Patents by Inventor Song Xue

Song Xue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210323951
    Abstract: The present disclosure relates to novel processes for the preparation of compounds useful as stimulators of soluble guanylate cyclase (sGC). These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyrazoles of Formula (I), including Compound (I), in high purity and yields. The present invention has the additional advantage of facile reaction conditions, amenable to scale up for large scale manufacturing. The disclosure also provides novel intermediates useful in the preparation of said compounds.
    Type: Application
    Filed: July 6, 2017
    Publication date: October 21, 2021
    Inventors: Song XUE, Vishnu Vardhan Reddy KARNATI, Robert C. LIVINGSTON
  • Publication number: 20210284632
    Abstract: The present disclosure relates to novel processes for the preparation of compounds useful as stimulators of soluble guanylate cyclase (sGC). These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyrazoles of Formula (I), including Compound (I), Compound (IA) and Compound (IB), in high purity and yields. The present invention has the additional advantage of facile reaction conditions, amenable to scale up for large scale manufacturing. The disclosure also provides novel intermediates useful in the preparation of said compounds.
    Type: Application
    Filed: July 6, 2017
    Publication date: September 16, 2021
    Inventors: Song Xue, Vishnu Vardhan Reddy Karnati, Robert C. Livingston, Timothy Claude Barden, Wayne C. Schairer
  • Publication number: 20210188830
    Abstract: The present disclosure relates to crystalline solid forms of a stimulator of soluble guanylate cyclase (sGC), Compound I. Also provided herein are methods for the preparation of these solid forms. The invention also relates to pharmaceutical formulations and dosage forms comprising these solid forms and their uses thereof, alone or in combination with one or more additional agents, for treating and/or preventing various diseases or disorders; these diseases or disorders are ones that may benefit from sGC stimulation or from an increase in the concentration of nitric oxide (NO) and/or cyclic guanosine monophosphate (cGMP).
    Type: Application
    Filed: December 29, 2020
    Publication date: June 24, 2021
    Inventors: Vasu Sethuraman, Ahmad Hashash, Song Xue, Robert C. Livingston, Kwame Wiredu Nti-Addae
  • Publication number: 20210053962
    Abstract: The present disclosure relates to novel processes for the preparation of compounds of Formula I. Some of these compounds are useful as simulators of soluble guanylate cyclase (sGC). Others are useful intermediates towards the preparation of said simulators. These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyrazoles of Formula I in high purity and yields. The present invention has the additional advantage of facile reaction conditions, amenable to scale up for large scale manufacturing. The disclosure also provides novel intermediates useful in the preparation of said compounds.
    Type: Application
    Filed: January 10, 2019
    Publication date: February 25, 2021
    Inventors: Debra Jane Wallace, Fenger Zhou, Yuguang Wang, Takashi Nakai, Vishnu Vardhan Reddy Karnati, Wayne C. Schairer, William Kissel, Song Xue, Ahmad Hashash
  • Publication number: 20210017160
    Abstract: This invention relates to deuterated compounds of Formula I, and pharmaceutically acceptable salts thereof. or a pharmaceutically acceptable salt thereof, wherein each of Y1, Y2, Y3, Y4, Y5a, Y5b, Y6, Y7, Y8, Y9, Y10, Y11a and Y11b is independently selected from hydrogen and deuterium, as well as pharmaceutical compositions, methods and uses thereof.
    Type: Application
    Filed: July 14, 2020
    Publication date: January 21, 2021
    Inventors: Thomas Wai-Ho Lee, Song Xue, Vishnu Vardhan Reddy Karnati, Debra Jane Wallace
  • Publication number: 20210017161
    Abstract: This invention relates to deuterated compounds of Formula I, and pharmaceutically acceptable salts thereof. or a pharmaceutically acceptable salt thereof, wherein each of Y1, Y2, Y3, Y4, Y5a, Y5b, Y6, Y7, Y8, Y9, Y10, Y11a, Y11b, Y12a and Y12b is independently selected from hydrogen and deuterium, as well as pharmaceutical compositions, methods and uses thereof.
    Type: Application
    Filed: July 14, 2020
    Publication date: January 21, 2021
    Inventors: Thomas Wai-Ho Lee, Song Xue, Vishnu Vardhan Reddy Karnati, Debra Jane Wallace
  • Patent number: 10889577
    Abstract: The present disclosure relates to crystalline solid forms of a stimulator of soluble guanylate cyclase (sGC), Compound I: Also provided herein are methods for the preparation of these solid forms. The invention also relates to pharmaceutical formulations and dosage forms comprising these solid forms and their uses thereof, alone or in combination with one or more additional agents, for treating and/or preventing various diseases or disorders; these diseases or disorders are ones that may benefit from sGC stimulation or from an increase in the concentration of nitric oxide (NO) and/or cyclic guanosine monophosphate (cGMP).
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: January 12, 2021
    Assignee: Cyclerion Therapeutics, Inc.
    Inventors: Vasu Sethuraman, Ahmad Hashash, Song Xue, Robert C. Livingston, Kwame Wiredu Nti-Addae
  • Publication number: 20200325903
    Abstract: Turbomachines such as air dynamometers are disclosed that include a radial outflow compressor and gas collector. In some examples, the gas collector is designed as a separate component that is coupled to the machine, such as coupled to a frame. In some examples, the collector and frame are intentionally spaced and coupled at discrete points to minimize the transfer of mechanical and thermal energy therebetween. Aspects of the present disclosure also include turbomachines that include at least one impeller bypass flow path for the direct transfer of air between ambient and a location in the collector downstream of the impeller blades. In some examples, such flowpath(s) may allow for the inflow of external ambient air into the collector.
    Type: Application
    Filed: June 24, 2020
    Publication date: October 15, 2020
    Inventors: Kevin Fairman, Song Xue
  • Patent number: 10594973
    Abstract: An image sensor architecture with multi-bit sampling is implemented within an image sensor system. A pixel signal produced in response to light incident upon a photosensitive element is converted to a multiple-bit digital value representative of the pixel signal. If the pixel signal exceeds a sampling threshold, the photosensitive element is reset. During an image capture period, digital values associated with pixel signals that exceed a sampling threshold are accumulated into image data.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: March 17, 2020
    Assignee: Rambus Inc.
    Inventors: Thomas Vogelsang, Michael Guidash, Song Xue, James E. Harris
  • Patent number: 10581230
    Abstract: A method of manufacturing a cold shrinkable termination for an electric power cable that includes an insulation tube and stress control glue. An electric power cable is provided having an exposed end including: a conductor core having an exposed portion and an unexposed portion; an insulation layer having an exposed portion and an unexposed portion covering the unexposed portion of conductor core; a semi-conductive shield layer having an exposed portion and an unexposed portion covering the unexposed portion of the insulation layer; a metal shield layer having an exposed portion and an unexposed portion covering the unexposed portion of the semi-conductive shield layer; and an outer protection layer covering the unexposed portion of the metal shield layer. A cold shrinkable termination is provided including: an insulation tube; a stress control glue; and, a support tube. The stress control glue is coated along a selected segment of an inner wall of the insulation tube.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: March 3, 2020
    Assignee: Tyco Electronics (Shanghai) Co. Ltd.
    Inventors: Yugang Li, Lizhang Yang, Haowei Yang, Peng Li, Song Xue
  • Patent number: 10554034
    Abstract: A cold shrinkable terminal comprises a terminal body fixed to a cable joint disposed at an end of the cable and a composite void filling mastic. The cable joint includes a conductor core, an inner insulation layer disposed on the conductor core, and a conductive shielding layer disposed on the inner insulation layer. The composite void filling mastic covers an incision of the conductive shielding layer and includes a filling layer in contact with the cable joint and a separating layer disposed between the filling layer and the terminal body. The separating layer is made of a material different than the terminal body.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: February 4, 2020
    Assignee: Tyco Electronics (Shanghai) Co. Ltd.
    Inventors: Yugang Li, Lizhang Yang, Peng Li, Song Xue
  • Patent number: 10412812
    Abstract: A street lamp controller comprises a switch configured to turn on and turn off a street lamp, a control module adapted to control the turning on and turning off of the switch, a detection module adapted to detect a data element relevant to operation of the street lamp, a data acquisition module connected to the detection module and adapted to acquire the data element detected by the detection module, and a wireless transmission module. The wireless transmission module communicates with a server and is adapted to transmit the data element acquired by the data acquisition module to the server and receive a control instruction sent from the server. The control module is adapted to communicate with the server via the wireless transmission module and is adapted to control the street lamp based on the control instruction received by the wireless transmission module.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: September 10, 2019
    Assignees: Tyco Electronics (Shanghai) Co. Ltd., TE Connectivity Australia Pty Ltd
    Inventors: Song Xue, Lizhang Yang, Michael John Baker, Andrew Jay Thompson
  • Patent number: 10321078
    Abstract: A hybrid bonded image sensor has a photodiode die with macrocells having at least one photodiode and a bond contact; a supporting circuitry die with multiple supercells, each supercell having at least one macrocell unit bonded to the bond contact of a macrocell of the photodiode die. Each macrocell unit has a reset transistor adapted to reset photodiodes of the photodiode die macrocell. Each supercell has a differential amplifier configurable to receive a noninverting input from a photodiode and an inverting input, the differential amplifier providing an output, each differential amplifier has an amplifier reset transistor coupled to the differential amplifier output and the inverting input; a first capacitor coupled between the differential amplifier output and the inverting input, and a second capacitor coupled between the inverting input and a signal ground. The first and second capacitor of embodiments has controllable capacitance to adjust gain.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: June 11, 2019
    Assignee: OmniVision Technologies, Inc.
    Inventor: Song Xue
  • Publication number: 20190169179
    Abstract: The present disclosure relates to crystalline solid forms of a stimulator of soluble guanylate cyclase (sGC), Compound I. Also provided herein are methods for the preparation of these solid forms. The invention also relates to pharmaceutical formulations and dosage forms comprising these solid forms and their uses thereof alone or in combination with one or more additional agents, for treating and/or preventing various diseases or disorders; these diseases or disorders are ones that may benefit from sGC stimulation or from an increase in the concentration of nitric oxide (NO) and/or cyclic guanosine monophosphate (cGMP).
    Type: Application
    Filed: July 6, 2017
    Publication date: June 6, 2019
    Inventors: Vasu Sethuraman, Ahmad Hashash, Song Xue, Robert C. Livingston, Kwame Wiredu Nti-Addae
  • Patent number: 10266529
    Abstract: The present invention provides crystalline Forms FUM-P3, FUM-P4, MLA-P3 and MLA-P4 of compound formula 1 and related methods of treating and/or preventing a disease, such as a central nervous system disease (e.g., an anxiety disorder), using a crystalline Form FUM-P3, FUM-P4, MLA-P3 and MLA-P4 of compound formula 1 and/or pharmaceutical compositions thereof.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: April 23, 2019
    Assignees: Bionomics Limited, Ironwood Pharmaceuticals, Inc.
    Inventors: Bernard Luke Flynn, Dharam Paul, Andrew John Harvey, Vasu V. Sethuraman, Raymond E. Forslund, Song Xue, Rob Livingston, Ahmad Hashash
  • Publication number: 20190027907
    Abstract: A method of manufacturing a cold shrinkable termination for an electric power cable that includes an insulation tube and stress control glue. An electric power cable is provided having an exposed end including: a conductor core having an exposed portion and an unexposed portion; an insulation layer having an exposed portion and an unexposed portion covering the unexposed portion of conductor core; a semi-conductive shield layer having an exposed portion and an unexposed portion covering the unexposed portion of the insulation layer; a metal shield layer having an exposed portion and an unexposed portion covering the unexposed portion of the semi-conductive shield layer; and an outer protection layer covering the unexposed portion of the metal shield layer. A cold shrinkable termination is provided including: an insulation tube; a stress control glue; and, a support tube. The stress control glue is coated along a selected segment of an inner wall of the insulation tube.
    Type: Application
    Filed: September 26, 2018
    Publication date: January 24, 2019
    Applicant: Tyco Electronics (Shanghai) Co. Ltd.
    Inventors: Yugang Li, Lizhang Yang, Haowei Yang, Peng Li, Song Xue
  • Patent number: 10136090
    Abstract: An image sensor architecture with multi-bit sampling is implemented within an image sensor system. A pixel signal produced in response to light incident upon a photosensitive element is converted to a multiple-bit digital value representative of the pixel signal. If the pixel signal exceeds a sampling threshold, the photosensitive element is reset. During an image capture period, digital values associated with pixel signals that exceed a sampling threshold are accumulated into image data.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 20, 2018
    Assignee: Rambus Inc.
    Inventors: Thomas Vogelsang, Michael Guidash, Song Xue, Maxim Smirnov, Craig M. Smith, Jay Endsley, James E. Harris
  • Patent number: 10116125
    Abstract: A cold shrinkable termination for an electric power cable that includes an insulation tube and stress control glue. When the cold shrinkable termination is mounted on the electric power cable, the stress control glue fills a gap between the electric power cable and the insulation tube so as to prevent local electric field concentration from occurring at an exposed end of the electric power cable. The stress control glue has a dielectric constant within a range of 5 to 100. In this cold shrinkable termination, a stress control glue with high dielectric constant is provided to optimize the electric-field distribution on an insulation surface of the electric power cable. Thereby, the structure of the cold shrinkable termination is simplified and the cost thereof is reduced. The cold shrinkable termination may be adapted to an electric power cable used to transmit voltage less than 26/35 kV.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: October 30, 2018
    Assignee: Tyco Electronics (Shanghai) Co. Ltd.
    Inventors: Yugang Li, Lizhang Yang, Haowei Yang, Peng Li, Song Xue
  • Publication number: 20180295703
    Abstract: A street lamp controller comprises a switch configured to turn on and turn off a street lamp, a control module adapted to control the turning on and turning off of the switch, a detection module adapted to detect a data element relevant to operation of the street lamp, a data acquisition module connected to the detection module and adapted to acquire the data element detected by the detection module, and a wireless transmission module. The wireless transmission module communicates with a server and is adapted to transmit the data element acquired by the data acquisition module to the server and receive a control instruction sent from the server. The control module is adapted to communicate with the server via the wireless transmission module and is adapted to control the street lamp based on the control instruction received by the wireless transmission module.
    Type: Application
    Filed: June 11, 2018
    Publication date: October 11, 2018
    Applicants: Tyco Electronics (Shanghai) Co. Ltd., TE Connectivity Australia Pty Ltd
    Inventors: Song Xue, Lizhang Yang, Michael John Baker, Andrew Jay Thompson
  • Publication number: 20180262704
    Abstract: A hybrid bonded image sensor has a photodiode die with macrocells having at least one photodiode and a bond contact; a supporting circuitry die with multiple supercells, each supercell having at least one macrocell unit bonded to the bond contact of a macrocell of the photodiode die. Each macrocell unit has a reset transistor adapted to reset photodiodes of the photodiode die macrocell. Each supercell has a differential amplifier configurable to receive a noninverting input from a photodiode and an inverting input, the differential amplifier providing an output, each differential amplifier has an amplifier reset transistor coupled to the differential amplifier output and the inverting input; a first capacitor coupled between the differential amplifier output and the inverting input, and a second capacitor coupled between the inverting input and a signal ground. The first and second capacitor of embodiments has controllable capacitance to adjust gain.
    Type: Application
    Filed: May 14, 2018
    Publication date: September 13, 2018
    Inventor: Song XUE