Abstract: A unitary optical ferrule is molded to include one or more elements for receiving and securing one or more optical waveguides one or more elements for affecting one or more characteristics of light from the optical waveguide while propagating the light within the ferrule. The optical ferrule also includes one or more first alignment features and one or more second alignment features that, when the ferrule is mated with a mating ferrule, each controls alignment of the ferrule with the mating ferrule along three mechanical degrees of freedom. The surface of the optical ferrule can be divided along the thickness axis into a first section and an opposing second section, wherein the first section of the surface includes the receiving and securing elements, the light affecting elements, and the first alignment features and the second section of the surface includes the second alignment features.

Abstract: Embodiments of this disclosure are directed to devices that allow for adjusting of device parameters in a manner that does not involve power dissipation in an essential way. Thus, power demands when such devices are used in applications can be insignificant. This applies to both springs and inerters, which constitute basic lossless building blocks of mechanical device systems, and are analogues of inductors and capacitors in electrical circuits. Embodiments of this disclosure are also directed to a lossless adjustable 2-port transformer, and realization of mechanical translational and rotary transformers are set forth in the following. Embodiments of this disclosure allow for reduction of power demands in adjusting device parameters.

Abstract: A bale retriever for retrieving bales which includes a bale pick up configured to contact and pick up a bale, a steering assembly configured to steer the bale retriever, at least one sensor configured to sense at least one bale feature of the bale, and a controller operatively coupled to the steering assembly and the at least one sensor. The controller is configured to receive bale drop location information, receive at least one bale feature signal from the at least one sensor, identify an exact bale location of the bale based at least partially on the bale drop location information and the at least one bale feature signal from the at least one sensor, generate a steering control signal based at least partially on the exact bale location, and output the steering control signal to the steering assembly.

Abstract: Methods of improving recombinant protein titer and cell titer in cell culture using cell culture media having reduced impurities are provided, and well as cell culture media having reduced impurities that can used for the production of a recombinant protein and cells with improved titer. The cell culture media having reduced impurities comprises a HEPES buffer, and the reduced impurities are HEPES related impurities. In certain aspects, methods and media improve protein titer, cell growth, and/or viable cell density.

Abstract: The disclosure provides an optical device for enhancing the well-being of a wearer. The optical device includes a frame, at least one lens connected to the frame, at least one filter configured to engage with the at least one lens, at least one second filter configured to engaged with the at least one lens, and a modulating mechanism in communication with the frame, the at least one lens, the at least one first filter and/or the at least one second filter for modulating the at least one first filter and the at least one second filter. The at least one first filter attenuates light at wavelengths in the visible blue light spectral region. The at least one second filter attenuates light at wavelengths of the visible spectral region outside of the visible blue light spectral region.

Abstract: A microporous substrate for detection of surface bound target analyte molecules includes a microporous substrate material having opposed surfaces and tapered micropores extending through the substrate with the micropores having wider openings on one side of the substrate compared to the other side. The micropores have bound therein analyte specific receptors complementary to the target molecules. When a liquid sample containing the target analyte molecules with optical probes attached to the target molecules is flowed through the substrate, they bind to their complementary analyte specific receptors and emit light. This substrate structure gives an increase in the collection efficiency of light emitted from optical probes when the light is detected by a light detector spaced from the side of the substrate facing the larger micropores openings compared to a light collection efficiency of light emitted from the optical probes when the micropores are straight and not tapered.

Abstract: Described herein are certain dosing schedules and amounts that effectively prevent and manage side effects associated with histone deacetylase inhibitor (HDACi) treatment. Optionally, these schedules and dosing regimens include treatment with an antiviral agent.

Abstract: Torque sensing devices, systems, and methods are capable of measuring and/or determining a torque being transmitted through a shaft by measuring the torsional deformation of the shaft over a short length thereof. Such devices, systems, and devices have a sensor positioned adjacent to the outer surface of the shaft as it rotates, the sensor being positioned to maintain a substantially constant distance between the sensor and the outer surface of the shaft. The sensors may be variable reluctance (VR) sensors rigidly attached to a frame mounted on a bearing (e.g., a hanger bearing), which is mounted on the shaft, such that relative radial motion between the shaft and the VR sensor is minimized (e.g., so that they move in unison). Reducing this amount of motion results in a more accurate torque measurement.

Abstract: In one general aspect, various embodiments of the present invention can include a motorized surgical cutting and fastening instrument having a drive shaft, a motor selectively engageable with the drive shaft, and a manual return mechanism configured to operably disengage the motor from the drive shaft and retract the drive shaft. In at least one embodiment, a surgeon, or other operator of the surgical instrument, can utilize the manual return mechanism to retract the drive shaft after it has been advanced, especially when the motor, or a power source supplying the motor, has failed or is otherwise unable to provide a force sufficient to retract the drive shaft.

Abstract: This disclosure relates to a single stage process for the direct conversion of alcohols, e.g. ethanol, to olefinic mixtures (C2-C7) with low levels of aromatics carried out in a single reactor with two fixed catalyst beds in series, or two catalytic fixed bed reactors in series wherein the first reactor operates at a lower or higher temperature than the operating temperature of the second reactor. The process transformation of ethanol is comprised of ethanol dehydration to ethylene and water in high yield with the first catalyst in the first reactor, or via the first fixed catalyst bed, followed by directly feeding the ethylene and water to the second reactor, or second fixed catalyst bed, with conversion of said ethylene and water to a C2-C7 olefinic mixture with the second catalyst(s) in high yields with minimal aromatic compound formation.

Abstract: A fire blocking system for building panels includes a fireproof block held in place between two beams or studs on opposing fastener members. The fireproof block is preferably held adjacent a slab or other structure, and is preferably of the same thickness. Thus, fire and smoke is prevented from or at least delayed from passing from one side of the structure to the other through the building panel (e.g., from passing from one floor to the next). The fire blocking system reduces the use of fire proofing materials required for building panels, while simultaneously improving the fire blocking capabilities of the building panels to meet building codes for fire resistance.

Abstract: A system includes a pressure ring positioned to abut a fluid end face, the pressure ring having a pressure ring bore with a diameter larger than a fluid end bore diameter. The system also includes an adjacent ring coupled to a fluid end, the pressure ring positioned between the adjacent ring and the fluid end face. The system further includes a face seal positioned at an interface of the pressure ring and the fluid end face, the face seal containing pressurized fluid associated with the fluid end. The system also includes packing material positioned within at least a portion of the pressure ring bore.

Abstract: A method for partially publishing edits to a document is described. A first document including a first cell and a second cell is displayed on first user account on a first computing device and on a second user account. A second document including a linked version of the first cell and a linked version of the second cell is displayed. An edit of the first cell is received from the first user account and an edit of the second cell is received. In response to receiving an indication from the first user account that the edit of the first cell is to be published, the edit of the first cell is made to the linked version of the first cell, while the linked version of the second cell is unchanged so that the content of the linked version of the second cell no longer matches that of the second cell.

Abstract: A foldable panel combination for a modular greenhouse is described. The combination includes a first side panel, a second side panel, a first roof panel, and a second roof panel that are hingedly connected. The combination is transitionable between a collapsed state and an open state. In the collapsed state, the four panels are in a stacked configuration. In the open state, the panels form a sidewall-to-roof-to-roof-to-sidewall structure that can be connected with other panel combinations for linear expansion. Each panel comprises a rectangular frame and a cover for enclosing art open space in the middle of the frame.

Abstract: Exemplary reach-based explicit dataflow processors and related computer-readable media and methods. The reach-based explicit dataflow processors are configured to support execution of producer instructions encoded with explicit naming of consumer instructions intended to consume the values produced by the producer instructions. The reach-based explicit dataflow processors are configured to make available produced values as inputs to explicitly named consumer instructions as a result of processing producer instructions. The reach-based explicit dataflow processors support execution of a producer instruction that explicitly names a consumer instruction based on using the producer instruction as a relative reference point from the producer instruction.

Abstract: A method of operating a gas turbine engine having a bleed air system with a switching valve, operable to switch between multiple air sources depending on an operating mode of the gas turbine engine (e.g. a motive powered mode or a standby mode), is described. The method includes operating the switching valve to provide pressurized air from a selected one or more of the multiple air sources to a cavity of the gas turbine engine having seals, and testing the switching valve to determine if the switching valve is functioning normally or abnormally. The switching valve is functioning normally when operable to switch between the multiple air sources and is functioning abnormally when switching between the multiple air sources is not possible. If the switching valve is determined to be functioning abnormally, the gas turbine engine is controlled to prevent a change of the operating mode.

Abstract: A printer includes: a body defining a media enclosure configured to receive a media supply; an indicator assembly supported by an outer wall of the body, the indicator assembly including a plurality of substantially contiguous illumination surfaces illuminated by respective ones of a set of lights supported within the body; a controller supported by the body, the controller configured to: (i) obtain an operational status of the printer, (ii) retrieve, from a mapping repository, a set of notification control parameters corresponding to the operational status, and (iii) control the set of lights according to the notification control parameters.

Abstract: A mixed-mode chromatography method for the determination of phosphorylated sugars in a sample is provided. The mixed-mode chromatography method includes obtaining a sample comprising at least one phosphorylated sugar. The sample is introduced onto a chromatography system. The chromatography system includes a column having a stationary phase material contained inside the column. The stationary phase material has a surface comprising a hydrophobic surface group and at least one ionizable modifier. The sample with a mobile phase eluent is flowed through the column, where the at least one phosphorylated sugar is substantially resolved and retained within seven minutes. The mobile phase eluent includes water with an additive and acetonitrile with the additive. The mobile phase eluent has a pH less than 6. The at least one phosphorylated sugar is detected using a detector.

Abstract: Briefly, a variety of embodiments, including the following, are described: a system embodiment and methods that allow random access to voice messages, in contrast to sequential access in existing system embodiments; a system embodiment and methods that allow for the optional use of voice recognition to enhance usability; and a system embodiment and methods that apply to the area of voicemail.

Abstract: In some implementations, a computing device can present accessory state information. For example, the computing device can receive accessory state information from various accessories and present status items representing the current state of the accessories. The status items can be prioritized according to classifications assigned to accessories and/or accessory state information. The status items can be filtered based on a role assigned to the user of the computing device. Additional implementations and details are described in the paragraphs that follow.