Abstract: A method for preparing a CKO/KI animal model by using Cas9 technology includes a Cas9 protein expressed and purified in vitro, high-efficiency sgRNA(s) screened by sgRNA cleavage efficiency test on embryos in advance, and single-stranded DNA as targeting vector(s) are mixed with Cas9 protein and sgRNA(s) and then subjected to embryo injection and transplantation; mice born after transplantation are marked as F0 and the genotype identification of F0 is carried out; sexually mature F0 with the correct genotype are bred, and the offspring mice thereof are marked as F1; and the F1 mice are analyzed and verified, and the F1 mice with the correct genotype are the prepared CKO/KI animal model.

Abstract: Provided are quinoline derivative compounds of Formulae (I), (II) and (III) with an inhibitory effect on mTOR and applications of their pharmaceutically acceptable salts, their stereoisomers, their hydrates or their solvates in preparation of medicine for preventing and/or treating diseases caused by enteroviruses.

Abstract: The present application falls within the field of medical technology, and in particular relates to the use of 9-[3-(6-amino)-pyridyl]-1-[(3-trifluoromethyl)-phenyl]benzo[h][1,6]naphthyridine-2(1H)-one (Formula I), and a pharmaceutically acceptable salt thereof, a stereoisomer thereof, or a hydrate or a solvate thereof, and a pharmaceutical composition containing the compound, which composition is used for resisting a wide spectrum of viruses, and especially relates to the use thereof for treating enterovirus infections.

Abstract: The present invention relates to a pharmaceutical composition of Tecovirimat for injection, comprising Tecovirimat as an active ingredient, cyclodextrin and an additive. The present invention also relates to a method for preparing the pharmaceutical composition. The composition improves the solubility of Tecovirimat in water by using cyclodextrin and meglumine in combination, as compared with the solubility of Tecovirimat in water by using cyclodextrin or meglumine alone.

Abstract: A device for removing burrs from bolt holes of an aluminum alloy wheel is composed of a frame, a support plate, clamping guide rails, clamping motors, clamping sliders, support rods, clamping wheels, racks, gears, a brush disc, a support sleeve, a feed slide, guide pillars, a feed linear motor, a pitch adjustment linear motor, a conical pitch head, horizontal push rods, sliders, springs, burr brush drive motors and burr brushes. The device can meet the requirements of an automatic production line and can be used for automatically removing burrs from the inner walls of bolt hole countersinks. The device has certain flexibility and can adjust pitch diameter, can be used for removing burrs from bolt hole countersinks having different diameters, and is easy to manufacture, economical, practical and convenient to operate.

Abstract: A power amplifier circuit, a transmitter, and a network device are provided. The power amplifier circuit includes N input ports, N power amplifier branches, one combiner circuit, and one output port. Each of the N input ports is connected to one power amplifier branch, each of the power amplifier branches is connected to the combiner circuit, and the combiner circuit is further connected to the output port; the N power amplifier branches and the combiner circuit are configured to perform power amplification and combining on N input signals, to generate an output signal. The N power amplifier branches include one first power amplifier branch operates in a class AB or class B operating mode, and N?1 second power amplifier branches operate in a class C operating mode with different gate bias voltages, the gate bias voltages of the N?1 second power amplifier branches become lower in order.

Abstract: Related is application of 2,4,5-trisubstituted 1,2,4-triazolones in antiviral therapy, particularly related to use of a compound of formula I in the preparation a medicament, wherein the medicament is used to prevent and/or treat a disease associated with a virus.

Abstract: The present invention relates to a pharmaceutical composition, comprising Tecovirimat, cyclodextrin and an additive, and optionally a pharmaceutically acceptable excipient. The present invention also relates to a method for preparing the pharmaceutical composition. The composition improves the solubility of Tecovirimat in water by using cyclodextrin and meglumine in combination, as compared with the solubility of Tecovirimat in water by using cyclodextrin or meglumine alone.

Abstract: The present application relates to a Favipiravir compound represented by Formula I, a geometric isomer, a pharmaceutically acceptable salt, a solvate and/or a hydrate thereof, and a pharmaceutical composition comprising the compound for treating a coronavirus infection.

Abstract: A shifting device includes a sleeve module and a shifting member movably disposed in the sleeve module. The sleeve module has a through hole. The through hole is divided into a first hole region, a buffering region, and a second hole region. The shifting member includes a third operating section and a fourth operating section. The shifting member is movable between a first position and a second position. The fourth operating section of the shifting member is situated in the buffering region when the shifting member assumes the first position, and the second hole region and the third working hole are adapted to turn a fastening member. The third operating section of the shifting member is situated in the buffering region when the shifting member assumes the second position, and the first hole region and the fourth working hole are adapted to turn the fastening member.

Abstract: A method for network access, a terminal, and a storage medium are provided. The method includes that: the terminal acquires a first frequency band corresponding to a first cell where the terminal camps; determines whether the first frequency band belongs to a second frequency band predetermined by the terminal; and performs handover to a second cell which is different from the first cell in response to determining that the first frequency band does not belong to the second frequency band.

Abstract: Related is application of 2,4,5-trisubstituted 1,2,4-triazolones in antiviral therapy, particularly related to use of a compound of formula I in the preparation a medicament, wherein the medicament is used to prevent and/or treat a disease associated with a virus.

Abstract: The present invention relates to the field of medicinal chemistry, and relates to an ethylenediamine compound represented by Formula A, pharmaceutically acceptable salts, stereoisomers, tautomers or isomer mixtures, hydrates thereof, solvates thereof, or prodrugs thereof, and use thereof in the treatment of tuberculosis.

Abstract: A display controller, comprising a 3D_LUT random access memory, which stores at least a 3D Lookup table; and a display control processing unit, comprising: a computing unit, a register, a color signal booster, and a color signal attenuator; wherein after input color signals are received by the color signal booster, and the color signal booster amplifies color signals by a first predetermined factor, wherein the computing unit calculates the address of the 3D Lookup table, and loads the 3D Lookup table from the 3D_LUT random access memory according to the register, wherein the color signal attenuator attenuates color signals by a second predetermined factor. The present disclosure significantly increases the precision of color conversion from one RGB color space to another RGB color space, and does not increase the RAM cost, since the cost of multiplying or dividing by power of 2, for example, is limited.

Abstract: Disclosed is a fracturing device for extraction of coalbed methane in low permeability reservoir. In the disclosure, by controlling the fracturing of fracturing pipes and the sealing of a segmented sealing mechanism for fracturing using a fracturing controller, the fracturing in fracturing holes can be effectively controlled. The segmented sealing mechanism for fracturing in the disclosure can separate each of the fracturing pipes in the fracturing holes separately in a sealed manner respectively, and perform segmented fracturing operations using each of the fracturing pipes, so as to effectively improve the uniformity and thoroughness of fracturing and ensure fracturing ability. In the disclosure, when the sealing operations are performed in each segment, the sealing effect of each segment can be ensured, and the sealing efficiency can be ensured, so that the fracturing ability of each segment of fracturing is improved to ensure the fracturing effect.

Abstract: Provided is a bi-functional fusion protein as well as its preparation method and use. The bi-functional fusion protein is composed of a monoclonal anti-human CD20 antibody linked to a first extracellular domain of human SIRP?. It is shown in in vitro tests that the bi-functional fusion protein is capable of binding to human CD20 and CD47 simultaneously, thus killing CD20+ tumor cells via antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity, and is also capable of blocking CD47-SIRP? interaction such that macrophages are activated to attack tumor cells, The bi-functional fusion protein has evident anti-tumor activities.

Abstract: A ratchet seat, a ratchet tool head, and a bidirectional ratchet hand tool are disclosed. A handle unit includes an annular groove and a cavity. A positioning ring is stretchably disposed in the annular groove. A first actuating unit and a second actuating unit are elastically placed one over another in the cavity. An outer peripheral surface of a ratchet seat forms a ratchet toothed portion and a positioning groove. The ratchet seat is movable between a first position and a second position in an up-down direction. When the first position is assumed, the positioning groove is slidably moved to engage with the positioning ring, and the first actuating unit meshes with the ratchet toothed portion. When the second position is assumed, the positioning groove disengages from the positioning ring, and the second actuating unit meshes with the ratchet toothed portion.

Abstract: The present disclosure provides a method for evaluating an electronic device. The method comprises determining, with an acoustic tube, a value of a first parameter, the value of the first parameter being indicative of the acoustic impedance of a reference termination. The method further comprises determining, with the acoustic tube, a value of a second parameter, the value of the second parameter being indicative of the acoustic impedance of the reference termination, when occluded by the electronic device. The method then comprises calculating a value of a third parameter, the value of the third parameter being indicative of the acoustic impedance of the electronic device, based on the value of the first parameter and the value of the second parameter.

Abstract: In the present disclosure, by providing a rotary torque sensor and an auxiliary drive mechanism, the drilling drive can be well controlled according to the required torque. For example, when encountering rock formations, the auxiliary drive mechanism can be used for simultaneous driving drilling, and when drilling in soft formations, only by disconnecting the transmission can the operation be completed, so as to effectively reduce energy consumption and improve utilization. In the present disclosure, when a rotary torque is greater than a set value, the controller controls the auxiliary drive mechanism to transmit to the main drive column and drive the main drive column, and when the rotary torque is smaller than or equal to the set value, the controller controls the power transmission between the auxiliary drive mechanism and the main drive column to be disconnected.

Abstract: An electronic component for an electronic device with a locking function and an unlocking method thereof are provided. The unlocking method includes: receiving a first sound extraction request by a first processing circuit when the electronic device is in a locked mode; determining, by the first processing circuit, whether a first voice input signal is received after receiving the first sound extraction request; determining, by the first processing circuit when the first processing circuit receives the first voice input signal, whether first voice data included in the first voice input signal matches first preset voice data; and transmitting, by the first processing circuit, the first voice input signal to the second processing circuit when the first voice data matches the first preset voice data, to trigger the second processing circuit to determine whether second voice data included in the first voice input signal matches second preset voice data.