Abstract: The present disclosure relates to multi-specific molecules which are capable of simultaneously binding at least two different target antigens or epitopes. The molecules comprise at least one binding domain molecule (BDM) which binds to a first target antigen or epitope, the BDM being modified for selective binding to a heterologous target, coupled to a pharmacologically active protein or peptide which is an antibody or antigen-binding fragment thereof or a non-antibody protein or peptide which binds to a second target antigen or epitope, the BDMs being coupled to a C-terminus of a polypeptide present within the pharmacologically active protein or peptide.

Abstract: Methods, systems, devices and apparatuses for a part lifecycle system. The part lifecycle system includes a part lifecycle apparatus. The part lifecycle apparatus includes a memory. The memory is configured to store multiple part profiles including a first part profile. The part lifecycle apparatus includes a sensor that is configured to determine performance data or lifecycle data of the first part. The part lifecycle apparatus includes an electronic control unit. The electronic control unit is configured to determine a baseline performance or a baseline lifecycle of the first part based on the first part profile. The electronic control unit is configured to determine that the performance data or the lifecycle data exceeds a threshold based on the baseline performance or the baseline lifecycle of the first part, respectively, and provide an indication to a user that the first part needs maintenance.

Abstract: The present disclosure relates to multi-specific molecules which are capable of simultaneously binding at least two different target antigens or epitopes. The molecules comprise at least one binding domain molecule (BDM) which hinds to a first target antigen or epitope, the BDM being modified for selective binding to a heterologous target, coupled to a pharmacologically active protein or peptide which is an antibody or antigen-binding fragment thereof or a non-antibody protein or peptide which binds to a second target antigen or epitope, the BDMs being coupled to a C-terminus of a polypeptide present within the pharmacologically active protein or peptide.

Abstract: A method for calculating a valve closure time includes performing a computational fluid dynamics model simulation of the valve. The method also includes performing multiple functional performance analysis model simulations of the valve based on the computational fluid dynamics model simulation of the valve to calculate the valve closure time. The functional performance analysis model simulations are based on a numerical solution of a second order differential equation according to an equation of motion given by: (I), where mL is a mass of translating components, y(t) is a piston displacement at a given time t, F? is a force on the valve due to fluid flow, E? is a friction force, FD is a hydraulic damping force on the piston, FD is a spring force, FPPA is a hydraulic piston pressure assist force, FBPA is a hydraulic bore pressure assist force, and FG is a force due to gravity.

Abstract: The present disclosure relates to multi-specific molecules which are capable of simultaneously binding at least two different target antigens or epitopes. The molecules comprise at least one binding domain molecule (BDM) which hinds to a first target antigen or epitope, the BDM being modified for selective binding to a heterologous target, coupled to a pharmacologically active protein or peptide which is an antibody or antigen-binding fragment thereof or a non-antibody protein or peptide which binds to a second target antigen or epitope, the BDMs being coupled to a C-terminus of a polypeptide present within the pharmacologically active protein or peptide.

Abstract: Methods, systems, devices and apparatuses for a part lifecycle system. The part lifecycle system includes a part lifecycle apparatus. The part lifecycle apparatus includes a memory. The memory is configured to store multiple part profiles including a first part profile. The part lifecycle apparatus includes a sensor that is configured to determine performance data or lifecycle data of the first part. The part lifecycle apparatus includes an electronic control unit. The electronic control unit is configured to determine a baseline performance or a baseline lifecycle of the first part based on the first part profile. The electronic control unit is configured to determine that the performance data or the lifecycle data exceeds a threshold based on the baseline performance or the baseline lifecycle of the first part, respectively, and provide an indication to a user that the first part needs maintenance.

Abstract: The present disclosure relates to multi-specific molecules which are capable of simultaneously binding at least two different target antigens or epitopes. The molecules comprise at least one binding domain molecule (BDM) which binds to a first target antigen or epitope, the BDM being modified for selective binding to a heterologous target, coupled to a pharmacologically active protein or peptide which is an antibody or antigen-binding fragment thereof or a non-antibody protein or peptide which binds to a second target antigen or epitope, the BDMs being coupled to a C-terminus of a polypeptide present within the pharmacologically active protein or peptide.

Abstract: Methods and computer program products for establishing communication events between an initiator user and a recipient user over a first communication system. The initiator and recipient users are contacts within a second communication system but are not contacts within the first communication system. For the initiator and recipient users, an association between a first user identity in the first communication system and a second user identity in the second communication system is determined. The initiator user device uses the association for the recipient user to determine the first user identity of the recipient user. A setup request to establish the communication event is sent over the first communication system from a first initiator client to a first recipient client. A communication event is authorized to proceed over the first communication system on the basis that the initiator user and the recipient user are contacts within the second communication system.

Abstract: Methods and computer program products for establishing communication events between an initiator user and a recipient user over a first communication system. The initiator and recipient users are contacts within a second communication system but are not contacts within the first communication system. For the initiator and recipient users, an association between a first user identity in the first communication system and a second user identity in the second communication system is determined. The initiator user device uses the association for the recipient user to determine the first user identity of the recipient user. A setup request to establish the communication event is sent over the first communication system from a first initiator client to a first recipient client. A communication event is authorized to proceed over the first communication system on the basis that the initiator user and the recipient user are contacts within the second communication system.

Abstract: Methods and computer program products for establishing communication events between an initiator user and a recipient user over a first communication system. The initiator and recipient users are contacts within a second communication system but are not contacts within the first communication system. For the initiator and recipient users, an association between a first user identity in the first communication system and a second user identity in the second communication system is determined. The initiator user device uses the association for the recipient user to determine the first user identity of the recipient user. A setup request to establish the communication event is sent over the first communication system from a first initiator client to a first recipient client. A communication event is authorized to proceed over the first communication system on the basis that the initiator user and the recipient user are contacts within the second communication system.

Abstract: The present disclosure relates to multi-specific molecules which are capable of simultaneously binding at least two different target antigens or epitopes. The molecules comprise at least one binding domain molecule (BDM) which binds to a first target antigen or epitope, the BDM being modified for selective binding to a heterologous target, coupled to a pharmacologically active protein or peptide which is an antibody or antigen-binding fragment thereof or a non-antibody protein or peptide which binds to a second target antigen or epitope, the BDMs being coupled to a C-terminus of a polypeptide present within the pharmacologically active protein or peptide.

Abstract: Methods and computer program products for establishing communication events between an initiator user and a recipient user over a first communication system. The initiator and recipient users are contacts within a second communication system but are not contacts within the first communication system. For the initiator and recipient users, an association between a first user identity in the first communication system and a second user identity in the second communication system is determined. The initiator user device uses the association for the recipient user to determine the first user identity of the recipient user. A setup request to establish the communication event is sent over the first communication system from a first initiator client to a first recipient client. A communication event is authorized to proceed over the first communication system on the basis that the initiator user and the recipient user are contacts within the second communication system.

Abstract: Methods and computer program products for establishing communication events between an initiator user and a recipient user over a first communication system. The initiator and recipient users are contacts within a second communication system but are not contacts within the first communication system. For the initiator and recipient users, an association between a first user identity in the first communication system and a second user identity in the second communication system is determined. The initiator user device uses the association for the recipient user to determine the first user identity of the recipient user. A setup request to establish the communication event is sent over the first communication system from a first initiator client to a first recipient client. A communication event is authorized to proceed over the first communication system on the basis that the initiator user and the recipient user are contacts within the second communication system.

Abstract: An object has at least one electrophoretic display. A filter overlay covers at least a part of the electrophoretic display. Control circuitry is operable to control the electrophoretic display such that the appearance of the object viewed through the filter overlay can be adjusted.

Abstract: In a process for recovering water, metals, soluble organics and insoluble organics from a process for the production of a polycarboxylic acid, the stream is cooled to a temperature at which dissolved organics precipitate. The precipitate organics are separated from a liquid stream and recycled to the production process. The liquid stream is then treated with an alkali to convert remaining organics to the alkali salt form and the metals present to be converted to an insoluble form. The insoluble metals are recovered from a liquid stream and this liquid stream, with the alkali salts of the organics, is passed to a membrane separation unit where it is separated into a permeate comprising water and a retentate comprising water and alkali organic salts. The permeate is recovered and recycled to the production process. The retentate also is recovered.

Abstract: In a process for recovering water, metals, soluble organics and insoluble organics from a process for the production of a polycarboxylic acid, the stream is cooled to a temperature at which dissolved organics precipitate. The precipitate organics are separated from a liquid stream and recycled to the production process. The liquid stream is then treated with an alkali to convert remaining organics to the alkali salt form and the metals present to be converted to an insoluble form. The insoluble metals are recovered from a liquid stream and this liquid stream, with the alkali salts of the organics, is passed to a membrane separation unit where it is separated into a permeate comprising water and a retentate comprising water and alkali organic salts. The permeate is recovered and recycled to the production process. The retentate also is recovered.

Abstract: System and method for automatically identifying a source of a run-time error in a computer system comprises a static analysis system (SAS), an instrumentation system (IS) and a post-execution analysis system (PEAS). The is arranged to generate static analysis data on computer program code (CPC) for the computer system, including information on possible behaviors of the CPC when executed. The IS is arranged to instrument the CPC by inserting marker triggers into the CPC that, generate a marker associated with each of a number of predetermined points in the CPC that would be reached during execution of the CPC. Each marker is, uniquely identifiable. The predetermined points are determined in dependence on the static analysis data. The PEASpost execution analysis system is arranged to processes data on a run-time error produced by execution of the instrumented CPC, wherein the generated markers and the static analysis data to identify the source of the run-time error.

Abstract: Methods and computer program products for establishing communication events between an initiator user and a recipient user over a first communication system. The initiator and recipient users are contacts within a second communication system but are not contacts within the first communication system. For the initiator and recipient users, an association between a first user identity in the first communication system and a second user identity in the second communication system is determined. The initiator user device uses the association for the recipient user to determine the first user identity of the recipient user. A setup request to establish the communication event is sent over the first communication system from a first initiator client to a first recipient client. A communication event is authorized to proceed over the first communication system on the basis that the initiator user and the recipient user are contacts within the second communication system.

Abstract: A monitor, which may be closely associated with a handrail, may determine the amount of force applied to the handrail. The monitor may also determine the pattern in which force is applied to the handrail in order to assess how the user is contacting the handrail. The user's application of force to the handrail can be monitored along the course of movement along the handrail and may be compared to historical usage patterns.

Abstract: The invention relates to a process for the production of diols with a special structure which are characterized by formula (I). These diols are substances which, besides two OH groups, contain a C?C double bond so that they are suitable as monomers for the production of polymers. The process comprises hydrolyzing a corresponding cyclic precursor in aqueous medium in the presence of an acid dissolved in that medium, the hydrolysis being accompanied by the elimination of a carbonyl compound, and subsequently neutralizing the acid present in the reaction mixture with a base, the base having a pKb value above 0.18 and preferably above 3.0 and being present in heterogeneous form.