Abstract: This invention relates to binding members, especially antibody molecules, specific for interleukin 1 receptor 1 (IL-1R1). For example, isolated binding members specific for IL-1R1 which competes with IL-1 and IL-1Ra for binding to IL-1R1 and binds Il-1R1 with a KD of 10 pM or less when measured by Kinexa™. The binding members are useful for, inter alia, treatment of disorders mediated by IL-1R1 including rheumatoid arthritis, asthma and chronic obstructive pulmonary disease (COPD).

Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.

Abstract: An inductively powered sensor system includes a primary conductive path 100 capable of being energised to provide an electromagnetic field in a defined space 1. An inductive power pick-up 120 is associated with a sensor 124 and is capable of receiving power from the field to supply the sensor 124. The system includes a first sensing means to sense the power available to the pick-up 120 and control means to increase or decrease the power available to the sensor dependant on the sensed power available. A method of inductively powering a sensor, an inductively powered sensor and an animal enclosure including one or more primary conductive path of an inductive power supply are also disclosed.

Abstract: An inductively powered sensor system includes a primary conductive path 100 capable of being energised to provide an electromagnetic field in a defined space 1. An inductive power pick-up 120 is associated with a sensor 124 and is capable of receiving power from the field to supply the sensor 124. The system includes a first sensing means to sense the power available to the pick-up 120 and control means to increase or decrease the power available to the sensor dependant on the sensed power available. A method of inductively powering a sensor, an inductively powered sensor and an animal enclosure including one or more primary conductive path of an inductive power supply are also disclosed.

Abstract: Enacted in a stereoscopic display system, a method to display a virtual object at a specified distance in front of an observer. The method includes sensing positions of the right and left eyes of the observer, and based on these positions, shifting a right or left display image of the virtual object. The shift is of such magnitude and direction as to confine the positional disparity between the right and left display images to a direction parallel to an interocular axis of the observer, in an amount to place the virtual object at the specified distance.

Abstract: Embodiments are described herein for determining a stabilization plane to reduce errors that occur when a homographic transformation is applied to a scene including 3D geometry and/or multiple non-coplanar planes. Such embodiments can be used, e.g., when displaying an image on a head mounted display (HMD) device, but are not limited thereto. In an embodiment, a rendered image is generated, a gaze location of a user is determined, and a stabilization plane, associated with a homographic transformation, is determined based on the determined gaze location. This can involve determining, based on the user's gaze location, variables of the homographic transformation that define the stabilization plane. The homographic transformation is applied to the rendered image to thereby generate an updated image, and at least a portion of the updated image is then displayed.

Abstract: A method for determining a flow rate of a substance in an environment includes positioning a device having a balanced circuit in or on an object or within a particular environment, wherein the balanced circuit comprises elements which are operationally sensitive to changes in a parameter of the object or the environment. The method further includes measuring a common mode signal of the balanced circuit and determining, from the common mode signal, a value of the flow rate. An exemplary implementation of the method includes determining temperature using a resistive sensor having a Wheatstone bridge circuit with two variable resistors and two fixed resistors. Embodiments of systems and devices configured to employ such methods are provided, particularly medical probes, electronic signal monitoring devices, and systems employing such devices.

Abstract: Various embodiments relating to selection of a user interface object displayed on a graphical user interface based on eye gaze are disclosed. In one embodiment, a selection input may be received. A plurality of eye gaze samples at different times within a time window may be evaluated. The time window may be selected based on a time at which the selection input is detected. A user interface object may be selected based on the plurality of eye gaze samples.

Abstract: Binding members, e.g. human antibody molecules, which bind interleukin-6 (IL-6) and neutralise its biological effects. Use of binding members for IL-6 in medical treatment e.g. for treating inflammatory diseases and tumours associated with IL-6.

Abstract: When a user takes a photograph or video of a scene with an image capture device, such as computing device having a camera, a point of interest in the scene is determined. The computing device includes an eye tracker to output a gaze vector of a user's eye viewing the scene through a view finder that indicates a point of interest in the scene. Selected operation may then be performed based on the determined point of interest in the scene. An amount of exposure used to capture the image may be selected based on the point of interest. Zooming or adjusting the field of view through a view finder may be anchored at the point of interest, and the image through the view finder may be zoomed about the point of interest, before the image is captured. Image enhancing effects may be performed about the point of interest.

Abstract: The present invention provides an inductively powered sensor system having a primary conductive path capable of being energized to provide an electromagnetic field in a defined space. An inductive power pick-up is associated with a sensor and is capable of receiving power from the field to supply the sensor. The system includes a first sensing unit to sense the power available to the pick-up and a control unit to increase or decrease the power available to the sensor dependant on the sensed power available. A method of inductively powering a sensor, an inductively powered sensor and an animal enclosure including one or more primary conductive path of an inductive power supply are also disclosed.

Abstract: Methods and apparatus for finding a bias voltage (20) corresponding to a quadrature point of an optical modulator, the modulator comprising a biasable component which is configurable to be biased by application of the bias voltage (20) such that the modulator operates at quadrature, the method comprising: providing a target for the output power of the modulator which corresponds to quadrature; applying, to the biasable component, a bias voltage (20) having an initial value; thereafter, finding a value for the bias voltage (20) that biases the biasable component such that the output power of the modulator is within a pre-defined range of the target by, starting at the initial value, alternately increasing and decreasing (or decreasing and increasing) the bias voltage (20) with gradually increasing amplitude; and identifying the found value for the bias voltage (20) as a bias voltage corresponding to a quadrature point of the optical modulator.

Abstract: Methods and apparatus for controlling a bias voltage supplied to an optical modulator, the modulator comprising a biasable component, the biasable component being configurable to be biased by application of the bias voltage (20) such that the modulator operates at quadrature, the method comprising: providing a target for the output power of the modulator, the target for the output power of the modulator being an output power corresponding to the modulator operating at quadrature; applying, to the biasable component, a bias voltage (20) having an initial value of 0V; and, thereafter, varying the bias voltage (20) until the value of the bias voltage (20) is the value that is closest to the initial value and that biases the biasable component so that the output power of the modulator is within a pre-defined range of the target output power.

Abstract: Binding members, e.g. human antibody molecules, which bind interleukin-6 (IL-6) and neutralize its biological effects. Use of binding members for IL-6 in medical treatment e.g. for treating inflammatory diseases and tumors associated with IL-6.

Abstract: A method of storing potatoes comprises storing a plurality of endodormant or ecodormant potatoes in a first gaseous environment including carbon dioxide in an amount of from greater than the amount of carbon dioxide present in atmospheric air to up to 5 mol % based on the composition of the first gaseous environment; and in a subsequent storage step storing the potatoes in a second gaseous environment including carbon dioxide in an amount of from 0.03 to 2 mol % based on the composition of the second gaseous environment, the first and second gaseous environments having different carbon dioxide contents. The method may comprise: monitoring the dormancy of the potatoes; in response to eye movement of a potato, changing the first gaseous environment to a second gaseous environment; maintaining a level of carbon dioxide in the second gaseous environment below a selected threshold to control sugar content of the potatoes.

Abstract: Embodiments are disclosed for adjusting alignment of a near-eye optic of a see-through head-mounted display system. In one embodiment, a method of detecting eye location for a head-mounted display system includes directing positioning light to an eye of a user and detecting the positioning light reflected from the eye of the user. The method further includes determining a distance between the eye and a near-eye optic of the head-mounted display system based on attributes of the detected positioning light, and providing feedback for adjusting the distance between the eye and the near-eye optic.

Abstract: Embodiments are disclosed for a see-through head-mounted display system. In one embodiment, the see-through head-mounted display system comprises a freeform prism, and a display device configured to emit display light through the freeform prism to an eye of a user. The see-through head-mounted display system may also comprise an imaging device having an entrance pupil positioned at a back focal plane of the freeform prism, the imaging device configured to receive gaze-detection light reflected from the eye and directed through the freeform prism.

Abstract: A system and method are disclosed for detecting angular displacement of a display element relative to a reference position on a head mounted display device for presenting a mixed reality or virtual reality experience. Once the displacement is detected, it may be corrected for to maintain the proper binocular disparity of virtual images displayed to the left and right display elements of the head mounted display device. In one example, the detection system uses an optical assembly including collimated LEDs and a camera which together are insensitive to linear displacement. Such a system provides a true measure of angular displacement of one or both display elements on the head mounted display device.

Abstract: Embodiments are disclosed herein that relate to aligning a near-eye display of a near-eye display device with an eye of a user. For example, one disclosed embodiment provides, on a near-eye display device, a method comprising receiving an image of an eye from a camera via a reverse display optical path, detecting a location of the eye in the image, and determining a relative position of the eye with regard to a target viewing position of the near-eye display. The method further comprises determining an adjustment to make to the near-eye display device to align the location of the eye with the target viewing position.

Abstract: A magnetic holding device uses an array of switchable magnets. A carrier holds the array of switchable magnets to form a working surface. Each switchable magnet has a coil of wire surrounding a magnetizable core element. The array is arranged in groups of magnets. A circuit is coupled to the coils to selectively magnetize and demagnetize each group of switchable magnets to selectively independently place each group into one of these states: an ON state that configures the selected group to have a first magnetic polarity at the working surface, an ON state that configures the selected group to have an opposite magnetic polarity at the working surface, and an OFF state that configures the magnets in the selected group to have no magnetism at the working surface. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.