Abstract: The disclosure provides to CRISPR/Cas systems and compositions which target the dystrophin gene. Also provided are methods for using the CRISPR/Cas systems, vectors and compositions in methods for genome engineering to correct a mutant dystrophin gene, and for treating Duchenne muscular dystrophy.

Abstract: An image capturing method includes: obtaining a video frame during capturing images through a camera; extracting a target histogram feature based on the video frame; inputting the target histogram feature into an image quality recognition model which is used to determine whether an image is fuzzy based on a histogram feature, and outputting an image quality recognition result of the video frame; and in response to the image quality recognition result indicating that the video frame is fuzzy, prompting the user to clean the camera.

Abstract: Embodiments of the disclosure provide systems and methods for detecting an intracerebral hemorrhage (ICH). The system includes a communication interface configured to receive a sequence of image slices and an end-to-end multi-task learning model. The sequence of image slices is the head scan images of a subject acquired by an image acquisition device. The end-to-end multi-task learning model includes an encoder, a bi-directional Convolutional Recurrent Neural Network (ConvRNN), a decoder, and a classifier. The system further includes at least one processor configured to extract feature maps from each image slice using the encoder, capture contextual information between adjacent image slices using the bi-directional ConvRNN, and detect the ICH of the subject using the classifier based on the extracted feature maps of the image slices and the contextual information or segment each image slice using the decoder to obtain an ICH region based on the extracted feature maps of the image slice.

Abstract: The present disclosure relates to a method for driving an organic light emitting display device, a driving controller, and a display device. When startup detection is required to be performed on the display compensation parameter of the organic light emitting display device, the startup detection is performed on the display compensation parameter of the organic light emitting display device to obtain a new compensation parameter value, and startup compensation display is performed based on the new compensation parameter value. When shutdown detection is required to be performed on the display compensation parameter of the organic light emitting display device, the shutdown detection is performed on the organic light emitting display device to obtain an updated compensation parameter value, and the updated compensation parameter value is stored.

Abstract: Disclosed by the present invention are an antibody targeting CTLA-4, a preparation method therefor and a use thereof. In particular, disclosed by the present invention is a novel fully human monoclonal antibody that targets CTLA-4. Further disclosed by the present invention is a method for preparing the monoclonal antibody. The monoclonal antibody of the present invention is capable of binding a CTLA-4 antigen with high specificity, has a high affinity, remarkable anti-tumor activity, and so on.

Abstract: The disclosure provides a speech control method, a speech control apparatus, an electronic device, and a storage medium. The method includes: acquiring target audio data sent by a client, the target audio data including audio data collected by the client within a target duration before wake-up and audio data collected by the client after wake-up; performing speech recognition on the target audio data; and controlling the client based on an instruction recognized from a second audio segment of the target audio data in response to recognizing a wake-up word from a first audio segment at beginning of the target audio data; in which, the second audio segment is later than the first audio segment or has an overlapping portion with the first audio segment.

Abstract: One embodiment provides a method, including: identifying, using one or more sensors, an orientation of a wearable device; determining, using a processor, whether the orientation corresponds to an inactive orientation; and providing, responsive to determining that the orientation corresponds to the inactive orientation, a power off notification to a user of the wearable device. A method, including: detecting, using an audio capture device operatively coupled to a wearable device, environmental audio, wherein the wearable device is an augmented reality device; identifying, using a processor, augmented reality contents presented on a display of the wearable device; determining, using a processor, whether the environmental audio and the augmented reality contents correspond to a similar context; and presenting, responsive to determining that the environmental audio and the augmented reality contents do not correspond to the similar context, a power save option to a user. Other aspects are described and claimed.

Abstract: A pill cutter and a method for using thereof are provided. The pill cutter includes: a bottom case; a pressing plate provided with a blade and a shield plate provided with a slit. When the pressing plate rotates relative to the bottom case, the blade at least has a protected state and a pill-cutting state, in the protected state, the blade is positioned between the shield plate and the pressing plate after the two plates are separated from each other, and in the pill-cutting state, the blade passes through the slit and reaches the bottom case. The blade can be shielded automatically when the pill cutler is opened for putting the pill in, and safety of using the pill cutter is largely enhanced.

Abstract: The present application discloses a method for compensating data voltages in a display apparatus. The method for individually compensating a data voltage to be applied to one of the multiple pixel circuits in the display apparatus. The method includes obtaining a threshold voltage of the driving transistor in the one of the multiple pixel circuits. Additionally, the method includes applying a testing voltage to a gate electrode of the driving transistor for charging the sense line up to a first time period to determine a first monitoring voltage associated with the sense line. The testing voltage is set to be a sum of the threshold voltage and a first setting voltage. Moreover, the method includes compensating a data voltage to be applied to the one of the multiple pixel circuits based on the first monitoring voltage and the threshold voltage.

Abstract: One embodiment provides a method, including: initiating, using at least one camera of an information handling device, a video feed; receiving marking input on an object in the video feed; identifying, using at least one distance sensor of the information handling device, distance information from the information handling device to the object; and providing, in the video feed and presented concurrently with the marking input, a visual overlay of the distance information. Other aspects are described and claimed.

Abstract: A lithium electrode and a lithium secondary battery including the same, and in particular, to a lithium electrode including a lithium metal layer; and a surface treatment layer formed on the lithium metal layer, wherein the surface treatment layer includes a surface treatment compound including a functional group capable of bonding with lithium metal and a hydrocarbon group substituted with one or more fluorine. By being provided with a surface treatment layer including a specific functional group, the lithium electrode improves stability of lithium metal as well as suppressing side reactions on the surface, and thereby allows high capacity, high stability and long lifetime of a lithium secondary battery.

Abstract: Disclosed are a display module, a display device and a viewing-angle switching method. The display module includes a backlight module, a display panel, a lower polarizer sheet, a viewing-angle switching element and a transparent cover plate; the viewing-angle switching element and the transparent cover plate are arranged between the display panel and the lower polarizer sheet, and the transparent cover plate is arranged on a side of the viewing-angle switching element that is close to the lower polarizer sheet; the backlight module is configured to supply light that meets a preset condition, the viewing-angle switching element is configured to switch viewing-angle modes of the display module; the viewing-angle modes include; a first viewing-angle mode and a second viewing-angle mode; and a viewing-angle range of the first viewing-angle mode is smaller than a viewing angle range of the second viewing-angle mode.

Abstract: The present invention provides novel compounds having the general formula (I): wherein R1, R2, R3, U, V, W, X and Y are as described herein, compositions including the compounds and methods of using the compounds.

Abstract: An identity certificate may be issued to a blockchain node. The issuance may include issuing a first identity certificate to a first terminal and receiving a second identity certificate issuance request that is from the first terminal. A second identity certificate may be issued to the first terminal, and a third identity certificate issuance request is received from the second terminal. A third identity certificate is issued to the second terminal, so that the second terminal forwards the third identity certificate to the third terminal.

Abstract: The present invention provides novel compounds having the general formula: wherein R1 to R4, A, W, Q and Y are as described herein, compositions including the compounds and methods of using the compounds.

Abstract: The present invention relates to a graphene material inlaid with single metal atoms, the preparation method thereof and its application of being used as the catalyst for the electroreduction of carbon dioxide. The graphene material inlaid with single metal atoms comprises single metal atoms and graphene; the single metal atoms are dispersed in the framework of the graphene; and the graphene is at least one selected from N doped graphene and N and S co-doped graphene. The material is used for the electrochemical reduction reaction of carbon dioxide, which significantly improves the utilization efficiency of the metal atoms and enhances the catalytic activity for the electroreduction of carbon dioxide, improves the catalytic stability, inhibits effectively the hydrogen evolution reaction, improves the selectivity for CO product, and broadens the electric potential window of reducing carbon dioxide to generate CO.

Abstract: The present disclosure relates to a display panel, a display device, a reflective filter and a control method thereof. The reflective filter includes: a substrate; a first dielectric layer having a first refractive index, and located on one side of the substrate; a periodic array structure located on one side of the first dielectric layer away from the substrate and in direct contact with the first dielectric layer, wherein the periodic array structure includes a plurality of solid material patterns spaced apart by gaps; and a second dielectric layer covering the periodic array structure and filling the gaps, wherein a material of the second dielectric layer is a variable refractive index material; wherein the first refractive index of the first dielectric layer is lower than an equivalent refractive index nneff of the periodic array structure with the gaps filled with the variable refractive index material.

Abstract: The present invention is directed to indazole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.

Abstract: The present disclosure provides a 3D display substrate including: a plurality of sub-pixels of different colors, a driver and a plurality of plano-convex lenses located at a light-emitting side of the plurality of sub-pixels. The plurality of sub-pixels are corresponding to the plurality of plano-convex lenses in a one-to-one manner. A light-emitting surface of each of the plurality of sub-pixels is located in a focal plane of the corresponding plano-convex lens. Each of the plurality of sub-pixels includes a plurality of sub-pixel sub-portions arranged in an array. The driver is configured to drive the plurality of sub-pixel sub-portions in the same sub-pixel to display images of different grayscales to form a 3D display image.

Abstract: The present disclosure relates to a display panel, a display device, a reflective filter and a control method thereof. The reflective filter includes: a substrate; a first dielectric layer having a first refractive index, and located on one side of the substrate; a periodic array structure located on one side of the first dielectric layer away from the substrate and in direct contact with the first dielectric layer, wherein the periodic array structure includes a plurality of solid material patterns spaced apart by gaps; and a second dielectric layer covering the periodic array structure and filling the gaps, wherein a material of the second dielectric layer is a variable refractive index material; wherein the first refractive index of the first dielectric layer is lower than an equivalent refractive index nneff of the periodic array structure with the gaps filled with the variable refractive index material.