Abstract: A process for synthesising methanol is described comprising the steps of (i) forming a synthesis gas containing hydrogen, carbon monoxide and carbon dioxide from a hydrocarbon feedstock in a reforming unit comprising a heat exchange reformer and autothermal reformer in series; (ii) cooling the synthesis gas in the heat exchange reformer and one or more further stages of heat exchange, and recovering process condensate from the cooled synthesis gas to form a make-up gas; (iii) passing a feed gas comprising the make-up gas to a methanol synthesis loop comprising one or more methanol synthesis reactors; (iv) recovering a product gas mixture containing methanol from the methanol synthesis loop, and separating the crude methanol from an unreacted gas mixture; and (v) recycling a portion of the unreacted gas mixture to the methanol synthesis loop and recovering a portion of the unreacted gas mixture as a purge gas stream.

Abstract: An investment powder which is safer than conventional powders comprising tricalcium phosphate, and being substantially or entirely free of free silica in the respiratory portion yet providing an overall expansion at 750° C. of 1% or higher sufficient to prevent mould cracking during casting. A method of making a casting comprising forming a slurry by mixing a gypsum bonded investment powder with water, pouring the slurry into a stainless steel flask around a low melting point material model, allowing the slurry to set to define a mould, heating the mould to burn out the model and casting material into the mould wherein the stainless steel flask consists of a 400 series martensitic stainless steel.

Abstract: The present disclosure relates to multi-specific molecules which are capable of simultaneously binding at least two different target antigens or epitopes. The molecules comprise at least one binding domain molecule (BDM) which hinds to a first target antigen or epitope, the BDM being modified for selective binding to a heterologous target, coupled to a pharmacologically active protein or peptide which is an antibody or antigen-binding fragment thereof or a non-antibody protein or peptide which binds to a second target antigen or epitope, the BDMs being coupled to a C-terminus of a polypeptide present within the pharmacologically active protein or peptide.

Abstract: A solidification or crystallization method is disclosed, which includes providing at least a first organic compound and at least one volatile co-former organic compound. A mixture of at least the first organic compound and the co-former organic compound is formed, wherein either the first organic compound or the volatile co-former organic compound includes a hydrogen acceptor moiety and the other includes a hydrogen donor moiety, thereby allowing the formation of hydrogen bonds between the first organic compound and the volatile co-former organic compound. The mixture is allowed to stand for sufficient time for the mixture to liquify at a temperature below that of the melting points of the components, thereby forming a liquid mixture. The volatile co-former organic compound is allowed to evaporate, thereby resulting in crystallization of at least the first organic compound. The method can be a co-crystallization method if there are two organic compounds.

Abstract: A method for calculating a valve closure time includes performing a computational fluid dynamics model simulation of the valve. The method also includes performing multiple functional performance analysis model simulations of the valve based on the computational fluid dynamics model simulation of the valve to calculate the valve closure time. The functional performance analysis model simulations are based on a numerical solution of a second order differential equation according to an equation of motion given by: (I), where mL is a mass of translating components, y(t) is a piston displacement at a given time t, F? is a force on the valve due to fluid flow, E? is a friction force, FD is a hydraulic damping force on the piston, FD is a spring force, FPPA is a hydraulic piston pressure assist force, FBPA is a hydraulic bore pressure assist force, and FG is a force due to gravity.

Abstract: A respiratory valve, such as a positive end expiratory pressure valve, permits pressure control for respiratory apparatus such as a ventilator or positive airway pressure device. The valve may include a flexible gas passage cover. The cover may be configured with a first side surface to operatively block and open an aperture of the gas passage at a valve seat to respectively prevent and permit gas flow through the aperture defined by the valve seat. The cover may include a second side surface opposite the first surface. The second surface may include at least one drop section forming a reduction in thickness of the cover between the first surface and the second surface. The first surface may include a coating to reduce friction of a membrane material of the first surface. The rim of the valve seat may comprise a variation in height relative the flexible cover.

Abstract: A process for synthesising methanol is described comprising the steps of (i) passing a feed gas comprising a make-up gas containing hydrogen and carbon dioxide to a methanol synthesis loop, (ii) recovering a product gas mixture containing methanol from the methanol synthesis loop, (iii) cooling the product gas mixture to below the dew point to condense crude methanol, (iv) separating the crude methanol from an unreacted gas mixture, (v) passing a portion of the unreacted gas mixture to the methanol synthesis loop and (vi) recovering a portion of the unreacted gas mixture as a purge gas stream, characterised by contacting the crude methanol and a portion of the purge gas in a stripping unit to strip dissolved gases from the crude methanol thereby forming a stripped crude methanol and an enriched gas mixture, and feeding at least a portion of the enriched gas mixture to the methanol synthesis loop.

Abstract: The present disclosure relates to multi-specific molecules which are capable of simultaneously binding at least two different target antigens or epitopes. The molecules comprise at least one binding domain molecule (BDM) which hinds to a first target antigen or epitope, the BDM being modified for selective binding to a heterologous target, coupled to a pharmacologically active protein or peptide which is an antibody or antigen-binding fragment thereof or a non-antibody protein or peptide which binds to a second target antigen or epitope, the BDMs being coupled to a C-terminus of a polypeptide present within the pharmacologically active protein or peptide.

Abstract: A seeding unit comprising: a support; a soil opening member mounted to the support; and a seed delivery outlet, defining an exit aperture for releasing seed; wherein the soil opening member comprises: an upper blade portion operative to form a seed collection slot in the ground; and a lower blade portion laterally offset from the upper blade portion and operative to form a deep rooting slot in the ground that is offset laterally from the seed collection slot.

Abstract: A respiratory treatment apparatus configured to provide a flow of breathable gas to a patient, including a breathable air outlet, an outside air inlet, and an pneumatic block module, wherein the pneumatic block module includes: a volute assembly including an inlet air passage, a mount for a blower and an outlet air passage; the blower being mounted in the mount such that an impeller of the blower is in a flow passage connecting the inlet air passage and the outlet air passage; a casing enclosing the volute assembly, wherein air passages within the casing connect air ports on the volute assembly, wherein the inlet air passage of the volute assembly is in fluid communication with the outside air inlet and the outlet air passage of the volute assembly is in fluid communication with the air outlet.

Abstract: Seed sowing apparatus comprising: a frame defining a leading part supporting a soil opening stage and a trailing part supporting a soil closing stage trailing the soil opening stage, wherein the soil opening stage comprises a plurality of laterally spaced seeding units, each seeding unit comprising a soil opening member associated with a respective seed delivery outlet connected to a seed source, wherein each seeding unit is configured to form a respective seeded trench in the ground when the apparatus is in use driven through soil in a forward direction of travel; wherein the soil closing stage comprises a plurality of laterally spaced soil deflection members each associated with a respective one of the seeding units, each soil deflection member being spaced laterally from the soil opening member of its respective seeding unit and configured to deflect soil toward the seeded trench formed by the seeding unit.

Abstract: A method is described for quantitative pay summaries from mud logs, real-time fluid typing, and to minimize logging expense in high-angle or horizontal wells. The method may include receiving at least one mud log; selecting extraction system type, operating, and drilling parameters for the at least one mud log; determining hydrocarbon parameters such as methane (C1) extraction efficiency, trap response factor (TRF), and relative responses for ethane-pentane (C2-C5); correcting gas-in-mud volume to an earth surface to generate a corrected C1-C5; calculating a gas-to-oil ratio (GOR) from the corrected C1-C5; calculating a reservoir gas volume from the gas-in-mud volume to an earth surface and the GOR; determining pay cutoffs; and generating least one pay summary. The method may be executed by a computer system.

Abstract: A device suitable for use as a distributor or collector in a radial-flow reaction vessel is described, comprising an open end and a plurality of rigid columnar portions, each columnar portion comprising a cylindrical outer screen formed from parallel spaced wires and a perforate inner screen fixed to the outer screen, said inner screen formed from a plurality of adjacent perforate support members that support the spaced wires, wherein the rigid columnar portions further comprise means for controlling a flow of a gaseous process fluid to or from the device. The device may be used in radial-flow vessels used in chemical processes such as methanol synthesis.

Abstract: A respiratory treatment apparatus configured to provide a flow of breathable gas to a patient, including a breathable air outlet, an outside air inlet, and an pneumatic block module, wherein the pneumatic block module includes: a volute assembly including an inlet air passage, a mount for a blower and an outlet air passage; the blower being mounted in the mount such that an impeller of the blower is in a flow passage connecting the inlet air passage and the outlet air passage; a casing enclosing the volute assembly, wherein air passages within the casing connect air ports on the volute assembly, wherein the inlet air passage of the volute assembly is in fluid communication with the outside air inlet and the outlet air passage of the volute assembly is in fluid communication with the air outlet.

Abstract: Methods, systems, devices and apparatuses for a part lifecycle system. The part lifecycle system includes a part lifecycle apparatus. The part lifecycle apparatus includes a memory. The memory is configured to store multiple part profiles including a first part profile. The part lifecycle apparatus includes a sensor that is configured to determine performance data or lifecycle data of the first part. The part lifecycle apparatus includes an electronic control unit. The electronic control unit is configured to determine a baseline performance or a baseline lifecycle of the first part based on the first part profile. The electronic control unit is configured to determine that the performance data or the lifecycle data exceeds a threshold based on the baseline performance or the baseline lifecycle of the first part, respectively, and provide an indication to a user that the first part needs maintenance.

Abstract: The present disclosure relates to multi-specific molecules which are capable of simultaneously binding at least two different target antigens or epitopes. The molecules comprise at least one binding domain molecule (BDM) which binds to a first target antigen or epitope, the BDM being modified for selective binding to a heterologous target, coupled to a pharmacologically active protein or peptide which is an antibody or antigen-binding fragment thereof or a non-antibody protein or peptide which binds to a second target antigen or epitope, the BDMs being coupled to a C-terminus of a polypeptide present within the pharmacologically active protein or peptide.

Abstract: A system for light source calibration and aging compensation is disclosed. In one or more embodiments, the system includes a light source driver, a sensor, and a controller. The light source driver is configured to generate one or more power signals for a plurality of light sources. The sensor is configured to detect an illumination power output by at least one light source of the plurality of light sources. The controller is communicatively coupled to the sensor and the light source driver. The controller is configured to compare the illumination power detected by the sensor to a target illumination power. The controller is further configured to generate one or more control signals to adjust an electrical power output of the light source driver based on the comparison of the illumination power detected by the sensor to the target illumination power.

Abstract: A respiratory treatment apparatus configured to provide a flow of breathable gas to a patient, including a breathable air outlet, an outside air inlet, and an pneumatic block module, wherein the pneumatic block module includes: a volute assembly including an inlet air passage, a mount for a blower and an outlet air passage; the blower being mounted in the mount such that an impeller of the blower is in a flow passage connecting the inlet air passage and the outlet air passage; a casing enclosing the volute assembly, wherein air passages within the casing connect air ports on the volute assembly, wherein the inlet air passage of the volute assembly is in fluid communication with the outside air inlet and the outlet air passage of the volute assembly is in fluid communication with the air outlet.

Abstract: Methods and computer program products for establishing communication events between an initiator user and a recipient user over a first communication system. The initiator and recipient users are contacts within a second communication system but are not contacts within the first communication system. For the initiator and recipient users, an association between a first user identity in the first communication system and a second user identity in the second communication system is determined. The initiator user device uses the association for the recipient user to determine the first user identity of the recipient user. A setup request to establish the communication event is sent over the first communication system from a first initiator client to a first recipient client. A communication event is authorized to proceed over the first communication system on the basis that the initiator user and the recipient user are contacts within the second communication system.

Abstract: Methods and computer program products for establishing communication events between an initiator user and a recipient user over a first communication system. The initiator and recipient users are contacts within a second communication system but are not contacts within the first communication system. For the initiator and recipient users, an association between a first user identity in the first communication system and a second user identity in the second communication system is determined. The initiator user device uses the association for the recipient user to determine the first user identity of the recipient user. A setup request to establish the communication event is sent over the first communication system from a first initiator client to a first recipient client. A communication event is authorized to proceed over the first communication system on the basis that the initiator user and the recipient user are contacts within the second communication system.