Abstract: The present invention relates to a magnetic block toy, and more particularly, to a magnetic block toy which makes assembly of blocks firm because caps having serrated coupling parts are combined to both sides of a block body, and which has block bodies and caps of various colors, thereby arousing children's interest and promoting development of intelligence. The magnetic block toy according to the present invention includes: a block body having a pair of brackets each of which has a protrusion and a groove formed on the inner face to correspond to each other and are coupled with each other; caps which are respectively combined to both sides of the block body and each of which has a serrated coupling part formed on the outer surface; and a magnet which is disposed inside the cap to generate a magnetic force.

Abstract: The present invention relates to a magnetic block toy, and more particularly, to a magnetic block toy which makes assembly of blocks firm because caps having serrated coupling parts are combined to both sides of a block body, and which has block bodies and caps of various colors, thereby arousing children's interest and promoting development of intelligence. The magnetic block toy according to the present invention includes: a block body having a pair of brackets each of which has a protrusion and a groove formed on the inner face to correspond to each other and are coupled with each other; caps which are respectively combined to both sides of the block body and each of which has a serrated coupling part formed on the outer surface; and a magnet which is disposed inside the cap to generate a magnetic force.

Abstract: The present invention relates to a surface structure, on which protuberances and slots are configured so that the protuberances interlock organically with the slots to secure stable combination between the blocks of a block toy when the blocks are stacked up, combined laterally or combined at right angles to each other.

Abstract: The present invention provides a skin care device with multiple functions. The skin care device includes a main body having a first connecting terminal formed on the upper portion thereof; a plurality of skin care heads individually and detachably combined with the main body, the skin care heads each having a second connecting terminal formed on the lower portion thereof and having at least one of a galvanic current generator, an ultrasonic vibrator, or a near-infrared light emitting diode (LED) installed therein; and a product identification displaying part displays an identification number of the heads or a relevant image of the heads on a display screen when the first connecting terminal and the second connection terminal are connected each other. The skin care device allows users to care their skin effectively through a variety of beneficial functions such as galvanic electric current, ultrasonic vibrations, and near-infrared LED.

Abstract: The present invention relates to an anticancer agent containing a TMPRSS4 (transmembrane protease, serine 4) inhibitor as an effective ingredient, more precisely an anticancer agent containing an inhibitor of TMPRSS4 activity as an effective ingredient. The anticancer agent of the present invention can be used effectively for the treatment of cancer by inhibiting TMPRSS4 expression in cancer cells and thereby inhibiting cancer cell invasion and cancer cell growth.

Abstract: The present invention relates to a human monoclonal antibody that specifically binds to VCAM-1, and a therapeutic composition for the treatment of inflammatory disease or cancer comprising the same. The human monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human or mouse endothelial cell, effectively inhibits leukocyte adhesion to activated endothelial cells expressing VCAM-1, and shows a low immunogenicity, thereby being used for the treatment of cancer or inflammatory disease such as asthma, rhinitis, arthritis, multiple sclerosis, bowel disease, arteriosclerosis, myocardial infarction and transplant rejection.

Abstract: The present invention relates to a transmembrane protease, serine (TMPRSS4)-specific human antibody, and more particularly to a human antibody including a complementarity determining region (CDR) and a framework region (FR) derived from a human antibody specifically bound to TMPRSS4. The TMPRSS4-specific human antibody expressed in the various kinds of cancer cells of the present invention may be used in diagnosis of the cancer, classification of the disease, visualization, treatment, and prognostic evaluation.

Abstract: The present invention relates to a human monoclonal antibody that specifically binds to VCAM-1, and a therapeutic composition for the treatment of inflammatory disease or cancer comprising the same. The human monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human or mouse endothelial cell, effectively inhibits leukocyte adhesion to activated endothelial cells expressing VCAM-1, and shows a low immunogenicity, thereby being used for the treatment of cancer or inflammatory disease such as asthma, rhinitis, arthritis, multiple sclerosis, bowel disease, arteriosclerosis, myocardial infarction and transplant rejection.

Abstract: The present invention relates to a vascular endothelial growth factor (VEGF)-specific human antibody, and more particularly to a human antibody including a complementarity determining region (CDR) and a framework region (FR) derived from a human antibody specifically bound to VEGF. The VEGF-specific human antibody of the present invention may be used in diagnosis of diseases caused by the VEGF-overexpression, classification of the diseases, visualization, treatment, and prognostic evaluation.

Abstract: Disclosed is a composition for whitening skin or improving skin wrinkles comprising black tea extract as an active ingredient. In a cell experiment for Melan-a cells and an animal experiment using the brown guinea pig model with artificial tanning spots induced by UVB, the black tea extract of the present disclosure greatly inhibited melanin synthesis. Also, in an experiment on SKH-1 hairless mouse, it remarkably inhibited wrinkle formation. Accordingly, the composition of the present disclosure can be developed as a skin whitening agent, an anti-wrinkle agent or a medicine for treating diseases associated with melanin hyperpigmentation, e.g. liver spots, freckles, senile spots or solar lentigo.

Abstract: The present invention relates to a CD9-specific human antibody, more precisely a CD9-specific human antibody composed of human derived CD9-specific complementarity determining region (CDR) and framework region (FR). The human antibody of the present invention recognizes CD9 extracellular loop 2 domain (CD9-ECL2) as an epitope and thereby strongly binding thereto. The human antibody of the present invention also has CD9 antigen neutralizing effect and at the same time inhibiting effect on tumor cell lines. Therefore, it can be effectively used for the prevention and treatment of cancer overexpressing CD9.

Abstract: The present invention relates to an anticancer agent containing a TMPRSS4 (transmembrane protease, serine 4) inhibitor as an effective ingredient, more precisely an anticancer agent containing an inhibitor of TMPRSS4 activity as an effective ingredient. The anticancer agent of the present invention can be used effectively for the treatment of cancer by inhibiting TMPRSS4 expression in cancer cells and thereby inhibiting cancer cell invasion and cancer cell growth.

Abstract: The present invention relates to a CD9-specific human antibody, more precisely a CD9-specific human antibody composed of human derived CD9-specific complementarity determining region (CDR) and framework region (FR). The human antibody of the present invention recognizes CD9 extracellular loop 2 domain (CD9-ECL2) as an epitope and thereby strongly binding thereto. The human antibody of the present invention also has CD9 antigen neutralizing effect and at the same time inhibiting effect on tumor cell lines. Therefore, it can be effectively used for the prevention and treatment of cancer overexpressing CD9.

Abstract: The present invention relates to a transmembrane protease, serine (TMPRSS4)-specific human antibody, and more particularly to a human antibody including a complementarity determining region (CDR) and a framework region (FR) derived from a human antibody specifically bound to TMPRSS4. The TMPRSS4-specific human antibody expressed in the various kinds of cancer cells of the present invention may be used in diagnosis of the cancer, classification of the disease, visualization, treatment, and prognostic evaluation.

Abstract: The present invention relates to a vascular endothelial growth factor (VEGF)-specific human antibody, and more particularly to a human antibody including a complementarity determining region (CDR) and a framework region (FR) derived from a human antibody specifically bound to VEGF. The VEGF-specific human antibody of the present invention may be used in diagnosis of diseases caused by the VEGF-overexpression, classification of the diseases, visualization, treatment, and prognostic evaluation.

Abstract: Disclosed is a vaccine composition that includes a peptide adjuvant, and a DNA vaccine encoding an immunogenic protein. Also, the present invention discloses a method of enhancing immune responses, which is based on the administration of the vaccine composition.