Abstract: The present disclosure provides 6-hydrazinoadenosine represented by the general Formula (I) and its derivatives with A2A adenosine receptor agonist activity, and pharmaceutical compositions containing them. The compound and composition can be used as A2A adenosine receptor agonists and used as medicament.

Abstract: A multi-line laser radar includes a first radar component, where the first radar component includes n lasers, an optical collimating unit, a scanning rotating mirror, and a detector, where n is greater than 1. Each laser is configured to emit one laser beam to the optical collimating unit. The optical collimating unit is configured to collimate n laser beams, where the collimated n laser beams are incident on a target reflector of the scanning rotating mirror. The scanning rotating mirror includes m reflectors rotating around a rotation axis, where a rotation plane of the rotation axis is perpendicular to an arrangement direction of the collimated n laser beams, and m is greater than 1. The target reflector reflects the received collimated n laser beams to a detection area of the first radar component. The detector receives echo signals of the reflected n laser beams in the detection area.

Abstract: The present application provides a small-molecule compound, represented by general Formula (I), having A2A adenosine receptor antagonistic activity and a pharmaceutical composition containing same. The compound and composition can be used as A2A adenosine receptor antagonistic agents.

Abstract: The present invention discloses an adjustable gas detection device for coal bed comprising a detection direction adjustment assembly, a suction head angle adjustment assembly and an analysis bin, wherein the suction head angle adjustment assembly includes a suction head first-level angle adjustment assembly and a suction head second-level angle adjustment assembly, and the suction head first-level angle adjustment assembly includes a suction head that sucks a gas through a suction pump and sends it into the analysis bin through a suction pipe for analysis; the detection direction adjustment assembly and the suction head angle adjustment assembly jointly adjust a position and a direction of the suction head. The gas detection device for coal bed of the present invention has many degrees of freedom, can quickly complete the angle adjustment, and realizes rapidly-oriented detection, as well as having advantages of high control efficiency, rapid response, flexibility and reliability.

Abstract: Disclosed is a recombinant protein containing 1) an anti-PD-L1 antibody heavy chain and an anti-PD-L1 antibody light chain, which two are linked by a disulfide bond to bind PD-L1, and 2) an extracellular Ig-like domain of a vascular epithelial growth factor receptor (VEGFR), linked via a linker to the N-terminus or C-terminus of the heavy chain or the light chain, wherein the recombinant protein is capable of binding PD-L1, VEGF and Fc receptor simultaneously. Also disclosed are a recombinant antibody containing two recombinant proteins of the disclosure, a polynucleotide encoding the recombinant protein, an expression vector containing the polynucleotide, a method for producing the recombinant protein and a method for treating a disease caused by over expression of VEGF and/or PD-L1 using the recombinant protein.

Abstract: Disclosed herein are an apparatus and method for generating a topological map for navigation of a robot. The method for generating a topological map for navigation of a robot, performed by the apparatus for building the topological map for the navigation of the robot, includes calculating the physical size of a single pixel on a metric map of a space in which a mobile robot is to navigate, extracting the physical coordinates of the pixel on the metric map, building node data and edge data for the navigation of the mobile robot using the physical coordinates, and generating a topological map for the navigation of the mobile robot based on the built node data and the built edge data.

Abstract: A microparticle is described comprising an antigen and a costimulatory component derived from an antigen presenting cell. The microparticle may be used for stimulating T cells ex vivo, followed by administration to a subject, e.g., as part of a personalized, customized therapeutic treatment of cancer or a tumor, an autoimmune disease or an allergic reaction, hypersensitivity reaction, an infection or infectious disease, an injury or other damage, a transplant or other surgical site, or a blood clot. It may also be used for the controlled release of a cytokine for the regulation of immunity in general and for other therapeutic uses. Methods of treating a disease or medical condition in a subject by exposing leukocytes from the subject to the microparticle, then reinfusing the leukocytes into the subject are provided. Methods of preparing an activated cytotoxic T cell population specific for an antigen are also provided.

Abstract: The present invention relates to a compound represented by Formula I, its pharmaceutically acceptable salt, its stereoisomer, its pharmaceutically acceptable hydrate or solvate, or its pharmaceutically acceptable ester, wherein R is selected from heteroaryl, substituted heteroaryl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, alkyl, and substituted alkyl, wherein the substituted heteroaryl, the substituted aryl, the substituted cycloalkyl and the substituted alkyl are each independently substituted with one or more hydroxyalkylene groups. The compound or its pharmaceutically acceptable salt, its stereoisomer, its pharmaceutically acceptable hydrate or solvate, its pharmaceutically acceptable ester of the present invention has agonistic activity on A2A adenosine receptor and can improve the permeability of blood-brain barrier to promote the delivery of drug across blood-brain barrier, and can also prevent or treat a disease associated with A2A adenosine receptor agonistic activity.

Abstract: An intelligent seal with cloud computing-based anti-forgery capability and a method for using the same. In various embodiments, the seal is provided with a special-shaped anti-forgery mark. All data files and log files are stored collectively at a seal management cloud platform, thereby achieving anti-forgery through cloud computing at the cloud platform, preventing theft and tampering of user data and seal data, allowing real-time query of seal usage information, and enabling third-party verification and anti-forgery of the seal information.

Abstract: A discharging control method and a charging control method for a rechargeable battery, and the rechargeable battery. An electric system of the rechargeable battery comprises a lithium ion cell and a discharging control circuit, and a charging control circuit. A positive electrode of the lithium ion cell is electrically connected to a common ground end (GND) of the charging and/or discharging control circuit, so that the common ground end (GND) serves as a positive electrode (P) of the charging input and/or discharging output of the rechargeable battery; a negative electrode of the lithium ion cell is electrically connected to an output end of the charging control circuit and an input end of the discharging control circuit; and the input end of the charging control circuit and the output end of the discharging control circuit are electrically connected to a negative electrode (N) of the rechargeable battery.

Abstract: The present disclosure provides a recombinant fusion protein containing an extracellular Ig-like domain of a signal-regulator protein (SIRP), linked via a linker, to a paratope of an Ig-like anti-HER2 antibody at the N-terminus of a heavy chain or a light chain constituting the paratope. The present disclosure also provides a polynucleotide encoding the recombinant fusion protein, an expression vector containing the polynucleotide, a method for producing the recombinant protein and a method for treating a disease caused by over-expression of CD47 and/or HER2.

Abstract: The present invention provides a compound of a general formula I, a stereomeride, pharmaceutically acceptable salt or a solvate thereof, a preparation method thereof, and usages in preparing medicines for preventing and/or treating diseases or symptoms caused by drug-resistant tumors or drug-resistant bacteria and in preparing medicines for preventing and/or treating diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection. Preferably, the diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection are diseases or symptoms caused by a heat shock protein 70 (Hsp70). The compound in the present invention is used for overcoming a difficult problem of drug resistance of tumors, improves the effect of tumor treatment, and provides a new medical strategy for clinical tumor treatment.

Abstract: Provided is a bi-functional fusion protein as well as its preparation method and use. The bi-functional fusion protein is composed of a monoclonal anti-human CD20 antibody linked to a first extracellular domain of human SIRP?. It is shown in in vitro tests that the bi-functional fusion protein is capable of binding to human CD20 and CD47 simultaneously, thus killing CD20+ tumor cells via antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity, and is also capable of blocking CD47-SIRP? interaction such that macrophages are activated to attack tumor cells. The bi-functional fusion protein has evident anti-tumor activities.

Abstract: Disclosed is a recombinant protein containing 1) an anti-PD-L1 antibody heavy chain and an anti-PD-L1 antibody light chain, which two are linked by a disulfide bond to bind PD-L1, and 2) an extracellular Ig-like domain of a vascular epithelial growth factor receptor (VEGFR), linked via a linker to the N-terminus or C-terminus of the heavy chain or the light chain, wherein the recombinant protein is capable of binding PD-L1, VEGF and Fc receptor simultaneously. Also disclosed are a recombinant antibody containing two recombinant proteins of the disclosure, a polynucleotide encoding the recombinant protein, an expression vector containing the polynucleotide, a method for producing the recombinant protein and a method for treating a disease caused by over expression of VEGF and/or PD-L1 using the recombinant protein.

Abstract: A stepless speed regulatable handy dust cleaner is disclosed, which includes: a housing, a battery, a blower mechanism, a control module, an air filter mechanism, and a blow pipe. A side of the housing is provided with an air outlet opening, and another side of the housing is provided with an air filter opening. The housing includes a first mounting shell and a second mounting shell, each of which includes a handgrip part and an air outlet part. The first mounting shell is provided with a knob slot, where a knob is provided. The blower mechanism includes a motor, a motor board, a blower casing and a fan blade. The motor is drivingly connected to the fan blade. The battery, the control module and the motor are electrically connected to each other. When the knob is rotated clockwise, the air volume and flow pressure gradually increase. When the knob is rotated counterclockwise, and the air volume and flow pressure gradually decrease.

Abstract: A method for processing an audio signal, the method including: processing the audio signal according to a pair of mouth to ear transfer functions to obtain a processed audio signal; filtering the processed audio signal, using a pair of equalization filters, to obtain a filtered audio signal, where a parameter of the equalization filter is depends on an acoustic impedance of a headphone; and outputting the filtered audio signal to the headphone. Accordingly, this method counteracts the occlusion effect and to provides a natural perceived sound pressure.

Abstract: A seal printer is provided, which performs printing by driving a nozzle to rotate through a motor in a printer shell, reduces a number of parts in the printer and a volume of the printer is similar to a volume of a traditional seal. The printer is realized to substitute for the traditional seal; meanwhile, a coaxial connection device is arranged in the printer, a structure thereof is simple and has a certain tolerance for an error of the coaxiality, so that the printer is simple to install, and is firm and durable.

Abstract: A method for preparing a CKO/KI animal model by using Cas9 technology includes a Cas9 protein expressed and purified in vitro, high-efficiency sgRNA(s) screened by sgRNA cleavage efficiency test on embryos in advance, and single-stranded DNA as targeting vector(s) are mixed with Cas9 protein and sgRNA(s) and then subjected to embryo injection and transplantation; mice born after transplantation are marked as F0 and the genotype identification of F0 is carried out; sexually mature F0 with the correct genotype are bred, and the offspring mice thereof are marked as F1; and the F1 mice are analyzed and verified, and the F1 mice with the correct genotype are the prepared CKO/KI animal model.