Patents by Inventor Sivakumaran Meenakshisunderam

Sivakumaran Meenakshisunderam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing an optically active proton pump inhibitor
    Patent number: 8492551
    Abstract: An improved process for the preparation of (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole of Formula I, (I) with high enantiomeric excess from racemic mixture.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: July 23, 2013
    Assignee: Aurobindo Pharma. Ltd.
    Inventors: Shankar Reddy Budidet, Brajesh Kumar Sinha, Somappa Somannavar Yallappa, Senthil Kumar Natarajan, Ramesh Dandala, Sivakumaran Meenakshisunderam
  • PROCESS FOR THE PREPARATION OF VALSARTAN
    Publication number: 20130144067
    Abstract: The present invention relates to a process for the preparation of pure Valsartan (I) substantially free from impurities of formulae (Ia), (Ib), and (Ic), which comprises: (i) condensing 2-(4?-bromomethylphenyl)benzonitrile of formula (II) with L-valine methyl ester hydrochloride of formula (V) in the presence of a base in a solvent to produce N-[(2?-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester of formula (VI); (ii) treating the compound VI of step (i) with acid followed by treating with base to produce pure compound VI substantially free from dimeric impurity of formula (Via); (iii) reacting the pure compound of formula (VI) with n-valeryl chloride in the presence of a base to produce pure N-valeryl-N-[(2?-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester (VII) substantially free from alkene impurity of formula (Vila); (iv) reacting the compound of formula (VII) with trialkyltin chloride and a metal azide in a solvent at a reflux temperature to produce N-(1-oxopentyl)-N-[[2?-(2-tributyltinte-trazol-5-y
    Type: Application
    Filed: June 24, 2011
    Publication date: June 6, 2013
    Inventors: Raveendra Reddy Chinta, Gangadhara Bhima Shankar Nangi, Mahendar Reddy Nayini, Somappa Somannavar Yallapa, Shankar Reddy Budidet, Islam Aminul, Sivakumaran Meenakshisunderam
  • PROCESS FOR THE PREPARATION OF LACOSAMIDE
    Publication number: 20130123537
    Abstract: The present invention relates to an improved process for the preparation of Lacosamide of Formula (I), comprising: O-methylating a compound of Formula (V) or a compound of Formula (XX) or a compound of Formula XXII; in the presence of a methylating agent and a base to produce Lacosamide of Formula (I).
    Type: Application
    Filed: May 16, 2011
    Publication date: May 16, 2013
    Inventors: K a s s Narayan Garimella, Subba Reddy Danda, Shankar Reddy Budidet, Srinivasachary Katuroju, Gowrisankar Rao Kaki, Srinivasa Rao Yatcherla, Islam Aminul, Sivakumaran Meenakshisunderam
  • NOVEL PROCESS FOR THE PREPARATION OF SOLIFENACIN SUCCINATE
    Publication number: 20130123502
    Abstract: The present invention relates to a process for the preparation of Solifenacin succinate by condensing a compound of formula (IVb) with (RS)-3-quinuclidinol, wherein, R represents methyl, ethyl, isopropyl; to produce a diastereomeric mixture of (1S)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylic acid (3RS)-1-azabicyclo[2.2.2]oct-3-yl ester, which is treated with succinic acid in a solvent or mixture of solvents to produce optically pure Solifenacin succinate, Formula (X).
    Type: Application
    Filed: June 20, 2011
    Publication date: May 16, 2013
    Inventors: Anand Gopalkrishna Kamat, Joseph Prabahar Koilpillai, Naga Trinadhachari Ganala, Venkata Lakshmi Upputuri, Venkata Balalji Boddu, Sivakumaran Meenakshisunderam
  • Solid Dosage Forms of Antipsychotics
    Publication number: 20130108701
    Abstract: The present invention relates to a solid dosage form comprising an antipsychotic, particularly ziprasidone. The present invention also relates to a process for preparation of solid dosage form comprising ziprasidone.
    Type: Application
    Filed: May 23, 2011
    Publication date: May 2, 2013
    Inventors: Krishna Murthy Bhavanasi, Nagaprasad Vishnubhotla, Sivakumaran Meenakshisunderam
  • Process for preparing pyrimidine propenaldehyde
    Patent number: 8394956
    Abstract: The present invention relates to an improved process for preparing (2E)-3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-propenal of formula (I), which is an useful intermediate in the preparation of Rosuvastatin.
    Type: Grant
    Filed: September 23, 2009
    Date of Patent: March 12, 2013
    Assignee: Aurobindo Pharma Ltd.
    Inventors: Sambhu Prasad Sarma Mallela, Sukumar Nandi, Gangadhara Bhima Shankar Nangi, Rani Ananta, Sivakumaran Meenakshisunderam
  • Process for preparing rosuvastatin calcium
    Patent number: 8318933
    Abstract: The present invention relates to an improved process for preparing Rosuvastatin calcium of Formula I.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: November 27, 2012
    Assignee: Aurobindo Pharma Ltd
    Inventors: Sambhu Prasad Sarma Mallela, Narayan K. A. S. S. Garimella, Sukumar Nandi, Sunil Kumar Buridipad, Gangadhar Bhima Shankar Nangi, Ramesh Dandala, Sivakumaran Meenakshisunderam
  • Process for preparing tamsulosin hydrochloride
    Patent number: 8273918
    Abstract: The invention relates to an process for preparing Tamsulosin hydrochloride of Formula (I) which comprises (i) reacting (R)-(?)-5-(2-amino-propyl)-2-methoxybenzenesulfonamide of Formula (II) with substituted phenoxy compound of Formula (III), wherein Z represents a removing group, such as —OSO2CH3, —OSO2C6H4CH3, —F, —Br, —Cl, or —I, in a solvent in the presence of an alkaline earth metal oxide to obtain Tamsulosin base and (ii) converting Tamsulosin base into hydrochloride salt in a solvent by addition of aqueous hydrochloric acid.
    Type: Grant
    Filed: August 10, 2006
    Date of Patent: September 25, 2012
    Assignee: Avrobindo Pharma Ltd.
    Inventors: Anand Gopalkrishna Kamat, Narsimha Reddy Penthala, Sivakumaran Meenakshisunderam
  • Process for the preparation of substantially pure (2S,3S,5S)-5-amino-2-N,N-dibenzylamino-3-hydroxy-1,6-diphenylhexane
    Patent number: 8236991
    Abstract: The present invention relates to the purification of (2S,3S,5S)-5-amino-2-N,N-dibenzylamino-3-hydroxy-1,6-diphenylhexane (III) by making its crystalline acid addition salt, which can be used as such to produce Lopinavir/Ritonavir with high purity and yield.
    Type: Grant
    Filed: June 5, 2008
    Date of Patent: August 7, 2012
    Assignee: Aurobindo Pharma Ltd.
    Inventors: V Raghava Reddy Ambati, Srinivas Garaga, Ramesh Dandala, Sivakumaran Meenakshisunderam
  • Extended release formulation of an antiepileptic agent
    Publication number: 20120178810
    Abstract: The present invention relates to an extended release formulation of an antiepileptic agent. More particularly, the present invention relates to an extended release formulation of divalproex sodium. The present invention also relates to a process for the preparation of extended release formulation of divalproex sodium.
    Type: Application
    Filed: September 10, 2007
    Publication date: July 12, 2012
    Inventors: Tailor Prakash Boya, Haranatha Babu Balanagu, Shailesh Suresh Bhamare, Kishor Dattatray Deo, Sivakumaran Meenakshisunderam
  • Process for preparing rosuvastatin calcium
    Patent number: 8212034
    Abstract: The present invention relates to an improved process for preparing (2E)-3-[4-(4-fluorophenyl)-6-iso-propyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-propenal of Formula I which is an intermediate useful in the preparation of bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoicacid]calcium salt of Formula II.
    Type: Grant
    Filed: December 11, 2007
    Date of Patent: July 3, 2012
    Assignee: Aurobindo Pharma Ltd.
    Inventors: Ramesh Dandala, Sambhu Prasad Sarma Mallela, Sukumar Nandi, Gangadhar Bhima Shankar Nangi, Sunil Kumar Buridipadu, Sivakumaran Meenakshisunderam
  • Process for preparation of rosuvastatin calcium field of the invention
    Patent number: 8212035
    Abstract: The present invention relates to an improved process for preparing (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid calcium of Formula (I).
    Type: Grant
    Filed: February 4, 2008
    Date of Patent: July 3, 2012
    Assignee: Aurobindo Pharma Ltd.
    Inventors: Ramesh Dandala, Sambhu Prasad Sarma Mallela, Sukumar Nandi, Gangadhar Bhima Shankar Nandi, Sunil Kumar Buridipadu, Sivakumaran Meenakshisunderam
  • Process for preparing nevirapine
    Patent number: 8212025
    Abstract: An improved process for preparing 11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2?,3?-e][1,4]diazepin-6-one of Formula (I).
    Type: Grant
    Filed: May 14, 2008
    Date of Patent: July 3, 2012
    Assignee: Aurobindo Pharma Ltd.
    Inventors: Jagan Mohan Reddy Sanapureddy, Ramesh Dandala, Sivakumaran Meenakshisunderam
  • PROCESS FOR THE PREPARATION OF DUTASTERIDE
    Publication number: 20120157683
    Abstract: The present invention provides an improved process for the preparation of Dutasteride (I) which comprises: (i) reacting 4-aza-5?-androst-1-en-3-one-17?-carboxylic acid (VII), Formula VII with sulfonic acid anhydride (RSO2)2O in presence of base to produce an intermediate compound of Formula (XIII), wherein R represents C1-6 alkyl, C1-6 halo alkyl, C6-10 aryl, halo aryl; (ii) condensing compound of Formula (XIII) with 2,5-bis(trifluoromethyl)aniline (III), Formula (III) in the presence or absence of a base to produce Dutasteride (I).
    Type: Application
    Filed: July 7, 2010
    Publication date: June 21, 2012
    Inventors: Sambhu Prasad Sarma Mallela, Sukumar Nandi, Balanarasimha Reddy Gona, Naresh Akkina, Rami Ananta, Islam Aminul, Sivakumaran Meenakshisunderam
  • PROCESS FOR THE MANUFACTURE OF ROSUVASTATIN CALCIUM USING CRYSTALLINE ROSUVASTATIN ETHYL ESTER
    Publication number: 20120149905
    Abstract: The present invention relates to an improved process to prepare Rosuvastatin calcium of Formula (I), with good quality. Further, the present invention also relates to a crystalline polymorphic form of Rosuvastatin ethyl ester.
    Type: Application
    Filed: August 17, 2009
    Publication date: June 14, 2012
    Inventors: Sambhu Prasad Sarma Mallela, Sukumar Nandi, Gangadhara Bhima Shankar Nangi, Ramesh Dandala, Sivakumaran Meenakshisunderam
  • Process for preparing olanzapine form I
    Patent number: 8106188
    Abstract: An improved for preparing Olanzapine Form I of Formula 1 in the presence of one solvent or a mixture of solvents.
    Type: Grant
    Filed: June 1, 2006
    Date of Patent: January 31, 2012
    Assignee: Aurobindo Pharma Ltd
    Inventors: Uttam Kumar Ray, Sreenivasa Rao Pathuri, Sivakumaran Meenakshisunderam
  • Process for the preparation of Irbesartan
    Patent number: 8106216
    Abstract: The present invention relates to an improved process for the preparation of 2-n-butyl-3-[[2?-(1H-tetrazol-5-yl)[1,1?-biphenyl]-4-yl]-1,3-diazaspiro[4.4]non-1-en-4-one (Irbesartan).
    Type: Grant
    Filed: April 23, 2007
    Date of Patent: January 31, 2012
    Assignee: Aurobindo Pharma Ltd.
    Inventors: Venkata vara prasada rao Korrapati, Venkata subramanyeswara rao Inti, Rani Ananta, Ramesh Dandala, Sivakumaran Meenakshisunderam
  • Solid dosage forms of fenofibrate
    Publication number: 20110311625
    Abstract: An improved solid dosage form of fenofibrate which exhibits improved dissolution properties leading to increased bioavailability of fenofibrate. A novel core-shell approach to the composition is provided as well as a process for the preparation of the improved solid dosage forms.
    Type: Application
    Filed: June 13, 2011
    Publication date: December 22, 2011
    Inventors: Amruth Gowda Doddaveerappa, Rajesh Jagannath Kasunde, Nagaprasad Vishnubhotla, Sivakumaran Meenakshisunderam
  • PROCESS FOR PREPARATION OF CIS-NUCLEOSIDE DERIVATIVE
    Publication number: 20110282046
    Abstract: The present invention relates to a novel and stereoselective synthetic process for the preparation of optically active cis-nucleoside derivatives of compound of Formula (I), wherein R3 represents H, F, Cl, C1-16 alkyl.
    Type: Application
    Filed: January 15, 2010
    Publication date: November 17, 2011
    Inventors: Rama Shankar, Ravinder Raddy Vennapureddy, Asif Parvez Sayyed, Murali Krishna Ankaraju, Suri Babu Madasu, Janardhan Rao Vascuri, Sivakumaran Meenakshisunderam
  • STABLE DOSAGE FORMS OF ANTIHYPERTENSIVE AGENTS
    Publication number: 20110206761
    Abstract: The technical field of the present invention relates to stable solid dosage form comprising combination of antihypertensive agents. More particularly, the present invention relates to stable solid dosage form comprising combination of angiotensin converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB) and calcium channel blocker (CCB).
    Type: Application
    Filed: September 2, 2009
    Publication date: August 25, 2011
    Inventors: Nishant Babanrao Naware, Shailesh Suresh Bhamare, Prem Kumar Gidigam, Kishor Dattatray Deo, Sivakumaran Meenakshisunderam