Patents by Inventor Simon P. Robinson

Simon P. Robinson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for making ultrasound contrast agents
    Patent number: 11529431
    Abstract: Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
    Type: Grant
    Filed: March 7, 2022
    Date of Patent: December 20, 2022
    Assignee: Lantheus Medical Imaging, Inc.
    Inventors: Simon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
  • LIPID-ENCAPSULATED GAS MICROSPHERE COMPOSITIONS AND RELATED METHODS
    Publication number: 20220395590
    Abstract: The invention provides, inter alia, improved lipid formulations used to generate lipid-encapsulated gas microspheres, and methods of their use.
    Type: Application
    Filed: June 24, 2022
    Publication date: December 15, 2022
    Applicant: Lantheus Medical Imaging, Inc.
    Inventors: Simon P. Robinson, Robert W. Siegler, David C. Onthank, Nhung Tuyet Nguyen
  • COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS
    Publication number: 20220339303
    Abstract: The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs. In some embodiments, methods and compositions for assessing perfusion and innervation mismatch in a portion of a subject are provided.
    Type: Application
    Filed: April 20, 2022
    Publication date: October 27, 2022
    Inventors: Heike S. Radeke, Richard R. Cesati, Ajay Purohit, Thomas D. Harris, Simon P. Robinson, Ming Yu, David S. Casebier, Carol Hui Hu, Matthias Broekema, David C. Onthank
  • LIGANDS FOR IMAGING CARDIAC INNERVATION
    Publication number: 20220288243
    Abstract: Novel compounds that find use as imaging agents within nuclear medicine applications (PET imaging) for imaging of cardiac innervation are disclosed. These PET based radiotracers may exhibit increased stability, decreased NE release (thereby reducing side effects), improved quantitative data, and/or high affinity for VMAT over prior radiotracers. Methods of using the compounds to image cardiac innervation are also provided. In some instances the compounds are developed by derivatizing certain compounds with 18F in a variety of positions: aryl, alkyl, a keto, benzylic, beta-alkylethers, gamma-propylalkylethers and beta-proplylalkylethers. Alternatively or additionally, a methyl group a is added to the amine, and/or the catechol functionality is either eliminated or masked as a way of making these compounds more stable.
    Type: Application
    Filed: January 28, 2022
    Publication date: September 15, 2022
    Applicant: Lantheus Medical Imaging, Inc.
    Inventors: Ajay Purohit, Thomas D. Harris, Heike S. Radeke, Simon P. Robinson, Ming Yu, David S. Casebier, Michael T. Azure
  • Lipid-encapsulated gas microsphere compositions and related methods
    Patent number: 11395856
    Abstract: The invention provides, inter alia, improved lipid formulations used to generate lipid-encapsulated gas microspheres, and methods of their use.
    Type: Grant
    Filed: February 3, 2020
    Date of Patent: July 26, 2022
    Assignee: Lantheus Medical Imaging, Inc.
    Inventors: Simon P. Robinson, Robert W. Siegler, David C. Onthank, Nhung Tuyet Nguyen
  • METHODS FOR MAKING ULTRASOUND CONTRAST AGENTS
    Publication number: 20220193273
    Abstract: Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
    Type: Application
    Filed: March 7, 2022
    Publication date: June 23, 2022
    Applicant: Lantheus Medical Imaging, Inc.
    Inventors: Simon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
  • METHODS FOR MAKING ULTRASOUND CONTRAST AGENTS
    Publication number: 20220193274
    Abstract: Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
    Type: Application
    Filed: May 19, 2021
    Publication date: June 23, 2022
    Applicant: Lantheus Medical Imaging, Inc.
    Inventors: Simon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
  • METHODS FOR MAKING ULTRASOUND CONTRAST AGENTS
    Publication number: 20220184237
    Abstract: Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
    Type: Application
    Filed: March 7, 2022
    Publication date: June 16, 2022
    Applicant: Lantheus Medical Imaging, Inc.
    Inventors: Simon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
  • Methods for making ultrasound contrast agents
    Patent number: 11344636
    Abstract: Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: May 31, 2022
    Assignee: Lantheus Medical Imaging, Inc.
    Inventors: Simon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
  • Methods for making ultrasound contrast agents
    Patent number: 11266750
    Abstract: Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
    Type: Grant
    Filed: May 19, 2021
    Date of Patent: March 8, 2022
    Assignee: Lantheus Medical Imaging, Inc.
    Inventors: Simon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
  • Methods for making ultrasound contrast agents
    Patent number: 11266749
    Abstract: Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: March 8, 2022
    Assignee: Lantheus Medical Imaging, Inc.
    Inventors: Simon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
  • Ligands for imaging cardiac innervation
    Patent number: 11241509
    Abstract: Novel compounds that find use as imaging agents within nuclear medicine applications (PET imaging) for imaging of cardiac innervation are disclosed. These PET based radiotracers may exhibit increased stability, decreased NE release thereby reducing side effects, improved quantitative data, and/or high affinity for VMAT over prior radiotracers. In some instances the compounds are developed by derivatizing certain compounds with 18F in a variety of positions: aryl, alkyl, a keto, benzylic, beta-alkylethers, gamma-propylalkylethers and beta-proplylalkylethers. Alternatively or additionally, a methyl group a is added to the amine, and/or the catechol functionality is either eliminated or masked as a way of making these compounds more stable.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: February 8, 2022
    Assignee: Lantheus Medical Imaging, Inc.
    Inventors: Ajay Purohit, Thomas D. Harris, Heike S. Radeke, Simon P. Robinson, Ming Yu, David S. Casebier, Michael T. Azure
  • METHODS FOR MAKING ULTRASOUND CONTRAST AGENTS
    Publication number: 20210338844
    Abstract: Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
    Type: Application
    Filed: May 19, 2021
    Publication date: November 4, 2021
    Applicant: Lantheus Medical Imaging, Inc.
    Inventors: Simon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
  • CONTRAST AGENTS FOR MYOCARDIAL PERFUSION IMAGING
    Publication number: 20210300878
    Abstract: The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds MC-1, and an imaging moiety, and scanning the patient using diagnostic imaging.
    Type: Application
    Filed: December 4, 2020
    Publication date: September 30, 2021
    Applicant: Lantheus Medical Imaging, Inc.
    Inventors: David S. Casebier, Simon P. Robinson, Ajay Purohit, Heike S. Radeke, Michael T. Azure, Douglas D. Dischino
  • METHODS FOR MAKING ULTRASOUND CONTRAST AGENTS
    Publication number: 20210268130
    Abstract: Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
    Type: Application
    Filed: May 19, 2021
    Publication date: September 2, 2021
    Inventors: Simon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
  • Contrast agents for myocardial perfusion imaging
    Patent number: 10889550
    Abstract: The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds MC-1, and an imaging moiety, and scanning the patient using diagnostic imaging.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: January 12, 2021
    Assignee: Lantheus Medical Imaging, Inc.
    Inventors: David S. Casebier, Simon P. Robinson, Ajay Purohit, Heike S. Radeke, Michael T. Azure, Douglas D. Dischino
  • COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS
    Publication number: 20200397927
    Abstract: The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs. In some embodiments, methods and compositions for assessing perfusion and innervation mismatch in a portion of a subject are provided.
    Type: Application
    Filed: March 24, 2020
    Publication date: December 24, 2020
    Applicant: Lantheus Medical Imaging, Inc.
    Inventors: Heike S. Radeke, Richard R. Cesati, Ajay Purohit, Thomas D. Harris, Simon P. Robinson, Ming Yu, David S. Casebier, Carol Hui Hu, Matthias Broekema, David C. Onthank
  • LIPID ENCAPSULATED GAS MICROSPHERE COMPOSITIONS AND RELATED METHODS
    Publication number: 20200390911
    Abstract: The invention provides improved compositions relating to lipid-encapsulated gas microspheres and methods of their use.
    Type: Application
    Filed: April 30, 2020
    Publication date: December 17, 2020
    Applicant: Lantheus Medical Imaging, Inc.
    Inventors: Simon P. Robinson, Nhung Tuyet Nguyen, Robert W. Siegler
  • LIPID-ENCAPSULATED GAS MICROSPHERE COMPOSITIONS AND RELATED METHODS
    Publication number: 20200384132
    Abstract: The invention provides, inter alia, improved lipid formulations used to generate lipid-encapsulated gas microspheres, and methods of their use.
    Type: Application
    Filed: February 3, 2020
    Publication date: December 10, 2020
    Applicant: Lantheus Medical Imaging, Inc.
    Inventors: Simon P. Robinson, Robert W. Siegler, David C. Onthank, Nhung Tuyet Nguyen
  • COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS
    Publication number: 20200230264
    Abstract: The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.
    Type: Application
    Filed: October 25, 2019
    Publication date: July 23, 2020
    Applicant: Lantheus Medical Imaging, Inc.
    Inventors: Richard R. Cesati, Heike S. Radeke, Suresh K. Pandey, Ajay Purohit, Simon P. Robinson