Abstract: Provided are a recombinant hyaluronan and proteoglycan link protein 1 (HAPLN1), and a composition for preventing or treating pulmonary diseases, the composition comprising at least one selected from the group consisting of HAPLN1 (hyaluronan and proteoglycan link protein 1) protein, a gene coding for the HAPLN1 protein, and an effective agent for promoting the expression or activating the functions of HAPLN1 protein or gene as an active ingredient. The recombinant HAPLN1 according to the present disclosure may have superior effects of improving alveolar damage caused by aging or elastin reduction, and thus may effectively prevent or treat pulmonary diseases, such as chronic bronchitis, asthma, emphysema, and chronic obstructive pulmonary disease.

Abstract: A thermal management system for a vehicle is provided. The system includes an interior air conditioning apparatus and a chiller that exchanges heat between first refrigerant and second refrigerant. A first line guides the first refrigerant to be circulated sequentially through a chiller, a high-voltage battery cooling core and a heating, ventilating and air conditioning (HVAC) core. A second line guides the second refrigerant to be circulated sequentially through a compressor, a condenser and the chiller. A controller operates the blower, a first pump and the compressor based on an exterior temperature of the vehicle and whether interior air conditioning is necessary, when cooling of the high-voltage battery is necessary.

Abstract: An indoor heating line is arranged to pass through a heater core for a coolant heater and indoor air conditioning, and is provided with a first pump so that coolant can flow. A battery heating line is branched from a downstream point of the heater core and connected to an upstream point of the coolant heater after passing through a battery heat exchange part for temperature-raising a high voltage battery, where the battery heating line includes a first heat exchange flow passage that connects a downstream point of the heater core to a first side of the battery heat exchange part, and a second heat exchange flow passage that connects a second side thereof and an upstream point of the coolant heater, where the first heat exchange flow passage and the second heat exchange flow passage are configured to mutually exchange heat.

Abstract: An indoor heating line is arranged to pass through a heater core for a coolant heater and indoor air conditioning, and is provided with a first pump so that coolant can flow. A battery heating line is branched from a downstream point of the heater core and connected to an upstream point of the coolant heater after passing through a battery heat exchange part for temperature-raising a high voltage battery, where the battery heating line includes a first heat exchange flow passage that connects a downstream point of the heater core to a first side of the battery heat exchange part, and a second heat exchange flow passage that connects a second side thereof and an upstream point of the coolant heater, where the first heat exchange flow passage and the second heat exchange flow passage are configured to mutually exchange heat.

Abstract: An indoor heating line is arranged to pass through a heater core for a coolant heater and indoor air conditioning, and is provided with a first pump so that coolant can flow. A battery heating line is branched from a downstream point of the heater core and connected to an upstream point of the coolant heater after passing through a battery heat exchange part for temperature-raising a high voltage battery, where the battery heating line includes a first heat exchange flow passage that connects a downstream point of the heater core to a first side of the battery heat exchange part, and a second heat exchange flow passage that connects a second side thereof and an upstream point of the coolant heater, where the first heat exchange flow passage and the second heat exchange flow passage are configured to mutually exchange heat.

Abstract: According to aspects of the present invention, a peptide with any one sequence of SEQ ID NOS:1 to 3 exhibits high selective binding affinity to a target and the microcapsule has superior physicochemical stability. Therefore, the cosmetic composition containing the microcapsule linked to the peptide manifests high delivery efficiency of an active ingredient included in the capsule to target cells, thereby exhibiting superior skin-condition improvement effects.

Abstract: An indoor heating line is arranged to pass through a heater core for a coolant heater and indoor air conditioning, and is provided with a first pump so that coolant can flow. A battery heating line is branched from a downstream point of the heater core and connected to an upstream point of the coolant heater after passing through a battery heat exchange part for temperature-raising a high voltage battery, where the battery heating line includes a first heat exchange flow passage that connects a downstream point of the heater core to a first side of the battery heat exchange part, and a second heat exchange flow passage that connects a second side thereof and an upstream point of the coolant heater, where the first heat exchange flow passage and the second heat exchange flow passage are configured to mutually exchange heat.

Abstract: A coolant heating apparatus for an electric vehicle includes a sheath heater formed in a coil form at a center side of the coolant heating apparatus; one or more inner tubes, one of which has an inlet formed at one side thereof for introduction of coolant, the one or more inner tubes being arranged to surround the sheath heater or to be surrounded by the sheath heater, and the one or more inner tubes having a plurality of through-holes formed on respective outer peripheral surfaces thereof so that the coolant introduced into the inlet is discharged through the through-holes; and an outer tube surrounding the sheath heater and the one or more inner tubes and having an outlet formed at one side thereof so that the coolant heated by the sheath heater is introduced through the through-holes of the one or more inner tubes and is discharged through the outlet.

Abstract: An air-conditioning apparatus for an electric vehicle and a method of controlling the same, may include a heat exchanger performing heat exchange between a first fluid and a second fluid while the first fluid and the second fluid flow separately from each other therethrough; a heat source connected to the heat exchanger through a line through which the second fluid flows to allow the second fluid to circulate between the heat exchanger and the heat source, and heating or cooling the second fluid; a circulator imparting a circulation force to the second fluid such that the second fluid circulates between the heat exchanger and the heat source; and a controller determining a required flow rate of the second fluid by use of a flow rate of the first fluid flowing through the heat exchanger and controlling the circulator on the basis of the required flow rate of the second fluid.

Abstract: A cooling system for vehicles is provided. The cooling system includes a cooling channel disposed in a wheel housing of a vehicle and having an inlet port and an outlet port, and a cooling line that connects the inlet port and the outlet port of the cooling channel to a heat-emitting part of the vehicle to cool the heat-emitting part using the cooling channel. A cooling medium is introduced into the cooling channel through the inlet port, circulates through the cooling channel, and is discharged through the outlet port. One surface of the cooling channel is exposed toward the wheel of the vehicle to exchange heat with air swirling in a space formed between the wheel and the wheel housing.

Abstract: A coolant heating apparatus includes: a housing having a coolant flow path therein and configured to cause coolant to flow into the housing and to flow out from the housing after being heated; a sheath heater provided in an inside of the housing and configured to heat the coolant; and a heat conduction plate provided inside the housing and made of a heat-conductive material. A portion of the heat conduction plate is bent in a shape to enclose an outer circumferential surface of the sheath heater and to be in surface contact with the sheath heater so as to carry out heat conduction with the sheath heater, and a remaining portion of the heat conduction plate is in surface contact with the coolant inside the housing such that the coolant is heated by heat conducted from the sheath heater.

Abstract: Disclosed is a coating composition for preventing odor. The coating composition may include one or more types of odorless microorganisms selected from the group consisting of Caulobacter vibrioides, Bradyrhizobium diazoefficiens, Bradyrhizobium daqingense and Methylobacterium brachiatum or a culture solution thereof. Further provided is a method for preventing odor, and the method may include applying the coating composition for preventing odor. When a biofilm is formed from the microorganisms in the coating composition by coating an object on which an odor-causing microorganism can live, the inflow and the inhabitation of external microorganisms generating odor may be significantly blocked, thereby enabling odor to be effectively prevented.

Abstract: A three-dimensional semiconductor device includes: a peripheral circuit structure disposed on a lower substrate, and including an internal peripheral pad portion; an upper substrate disposed on the peripheral circuit structure; a stack structure disposed on the upper substrate, and including gate horizontal patterns; a vertical channel structure passing through the stack structure in a first region on the upper substrate; a first vertical support structure passing through the stack structure in a second region on the upper substrate; and an internal peripheral contact structure passing through the stack structure and the upper substrate, and electrically connected to the internal peripheral pad portion, wherein an upper surface of the first vertical support structure is disposed on a different level from an upper surface of the vertical channel structure, and is coplanar with an upper surface of the internal peripheral contact structure.

Abstract: Disclosed is a cooling and heating system for a high-voltage battery of a vehicle, which includes: a radiator provided adjacent to a lower portion of a high-voltage battery module to radiate heat to outside air; an outside air cooling line configured such that cooling water circulates between the radiator and the high-voltage battery module, with a main valve being provided on the outside air cooling line; a bypass line configured such that a first end thereof branches from the main valve and a second end thereof is connected to the outside air cooling line to bypass the radiator, with a heat exchanger being provided on the bypass line; and a controller configured to control the high-voltage battery module to radiate heat through the radiator or to exchange heat with the heat exchanger by controlling the main valve when heat exchange of the high-voltage battery module is required.

Abstract: A three-dimensional semiconductor device includes: a peripheral circuit structure disposed on a lower substrate, and including an internal peripheral pad portion; an upper substrate disposed on the peripheral circuit structure; a stack structure disposed on the upper substrate, and including gate horizontal patterns; a vertical channel structure passing through the stack structure in a first region on the upper substrate; a first vertical support structure passing through the stack structure in a second region on the upper substrate; and an internal peripheral contact structure passing through the stack structure and the upper substrate, and electrically connected to the internal peripheral pad portion, wherein an upper surface of the first vertical support structure is disposed on a different level from an upper surface of the vertical channel structure, and is coplanar with an upper surface of the internal peripheral contact structure.

Abstract: A heating and cooling system for a vehicle may include: a refrigerant line provided to pass through a compressor, an interior heat exchanger for interior air-conditioning, an air-cooled condenser, and an evaporator core for interior air-conditioning, the refrigerant line configured such that a refrigerant flows therethrough; a coolant line provided to pass through a high-voltage battery core, an electric part core for an electric part, and a radiator for the electric part, the coolant line configured such that a coolant flows therethrough; and a heat exchanging part configured to exchange heat between the refrigerant flowing between the interior heat exchanger and the air-cooled condenser, and the coolant flowing between the electric part core and the radiator.

Abstract: Disclosed is an air conditioning apparatus for a vehicle, the air conditioning apparatus including: an air conditioning duct forming a passage for conditioned air, and provided with an outlet on a wall surface thereof for directing conditioned air. A door is provided inside the air conditioning duct, with a rotation shaft being provided on a wall surface opposite to the wall surface of the air conditioning duct. The door opens and closes the air conditioning duct by a rotation thereof. A partition wall protrudes from a surface of the door along the wall surface of the air conditioning duct. The partition wall opens and closes the outlet in response to the rotation of the door.

Abstract: A three-dimensional semiconductor device includes: a peripheral circuit structure disposed on a lower substrate, and including an internal peripheral pad portion; an upper substrate disposed on the peripheral circuit structure; a stack structure disposed on the upper substrate, and including gate horizontal patterns; a vertical channel structure passing through the stack structure in a first region on the upper substrate; a first vertical support structure passing through the stack structure in a second region on the upper substrate; and an internal peripheral contact structure passing through the stack structure and the upper substrate, and electrically connected to the internal peripheral pad portion, wherein an upper surface of the first vertical support structure is disposed on a different level from an upper surface of the vertical channel structure, and is coplanar with an upper surface of the internal peripheral contact structure.

Abstract: A coolant heating device for a vehicle includes: a housing storing coolant therein and having a sheath heater therein; an upper space part protruding upwards from a top surface of the housing and having an inner space via which an inner space of the housing communicates with the upper space part; a water-level-sensing part disposed inside the upper space part to sense a level of coolant in the housing; and a controller for controlling operation of the sheath heater based on the level of coolant sensed by the water-level-sensing part.

Abstract: A composition for alleviating, preventing, or treating hyperoxia-induced lung injury, the composition including the WKYMVm peptide as an active ingredient is described. The composition has an effect of increasing FPR2 activation and ERK phosphorylation, and also has an effect of improving alveolarization and angiogenesis in hyperoxia-induced lung injury models, and thus the composition is anticipated to be usefully used for the alleviation, prevention, or treatment of hyperoxia-induced lung injury, particularly bronchopulmonary dysplasia.