Abstract: A mixed-reality system causes a magnetic transmission device to transmit a magnetic field signal. The mixed-reality system also causes a magnetic-field sensing device to determine a measurement of the magnetic field signal. The mixed-reality system then identifies, using one or more input devices, that a magnetically-interfering object is located within a same environment as both the magnetic transmission device and the magnetic-field sensing device. The mixed-reality system also determines one or more characteristics of magnetic field interference that the magnetically-interfering object is imparting on the magnetic transmission device or the magnetic-field sensing device. The mixed-reality system then computes an adjustment to a pose-estimation model based upon the one or more characteristics of magnetic field interference. The pose-estimation model is used to calculate a pose of at least one of the magnetic transmission device or the magnetic-field sensing device.

Abstract: A technique is described herein for using a parent computing device and at least one companion computing device to simultaneously interact with an environment. In one implementation, the parent computing device progressively builds parent map information through its interaction with the environment. The technique leverages the parent map information to identify a current pose of the companion computing device. In one case, for instance, the parent computing device sends the parent map information to the companion computing device, and the companion computing device determines its current pose based on the parent map information in conjunction with sensor information collected by the companion computing device.

Abstract: An apparatus for dynamically determining a displacement of a target sensor in an electronic system is disclosed. The apparatus can comprise a non-line-of-sight sensor rigidly mounted on or proximate to the target sensor and configured to measure a parameter that varies with the displacement of the target sensor. The apparatus further can comprise at least one processor coupled to the non-line-of-sight sensor and configured to compute the displacement of the target sensor based on the parameter, and to compute an adjustment value based on the computed displacement.

Abstract: Binding members, e.g. human antibody molecules, which bind interleukin-6 (IL-6 ) and neutralise its biological effects. Use of binding members for IL-6 in medical treatment e.g. for treating inflammatory diseases and tumours associated with IL-6.

Abstract: Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: Disclosed is a self-contained, pluggable tracking system that monitors six degree of freedom (“6DoF”) without external apparatus, e.g., visual tracking or magnetic. The tracking core can communicate with a host device and with an external computing device. The external computing device can display a virtual (“VR”) or augmented reality (“AR”) world. The VR or AR world may be supplemented by overlay displays positioned according to the shape of the host device as tracked by the tracking core.

Abstract: A graphics processing system for processing polygons includes a cache with cache lines for storing data entries, each line having a tag for identifying the data stored in the line. The polygons have vertices with which pieces of vertex attribute data are associated. The system also includes processing circuitry which writes, to a line in a first set of lines, data entries associated with pieces of vertex attribute data. The pieces of vertex attribute data are associated with the vertices of a polygon. The processing circuitry also writes a tag including a polygon identifier to identify the polygon associated with the data entries to the line in the first set of lines, and writes, to a second set of lines of the cache, data entries associated with pieces of vertex attribute data. The processing circuitry also writes tags including vertex identifiers to the second set of lines to identify the vertices associated with the data entries.

Abstract: Provided are triazolopyridine compounds that are inhibitors of JAK kinase, such as JAK1, compositions containing these compounds and methods for treating diseases mediated by a JAK kinase. In particular, provided are compounds of formula (I), stereoisomers, tautomers, solvates, prodrugs or pharmaceutically acceptable salts thereof, where R1a, R1b, R1c, R2, R3, R4 and R5 are defined herein, pharmaceutical compositions comprising the compound and a pharmaceutically acceptable carrier, adjuvant or vehicle, methods of using the compound or composition in therapy, for example, for treating a disease or condition mediated by a JAK kinase in a patient.

Abstract: An erosion management system is configured to monitor erosion of a component of a mineral extraction system. The erosion management system includes a controller configured to receive feedback from a flow meter related to a flow rate of a production fluid flowing through the component. Additionally, the controller is configured to receive feedback from an erosion detector related to an amount of solids in the production fluid. The controller is configured to determine an erosion rate of the component based on the feedback from the flow meter and the feedback from the erosion detector.

Abstract: In various embodiments, methods and systems for implementing integrated free space and surface inputs are provided. An integrated free space and surface input system includes a mixed-input pointing device for interacting and controlling interface objects using free space inputs and surface inputs, trigger buttons, pressure sensors, and haptic feedback associated with the mixed-input pointing device. Free space movement data and surface movement data are tracked and determined for the mixed-input pointing device. An interface input is detected for the mixed-input pointing device transitioning from a first input to a second input, such as, from a free space input to a surface input or from the surface input to the free space input. The interface input is processed based on accessing the free space movement data and the surface movement data. An output for the interface input is communicated from the mixed-input pointing device to interact and control an interface.

Abstract: Described herein are compounds that are estrogen receptor modulators of Formula (I): and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein SERMF is a selective estrogen receptor modulator fragment and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: A reverse transmission system for a vehicle for engaging a reverse action on a normally forward action only engine transmission having a longitudinal orientation driveshaft output, the reverse transmission system comprising a gear rotatably connected to the longitudinal orientation driveshaft output of a normally forward action only engine transmission output; a shaft rotatably connected to the gear for transmitting power from the normally forward action only engine transmission output to the shaft; a chain sprocket connected to a chain drive and to the shaft for providing a transverse orientation output to the chain drive to change the direction of rotation of the driveshaft output, thereby for engaging the vehicle in the reverse action; and a reverse fork configured to actuate a reverse dog configured to slide upon the shaft to reversibly engage a reverse gear engaged to a first gear of the engine transmission.

Abstract: Various embodiments relating to selection of a user interface object displayed on a graphical user interface based on eye gaze are disclosed. In one embodiment, a selection input may be received. A plurality of eye gaze samples at different times within a time window may be evaluated. The time window may be selected based on a time at which the selection input is detected. A user interface object may be selected based on the plurality of eye gaze samples.

Abstract: An optical signal transmission apparatus (1) for a rotating antenna comprising a plurality of optical modulators (6) arranged for receiving a respective plurality of analog RF signals (5) and for modulating a respective plurality of optical signals therewith to produce a plurality of modulated analog optical signals (8). A plurality of opto-electrical converters (14) each converts a respective modulated analog optical signal (13) into an analog electrical signal. The plurality of optical modulators (6) are rotationally coupled in optical communication with the plurality of opto-electrical converters (14) via an optical rotary joint (10) including a reversion prism.

Abstract: A system including an additive management system configured to oversee hydrate formation in a hydrocarbon extraction system, the additive management system including a flow meter configured to measure a fluid flow rate, a first sensor configured to measure at least one of a fluid property and an environmental condition, and a chemical injection device configured to inject a hydrate inhibitor into a fluid flow.

Abstract: A head-mounted display device is disclosed, which includes an at least partially see-through display, a processor configured to detect a physical feature, generate an alignment hologram based on the physical feature, determine a view of the alignment hologram based on a default view matrix for a first eye of a user of the head-mounted display device, display the view of the alignment hologram to the first eye of the user on the at least partially see-through display, output an instruction to the user to enter an adjustment input to visually align the alignment hologram with the physical feature, determine a calibrated view matrix based on the default view matrix and the adjustment input, and adjust a view matrix setting of the head-mounted display device based on the calibrated view matrix.

Abstract: Described herein are compounds that are estrogen receptor modulators of Formula (I): and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein SERMF is a selective estrogen receptor modulator fragment and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: According to a first aspect of the present invention, there is provided a duplexer for a radio frequency antenna, comprising: a radio frequency signal transmitter port arranged for connection to a radio frequency signal transmitter; a radio frequency signal receiver port arranged for connection to a radio frequency signal receiver; a switch arranged selectively to adopt either one of: a first state which connects the transmitter port to a common input/output port of the switch arranged for connection to a radio frequency antenna; and a second state which connects the receiver port to the common input/output port; a switch control unit arranged to monitor radio frequency power at the common input/output port and to receive a transmission gate signal; wherein the switch control unit is arranged to control the switch to adopt the first state upon receipt of the transmission gate signal, and, subsequently, to control the switch to adopt the second state when the monitored radio frequency power falls below a thres

Abstract: Embodiments are described herein for determining a stabilization plane to reduce errors that occur when a homographic transformation is applied to a scene including 3D geometry and/or multiple non-coplanar planes. Such embodiments can be used, e.g., when displaying an image on a head mounted display (HMD) device, but are not limited thereto. In an embodiment, a rendered image is generated, a gaze location of a user is determined, and a stabilization plane, associated with a homographic transformation, is determined based on the determined gaze location. This can involve determining, based on the user's gaze location, variables of the homographic transformation that define the stabilization plane. The homographic transformation is applied to the rendered image to thereby generate an updated image, and at least a portion of the updated image is then displayed.

Abstract: An inductively powered sensor system includes a primary conductive path 100 capable of being energized to provide an electromagnetic field in a defined space 1. An inductive power pick-up 120 is associated with a sensor 124 and is capable of receiving power from the field to supply the sensor 124. The system includes a first sensing means to sense the power available to the pick-up 120 and control means to increase or decrease the power available to the sensor dependant on the sensed power available. A method of inductively powering a sensor, an inductively powered sensor and an animal enclosure including one or more primary conductive path of an inductive power supply are also disclosed.