Patents by Inventor Simon Benita
Simon Benita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20060292186Abstract: A pharmaceutical composition in a form of an anhydrous self-nanoemulsifying oily formulation comprising: one or more therapeutic agent(s) which have low solubility in water or are water-insoluble, vitamin E, one co-solvent selected from propylene glycol and ethanol and mixture thereof one surfactant selected from tyloxapol and from mixture of tyloxapol and TPGS, and optionally, a bioenhancer.Type: ApplicationFiled: August 27, 2004Publication date: December 28, 2006Applicant: Novagali Pharma SAInventors: Jean-Sebastien Garrigue, Gregory Lambert, Alain Razafindratsita, Simon Benita, Shicheng Yang, Neslihan Gursoy
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Patent number: 7138559Abstract: A formulation effective in reducing the pH in a menstruating vagina or in a tampon inserted therein to below pH 5.5, comprising (a) 3–80% by weight of a solid organic acid polymer; (b) 92–15% by weight of a solid organic acid; and (c) 5–30% of a wetting agent. Also disclosed is a delivery system for releasing an active agent comprising: (a) a deposition comprising the active agent; and (b) a polymeric support on which the deposition is deposited. The delivery system is especially useful in a catamenial tampon for insertion in a human vagina which comprises (a) an inner core comprising an absorbent material; (b) an outer layer comprising a liquid permeable material; and (c) the delivery system.Type: GrantFiled: May 21, 2003Date of Patent: November 21, 2006Assignee: Hi-Gienic Ltd.Inventors: Ram Kluger, Simon Benita, Theodor Stern
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Patent number: 7004171Abstract: A transvaginal drug delivery system comprising: (a) a deposition comprising an effective amount of said drug and, optionally, a wetting agent; and (b) a polymeric support on which said deposition is deposited. Also disclosed is a catamenial tampon for insertion in a human vagina comprising: (a) an inner core comprising an absorbent material; (b) an outer layer comprising a liquid-permeable material; and (c) a delivery system according to the invention. A method of transvaginal drug delivery is also described.Type: GrantFiled: February 25, 2002Date of Patent: February 28, 2006Assignees: Hi-Gienic Intra Vaginal Technologies Ltd., Yissum Research Development Company of the Hebrew University of JerusalemInventors: Simon Benita, Ram Kluger, Theodor Stern
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Publication number: 20060002963Abstract: A method for treating eye diseases by injecting intraocularly or periocularly a composition comprising an emulsion and optionally at least a pharmaceutical active ingredient.Type: ApplicationFiled: July 15, 2004Publication date: January 5, 2006Inventors: Laura Rabinovich-Guilatt, Yvonne De Kozak, Catherine Dubernet, Gregory Lambert, Simon Benita, Patrick Couvreur, Francine Behar-Cohen
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Publication number: 20050232952Abstract: A pharmaceutical composition in a form of a self-microemulsifying drug delivery system comprising: one or more therapeutic agent(s) which have low solubility in water or are water-insoluble, vitamin E, one co-solvent selected from propylene glycol and ethanol, one or more bile salts, TPGS, and one further surfactant selected from Tyloxapol and polyoxyl hydrogenated castor oil.Type: ApplicationFiled: February 28, 2003Publication date: October 20, 2005Inventors: Gregory Lambert, Alain Razafindratsita, Jean-Sebastien Garrigue, Shicheng Yang, Neslihan Gursoy, Simon Benita
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Publication number: 20050180997Abstract: A combination product comprising a positive oil in water emulsion wherein said emulsion comprises a compound presenting free NH2 groups, at its natural state, at the oil-water interface, and an antibody, wherein said compound is linked to said antibody by a heterobifunctional linker, linking said NH2 groups to SH groups on the antibody hinge region.Type: ApplicationFiled: February 27, 2004Publication date: August 18, 2005Inventors: Simon Benita, Danny Goldstein, Taher Nassar, Ola Sader, Alain Razafindratsita, Gregory Lambert, Jean Kadouche
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Patent number: 6710220Abstract: A formulation effective in reducing the pH in a menstruating vagina or in a tampon inserted therein to below pH 5.5, comprising (a) 3-80% by weight of a solid organic acid polymer; (b) 92-15% by weight of a solid organic acid, and (c) 5-30% of a wetting agent. Also disclosed is a delivery system for releasing an active agent comprising: (a) a deposition comprising the active agent; and (b) a polymeric support on which the deposition is deposited. The delivery system is especially useful in a catamenial tampon for insertion in a human vagina which comprises (a) an inner core comprising an absorbent material; (b) an outer layer comprising a liquid permeable material; and (c) the delivery system.Type: GrantFiled: May 15, 2001Date of Patent: March 23, 2004Assignee: Hi-Gienic Ltd.Inventors: Ram Kluger, Simon Benita, Theodor Stern
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Patent number: 6656460Abstract: A method and composition for treating a dry eye condition by topically applying to the eye surfaces an emulsion forming a tear film that acts to lubricate the eye and to inhibit evaporation therefrom. The emulsion is constituted by water in which is dispersed a mixture that includes a phospholipid, a non-polar oil, a non-toxic emulsifying agent and a polar lipid that imparts a net positive charge to the film that is distributed throughout the film, causing the film to be electrostatically attracted to the anionic surface of the eye whereby the film adheres thereto and cannot be washed away. Includable in the mixture is a non-soluble therapeutic agent, such as cyclosporin which is effective against an eye disease and is delivered to the eye by the film.Type: GrantFiled: November 1, 2001Date of Patent: December 2, 2003Assignees: Yissum Research Development, Company of the Hebrew University of Jerusalem Novagali S.A.S.Inventors: Simon Benita, Gregory Lambert
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Publication number: 20030216703Abstract: A formulation effective in reducing the pH in a menstruating vagina or in a tampon inserted therein to below pH 5.5, comprising (a) 3-80% by weight of a solid organic acid polymer; (b) 92-15% by weight of a solid organic acid; and (c) 5-30% of a wetting agent. Also disclosed is a delivery system for releasing an active agent comprising: (a) a deposition comprising the active agent; and (b) a polymeric support on which the deposition is deposited. The delivery system is especially useful in a catamenial tampon for insertion in a human vagina which comprises (a) an inner core comprising an absorbent material; (b) an outer layer comprising a liquid permeable material; and (c) the delivery system.Type: ApplicationFiled: May 21, 2003Publication date: November 20, 2003Inventors: Ram Kluger, Simon Benita, Theodor Stern
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Publication number: 20030163103Abstract: A transvaginal drug delivery system comprising: (a) a deposition comprising an effective amount of said drug and, optionally, a wetting agent; and (b) a polymeric support on which said deposition is deposited. Also disclosed is a catamenial tampon for insertion in a human vagina comprising: (a) an inner core comprising an absorbent material; (b) an outer layer comprising a liquid-permeable material; and (c) a delivery system according to the invention. A method of transvaginal drug delivery is also described.Type: ApplicationFiled: February 25, 2002Publication date: August 28, 2003Inventors: Simon Benita, Ram Kluger, Theodor Stern
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Publication number: 20030108626Abstract: A method and composition for treating a dry eye condition by topically applying to the eye surfaces an emulsion forming a tear film that acts to lubricate the eye and to inhibit evaporation therefrom. The emulsion is constituted by water in which is dispersed a mixture that includes a phospholipid, a non-polar oil, a non-toxic emulsifying agent and a polar lipid that imparts a net positive charge to the film that is distributed throughout the film, causing the film to be electrostatically attracted to the anionic surface of the eye whereby the film adheres thereto and cannot be washed away. Includable in the mixture is a non-soluble therapeutic agent, such as cyclosporin which is effective against an eye disease and is delivered to the eye by the film.Type: ApplicationFiled: November 1, 2001Publication date: June 12, 2003Applicants: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, NOVAGALI S.A.SInventors: Simon Benita, Gregory Lambert
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Publication number: 20020045873Abstract: A formulation effective in reducing the pH in a menstruating vagina or in a tampon inserted therein to below pH 5.5, comprising (a) 3-80% by weight of a solid organic acid polymer; (b) 92-15% by weight of a solid organic acid, and (c) 5-30% of a wetting agent. Also disclosed is a delivery system for releasing an active agent comprising: (a) a deposition comprising the active agent; and (b) a polymeric support on which the deposition is deposited, The delivery system is especially useful in a catamenial tampon for insertion in a human vagina which comprises (a) an inner core comprising an absorbent material; (b) an outer layer comprising a liquid permeable material; and (c) the delivery system.Type: ApplicationFiled: May 15, 2001Publication date: April 18, 2002Inventors: Ram Kluger, Simon Benita, Theodor Stern
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Patent number: 6007826Abstract: An oil-in-water emulsion useful as a delivery vehicle of hydrophobic ingredients such as pharmaceutical drugs and cosmetic active agent; wherein the emulsion particles have a net positive charge (i.e. a positive zeta potential).Type: GrantFiled: October 15, 1996Date of Patent: December 28, 1999Assignee: Yisum Research Development Company of the Hebrew University of JerusalemInventors: Simon Benita, Efrat Elbaz
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Patent number: 5965160Abstract: A self-emulsifying oily formulation (SEOF) comprising an oil component and a surfactant, the SEOF being characterized in that the oil component comprises an oily carrier and a cationic lipid and optionally, a lipophilic oily fatty alcohol, the oil-in-water emulsion which forms upon mixture of the SEOF, having oily droplets which are positively charged.Type: GrantFiled: January 9, 1998Date of Patent: October 12, 1999Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventors: Simon Benita, Jackie Kleinstern, Tatyana Gershanik
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Patent number: 5364632Abstract: A pharmaceutical composition being an oil in water type emulsion which comprises an effective amount of a lypophilic drug is provided. The composition comprises a synergistic combination consisting of about 3-50% of an oily carrier consisting of MCT oil optionally in combination with vegetable oil, about 0.05%-20% of a phospholipid, about 0.03-10% of a non-ionic surfactant, and about 0.05-5% of an ionic surfactant selected from the group consisting of bile-duct surface active agent, cholic acid and their derivatives.Type: GrantFiled: March 9, 1993Date of Patent: November 15, 1994Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventors: Simon Benita, Menashe Levy
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Patent number: 5284867Abstract: The use of a compound of the formula: ##STR1## having the (3S,4S) configuration, and which is essentially free of the (3R,4R) enantiomer, wherein A--B designates a 1(2) or a 6(1) double bond, R designates --CH.sub.3 or --CH.sub.2 OH, R.sup.1 designates a hydrogen atom or a lower acyl group, and R.sup.2 designates (A) a straight-chained or branched C.sub.6-12 alkyl radical; or (B) a group --O--R.sup.3, in which R.sup.3 is a straight-chained or branched C.sub.5-9 alkyl radical or a straight-chained or branched alkyl radical substituted at the terminal carbon atom by a phenyl group in the manufacture of a medicament for reducing or preventing glutamate neurotoxicity. Some of the above compounds are novel, and their preparation is described.Type: GrantFiled: April 8, 1992Date of Patent: February 8, 1994Assignees: Yissum Research Development Company of the Hebrew University in Jerusalem, Ramot University, Authority for Applied Research and Industrial Development Ltd.Inventors: Yoel Kloog, Jeffrey J. Feigenbaum, Raphael Mechoulam, Mordechai Sokolovsky, Simon Benita
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Patent number: 4666641Abstract: The present invention relates to biodegradable microcapsules based on serum albumin, the preparation thereof and the application thereof to the release of drugs in situ.A feature of the microcapsules according to the present invention is that their wall consists of serum albumin, a portion of which is crosslinked by interfacial polymerization with the aid of an acylating bifunctional reagent, and the other, non-crosslinked portion of which is denatured by means of an alcohol.Type: GrantFiled: June 4, 1985Date of Patent: May 19, 1987Assignee: Universite Paris-Sud (Paris XI)Inventors: Rene Fickat, Simon Benita, Francis Puisieux