic compounds, compositions, kits and unit dosage forms thereof, as well as processes for their preparation.
    Type: Application
    Filed: April 7, 2020
    Publication date: June 30, 2022
    Inventors: Simon Benita, Taher Nassar
  • Publication number: 20220119365
    Abstract: The invention generally concerns a novel class of CB 1 receptor binding molecules and uses thereof.
    Type: Application
    Filed: January 15, 2020
    Publication date: April 21, 2022
    Inventors: Simon Benita, Taher Nassar, Joseph Tam, Shira Hirsh
  • Publication number: 20210128534
    Abstract: A novel platform for manufacturing storage stable and effective drug delivery systems.
    Type: Application
    Filed: February 26, 2019
    Publication date: May 6, 2021
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Simon BENITA, Taher NASSAR, Leslie REBIBO, Amit BADIHI
  • Publication number: 20190209466
    Abstract: An ophthalmic composition useful for the treatment of bacterial eye infections is provided. The ophthalmic composition includes the suspension of particles of active anti-bacterial agent in a gelled matrix.
    Type: Application
    Filed: September 3, 2017
    Publication date: July 11, 2019
    Applicants: DEXCEL PHARMA TECHNOLOGIES LTD., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Simon BENITA, Taher NASSAR
  • Publication number: 20190201478
    Abstract: Provided is a nanoparticle associated with a plurality of oleylcysteineamide (OCA) molecules for a variety of therapeutic applications. At least a portion of the OCA molecules may be associated with at least one therapeutic agent or at least one non-active agent. Also provided is a drug delivery agent including at least one nanoparticle associated with a plurality of OCA molecules. At least a portion of the OCA molecules is associated with at least one therapeutic agent or at least one or non-active agent. Also provided is a method of delivering a drug to a subject. The method includes administering the drug delivery agent (associated with the drug) to the subject.
    Type: Application
    Filed: March 7, 2019
    Publication date: July 4, 2019
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Simon BENITA, Taher NASSER, Nour KARRA, Amit BADIHI
  • Patent number: 10239903
    Abstract: Provided are Pt (IV) lipophilic derivatives for improved drug performance in cancer therapy, as well as nanocarriers including the same.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: March 26, 2019
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Simon Benita, Taher Nassar, Dan Gibson, Aiman Abu Ammar
  • Patent number: 9839617
    Abstract: Provided is a nanoparticle including a water-soluble protein, a glucan and a hydrophilic active agent, the glucan being at least partially cross-linked by a metaphosphate.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: December 12, 2017
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Simon Benita, Taher Nassar, Liat Kochavi-Soudry
  • Publication number: 20170081352
    Abstract: Provided are Pt (IV) lipophilic derivatives for improved drug performance in cancer therapy, as well as nanocarriers including the same.
    Type: Application
    Filed: April 30, 2015
    Publication date: March 23, 2017
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Simon BENITA, Taher NASSAR, Dan GIBSON, Aiman Abu AMMAR
  • Publication number: 20170065533
    Abstract: The present invention relates to a poly(lactic glycolic) acid (PLGA) nanoparticle associated with therapeutic agents for a variety of therapeutic applications.
    Type: Application
    Filed: September 12, 2016
    Publication date: March 9, 2017
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Simon BENITA, Taher NASSER, Nour KARRA, Amit BADIHI
  • Publication number: 20160361267
    Abstract: Provided is a nanoparticle including a water-soluble protein, a glucan and a hydrophilic active agent, the glucan being at least partially cross-linked by a metaphosphate.
    Type: Application
    Filed: January 26, 2015
    Publication date: December 15, 2016
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Simon BENITA, Taher NASSAR, Liat KOCHAVI-SOUDRY
  • Publication number: 20160317460
    Abstract: The present invention makes use of a unique methodology of double nano-encapsulation for protecting and controlling the release of active agents, either hydrophobic or hydrophilic, from stable nanoparticles of opposite characteristics. The protection of the active agent was achieved by loading the agent to be protected, into nanocarriers, which were subsequently encapsulated into sub-micron nanoparticles. The sub-micron nanoparticles formation has been successfully achieved by the use of novel nanospray techniques.
    Type: Application
    Filed: June 14, 2016
    Publication date: November 3, 2016
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LT
    Inventors: Simon BENITA, Orit AMSALEM, Taher NASSAR
  • Patent number: 9421173
    Abstract: The present invention makes use of a unique methodology of double nano-encapsulation for protecting and controlling the release of active agents, either hydrophobic or hydrophilic, from stable nanoparticles of opposite characteristics. The protection of the active agent was achieved by loading the agent to be protected, into nanocarriers, which were subsequently encapsulated into sub-micron nanoparticles. The sub-micron nanoparticles formation has been successfully achieved by the use of novel nano spray techniques.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: August 23, 2016
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Simon Benita, Orit Amsalem, Taher Nassar
  • Publication number: 20160235749
    Abstract: The present disclosure provides controlled-release delivery systems for oral delivery of active agents, e.g. lopinavir, comprising micro-particulated with enhanced oral bioavailability and efficacy, which may be used for treating HIV.
    Type: Application
    Filed: February 11, 2016
    Publication date: August 18, 2016
    Inventors: Simon BENITA, Taher NASSAR
  • Publication number: 20160228497
    Abstract: The present invention relates to a poly(lactic glycolic) acid (PLGA) nanoparticle associated with therapeutic agents for a variety of therapeutic applications.
    Type: Application
    Filed: April 14, 2016
    Publication date: August 11, 2016
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Simon BENITA, Taher NASSAR, Nour KARRA, Amit BADIHI
  • Patent number: 9387180
    Abstract: The present invention makes use of a unique methodology of double nano-encapsulation for protecting and controlling the release of active agents, either hydrophobic or hydrophilic, from stable nanoparticles of opposite characteristics. The protection of the active agent was achieved by loading the agent to be protected, into nanocarriers, which were subsequently encapsulated into sub-micron nanoparticles. The sub-micron nanoparticles formation has been successfully achieved by the use of novel nano spray techniques.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: July 12, 2016
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Simon Benita, Orit Amsalem, Taher Nassar
  • Publication number: 20150374627
    Abstract: The present invention relates to a poly(lactic glycolic) acid (PLGA) nanoparticle associated with therapeutic agents for a variety of therapeutic applications.
    Type: Application
    Filed: September 10, 2015
    Publication date: December 31, 2015
    Inventors: Simon BENITA, Taher NASSER, Nour KARRA, Amit BADIHI
  • Publication number: 20150037427
    Abstract: The present invention makes use of a unique methodology of double nano-encapsulation for protecting and controlling the release of active agents, either hydrophobic or hydrophilic, from stable nanoparticles of opposite characteristics. The protection of the active agent was achieved by loading the agent to be protected, into nanocarriers, which were subsequently encapsulated into sub-micron nanoparticles. The sub-micron nanoparticles formation has been successfully achieved by the use of novel nano spray techniques.
    Type: Application
    Filed: September 20, 2012
    Publication date: February 5, 2015
    Inventors: Simon Benita, Orit Amsalem, Taher Nassar
  • Publication number: 20140079642
    Abstract: The present invention relates to a poly(lactic glycolic) acid (PLGA) nanoparticle associated with therapeutic agents for a variety of therapeutic applications.
    Type: Application
    Filed: January 24, 2012
    Publication date: March 20, 2014
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem LTD
    Inventors: Simon Benita, Taher Nasser, Nour Karra, Amit Badihi
  • Publication number: 20130266625
    Abstract: On one hand, the present invention relates to cosmetic compositions comprising poly(lactic glycolic)acid (PLGA) nanoparticles for applications to the skin. On the other hand, it also concerns polymeric nanoparticles having on its surface a plurality of cosmetically active agents, each of said agents being associated to said nanoparticle via oleylcysteineamide, delivery systems for topical application based on said particles and cosmetic formulations comprising said particles.
    Type: Application
    Filed: January 24, 2012
    Publication date: October 10, 2013
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Simon Benita, Taher Nasser, Nour Karra, Amit Badihi
  • Publication number: 20060292186
    Abstract: A pharmaceutical composition in a form of an anhydrous self-nanoemulsifying oily formulation comprising: one or more therapeutic agent(s) which have low solubility in water or are water-insoluble, vitamin E, one co-solvent selected from propylene glycol and ethanol and mixture thereof one surfactant selected from tyloxapol and from mixture of tyloxapol and TPGS, and optionally, a bioenhancer.
    Type: Application
    Filed: August 27, 2004
    Publication date: December 28, 2006
    Applicant: Novagali Pharma SA
    Inventors: Jean-Sebastien Garrigue, Gregory Lambert, Alain Razafindratsita, Simon Benita, Shicheng Yang, Neslihan Gursoy