Abstract: A method may include applying a protein sequence computation model to generate, based on an input protein sequence, a plurality of proposed protein sequences. A set of possible amino acid residues for each position in at least a portion of an output protein sequence may be identified based on the plurality of proposed protein sequences. A first protein structure having the output protein sequence may be generated by applying a protein structure computation model to select, for each position in at least the portion of the output protein sequence, an amino acid residue from a corresponding set of possible amino acid residues. The protein structure computation model may further determine the conformation of the amino acid residues selected for inclusion in the output protein sequence. In some cases, the first protein structure may be grafted onto a second protein structure to form a third protein structure.

Abstract: The invention relates to compounds of Formula (I)-(III) and pharmaceutically acceptable salts thereof to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The compounds the present invention may be useful in the treatment, prevention, suppression and amelioration diseases, disorders and conditions such as cancers.

Abstract: Aspects of the invention are directed to characteristics and parameters of color coatings on keratin fibers. The color coatings are produced from compositions of several kinds of polymers that enable the color coatings to exhibit adherence, remanence, wear fastness and resistance to environmental attack.

Abstract: The invention is related to security systems and methods for proactively informing a user about an artifact associated with a clickable object on a user interface with which the user is interacting, where such information is provided to the user prior to selection of the clickable object. The information includes a safety assessment of the clickable object, details about the underlying artifact, such as the contents of an archive file, and general information helpful in assisting the user with making a decision as to whether to select the clickable object.

Abstract: In various exemplary embodiments, a security continuity system allows users to continue accessing certain user accounts (e.g., email, calendar, contacts, documents, instant messaging, cloud storage, etc.) through alternate logon identity credentials that are automatically provisioned such as when a security event is detected or suspected. The alternate logon identity credentials may be temporary (e.g., just used during security continuity until the original user logon identity credentials can be secured such as by establishing a new password or by having the user select a new logon identity) or permanent (e.g., the alternate logon identity can become the user's new logon identity). Security continuity may be invoked manually (e.g., by the user or by an administrator) or automatically when certain conditions are detected (e.g., through detection of suspicious activities such as repeated user lockouts due to multiple failed logon attempts or upon detection of a successful breach by an attacker).

Abstract: A coating, preferably a color coating, method for keratin fibers is described which includes three steps: activation, pretreatment and binding. The activation step includes one or both of a Praeparatur procedure and a Fundamenta procedure to produce modified fibers. The pretreatment step applies a pretreatment composition of at least a PTH alkoxysilane with PTH as a thiol, a protected thiol or a group complementarily reactive with thiol to the modified fibers to form pretreated fibers. The binding step applies a film forming composition to the pretreated fibers to form the color coating.

Abstract: The invention relates to compounds of Formula (I)-(III) and pharmaceutically acceptable salts thereof to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The compounds the present invention may be useful in the treatment, prevention, suppression and amelioration diseases, disorders and conditions such as cancers.

Abstract: The invention is related to security systems and methods for proactively informing a user about an artifact associated with a clickable object on a user interface with which the user is interacting, where such information is provided to the user prior to selection of the clickable object. The information includes a safety assessment of the clickable object, details about the underlying artifact, such as the contents of an archive file, and general information helpful in assisting the user with making a decision as to whether to select the clickable object.

Abstract: The instant disclosure generally relates to a multicomponent composition for coloring mammalian or synthetic keratin fibers, the multicomponent composition comprising first, second, third and fourth components. The first component includes an organic polymer, the second component includes an in situ linking material, the third component includes a base compound and the fourth component includes a catalyst or other substance. One or more of the components includes pigment microparticles. The multicomponent composition in situ links upon application, forms a solid coating on treated material such as hair and has a substantially long color remanence following development. Methods of using such compositions are also described herein.

Abstract: Among other things, we describe techniques for encoding data that is included in electronic communications. In one aspect, a first electronic communication system sends, to an entity, a first email message that includes a Message-ID field including data that identifies an action to be carried out by a second electronic communication system. The first electronic communication system receives, from the entity, a second email message that includes an In-Reply-To field containing the data that identifies the action to be carried out by the second electronic communication system. The first electronic communication extracts the data from the In-Reply-To field in a message header of the first electronic communication. The second electronic communication system may be the same as the first electronic communication system, or may be an electronic communication system other than the first electronic communication system.

Abstract: Among other things, we describe techniques for carrying encoded data in a header field of an email message wherein the encoded data is homomorphically encrypted such that the encoded data is only interpretable by one or more authorized recipients and operable by any recipient. A recipient of such an email message (which may be the sender or another recipient) can derive an action to be carried out from the homomorphically-encrypted encoded data.

Abstract: The invention relates to compounds of Formula (I)-(III) and pharmaceutically acceptable salts thereof to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The compounds the present invention may be useful in the treatment, prevention, suppression and amelioration diseases, disorders and conditions such as cancers.

Abstract: Systems and methods for treating water containing PFAS are disclosed. Plasma activated excited gas is encapsulated with nanobubbles in water comprising PFAS to be treated. Liquid-phase reaction of the PFAS with the encapsulated plasma activated excited gas at the air-water interface of the nanobubbles is promoted. The PFAS can be concentrated upstream of the plasma reactor. A foam fractionation process may be used in conjunction with the plasma reactor to facilitate PFAS removal.

Abstract: A composition is provided for removal of a target substance from a fluid stream. The composition may be used to remove polyfluorinated alkyl substances (PFAS) from water. The composition comprises a support material comprising an alumina; and a sorbent molecule that comprises a core polymer; wherein the core polymer is covalently linked to the support material; and wherein the sorbent molecule further comprises one or more covalently linked sorbent groups. Processes for removal of target substances such as PFAS are also provided.

Abstract: An aeronautical thruster having a longitudinal axis and having a hub and at least two annular rows of unducted blades including an upstream annular row and a downstream annular row which are spaced apart from one another along the longitudinal axis, the upstream annular row being rotatable around the longitudinal axis, and the downstream annular row comprising a series of blades including a first blade and a second blade each extending in a radial direction from the hub to define a radial dimension between the hub and a radially outer end of the corresponding blade, wherein the radial dimension of the first blade is greater than the radial dimension of the second blade.

Abstract: Disclosed are various approaches for secure inter-application communication with unmanaged applications using certificate enrollment. A certificate signing request can be received from an unmanaged application via an inter-application communication method supported by an operating system of a computing device, and an identity of the unmanaged application can be verified. The certificate signing request can be provided to a certifying authority, and a certificate can be received from the certifying authority. The certificate can be provided to the unmanaged application.

Abstract: The instant disclosure generally relates to a multicomponent composition for coloring mammalian or synthetic keratin fibers, the multicomponent composition comprising first, second, third and fourth components. The first component includes an organic polymer, the second component includes an in situ linking material, the third component includes a base compound and the fourth component includes a catalyst or other substance. One or more of the components includes pigment microparticles. The multicomponent composition in situ links upon application, forms a solid coating on treated material such as hair and has a substantially long color remanence following development. Methods of using such compositions are also described herein.

Abstract: The instant disclosure generally relates to a multicomponent composition for coloring mammalian or synthetic substrate material and textiles, the composition comprising a first and second components and a third component. The first and second components comprise first and second silicone polymers respectively. Any one or more of the first, second and third components may also comprise pigment microparticles. The first, second and third compounds meld together on substrate material and textiles and especially on hair to form a highly remanent colored coating. The multicomponent composition formed and set in situ as a solid linked coating has a substantially permanent pigment lastingness and minimally alters the substrate material and textiles.

Abstract: A composition is provided for removal of a target substance from a fluid stream. The composition may be used to remove polyfluorinated alkyl substances (PFAS) from water. The composition comprises a support material comprising an alumina; and a sorbent molecule that comprises a core polymer; wherein the core polymer is covalently linked to the support material; and wherein the sorbent molecule further comprises one or more covalently linked sorbent groups. Processes for removal of target substances such as PFAS are also provided.