Abstract: The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.

Abstract: A drive for a leaf of a door, window, or the like, comprising at least one mechanical energy store, which is charged by an opening movement of the leaf and discharged by a closing movement of the leaf, at least one electric motor, which is operatively connected to the leaf via at least one motor shaft and can be operated as a generator in order to dampen the leaf movements, and a control and/or regulator electronics unit for controlling the electric motor. The control and/or regulator electronics unit comprises means via which the drive behaviour can be variably specified repeatedly by a respective user and/or via which the drive behaviour can be variably adjusted repeatedly in accordance with the behaviour of a respective user.

Abstract: The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.

Abstract: The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor, a chemokine and a cell-surface antigen; and (ii) a cytokine receptor endodomain.

Abstract: A drive unit for closing a leaf of a door or a window comprises an energy accumulator for providing a closing force for closing the leaf, a damping device which counteracts the closing force and has an electric motor which can be operated as a generator and can be coupled to an actuating element of the drive unit, and a control device for controlling the electric motor. The control device is designed to determine a nominal path curve which indicates a position of the leaf or a closing speed of the leaf in dependence upon time, and to perform the control of the electric motor in order to damp the closing movement of the leaf on the basis of the established target path curve.

Abstract: Methods of encoding and decoding are described which use a variable number of instruction words to encode instructions from an instruction set, such that different instructions within the instruction set may be encoded using different numbers of instruction words. To encode an instruction, the bits within the instruction are re-ordered and formed into instruction words based upon their variance as determined using empirical or simulation data. The bits in the instruction words are compared to corresponding predicted values and some or all of the instruction words that match the predicted values are omitted from the encoded instruction.

Abstract: A liner for use with a cable spacer clamp arm is provided. The liner includes a first portion formed in an arcuate configuration and made from a first elastomeric material. A second portion is formed in the arcuate configuration and is receivable within the first portion. The second portion is made from a second elastomeric material different from the first elastomeric material. The first portion attaches to the second portion.

Abstract: The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.

Abstract: The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.

Abstract: The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.

Abstract: A liner for use with a cable spacer clamp arm is provided. The liner includes a first portion formed in an arcuate configuration and made from a first elastomeric material. A second portion is formed in the arcuate configuration and is receivable within the first portion. The second portion is made from a second elastomeric material different from the first elastomeric material. The first portion attaches to the second portion.

Abstract: A flood barrier unit having a base and at least one side wall is provided. The walls of the unit are tapered such that it is capable of being stacked vertically with other such units when not in use. The unit preferably includes at least one connection slot on each wall, wherein each connection slot is adapted to sealingly accept a connection piece. A plurality of such units may be connected together to form a watertight flood barrier, where adjacent units are adapted to be connected together in a watertight manner using one connection piece. Additional connection pieces suitable for sealingly engaging a vertical structure such as the wall of a building are also provided.

Abstract: An electrical assembly is disclosed in which two flexible printed circuits are electrically joined. This allows greater lengths of flexible printed circuits to be provided, for example for gas turbine engine harnesses. Each flexible printed circuit has a terminating region having electrically conductive through holes that are connected to respective electrical tracks of the flexible printed circuit. The terminating regions are adjacent each other in the electrical assembly, and an electrically conductive pin is passed through the aligned through holes, then permanently bonded in position, for example by welding. This results in a robust, reliable connection of two flexible printed circuits.

Abstract: Provision of a chimeric antigen receptor (CAR) comprising a disialoganglioside (GD2)-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: b) a light chain variable region (VL) having CDRs with the following sequences: T cells expressing such a CAR are useful in the treatment of some cancers.

Abstract: An intake manifold with a single and dual plane adapter is provided. The intake manifold includes a plenum chamber. The plenum chamber may include a first side, a second side, a bottom portion, and a top portion. The adapter may include a guide rail attached to the plenum chamber and forming a channel in between. A divider is formed to fit within the channel. An actuator is operatively connected to extend and retract the divider within the channel. Therefore, the divider includes an extended position forming a dual chamber within the plenum chamber, and a retracted position forming a single chamber within the plenum chamber.

Abstract: The present invention relates to a method for producing a cell line expressing a stabilized functional single chain-antigen-recognizing genetic construct (scARC), comprising a genetic construct of the human scARC to be expressed, comprising the domains huV1/2—Li-huV2/1—C4/3 and a genetic construct comprising the corresponding hetero-/(homo-)dimeric domain C3/4, containing xenogenic, in its special case murine amino acid exchanges in the domains C4/3 and C3/4, wherein co-expression of the genetic constructs of the scARC-fragments occurs through the cell. Preferably, the scARCs are single chain-TCRs (scTCRs) or antibody-scFv-fragments, which further preferably recognize tumor associated peptide antigens (TAA). The present invention further relates to a gp100-protein-specific T-cell response mediated ?/? T-cell receptor rationally mutated by means of the method of the present invention and its uses.

Abstract: An intake manifold with a single and dual plane adapter is provided. The intake manifold includes a plenum chamber. The plenum chamber may include a first side, a second side, a bottom portion, and a top portion. The adapter may include a guide rail attached to the plenum chamber and forming a channel in between. A divider is formed to fit within the channel. An actuator is operatively connected to extend and retract the divider within the channel. Therefore, the divider includes an extended position forming a dual chamber within the plenum chamber, and a retracted position forming a single chamber within the plenum chamber.