Abstract: This application discloses a beam scanning apparatus with arrayed rotating mirrors, and the beam scanning apparatus includes a motor (1), a worm (2), a wormgear (3), a mounting rack (4), and a rotating mirror (5), where the worm (2) and the wormgear (3) are located on the mounting rack (4), and engage with each other by using a gear (11) for a linkage connection; the rotating mirror (5) is located in the mounting rack (4), and is coaxially connected to the wormgear (3); and the motor (1) is configured to drive the worm (2) to rotate, to drive the wormgear (3) and the rotating mirror (5) to rotate coaxially. The rotating mirror (5) may be replaced with another rotating mirror (5) with a different structure and a different optical parameter, to adjust output performance of the beam scanning apparatus, thereby improving extensibility.

Abstract: An indoor unit of an air conditioner includes: a bottom shell, at least two air passages (11) are provided abreast in the bottom shell (1); an air passage cover plate (2), provided on the at least two air passages (11) in a covering manner, flow guide openings (21) corresponding to the at least two air passages (11) are provided in the air passage cover plate (2) respectively; at least two centrifugal fans (3), provided in the at least two air passages (11) respectively and provided opposite to the corresponding flow guide openings (21); and an evaporator (4), provided on a side, far away from the bottom shell (1), of the air passage cover plate (2), each of the flow guide openings (21) is provided opposite to the evaporator (4).

Abstract: Disclosed in the present invention is a compound of Formula (I), a geometric or optical isomer, a pharmaceutically acceptable salt, a solvate or a polymorph thereof. Also disclosed in the present invention is a composition comprising the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof. Also disclosed in the present invention is a use of the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof in the treatment of a disease or disorder such as a hypoglutamatergic condition, a neurodegenerative disease or respiratory depression, particularly in the treatment of a disease or disorder associated with AMPA receptor.

Abstract: A bogie wheelset radial mechanism with a structure of adjustable rigidity, composing two secondary frames (21) which are pin-connected via two connecting rods (22) arranged in a crosswise manner. The connecting rods (22) are pin-connected to the secondary frames (21) with round pins (24). Joints between the round pins (24) and the connecting rods (22) and/or joints between the round pins and the secondary frames (21) are provided with replaceable elastic materials. The materials can be made into rings. End portions of the connecting rods (22) are embedded into mounting grooves (25) located in the secondary frames (21) and are connected to the same with the round pins (24).

Abstract: An elasticity changeable structure of a curtain reeling device contains: a main tension wheel, a first drive wheel, an auxiliary tension wheel, and a second drive wheel. The main tension wheel includes a spiral spring rolled on the main tension spring and abutting against the auxiliary tension wheel, and an operation rope are rolled on the first and second drive wheels respectively. The spiral spring includes an elasticity section having a fixed part made in a common curvature, a buffer part made in an increased curvature, a first resisting part made in a decreased curvature, a second resisting part made in a lowest curvature, and a fixing part formed on a distal end of the second resisting part. An elasticity of the second resisting part is more than the first resisting part, and an elasticity of the first resisting part is more than the buffer part.

Abstract: A screen display method includes: determining, in a flexible display screen, a target display region in a display state when a foldable device is in a folded state; acquiring a target brightness difference value of each pixel unit in the target display region according to a position of the pixel unit in the target display region; adjusting a current brightness value of each pixel unit in the target display region according to the target brightness difference value of the pixel unit, to obtain an adjusted brightness value of each pixel unit in the target display region; and performing a screen display according to the adjusted brightness value of each pixel unit in the target display region.

Abstract: Disclosed is a recombinant protein containing 1) an anti-PD-L1 antibody heavy chain and an anti-PD-L1 antibody light chain, which two are linked by a disulfide bond to bind PD-L1, and 2) an extracellular Ig-like domain of a vascular epithelial growth factor receptor (VEGFR), linked via a linker to the N-terminus or C-terminus of the heavy chain or the light chain, wherein the recombinant protein is capable of binding PD-L1, VEGF and Fc receptor simultaneously. Also disclosed are a recombinant antibody containing two recombinant proteins of the disclosure, a polynucleotide encoding the recombinant protein, an expression vector containing the polynucleotide, a method for producing the recombinant protein and a method for treating a disease caused by over expression of VEGF and/or PD-L1 using the recombinant protein.

Abstract: An indoor unit of an air conditioner includes: a bottom shell, at least two air passages (11) are provided abreast in the bottom shell (1); an air passage cover plate (2), provided on the at least two air passages (11) in a covering manner, flow guide openings (21) corresponding to the at least two air passages (11) are provided in the air passage cover plate (2) respectively; at least two centrifugal fans (3), provided in the at least two air passages (11) respectively and provided opposite to the corresponding flow guide openings (21); and an evaporator (4), provided on a side, far away from the bottom shell (1), of the air passage cover plate (2), each of the flow guide openings (21) is provided opposite to the evaporator (4).

Abstract: The present invention relates to a 2,3-epoxy succinyl derivative, a preparation method and a use thereof, in particular, the present invention relates to a compound represented by Formula (1), a racemate or an optical isomer thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof. The compound according to the present invention has good inhibitory activity and/or selectivity against cathepsin, especially Cathepsin B, can be used in the treatment of multiple diseases associated with cathepsin, for example, osteoporosis, rheumatoid arthritis and osteoarthritis that are associated with Cathepsin K, Ebola virus infection, a degenerative disease and an autoimmune disease that are associated with Cathepsin L, S, especially Cathepsin B-related tumor diseases, such as gastric cancer, cervical cancer, lung cancer, breast cancer, prostate cancer, bladder cancer, colon cancer, neuroglioma, and melanoma.

Abstract: The present invention relates to a compound represented by Formula I, a racemate or optical isomer thereof, or a pharmaceutically acceptable salt, a solvate or a hydrate thereof, a pharmaceutical composition comprising the compound, and a use thereof in the manufacture of a medicament for preventing and/or treating a disease or disorder associated with a viral infection.

Abstract: Provided is a bi-functional fusion protein as well as its preparation method and use. The bi-functional fusion protein is composed of a monoclonal anti-human CD20 antibody linked to a first extracellular domain of human SIRP?. It is shown in in vitro tests that the bi-functional fusion protein is capable of binding to human CD20 and CD47 simultaneously, thus killing CD20+ tumor cells via antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity, and is also capable of blocking CD47-SIRP? interaction such that macrophages are activated to attack tumor cells, The bi-functional fusion protein has evident anti-tumor activities.

Abstract: Provided are a supramolecular composite comprising an angiotensin II receptor (AT1) blocking compound, a neutral endopeptidase inhibitor (NEPi), and a pharmaceutically acceptable cation. The invention further provides a method for preparing the composite and an application of the composite for preparing a pharmaceutical product for treating heart failure.

Abstract: The present disclosure provides a recombinant fusion protein containing an extracellular Ig-like domain of a signal-regulator protein (SIRP), linked via a linker, to a paratope of an Ig-like anti-HER2 antibody at the N-terminus of a heavy chain or a light chain constituting the paratope. The present disclosure also provides a polynucleotide encoding the recombinant fusion protein, an expression vector containing the polynucleotide, a method for producing the recombinant protein and a method for treating a disease caused by over-expression of CD47 and/or HER2.

Abstract: The present invention relates to the technical field of pesticides, particularly relates to a pyrazole compound or a salt thereof, a preparation method therefor, a herbicidal composition and use thereof. A pyrazole compound of formula (I) or a salt thereof: wherein, R1 represents hydrogen or C1-C4 alkyl; R2 represents C1-C3 alkyl; R3 represents C1-C6 linear chain or cyclic group containing one or more heteroatoms selected from O, S, and N; R4 represents C1-C3 alkyl or halogen; R5 represents pyrazole ring or pyrazole ring substituted with one or more groups selected from alkyl, alkoxyl, halogen, halogenated alkyl, amino, and nitro. The pyrazole compound is an excellent herbicide with broad spectrum biological activity and outstanding safety for crops.

Abstract: An injectable pharmaceutical composition of a sulfonylurea drug and a preparation method thereof were described. The pharmaceutical composition contains a sulfonylurea drug, a cyclodextrin and an additive.

Abstract: The present invention relates to a pharmaceutical composition, comprising Tecovirimat, cyclodextrin and an additive, and optionally a pharmaceutically acceptable excipient. The present invention also relates to a method for preparing the pharmaceutical composition. The composition improves the solubility of Tecovirimat in water by using cyclodextrin and meglumine in combination, as compared with the solubility of Tecovirimat in water by using cyclodextrin or meglumine alone.

Abstract: The present invention relates to a pharmaceutical composition of Tecovirimat for injection, comprising Tecovirimat as an active ingredient, cyclodextrin and an additive. The present invention also relates to a method for preparing the pharmaceutical composition. The composition improves the solubility of Tecovirimat in water by using cyclodextrin and meglumine in combination, as compared with the solubility of Tecovirimat in water by using cyclodextrin or meglumine alone.

Abstract: The present application discloses a portable curtain cutter assembly comprising a base and a portable cutter. The base comprises a supporting plate; a side wall; and a slider. The side all is coupled to the supporting plate and comprises a first groove. The slider is slidably coupled to the side wall through the first groove, wherein the slider comprises a slot. The portable cutter comprises a blade, wherein the blade is capable of being inserted partially into the slot. A method or using the aforementioned portable curtain cutter assembly is also disclosed.

Abstract: The present disclosure provides a terminal, a method for controlling a terminal, a method for manufacturing a terminal, and a storage medium. The terminal may include a housing. A side of the housing may have a button hole. A physical button may be provided at the button hole. The side of the housing may be further provided with a fingerprint recognition region surrounding the button hole.