Patents by Inventor Song Li

Song Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANGIOTENSIN II RECEPTOR ANTAGONIST METABOLITE AND NEP INHIBITOR COMPOSITE AND PREPARATION METHOD THEREOF
    Publication number: 20200061025
    Abstract: Provided are a supramolecular composite comprising an angiotensin II receptor (AT1) blocking compound, a neutral endopeptidase inhibitor (NEPi), and a pharmaceutically acceptable cation. The invention further provides a method for preparing the composite and an application of the composite for preparing a pharmaceutical product for treating heart failure.
    Type: Application
    Filed: January 19, 2017
    Publication date: February 27, 2020
    Inventors: Jie YAN, Wenjie XU, Jianqiong ZHI, Song LI, Yang WANG, Yanxin ZHENG
  • RECOMBINANT BIFUNCTIONAL PROTEIN TARGETING CD47 AND HER2
    Publication number: 20200048364
    Abstract: The present disclosure provides a recombinant fusion protein containing an extracellular Ig-like domain of a signal-regulator protein (SIRP), linked via a linker, to a paratope of an Ig-like anti-HER2 antibody at the N-terminus of a heavy chain or a light chain constituting the paratope. The present disclosure also provides a polynucleotide encoding the recombinant fusion protein, an expression vector containing the polynucleotide, a method for producing the recombinant protein and a method for treating a disease caused by over-expression of CD47 and/or HER2.
    Type: Application
    Filed: August 8, 2019
    Publication date: February 13, 2020
    Inventors: Wenzhi Tian, Song Li
  • Pyrazole compounds or salts thereof, preparation methods therefor, herbicidal compositions and use thereof
    Patent number: 10556888
    Abstract: The present invention relates to the technical field of pesticides, particularly relates to a pyrazole compound or a salt thereof, a preparation method therefor, a herbicidal composition and use thereof. A pyrazole compound of formula (I) or a salt thereof: wherein, R1 represents hydrogen or C1-C4 alkyl; R2 represents C1-C3 alkyl; R3 represents C1-C6 linear chain or cyclic group containing one or more heteroatoms selected from O, S, and N; R4 represents C1-C3 alkyl or halogen; R5 represents pyrazole ring or pyrazole ring substituted with one or more groups selected from alkyl, alkoxyl, halogen, halogenated alkyl, amino, and nitro. The pyrazole compound is an excellent herbicide with broad spectrum biological activity and outstanding safety for crops.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: February 11, 2020
    Assignee: QINGDAO KINGAGROOT CHEMICAL COMPOUNDS CO., LTD.
    Inventors: Lei Lian, Yurong Zheng, Song Li, Xuegang Peng, Tao Jin, Qi Cui
  • A PHARMACEUTICAL COMPOSITION COMPRISING A SULFONYLUREA DRUG AND PREPARATION METHOD THEREOF
    Publication number: 20200022993
    Abstract: An injectable pharmaceutical composition of a sulfonylurea drug and a preparation method thereof were described. The pharmaceutical composition contains a sulfonylurea drug, a cyclodextrin and an additive.
    Type: Application
    Filed: December 13, 2017
    Publication date: January 23, 2020
    Inventors: Wu ZHONG, Chunsheng GAO, Wei GONG, Song LI, Hongyu CHEN
  • Oral Pharmaceutical Composition of Tecovirimat and Preparation Method Thereof
    Publication number: 20190358203
    Abstract: The present invention relates to a pharmaceutical composition, comprising Tecovirimat, cyclodextrin and an additive, and optionally a pharmaceutically acceptable excipient. The present invention also relates to a method for preparing the pharmaceutical composition. The composition improves the solubility of Tecovirimat in water by using cyclodextrin and meglumine in combination, as compared with the solubility of Tecovirimat in water by using cyclodextrin or meglumine alone.
    Type: Application
    Filed: July 4, 2017
    Publication date: November 28, 2019
    Applicant: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L..A. China
    Inventors: Wu ZHONG, Meiyan YANG, Wei GONG, Yuli WANG, Chunsheng GAO, Xinbo ZHOU, Song LI
  • Injectable Pharmaceutical Composition of Tecovirimat and Preparation Method Thereof
    Publication number: 20190336479
    Abstract: The present invention relates to a pharmaceutical composition of Tecovirimat for injection, comprising Tecovirimat as an active ingredient, cyclodextrin and an additive. The present invention also relates to a method for preparing the pharmaceutical composition. The composition improves the solubility of Tecovirimat in water by using cyclodextrin and meglumine in combination, as compared with the solubility of Tecovirimat in water by using cyclodextrin or meglumine alone.
    Type: Application
    Filed: July 4, 2017
    Publication date: November 7, 2019
    Inventors: Wu Zhong, Meiyan Yang, Wei Gong, Yuli Wang, Chunsheng Gao, Xinbo Zhou, Song Li
  • PORTABLE CURTAIN CUTTER ASSEMBLY AND METHOD FOR USING THEREOF
    Publication number: 20190330793
    Abstract: The present application discloses a portable curtain cutter assembly comprising a base and a portable cutter. The base comprises a supporting plate; a side wall; and a slider. The side all is coupled to the supporting plate and comprises a first groove. The slider is slidably coupled to the side wall through the first groove, wherein the slider comprises a slot. The portable cutter comprises a blade, wherein the blade is capable of being inserted partially into the slot. A method or using the aforementioned portable curtain cutter assembly is also disclosed.
    Type: Application
    Filed: June 29, 2018
    Publication date: October 31, 2019
    Inventor: Song Li
  • TERMINAL, METHOD FOR CONTROLLING TERMINAL, METHOD FOR MANUFACTURING TERMINAL, AND STORAGE MEDIUM
    Publication number: 20190325187
    Abstract: The present disclosure provides a terminal, a method for controlling a terminal, a method for manufacturing a terminal, and a storage medium. The terminal may include a housing. A side of the housing may have a button hole. A physical button may be provided at the button hole. The side of the housing may be further provided with a fingerprint recognition region surrounding the button hole.
    Type: Application
    Filed: February 15, 2019
    Publication date: October 24, 2019
    Inventors: Anyu LIU, Zhongsheng Jiang, Song Li
  • TOPOLOGICAL MAP GENERATION APPARATUS FOR NAVIGATION OF ROBOT AND METHOD THEREOF
    Publication number: 20190310653
    Abstract: Disclosed herein are an apparatus and method for generating a topological map for navigation of a robot. The method for generating a topological map for navigation of a robot, performed by the apparatus for building the topological map for the navigation of the robot, includes calculating the physical size of a single pixel on a metric map of a space in which a mobile robot is to navigate, extracting the physical coordinates of the pixel on the metric map, building node data and edge data for the navigation of the mobile robot using the physical coordinates, and generating a topological map for the navigation of the mobile robot based on the built node data and the built edge data.
    Type: Application
    Filed: April 3, 2019
    Publication date: October 10, 2019
    Applicant: Electronics and Telecommunications Research Institute
    Inventors: Yu-Cheol LEE, Won-Pil YU, Song LI
  • Lifting device for vehicle tailgate and driving device thereof
    Patent number: 10400499
    Abstract: A driving device includes an electric motor including a stator and a rotor rotatable relative to the stator, and a gear train connected to the rotor. The stator includes a cylindrical housing and an endcap mounted to an end of the housing; The gear train includes a gear mechanism with at least one stage, which includes a ring gear, a sun gear, planetary gears and a carrier. The ring gear is directly engaged with the endcap, which limits the position of the planetary gears of the gear train in an axial direction of the gear train.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: September 3, 2019
    Assignee: JOHNSON ELECTRIC INTERNATIONAL AG
    Inventors: Dennis Francis Gorosin, Xue Song Li, Man Ino Cheong
  • Formulations and carrier systems including farnesylthiosalicylic moieties
    Patent number: 10376591
    Abstract: A formulation includes a carrier agent formed by conjugating at least one biologically active hydrophobic compound with at least one hydrophilic compound, the at least one biologically active hydrophobic compound selected from the group of farnesylthiosalicylic acid and a derivative of farnesylthiosalicylic acid which is biologically active as an RAS antagonist, wherein a plurality of the carrier agents are adapted to assemble into a structure and the at least one biologically active hydrophobic compound is conjugated with the at least one hydrophilic compound via a linkage which is labile in vivo, and a biologically active compound associated with the carrier agent.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: August 13, 2019
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Song Li, Yixian Huang, Xiaolan Zhang, Xiang Gao
  • NOVEL PIPERIDINE CARBOXAMIDE COMPOUND, PREPARATION METHOD, AND USE THEREOF
    Publication number: 20190233390
    Abstract: The present invention provides a compound of a general formula I, a stereomeride, pharmaceutically acceptable salt or a solvate thereof, a preparation method thereof, and usages in preparing medicines for preventing and/or treating diseases or symptoms caused by drug-resistant tumors or drug-resistant bacteria and in preparing medicines for preventing and/or treating diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection. Preferably, the diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection are diseases or symptoms caused by a heat shock protein 70 (Hsp70). The compound in the present invention is used for overcoming a difficult problem of drug resistance of tumors, improves the effect of tumor treatment, and provides a new medical strategy for clinical tumor treatment.
    Type: Application
    Filed: April 9, 2019
    Publication date: August 1, 2019
    Applicant: Institute of Pharmacology and Toxicology Academy of Millitary Medical Sciences P.L.A. China
    Inventors: Wu ZHONG, Song Li, Yanqun Zeng, Junhai Xiao, Xinbo Zhou, Zhibing Zheng, Xingzhou Li, Xiaokui Wang
  • THIAZOLE INNER SALT COMPOUNDS, AND PREPARATION METHODS AND USES THEREOF
    Publication number: 20190233383
    Abstract: The present invention pertains to field of pharmaceutical chemicals, and relates to thiazole inner salt compounds, preparation methods and uses thereof. Specifically, the present invention relates to a compound of Formula I, hydrates or pharmaceutically acceptable salts thereof. The compound of Formula I of the present invention is a potent cross-linking protein cleavage agent, has a stable structure, good physical and chemical properties, and good pharmacological activities, and is suitable for large scale production to obtain samples with stable, controllable and reliable quality, thereby being suitable for pharmaceutical development.
    Type: Application
    Filed: April 12, 2019
    Publication date: August 1, 2019
    Applicant: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
    Inventors: Song LI, Wu ZHONG, Shuang CAO, Lili WANG, Zhibing ZHENG, Junhai XIAO, Xinbo ZHOU
  • INTRAESOPHAGEAL ADMINISTRATION OF TARGETED NITROXIDE AGENTS FOR PROTECTION AGAINST IONIZING IRRADIATION-INDUCED ESOPHAGITIS
    Publication number: 20190210969
    Abstract: Provided herein are compositions and related methods useful for prevention or mitigation of ionizing radiation-induced esophagitis. The compositions comprise compounds comprising a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent or mitigate esophageal damage caused by radiation.
    Type: Application
    Filed: January 4, 2019
    Publication date: July 11, 2019
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Michael W. Epperly, Xiang Gao, Joel S. Greenberger, Song Li, Peter Wipf
  • Thiazideamide derivative and use thereof
    Patent number: 10335417
    Abstract: The invention belongs to the technical field of medicines. In particular, the invention relates to a thiazideamide derivative compound or a pharmaceutically acceptable salt or solvate thereof, a pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt or solvate thereof, a method for preparing the compound or a pharmaceutically acceptable salt or solvate thereof, and a use of the compound or a pharmaceutically acceptable salt or solvate thereof. For example, the compound or a pharmaceutically acceptable salt or solvate thereof according to the invention can be used to prevent and/or treat a neurodegenerative disease or a neuropathic disease caused by a physical trauma or a related disease.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: July 2, 2019
    Assignee: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
    Inventors: Song Li, Junhai Xiao, Boqun Lyu, Hongqiang Wang, Wu Zhong, Lili Wang, Zhibing Zheng, Yunde Xie, Xinbo Zhou, Xingzhou Li, Xiaokui Wang
  • Marking method and device, and repair system for display panel
    Patent number: 10328717
    Abstract: The present disclosure relates to a marking method and device, and a repair system for a display panel in the field of display panel detection. The marking device includes: magnifying component and a marking component. The magnifying component is configured to magnify a target position point on a target object, and the marking component is configured to mark the target position point on the target object in accordance with the magnified target position point. The present disclosure may solve the problem that the operation process of marking the defective position point is complicated and simplify the operation process of marking the defective position point. The present disclosure may mark the defects of the display panel.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: June 25, 2019
    Assignees: BOE TECHNOLOGY GROUP CO., LTD., CHENGDU BOE OPTOELECTRONICS TECHNOLOGY CO., LTD.
    Inventors: Zijian Zheng, Zemin Wu, Junyang Xiao, Zhihui Yang, Xicong Li, Song Li, Bo Wang, Wei Guo
  • Piperidine carboxamide compound, preparation method, and use thereof
    Patent number: 10301279
    Abstract: The present invention provides a compound of a general formula I, a stereomeride, pharmaceutically acceptable salt or a solvate thereof, a preparation method thereof, and usages in preparing medicines for preventing and/or treating diseases or symptoms caused by drug-resistant tumors or drug-resistant bacteria and in preparing medicines for preventing and/or treating diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection. Preferably, the diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection are diseases or symptoms caused by a heat shock protein 70 (Hsp70). The compound in the present invention is used for overcoming a difficult problem of drug resistance of tumors, improves the effect of tumor treatment, and provides a new medical strategy for clinical tumor treatment.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: May 28, 2019
    Assignee: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
    Inventors: Wu Zhong, Song Li, Yanqun Zeng, Junhai Xiao, Xinbo Zhou, Zhibing Zheng, Xingzhou Li, Xiaokui Wang
  • Lithium secondary battery
    Patent number: 10290848
    Abstract: The present application relates to the field of energy storage devices, in particular to a lithium secondary battery.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: May 14, 2019
    Assignees: DONGGUAN AMPEREX TECHNOLOGY LIMITED, NINGDE AMPEREX TECHNOLOGY LIMITED
    Inventors: Minmin Zou, Song Li, Dengjun Ai
  • Reversible ratchet wrench without switch knob
    Patent number: 10279458
    Abstract: A reversible ratchet wrench without a switch knob has a handle portion and a head portion. The head portion has an accommodation trough, a detent trough, and a blind hole. A ratchet wheel is disposed in the accommodation trough and displaceable in the accommodation trough toward the handle portion to form a first position and a second position. A detent is disposed in the detent trough. Left and right sides of one surface of the detent are formed with push portions, respectively. An elastic member is disposed in the blind hole and pressed against one of the push portions. For a reverse switch, the ratchet wheel is displaced to the second position and then the ratchet wheel is turned, so that the elastic member is pressed against the other push portion.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: May 7, 2019
    Assignee: HUA WEI TOOLS CO., LTD.
    Inventor: Zhong-Song Li
  • NOVEL RECOMBINANT FUSION PROTEINS, PREPARATION AND USE THEREOF
    Publication number: 20190125834
    Abstract: The present invention provides a recombinant fusion protein containing an anti-PD-L1 antibody, with at least one paratope of the anti-PD-L1 antibody linked via a linker to an extracellular Ig-like domain of a signal-regulator protein (SIRP) at N-terminus of a heavy chain or a light chain, wherein the recombinant fusion protein can bind to CD47, PD-L1 and FcR simultaneously. The present invention also provides a polynucleotide encoding the recombinant fusion protein, an expression vector containing the polynucleotide, a method for producing the recombinant protein and a method for treating a disease caused by over expression of CD47 and/or PD-L1 using the recombinant protein.
    Type: Application
    Filed: October 24, 2018
    Publication date: May 2, 2019
    Inventors: Wenzhi TIAN, Song LI