Abstract: An Injection device for administering a dose of a liquid medicament to a patient comprises a syringe containing the dose of the medicament a hollow injection needle adapted to penetrate the skin of the patient, a stopper translatably disposed within the syringe, a plunger connectable to the stopper and translatable in at least a proximal direction to displace the stopper in the proximal direction and a releasable noise component capable of, upon release, generating an audible and/or tactile feedback. The proximal displacement of the stopper causes the dose of the medicament to be expelled through the hollow injection needle. The noise component is released when the plunger reaches a position relative to the syringe in which the stopper is located in proximity of a proximal end of the syringe. The released noise component impacts on at least one component of the injection device to generate the audible and/or tactile feedback indicating the end of the injection.

Abstract: The invention relates to an auto-injector for administering a dose of a liquid medicament, comprising: a tubular chassis, a carrier subassembly comprising a tubular carrier slidably arranged partially inside the chassis, the carrier adapted to contain a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier, a control spring arranged around the carrier, a needle insertion control mechanism for coupling a proximal end of the control spring to either the carrier for advancing it for needle insertion or to the chassis for needle retraction depending on the relative axial position of the carrier and the chassis, wherein the needle insertion control mechanism comprises a first collar biased by the control spring in a proximal direction, wherein at least one resilient beam is proximally arranged on the first collar, wherein respective recesses are arrang

Abstract: The invention relates to an auto-injector for administering a dose of a liquid medicament, comprising: an elongate case arranged to be held by a user, a tubular chassis telescopable in the case and biased against the case so as to protrude from the case, a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, a trigger button which is initially abutted against the case thus preventing actuation, wherein the chassis is arranged to translate into the case against the bias when pressed against an injection site, wherein the trigger button is at least initially coupled to the chassis in such a manner that the trigger button emerges from the case when the chassis is being pressed against the injection site so as to allow actuation by being translated towards the case for starting an injection cycle.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is presented having a tubular chassis telescopable in an elongate chassis, a carrier subassembly comprising a tubular carrier slidably arranged partially inside the chassis and inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier.

Abstract: The invention refers to a shuttering mechanism (1) for controlling translation of a longitudinally moveable component (2) within a housing (4), the shuttering mechanism (1) comprising at least one fixed shutter (3) attached to or integrated with the housing (4) and at least one moving shutter arm (7) moveable between at least one locking position and at least one unlocking position, wherein at least one resilient arm (5) is associated with the longitudinally moveable component (2), the resilient arm (5) having a dog (6) resiliently biased towards the fixed shutter (3), wherein the moving shutter arm (7) is arranged alongside the fixed shutter (3), wherein at least one fixed protrusion (3.1 to 3.n) is arranged on the fixed shutter (3) at least one of them arranged for engaging the dog (6) so as to prevent translation of the longitudinally moveable component in a proximal direction (P), wherein at least one moving protrusion (7.1 to 7.

Abstract: An auto-injector for administering a dose of a liquid medicament is presented that has a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier adapted to contain a syringe with a hollow injection needle. The injector has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. There is also a trigger button arranged distally or laterally in or on the case, a control spring arranged around the carrier, and a needle extension control mechanism for coupling a proximal end of the control spring to either the carrier for advancing it for needle extension or to the chassis for needle retraction depending on the relative axial position of the carrier and the chassis.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is presented having an elongate case arranged to be held by a user, a tubular chassis telescoped in the case and biased against the case so as to protrude from the case. The injector also includes a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe. A trigger button is distally arranged in or on the case, wherein the trigger button is initially coupled to the case in a manner to protrude distally from the case and interlocked to the chassis in a manner preventing the trigger button from disengaging the case.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.

Abstract: The invention refers to a finger guard for an injection device with a hollow injection needle arranged to be hidden inside a component with an orifice prior to use and to be advanced relative to the component through the orifice for inserting it into an injection site, the finger guard comprising a spring wire attached to the component and comprising an arcuate transversal section biased in a manner to flex inwards so as to essentially obstruct the orifice for finger access when released but staying enough off-centre to allow the needle to advance through the orifice without touching the spring wire.

Abstract: The invention relates to a detent mechanism for controlling translation between two components in a longitudinal direction (P, D), the detent mechanism comprising at least one clip on one of the components arranged to be in a ramped engagement with a recess in the other one of the components in an initial state in such a manner that translation between the components is constrained and that application of a translative force between the components in one longitudinal direction (P, D) with the clip engaged with the recess deflects the clip out of the recess when a predetermined value of the translative force, at least depending on the resilience of the clip, is overcome so as to allow translation between the components.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is presented having an elongate case, a carrier subassembly comprising a tubular carrier slidably arranged inside the case, where the carrier adapted to contain a syringe with a hollow injection needle. The injector also has, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for advancing the needle beyond a proximal end of the auto-injector, and a trigger button is used for releasing the control spring on actuation.

Abstract: The invention refers to a needle safety arrangement for protecting a hollow injection needle of a syringe after an injection, the needle safety arrangement comprising: a needle sheath having essentially the shape of a hollow cylinder arranged to surround the needle, the needle sheath slidable in longitudinal direction with respect to the syringe and biased in proximal direction (P), a sheath linkage, slidable in longitudinal direction, a syringe carrier for holding the syringe, the syringe and syringe carrier arranged for joint axial translation and rotation relative to the needle sheath, wherein the sheath linkage comprises means for restricting translation in proximal direction (P) with respect to the syringe by abutting against the syringe carrier, wherein in an initial state the sheath linkage is abutted against the syringe carrier and latched to the needle sheath for joint axial translation, wherein the syringe carrier exhibits at least one cam on its circumference, wherein the cam is arranged to de-l

Abstract: The invention refers to an auto-injector for delivering a liquid medicament, comprising: an elongate housing arranged to contain a syringe with a hollow injection needle and a stopper, wherein the syringe is slidably arranged with respect to the housing, spring means capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position for insertion into the injection site, operating the syringe to inject the dose of medicament, and advancing a needle shroud over the needle for providing needle safety, activating means arranged to lock and release the spring means, wherein the spring means is a single drive spring in the shape of a compression spring grounded distally in the housing and proximally bearing against a thrust collar arranged to transmit load from the spring means via a plunger to the syringe and/or the stopper for needle insertion and injection, wherein the plunger is engageable to the thrust collar for joint axial translation, wherein the plunge

Abstract: The invention refers to a shuttering mechanism for controlling translation of a longitudinally moveable component within an elongate housing, the shuttering mechanism comprising at least one set of castellations on the housing and at least one resilient arm associated with the longitudinally moveable component, the resilient arm having a dog resiliently biased towards the castellations so as to engage between or behind the castellations and block the translation, wherein a respective shutter arm is arranged alongside the set of castellations, the shutter arm having a number of consecutive ramped protrusions spaced from each other, wherein the castellations and the ramped protrusions have the same pitch, wherein a profiled surface is formed by the castellations and the ramped protrusions, wherein the shutter arm is moveable in longitudinal direction with respect to the set of castellations, wherein the shutter arm has at least one locking position with its ramped protrusions essentially in phase with the caste

Abstract: The invention refers to an auto-injector comprising an elongate housing, a syringe with a hollow injection needle and a stopper, wherein the syringe is arranged in a syringe carrier slidably with respect to the housing, a single compression spring capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end for insertion into an injection site, operating the syringe to inject the dose of medicament, and retracting the syringe with the needle into the covered position after at least partially delivering the medicament, activating means arranged to lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the compression spring for injection.

Abstract: The invention refers to an auto-injector for administering a dose of a liquid medicament (M), the auto-injector having a distal end (P) and a proximal end (D) with an orifice intended to be applied against an injection site and comprising: an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament (M), wherein the syringe (3) is slidably arranged with respect to the housing, a drive means capable of, upon activation: pushing the needle from a retracted position into an advanced position through the orifice and past the proximal end (P), and operating the syringe to supply the dose of medicament (M), a plunger for transmitting power from the drive means to the syringe and/or stopper, activating means arranged to lock the drive means in a compressed state prior to manual operation and capable of, upon manual operation, releasing the drive means for injection, characterized in that translation of the needle and the syringe and/

Abstract: An auto-injector for administering a dose of a liquid medicament (M) comprises of a substantially cylindrical housing arranged to contain a pre-filled syringe with an injection needle, a plunger and a stopper for sealing a syringe barrel and a drive means releasably coupled to the plunger for advancing the syringe in the proximal direction (P) for needle insertion into an injection site and for displacing the dose of medicament (M) into the injection site. The drive means is arranged to be decoupled from the plunger for advancing a needle shroud to a safe position (PS) to surround the injection needle after the injection. According to the invention, the drive means bears against a thrust collar arranged to be releasably coupled to the plunger through a ramped engagement of a first tongue and a first recess so as to rotate the thrust collar on translation in proximal direction (P).

Abstract: The invention refers to an auto-injector for administering a medicament (M), comprising of a chassis, a syringe with a hollow needle and a stopper; a drive spring capable of, upon activation: advancing the needle (3), injecting the medicament (M), and retracting the syringe with the needle after delivering the medicament (M); and; activating means arranged to lock and release the drive spring, wherein the drive spring is a compression spring arranged to be grounded at a distal end in the chassis for advancing the needle and for injecting the dose of medicament (M) via a plunger and wherein the drive spring is arranged to have its ground in the chassis switched to its proximal end for retracting the syringe.

Abstract: Various delivery devices and methods are disclosed, including a delivery device (200) for delivering a dose substance (110) in powdered form to an eye. The device can include a pocket (100A, 100B, 100C) for holding dose substance and a propulsion system (202, 204, 908, 1004, 1006) for propelling a dose consisting of a predetermined volume of said dose substance from said pocket towards said eye, wherein one or both of said pocket and said propulsion system are configured to inhibit propulsion of particles having a size greater than a predetermined threshold to said eye.