Patents by Inventor Simone Thomas

Simone Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11545558
    Abstract: There is provided a method of manufacturing a transistor, the method comprising: (a) providing a substrate having a semiconductor surface; (b) providing a graphene layer structure on a first portion of the semiconductor surface, wherein the graphene layer structure has a thickness of n graphene monolayers, wherein n is at least 2; (c) etching a first portion of the graphene layer structure to reduce the thickness of the graphene layer structure in said first portion to from n?1 to 1 graphene monolayers; (d) forming a layer of dielectric material on the first portion of the graphene layer structure; and (e) providing: a source contact on a second portion of the graphene layer structure; a gate contact on the layer of dielectric material; and a drain contact on a second portion of the semiconductor surface of the substrate.
    Type: Grant
    Filed: September 13, 2021
    Date of Patent: January 3, 2023
    Assignee: Paragraf Limited
    Inventors: Thomas James Badcock, Robert Wallis, Ivor Guiney, Simon Thomas
  • Publication number: 20220356260
    Abstract: The present invention provides a chimeric antigen receptor (CAR) which binds a low density target antigen, which comprises a Fab antigen binding domain. The invention also relates to cells expressing such a CAR and their use in the treatment of disease.
    Type: Application
    Filed: May 17, 2022
    Publication date: November 10, 2022
    Inventors: Martin Pulé, Shaun Cordoba, Simon Thomas, Shimobi Onuoha, Mathieu Ferrari, Wen Chean Lim, Biao Ma
  • Patent number: 11479614
    Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.
    Type: Grant
    Filed: August 20, 2020
    Date of Patent: October 25, 2022
    Assignee: AUTOLUS LIMITED
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne, Shimobi Onuoha, Simon Thomas
  • Patent number: 11479613
    Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.
    Type: Grant
    Filed: August 20, 2020
    Date of Patent: October 25, 2022
    Assignee: AUTOLUS LIMITED
    Inventors: Martin Pulé, Shaun Cordoba, Matteo Righi, James Sillibourne, Shimobi Onuoha, Simon Thomas
  • Publication number: 20220332585
    Abstract: There is provided a method for manufacturing graphene, the method comprising: forming graphene on a non-metallic surface of a substrate by CVD in a CVD reaction chamber, wherein the step of forming graphene comprises introducing a precursor in a gas phase and/or suspended in a gas into the CVD reaction chamber; wherein the precursor consists of one or more compounds selected from a C4—C10 organic compound; wherein the organic compound is branched such that the organic compound has at least three methyl groups; and wherein the organic compound consists of carbon and hydrogen and, optionally, oxygen, fluorine, chlorine and/or bromine.
    Type: Application
    Filed: March 3, 2022
    Publication date: October 20, 2022
    Applicant: Paragraf Limited
    Inventors: Sebastian Dixon, James Griffiths, Ross Matthew Griffin, Ivor Guiney, Simon Thomas
  • Patent number: 11472708
    Abstract: A method for the production of a graphene layer structure having from 1 to 100 graphene layers, the method comprising providing a substrate having a thermal resistance equal to or greater than that of sapphire, on a heated susceptor in a reaction chamber, the chamber having a plurality of cooled inlets arranged so that, in use, the inlets are distributed across the substrate and have a constant separation from the substrate, supplying a flow comprising a precursor compound through the inlets and into the reaction chamber to thereby decompose the precursor compound and form graphene on the substrate, wherein the inlets are cooled to less than 100° C., preferably 50 to 60° C., and the susceptor is heated to a temperature of at least 50° C. in excess of a decomposition temperature of the precursor, using a laser to selectively ablate graphene from the substrate, wherein the laser has a wavelength in excess of 600 nm and a power of less than 50 Watts.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: October 18, 2022
    Assignee: Paragraf Limited
    Inventors: Simon Thomas, Ivor Guiney
  • Patent number: 11466070
    Abstract: The present invention provides a chimeric antigen receptor (CAR) system comprising; (i) a receptor component comprising a antigen binding domain and a first binding domain; and (ii) a signalling component comprising a signalling domain and a second binding domain which binds the single domain binder of the first binding domain of the receptor component wherein either the first or second binding domains comprise a single domain binder, and wherein, binding of the first and second binding domains is disrupted by the presence of an agent, such that in the absence of the agent, the receptor component and the signalling component heterodimerize and binding of the antigen binding domain to antigen results in signalling through the signalling domain; whereas in the presence of the agent, the receptor component and the signalling component do not heterodimerize and binding of the antigen binding domain to antigen does not result in signalling through the signalling domain.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: October 11, 2022
    Assignee: AUTOLUS LIMITED
    Inventors: Martin Pulé, Shaun Cordoba, Simon Thomas, Shimobi Onuoha, Maria Stavrou
  • Publication number: 20220289820
    Abstract: The present invention provides a chimeric cytokine receptor comprising a cytokine receptor endodomain which comprises a first chain and a second chain, wherein the first and/or second chain of the cytokine-receptor endodomain is/are truncated. The invention also provides cells comprising such a chimeric cytokine receptor, optionally in combination with a chimeric antigen receptor (CAR) and their use in the treatment of diseases such as cancer.
    Type: Application
    Filed: August 4, 2020
    Publication date: September 15, 2022
    Inventors: Martin Pulé, Shaun Cordoba, Simon Thomas, Shimobi Onouha, Matteo Righi
  • Patent number: 11440961
    Abstract: The present disclosure relates to anti-TRBC1 antigen binding domains characterized by the sequences of the variable chains. The CDRs sequences of the variable chains are: (VH CDR1) GYTFT, (VH CDR2) NPYNDDIQS, (VH CDR3) GAGY-NFDGAYRFFDF; and (VL CDR1) RSSQRLVHSNGNTYL, (VL CDR2) RVSNRFP, (VL CDR3) SQSTHVPYT. The claimed humanized antibodies derive from the murine JOVI antibody. Uses in cancer therapy.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: September 13, 2022
    Assignee: AUTOLUS LIMITED
    Inventors: Shaun Cordoba, Simon Thomas, Shimobi Onuoha, Ram Jha, Wen Chean Lim
  • Patent number: 11434293
    Abstract: The present disclosure relates to anti-TRBC1 antigen binding domains characterized by the sequences of the variable chains. The CDRs sequences of the variable chains are: (VH CDR1) GYTFT, (VH CDR2) NPYNDDIQS, (VH CDR3) GAGYNFDGAYRFFDF; and (VL CDR1) RSSQRLVHSNGNTYL, (VL CDR2) RVSNRFP, (VL CDR3) SQSTHVPYT. The claimed humanized antibodies derive from the murine JOVI antibody. Uses in cancer therapy.
    Type: Grant
    Filed: October 12, 2021
    Date of Patent: September 6, 2022
    Assignee: AUTOLUS LIMITED
    Inventors: Shaun Cordoba, Simon Thomas, Shimobi Onuoha, Ram Jha, Wen Chean Lim
  • Publication number: 20220273710
    Abstract: The present invention provides a chimeric antigen receptor (CAR) which specifically binds CD79. It further provides a nucleic acid sequence and a vector encoding said CAR. It further provides a cell which expresses said CAR at the cell surface.
    Type: Application
    Filed: May 15, 2019
    Publication date: September 1, 2022
    Inventors: Martin Pulé, Shaun Cordoba, Simon Thomas, Shimobi Onuoha, Mathieu Ferrari
  • Publication number: 20220267404
    Abstract: The present invention relates to a cell which comprises a chimeric antigen receptor (CAR) and a signal transduction modifying protein, selected from one of the following: (i) a truncated protein which comprises an SH2 domain from a protein which binds a phosphorylated immunoreceptor tyrosine-based activation motif (ITAM), but lacks a kinase domain; (ii) a truncated protein which comprises an SH2 domain from a protein which binds a phosphorylated immunoreceptor tyrosine-based inhibition motif (ITIM) but lacks a phosphatase domain; (iii) a fusion protein which comprises (a) an SH2 domain from a protein which binds a phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) or from a protein which binds a phosphorylated immunoreceptor tyrosine-based inhibition motif (ITIM); and (ii) a heterologous domain.
    Type: Application
    Filed: November 12, 2021
    Publication date: August 25, 2022
    Inventors: Martin Pulé, Shaun Cordoba, Simon Thomas, Khai Kong
  • Publication number: 20220258039
    Abstract: The disclosure relates to a method for controlling a graphic interface for displaying images of a digital representation of a launcher in a virtual environment Ev, the launcher comprising a launching arm equipped with a magnet. An array of magnetometers Mi measures the magnetic field generated by the magnet, a state vector of the launching arm in a virtual reference frame Rv is determined, and a phase of arming then firing a projectile in the virtual reference frame Rv are identified. An image is then constructed and displayed on the graphic interface.
    Type: Application
    Filed: July 16, 2020
    Publication date: August 18, 2022
    Inventors: Sophie Bonneau, Romain Chesney, Jean-Marie Dupré la Tour, Tristan Hautson, Ons Manchoul, Simon Thomas, Jean-Pierre Traveaux
  • Publication number: 20220257659
    Abstract: The present invention provides a chimeric antigen receptor (CAR) which binds a target antigen having a bulky extracellular domain, wherein the CAR comprises a Fab antigen binding domain. The present invention also provides nucleic acid sequences and constructs encoding such a CAR, cells expressing such a CAR and their therapeutic uses.
    Type: Application
    Filed: April 18, 2022
    Publication date: August 18, 2022
    Inventors: Martin Pulé, Evangelia Kokalaki, Shaun Cordoba, Shimobi Onuoha, Simon Thomas, Biao Ma, Mathieu Ferrari
  • Publication number: 20220261248
    Abstract: Methods of encoding and decoding are described which use a variable number of instruction words to encode instructions from an instruction set, such that different instructions within the instruction set may be encoded using different numbers of instruction words. To encode an instruction, the bits within the instruction are re-ordered and formed into instruction words based upon their variance as determined using empirical or simulation data. The bits in the instruction words are compared to corresponding predicted values and some or all of the instruction words that match the predicted values are omitted from the encoded instruction.
    Type: Application
    Filed: May 5, 2022
    Publication date: August 18, 2022
    Inventors: Simon Thomas Nield, James McCarthy
  • Publication number: 20220242965
    Abstract: The present invention provides a cell which expresses a chimeric antigen receptor (CAR) or engineered T-cell receptor (TCR) and secretes an agent which blocks or reduces the activity of an ectoenzyme. The cells may be used in adoptive immunotherapy approaches for the treatment of diseases such as cancer.
    Type: Application
    Filed: May 1, 2020
    Publication date: August 4, 2022
    Inventors: Martin Pulé, Shaun Cordoba, Simon Thomas, Shimobi Onuoha, Reyisa Bughda, Mathieu Ferrari, Zulaikha Akbar
  • Publication number: 20220211830
    Abstract: The present invention provides a cell which comprises; (i) a chimeric antigen receptor (CAR) or a transgenic T-cell receptor (TCR); and (ii) at least one polypeptide capable of co-localizing an MHC class I polypeptide or an MHC class II polypeptide with an intracellular signalling domain within the cell.
    Type: Application
    Filed: April 7, 2020
    Publication date: July 7, 2022
    Inventors: Martin Pulé, Shaun Cordoba, Simon Thomas, Shimobi Onuoha, James Sillibourne, Farhaan Parekh
  • Publication number: 20220178872
    Abstract: The present invention relates to a method of forming a material on a graphene layer structure 5 for injecting charge into, or extracting charge out of, the graphene layer structure 5, the method comprising: providing a graphene layer structure 5 having one or more first portions 25 on a non-metallic substrate 10, said one or more first portions 25 having one or more surface defects comprising excess out-of-plane material 15; plasma etching the one or more first portions 25 of the graphene layer structure 5 to remove the out-of-plane material 15; depositing a material 30 for injecting charge into, or extracting charge out of, the graphene layer structure 5 onto the one or more plasma-etched first portions 25.
    Type: Application
    Filed: November 23, 2021
    Publication date: June 9, 2022
    Applicant: PARAGRAF LIMITED
    Inventors: Lok Yi Lee, Hugh Glass, Simon Thomas, Ivor Guiney
  • Patent number: 11345734
    Abstract: The present invention relates to a cell which comprises a chimeric antigen receptor (CAR) and a signal transduction modifying protein, selected from one of the following: (i) a truncated protein which comprises an SH2 domain from a protein which binds a phosphorylated immunoreceptor tyrosine-based activation motif (ITAM), but lacks a kinase domain; (ii) a truncated protein which comprises an SH2 domain from a protein which binds a phosphorylated immunoreceptor tyrosine-based inhibition motif (ITIM) but lacks a phosphatase domain; (iii) a fusion protein which comprises (a) an SH2 domain from a protein which binds a phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) or from a protein which binds a phosphorylated immunoreceptor tyrosine-based inhibition motif (ITIM); and (ii) a heterologous domain.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: May 31, 2022
    Assignee: AUTOLUS LIMITED
    Inventors: Martin Pulé, Shaun Cordoba, Simon Thomas, Khai Kong
  • Patent number: 11347509
    Abstract: Methods of encoding and decoding are described which use a variable number of instruction words to encode instructions from an instruction set, such that different instructions within the instruction set may be encoded using different numbers of instruction words. To encode an instruction, the bits within the instruction are reordered and formed into instruction words based upon their variance as determined using empirical or simulation data. The bits in the instruction words are compared to corresponding predicted values and some or all of the instruction words that match the predicted values are omitted from the encoded instruction.
    Type: Grant
    Filed: February 12, 2020
    Date of Patent: May 31, 2022
    Assignee: Imagination Technologies Limited
    Inventors: Simon Thomas Nield, James McCarthy