Patents by Inventor Siyuan Wang
Siyuan Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240158840Abstract: Provided herein are methods for decoding nucleic acid barcodes in situ by using rolling circle amplification and labeled probes. Also provided herein are methods of performing an in situ genetic screen, using the nucleic acid barcode decoding techniques described herein.Type: ApplicationFiled: March 16, 2022Publication date: May 16, 2024Applicant: YALE UNIVERSITYInventors: Siyuan WANG, Bing YANG, Mengwei HU
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Patent number: 11959075Abstract: The present invention generally relates to systems and methods for imaging or determining nucleic acids, for instance, within cells. In some embodiments, the transcriptome of a cell may be determined. Certain embodiments are directed to determining nucleic acids, such as mRNA, within cells at relatively high resolutions. In some embodiments, a plurality of nucleic acid probes may be applied to a sample, and their binding within the sample determined, e.g., using fluorescence, to determine locations of the nucleic acid probes within the sample. In some embodiments, codewords may be based on the binding of the plurality of nucleic acid probes, and in some cases, the codewords may define an error-correcting code to reduce or prevent misidentification of the nucleic acids. In certain cases, a relatively large number of different targets may be identified using a relatively small number of labels, e.g., by using various combinatorial approaches.Type: GrantFiled: March 16, 2023Date of Patent: April 16, 2024Assignee: President and Fellows of Harvard CollegeInventors: Xiaowei Zhuang, Kok-Hao Chen, Alistair Boettiger, Jeffrey R. Moffitt, Siyuan Wang
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Publication number: 20240087231Abstract: The disclosure provides a method, an apparatus and a computer device for three-dimensional reconstruction of an indoor structure based on a two-dimensional video, wherein the method comprises: generating a color point cloud of three-dimensional structure of a house by using the video data of the house; regularizing the color point cloud of the house; extracting a plan of the house based on the color point cloud of the house; and constructing a three-dimensional model of the house in real life. The disclosure realizes autonomous and rapid construction of a three-dimensional model of a house by the general public, and realizes a low-cost, efficient and convenient three-dimensional visual digital representation of the house.Type: ApplicationFiled: August 21, 2023Publication date: March 14, 2024Applicant: WUHAN UNIVERSITYInventors: Jiangping CHEN, Siyuan WANG, Pengcheng ZHAO, Bin ZHANG, Bohua WANG
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Publication number: 20230323339Abstract: The present invention generally relates to systems and methods for imaging or determining nucleic acids, for instance, within cells. In some embodiments, the transcriptome of a cell may be determined. Certain embodiments are directed to determining nucleic acids, such as mRNA, within cells at relatively high resolutions. In some embodiments, a plurality of nucleic acid probes may be applied to a sample, and their binding within the sample determined, e.g., using fluorescence, to determine locations of the nucleic acid probes within the sample. In some embodiments, codewords may be based on the binding of the plurality of nucleic acid probes, and in some cases, the codewords may define an error-correcting code to reduce or prevent misidentification of the nucleic acids. In certain cases, a relatively large number of different targets may be identified using a relatively small number of labels, e.g., by using various combinatorial approaches.Type: ApplicationFiled: March 16, 2023Publication date: October 12, 2023Applicant: President and Fellows of Harvard CollegeInventors: Xiaowei Zhuang, Kok-Hao Chen, Alistair Boettiger, Jeffrey R. Moffitt, Siyuan Wang
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Publication number: 20230323338Abstract: The present invention generally relates to systems and methods for imaging or determining nucleic acids, for instance, within cells. In some embodiments, the transcriptome of a cell may be determined. Certain embodiments are directed to determining nucleic acids, such as mRNA, within cells at relatively high resolutions. In some embodiments, a plurality of nucleic acid probes may be applied to a sample, and their binding within the sample determined, e.g., using fluorescence, to determine locations of the nucleic acid probes within the sample. In some embodiments, codewords may be based on the binding of the plurality of nucleic acid probes, and in some cases, the codewords may define an error-correcting code to reduce or prevent misidentification of the nucleic acids. In certain cases, a relatively large number of different targets may be identified using a relatively small number of labels, e.g., by using various combinatorial approaches.Type: ApplicationFiled: March 16, 2023Publication date: October 12, 2023Applicant: President and Fellows of Harvard CollegeInventors: Xiaowei Zhuang, Kok-Hao Chen, Alistair Boettiger, Jeffrey R. Moffitt, Siyuan Wang
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Publication number: 20230279383Abstract: The present invention generally relates to systems and methods for imaging or determining nucleic acids, for instance, within cells. In some embodiments, the transcriptome of a cell may be determined. Certain embodiments are directed to determining nucleic acids, such as mRNA, within cells at relatively high resolutions. In some embodiments, a plurality of nucleic acid probes may be applied to a sample, and their binding within the sample determined, e.g., using fluorescence, to determine locations of the nucleic acid probes within the sample. In some embodiments, codewords may be based on the binding of the plurality of nucleic acid probes, and in some cases, the codewords may define an error-correcting code to reduce or prevent misidentification of the nucleic acids. In certain cases, a relatively large number of different targets may be identified using a relatively small number of labels, e.g., by using various combinatorial approaches.Type: ApplicationFiled: October 13, 2022Publication date: September 7, 2023Applicant: President and Fellows of Harvard CollegeInventors: Xiaowei Zhuang, Kok-Hao Chen, Alistair Boettiger, Jeffrey R. Moffitt, Siyuan Wang
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Publication number: 20230279387Abstract: The present invention generally relates to systems and methods for imaging or determining nucleic acids, for instance, within cells. In some embodiments, the transcriptome of a cell may be determined. Certain embodiments are directed to determining nucleic acids, such as mRNA, within cells at relatively high resolutions. In some embodiments, a plurality of nucleic acid probes may be applied to a sample, and their binding within the sample determined, e.g., using fluorescence, to determine locations of the nucleic acid probes within the sample. In some embodiments, codewords may be based on the binding of the plurality of nucleic acid probes, and in some cases, the codewords may define an error-correcting code to reduce or prevent misidentification of the nucleic acids. In certain cases, a relatively large number of different targets may be identified using a relatively small number of labels, e.g., by using various combinatorial approaches.Type: ApplicationFiled: April 7, 2023Publication date: September 7, 2023Applicant: President and Fellows of Harvard CollegeInventors: Xiaowei Zhuang, Kok-Hao Chen, Alistair Boettiger, Jeffrey R. Moffitt, Siyuan Wang
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Publication number: 20230195850Abstract: A method for predicting matching degree between a resume and a post, and a related device are provided in this disclosure. In the method for predicting the matching degree between the resume and the post, and the related device according to this disclosure, firstly the semi-structured keys and values in post information and resume information and their source are obtained. Then, the matching degree between the resume information and the post information is predicted by a prediction model including a cascaded pre-trained language model, a Transformer encoder and a single label classification model, based on the keys and values of a respective post information and resume information attribute, and corresponding source representations. Thus, by comprehensively searching internal interaction and external interaction of semi-structured multivariate attributes in person-post matching, the matching result is more accurate.Type: ApplicationFiled: December 16, 2022Publication date: June 22, 2023Inventors: Honghui CHEN, Taihua SHAO, Chengyu SONG, Miao JIANG, Mengru WANG, Xin ZHANG, Fei CAI, Dengfeng LIU, Siyuan WANG
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Publication number: 20230176545Abstract: A device for digitally controlling a system, operating by discrete time steps, based on an error vector received at each time step, which includes: an estimator determining a homogenous canonical norm value range for a current time step, an error vector of a current time step, an expansion generator matrix, a Lyapunov matrix, lower and upper limits; and a computer that returns a control for the current time step based on the sum between the error vector of the current time step multiplied by a factor of a feedback gain matrix, the homogenous canonical norm value range for a current time step, proportional and derivative coefficients and the expansion generator matrix, and the integral between the first time step and the current time step of a product associating an integral coefficient, the expansion generator matrix, the homogenous canonical norm value range for all the time steps and the error vector.Type: ApplicationFiled: May 11, 2021Publication date: June 8, 2023Inventors: Siyuan Wang, Andrey Polyakov, Gang Zheng
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Publication number: 20230154548Abstract: A method for operating a three-dimensional (3D) memory device includes performing a first read operation for sensing a first memory cell of a first transistor string, and performing a subsequent second read operation for sensing a second memory cell of a second transistor string. Performing the first read operation includes applying a first bit line voltage to a first bit line, and maintaining the first bit line basically undischarged after data state of the first memory cell is detected.Type: ApplicationFiled: January 19, 2023Publication date: May 18, 2023Applicant: Yangtze Memory Technologies Co., Ltd.Inventors: Siyuan WANG, Jin Yong OH, Yu WANG, Ye TIAN, Zhichao DU, Xiaojiang GUO
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Patent number: 11594284Abstract: A method for operating a three-dimensional (3D) memory device includes performing a first read operation for sensing a first memory cell of a first transistor string, and performing a subsequent second read operation for sensing a second memory cell of a second transistor string. Performing the first read operation includes applying a first bit line voltage to a first bit line, and maintaining the first bit line basically undischarged after data state of the first memory cell is detected.Type: GrantFiled: March 25, 2021Date of Patent: February 28, 2023Assignee: YANGTZE MEMORY TECHNOLOGIES CO., LTD.Inventors: Siyuan Wang, Jin Yong Oh, Yu Wang, Ye Tian, Zhichao Du, Xiaojiang Guo
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Publication number: 20220254417Abstract: A method for operating a three-dimensional (3D) memory device includes performing a first read operation for sensing a first memory cell of a first transistor string, and performing a subsequent second read operation for sensing a second memory cell of a second transistor string. Performing the first read operation includes applying a first bit line voltage to a first bit line, and maintaining the first bit line basically undischarged after data state of the first memory cell is detected.Type: ApplicationFiled: March 25, 2021Publication date: August 11, 2022Inventors: Siyuan WANG, Jin Yong OH, Yu WANG, Ye TIAN, Zhichao DU, Xiaojiang GUO
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Publication number: 20220173593Abstract: A method of assessing dynamic flexibility for a virtual power plant, which belongs to the technical field of operating and controlling a power system. The method equals a virtual power plant to an equivalent energy storage device and an equivalent generator and decouples a network constraint condition between the two types of devices through a Robust optimization method. Subsequently, by using a two-stage Robust optimization algorithm, parameters of the equivalent energy storage device and the equivalent generator are calculated and finally accurate depiction is realized on adjusting ability of a distributed resource, so as to provide a scientific decision basis for the virtual power plant to participate in grid control, such that it has a great value in an actual application.Type: ApplicationFiled: September 1, 2021Publication date: June 2, 2022Inventors: Wenchuan WU, Siyuan WANG, Hongbin SUN, Bin WANG, Qinglai GUO
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Patent number: 11325210Abstract: A micro/nanoparticle-reinforced composite solder for low-temperature soldering and a preparation method thereof belong to the manufacturing field of lead-free low-temperature soldering solders. Micro/nanoparticle-reinforced tin-based alloy solder powder is formed by diffusely mixing micro/nano-sized Cu, Ag and Sb particles with a molten metal tin and atomizing the mixture, and then blended with low-melting-point SnBi-based alloy solder powder and a conventional flux to prepare a micro/nanoparticle-reinforced composite solder. In soldering at a temperature below 200° C.Type: GrantFiled: December 7, 2017Date of Patent: May 10, 2022Assignee: Shenzhen Fitech Co., Ltd.Inventors: Pu Xu, Siyuan Wang, Daoke Yu, Kui Chen, Jianhao Shi
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Publication number: 20220025442Abstract: The present invention generally relates to systems and methods for imaging or determining nucleic acids, for instance, within cells. In some embodiments, the transcriptome of a cell may be determined. Certain embodiments are directed to determining nucleic acids, such as mRNA, within cells at relatively high resolutions. In some embodiments, a plurality of nucleic acid probes may be applied to a sample, and their binding within the sample determined, e.g., using fluorescence, to determine locations of the nucleic acid probes within the sample. In some embodiments, codewords may be based on the binding of the plurality of nucleic acid probes, and in some cases, the codewords may define an error-correcting code to reduce or prevent misidentification of the nucleic acids. In certain cases, a relatively large number of different targets may be identified using a relatively small number of labels, e.g., by using various combinatorial approaches.Type: ApplicationFiled: July 13, 2021Publication date: January 27, 2022Applicant: President and Fellows of Harvard CollegeInventors: Xiaowei Zhuang, Kok-Hao Chen, Alistair Boettiger, Jeffrey R. Moffitt, Siyuan Wang
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Patent number: 11210624Abstract: Generally described, one or more aspects of the present application correspond to machine learning techniques for generating predictions about how much of an item will sell to certain destination regions at certain shipping speeds. A machine learning model, such as a neural network, can be trained to make such predictions based on historical data. The predictions can be presented in a user interface that enables sellers to evaluate the predicted sales and opt in to supporting particular shipping speeds to particular destinations, for example enabling the sellers to create offers for the items with terms corresponding to desired shipping speeds and destinations.Type: GrantFiled: September 18, 2018Date of Patent: December 28, 2021Assignee: Amazon Technologies, Inc.Inventors: Siyuan Wang, Nikhil Bhardwaj, Tanvir Talukder
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Patent number: 11098303Abstract: The present invention generally relates to systems and methods for imaging or determining nucleic acids, for instance, within cells. In some embodiments, the transcriptome of a cell may be determined. Certain embodiments are directed to determining nucleic acids, such as mRNA, within cells at relatively high resolutions. In some embodiments, a plurality of nucleic acid probes may be applied to a sample, and their binding within the sample determined, e.g., using fluorescence, to determine locations of the nucleic acid probes within the sample. In some embodiments, codewords may be based on the binding of the plurality of nucleic acid probes, and in some cases, the codewords may define an error-correcting code to reduce or prevent misidentification of the nucleic acids. In certain cases, a relatively large number of different targets may be identified using a relatively small number of labels, e.g., by using various combinatorial approaches.Type: GrantFiled: July 29, 2015Date of Patent: August 24, 2021Assignee: President and Fellows of Harvard CollegeInventors: Xiaowei Zhuang, Kok-Hao Chen, Alistair Boettiger, Jeffrey R. Moffitt, Siyuan Wang
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Publication number: 20200272013Abstract: Provided are an electrochromic device based on three-dimensional motion of lithium ions and an application thereof. The electrochromic device based on three-dimensional motion of lithium ions comprises an upper and an lower transparent electrode layer, and an electrolyte layer and a discoloration layer which are arranged between the upper transparent electrode layer and the lower transparent electrode layer. A first external circuit is connected between the upper transparent electrode layer and the lower transparent electrode layer; and a second external circuit is connected between two ends of the transparent electrode layer adjacent to the discoloration layer. The electrochromic device realizes intelligent dimming based on three-dimensional motion of lithium ions.Type: ApplicationFiled: March 2, 2018Publication date: August 27, 2020Inventors: Xiufeng TANG, Jianyi LUO, Siyuan WANG, Jingcheng HUANG, Guoxin CHEN, Zhaopeng MO, Guoxiang ZHENG
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Patent number: 10671403Abstract: A method for identifying a hardware device in an operating system and a computer apparatus are provided. The method includes determining a unique index identifier of a hardware device, and establishing a mapping relationship between the unique index identifier and a device number of the hardware device. The method also includes obtaining the unique index identifier of the hardware device, in response to a status change of a hardware interface. Further, the method includes according to the mapping relationship, obtaining and allocating the device number to the hardware device to enable an access to the hardware device according to the device number of the hardware device.Type: GrantFiled: February 20, 2018Date of Patent: June 2, 2020Assignee: LENOVO (BEIJING) CO., LTD.Inventors: Haiyang He, Siyuan Wang, Aili Yao
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Publication number: 20200001406Abstract: A micro/nanoparticle-reinforced composite solder for low-temperature soldering and a preparation method thereof belong to the manufacturing field of lead-free low-temperature soldering solders. Micro/nanoparticle-reinforced tin-based alloy solder powder is formed by diffusely mixing micro/nano-sized Cu, Ag and Sb particles with a molten metal tin and atomizing the mixture, and then blended with low-melting-point SnBi-based alloy solder powder and a conventional flux to prepare a micro/nanoparticle-reinforced composite solder. In soldering at a temperature below 200° C.Type: ApplicationFiled: December 7, 2017Publication date: January 2, 2020Applicant: Shenzhen Fitech Co., Ltd.Inventors: Pu XU, Siyuan WANG, Daoke YU, Kui CHEN, Jainhao SHI