Patents by Inventor Snahel Patel

Snahel Patel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • KRAS G12C inhibitors
    Patent number: 12291539
    Abstract: The present disclosure provides compounds and methods useful in the treatment and suppression of cancer, for example, useful for treating or suppressing cancers characterized by KRAS G12C. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
    Type: Grant
    Filed: July 24, 2024
    Date of Patent: May 6, 2025
    Assignee: Frontier Medicines Corporation
    Inventors: Snahel Patel, Philip A. Gerken, Monika Jane Williams
  • METHODS FOR TREATMENT OF CANCER
    Publication number: 20250129103
    Abstract: The present disclosure provides compounds and methods useful in the treatment and suppression of cancer, for example, useful for treating or suppressing cancers characterized by KRAS G12C. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
    Type: Application
    Filed: February 7, 2023
    Publication date: April 24, 2025
    Inventors: Snahel Patel, Philip A. Gerken, Monika Jane Williams
  • Bicyclic lactams and methods of use thereof
    Patent number: 12281101
    Abstract: The invention provides novel compounds having the general formula I: wherein R1, X, Z1, L, n, the A ring, the B ring, and the C ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: March 10, 2021
    Date of Patent: April 22, 2025
    Assignee: Genentech, Inc.
    Inventors: Snahel Patel, Gregory Hamilton, Craig Stivala, Huifen Chen, Guiling Zhao
  • KRAS G12C INHIBITORS
    Publication number: 20250019387
    Abstract: The present disclosure provides compounds and methods useful in the treatment and suppression of cancer, for example, useful for treating or suppressing cancers characterized by KRAS G12C. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
    Type: Application
    Filed: July 24, 2024
    Publication date: January 16, 2025
    Inventors: Snahel PATEL, Hiroko TANAKA, Daniel A. ERLANSON, Philip A. GERKEN, John C. WIDEN, Monika Jane WILLIAMS, Irina DOTSENKO
  • Bicyclic pyridone lactams and methods of use thereof
    Patent number: 12139482
    Abstract: The invention provides novel compounds having the general formula I: wherein R1, X, Z1 to Z5, L, n, the A ring, and the B ring, are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: February 4, 2021
    Date of Patent: November 12, 2024
    Assignee: Genentech, Inc.
    Inventor: Snahel Patel
  • BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20240300974
    Abstract: The invention provides novel compounds having the general formula I: wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
    Type: Application
    Filed: November 21, 2023
    Publication date: September 12, 2024
    Applicant: Genentech, Inc.
    Inventors: Snahel PATEL, Gregory HAMILTON, Guiling ZHAO, Huifen CHEN, Blake DANIELS, Craig STIVALA
  • FLUOROALKYL-OXADIAZOLES AND USES THEREOF
    Publication number: 20240182462
    Abstract: Provided herein are compounds identified as inhibitors of HDAC6 activity having the formula: or a pharmaceutically acceptable salt thereof, that can be used to treat various diseases and disorders.
    Type: Application
    Filed: December 1, 2023
    Publication date: June 6, 2024
    Inventors: Snahel PATEL, Mohammad A. MANDEGAR, Pingyu DING, Ulhas BHATT, Martin HOLAN, John LEE, Yihong LI, Julio MEDINA, Alok NERURKAR, Frederick SEIDL, David SPERANDIO, Tien WIDJAJA
  • Fluoroalkyl-oxadiazoles and uses thereof
    Patent number: 11926622
    Abstract: Provided herein are compounds identified as inhibitors of HDAC6 activity having the formula: or a pharmaceutically acceptable salt thereof, that can be used to treat various diseases and disorders.
    Type: Grant
    Filed: December 23, 2022
    Date of Patent: March 12, 2024
    Assignee: Tenaya Therapeutics, Inc.
    Inventors: Snahel Patel, Mohammad A. Mandegar, David Sperandio, Julio Medina, Ulhas Bhatt, Alok Nerurkar, Tien Widjaja
  • Bicyclic ketone compounds and methods of use thereof
    Patent number: 11834461
    Abstract: The invention provides novel compounds having the general formula I: wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
    Type: Grant
    Filed: January 12, 2021
    Date of Patent: December 5, 2023
    Assignee: Genentech, Inc.
    Inventors: Snahel Patel, Gregory Hamilton, Guiling Zhao, Huifen Chen, Blake Daniels, Craig Stivala
  • Bicyclic compounds for use as RIP1 kinase inhibitors
    Patent number: 11673892
    Abstract: The invention provides novel compounds having the general formula I: or pharmaceutically acceptable salts thereof, wherein RA, RB1, RB2, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
    Type: Grant
    Filed: April 9, 2020
    Date of Patent: June 13, 2023
    Assignee: Genentech, Inc.
    Inventors: Huifen Chen, Gregory Hamilton, Snahel Patel, Guiling Zhao, Blake Daniels, Craig Stivala
  • FLUOROALKYL-OXADIAZOLES AND USES THEREOF
    Publication number: 20230143804
    Abstract: Provided herein are compounds identified as inhibitors of HDAC6 activity that can be used to treat various diseases and disorders.
    Type: Application
    Filed: December 23, 2022
    Publication date: May 11, 2023
    Inventors: Snahel PATEL, Mohammad A. MANDEGAR, David SPERANDIO, Julio MEDINA, Ulhas BHATT, Alok NERUKAR, Tien WIDJAJA
  • Pyridine lactam compounds and methods of use thereof
    Patent number: 11634436
    Abstract: The invention provides compounds having the general formula I: or pharmaceutically acceptable salts thereof, wherein X, Y, R1, R2, R7a, R7b, X, RB1, RB2, n, p, q, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of use thereof.
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: April 25, 2023
    Assignee: Genentech, Inc.
    Inventor: Snahel Patel
  • 5-FLUORONICOTINAMIDE DERIVATIVES AND USES THEREOF
    Publication number: 20230123856
    Abstract: Provided herein is a compound of Formula (I), or pharmaceutically acceptable salt thereof, wherein R1, Y, X, and n are defined herein. Also provided herein are compositions comprising a compound of Formula (I) or pharmaceutically acceptable salt thereof, and methods of using a compound of Formula (I) or pharmaceutically acceptable salt thereof, e.g., in the treatment of heart disease.
    Type: Application
    Filed: April 4, 2022
    Publication date: April 20, 2023
    Applicant: Tenaya Therapeutics, Inc.
    Inventors: Mohammad A. MANDEGAR, Snahel PATEL, Ulhas BHATT, Pingyu DING, Martin HOLAN, John LEE, Yihong LI, Julio MEDINA, Alok NERURKAR, Frederick SEIDL, David SPERANDIO, Tien WIDJAJA, Xiaodong WANG
  • Bicyclic amide compounds and methods of use thereof
    Patent number: 11607396
    Abstract: The invention provides novel compounds having the general formula I: wherein R1, R2, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: March 21, 2023
    Assignee: Genentech, Inc.
    Inventors: Snahel Patel, Gregory Hamilton, Guiling Zhao, Huifen Chen
  • Fluoroalkyl-oxadiazoles and uses thereof
    Patent number: 11578066
    Abstract: Provided herein are compounds identified as inhibitors of HDAC6 activity having the formula: or a pharmaceutically acceptable salt thereof, that can be used to treat various diseases and disorders.
    Type: Grant
    Filed: April 28, 2022
    Date of Patent: February 14, 2023
    Assignee: Tenaya Therapeutics, Inc.
    Inventors: Snahel Patel, Mohammad A. Mandegar, David Sperandio, Julio Medina, Ulhas Bhatt, Alok Nerurkar, Tien Widjaja
  • BICYCLIC SULFONES AND SULFOXIDES AND METHODS OF USE THEREOF
    Publication number: 20230002391
    Abstract: The invention provides novel compounds having the general formula I: wherein R1, RB1, RB2, n, p, q, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
    Type: Application
    Filed: June 6, 2021
    Publication date: January 5, 2023
    Applicant: Genentech, Inc.
    Inventors: Snahel Patel, Gregory Hamilton, Craig Stivala, Huifen Chen, Blake Daniels
  • BICYCLIC LACTAMS AND METHODS OF USE THEREOF
    Publication number: 20220348559
    Abstract: The invention provides novel compounds having the general formula I: wherein R1, X, Z1, L, n, the A ring, the B ring, and the C ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: March 10, 2021
    Publication date: November 3, 2022
    Applicant: Genentech, Inc.
    Inventors: Snahel PATEL, Gregory HAMILTON, Craig STIVALA, Huifen CHEN, Guiling ZHAO
  • Amido spirocyclic amide and sulfonamide derivatives
    Patent number: 11485745
    Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: November 1, 2022
    Assignees: Valo Health, Inc., Genentech, Inc.
    Inventors: Kenneth W. Bair, Timm R. Baumeister, Peter Dragovich, Xiongcai Liu, Snahel Patel, Po-Wai Yuen, Mark Zak, Guiling Zhao, Yamin Zhang, Xiaozhang Zheng
  • BICYCLIC AMIDE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20220339129
    Abstract: The invention provides novel compounds having the general formula I: wherein R1, R2, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: January 4, 2021
    Publication date: October 27, 2022
    Applicant: Genentech, Inc.
    Inventors: Snahel Patel, Gregory Hamilton, Guiling Zhao, Huifen Chen
  • BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20210340151
    Abstract: Some embodiments of the invention provide compounds having the general formula I: wherein R1, R2, R3a and R3b are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
    Type: Application
    Filed: July 8, 2021
    Publication date: November 4, 2021
    Applicant: Genentech, Inc.
    Inventors: Snahel PATEL, Gregory HAMILTON, Guiling ZHAO, Huifen CHEN, Blake DANIELS, Craig STIVALA