Abstract: Disclosed is a simple synthesis method of lactam derivatives, comprising: with formamide functioning as both an amine source and a hydrogen source (hydrolyzed to produce formic acid), carrying out a cycloamination reaction on a raw material keto acid in the absence of a solvent or a catalyst to simply synthesize a lactam derivative. Compared with previous reports, the present disclosure has the following advantages: the time required for the reaction is greatly shortened, the selectivity is remarkably improved, a conversion rate of a keto acid derivative is greater than 99%, and the yield of the lactam derivative can reach 70% to 94%.

Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age related macular edema, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.

Abstract: A color filter substrate, a display panel and a display device are provided. The color filter substrate includes: a base substrate; a color conversion layer on the base substrate; a covering layer on a side of the color conversion layer away from the base substrate; and a polarizing layer on a side of the covering layer away from the base substrate. The polarizing layer includes a wire grid polarizer. The covering layer includes a first covering sub-layer and a second covering sub-layer, the first covering sub-layer is located on the side of the color conversion layer away from the base substrate, the second covering sub-layer is located on a side of the first covering sub-layer away from the base substrate, and a material of the first covering sub-layer is different from a material of the second covering sub-layer.

Abstract: An embodiment of the present disclosure relates to a method for video anti-shake processing, an electronic apparatus and a storage medium, and the method includes: determining a moving track of a shooting position of a video by performing feature point tracking between different image frames in the video, wherein the moving track indicates shooting positions of the different image frames in the video; performing smoothing processing on a shooting position of each of the different image frames in the moving track, to obtain a smooth track; deforming the video based on a difference between the smooth track and the moving track, to obtain an anti-shake processed video, wherein at least one of the moving track and the smooth track is dynamically determined for the different image frames in the video.

Abstract: A user interface display method, apparatus, and system are provided. The method includes: displaying a first user interface for a first application program in a main display region; displaying a program icon of a second application in an auxiliary display region when a first sliding signal on the auxiliary display region is received; when a first operation signal on the program icon of the second application is received, displaying a floating window on the first user interface; and canceling displaying of the program icon of the second application program in the auxiliary display region when a second sliding signal on the first auxiliary display region is received.

Abstract: A method for implementing storage service continuity in a storage system includes a front-end interface detecting a status of a first storage controller. The storage system includes the front-end interface card and a plurality of storage controllers. The front-end interface card communicates with the storage controllers, and the front-end interface card communicates with a host. When the first storage controller is in an abnormal state, the front-end interface card selects a second storage controller from the storage controllers for the host to process an access request of the host.

Abstract: The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X, D, R1 to R4, and R6 to R10 are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

Abstract: An unit narrow board glue application device and method suitable for high-frequency hot pressing of solid wood edge glued panel is disclosed, including a transverse chain feeding device, a longitudinal roller feeding device and a gluing device. The transverse chain feeding device includes a fixed chain transport mechanism and a movable chain transport mechanism. The longitudinal roller feeding device includes the lifting power roller assembly, the longitudinal feed roller assembly and the pneumatic compression roller assemblies. The gluing device includes a glue pump, a glue application head, and a pneumatic slide table. The front end face of the hollow structure glue application head has a number of small round holes for glue liquid discharge and horizontal glue guiding grooves. The disclosure has a high degree of automation, can give full play to the efficiency of the high-frequency hot press, and is conducive to the intelligent manufacturing of solid wood furniture.

Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age related macular edema, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.

Abstract: The invention provides novel heteroaryl-substituted imidazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein A and R1 to R6 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

Abstract: The present disclosure relates to radar signal processing, and a harmonic radar based on a field programmable gate array (FPGA) and deep learning. Specifically, a signal processing module generates a baseband linear frequency modulation (LFM) signal, converts the baseband LFM signal into an analog signal, and mixes the analog signal with a local carrier frequency signal to obtain a radio frequency (RF) transmitting signal.

Abstract: A color filter substrate, a display panel and a display device are provided. The color filter substrate includes: a base substrate; a color conversion layer on the base substrate; a covering layer on a side of the color conversion layer away from the base substrate; and a polarizing layer on a side of the covering layer away from the base substrate. The polarizing layer includes a wire grid polarizer. The covering layer includes a first covering sub-layer and a second covering sub-layer, the first covering sub-layer is located on the side of the color conversion layer away from the base substrate, the second covering sub-layer is located on a side of the first covering sub-layer away from the base substrate, and a material of the first covering sub-layer is different from a material of the second covering sub-layer.

Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age related macular edema, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.

Abstract: A massage head assembly, including a massage head base disc (1), a massage head support (2), and silicone massage heads (3). The silicone massage heads (3) are fixed on the massage head support (2), the massage head support (2) is detachably fixed on the massage head base disc (1), the silicone massage heads (3) are hollow, and a buffer space (31) is formed between inner walls of the silicone massage heads (3) and the massage head support (2). The overall structure of the massage head assembly is simple, and when used for massaging the human body, the massage head assembly provides a comfortable massage.

Abstract: An optical fiber interface is configured to connect to an optical fiber patch cable plug, and includes: a main body, where a plug-in port for insertion is disposed on the main body, and the plug-in port is configured to accommodate an inserted optical fiber patch cable plug; a cover plate, where the cover plate is disposed above the main body and is fixed to the main body; and a clamping unlocking mechanism, where the clamping unlocking mechanism is disposed between the plug-in port and the cover plate and includes a clamping component and an elastic component, the clamping component is disposed in a radial direction of the plug-in port and is configured to clamp the optical fiber patch cable plug when the optical fiber patch cable plug is inserted into the plug-in port. The optical fiber interface provided in embodiments of this application can be used for optical fiber connection.

Abstract: In some embodiments, an electronic device displays suggested routes based on the characteristics of respective vehicles. In some embodiments, an electronic device receives data for respective vehicles from a source external to the electronic device. In some embodiments, an electronic device anonymizes a vehicle identifier and determines customized suggested routes using the anonymized vehicle identifier.

Abstract: A preparation method of the microcapsules for low-temperature well cementation to be used to control cement hydration heat includes: (S1) a shell material, and added into deionized water, then the resultant mixture being stirred in a thermostat water bath so as to completely dissolve it into a homogeneous and stable shell material solution; (S2) a core material and an emulsifier being put into a three-necked flask and stirred in a thermostat water bath so as to uniformly emulsify and disperse them, forming a stable oil-in-water core material emulsion, while adjusting the pH value of the emulsion with a pH adjuster; (S3) the three-necked flask containing the core material emulsion being transferred to a water bath, and then the shell material solution being dropwise added into it with stirring, after reacting, a solid-liquid mixture being poured out so as to naturally cool it to room temperature.

Abstract: An unit narrow board glue application device and method suitable for high-frequency hot pressing of solid wood edge glued panel is disclosed, including a transverse chain feeding device, a longitudinal roller feeding device and a gluing device. The transverse chain feeding device includes a fixed chain transport mechanism and a movable chain transport mechanism. The longitudinal roller feeding device includes the lifting power roller assembly, the longitudinal feed roller assembly and the pneumatic compression roller assemblies. The gluing device includes a glue pump, a glue application head, and a pneumatic slide table. The front end face of the hollow structure glue application head has a number of small round holes for glue liquid discharge and horizontal glue guiding grooves. The disclosure has a high degree of automation, can give full play to the efficiency of the high-frequency hot press, and is conducive to the intelligent manufacturing of solid wood furniture.

Abstract: Systems and methods for predicting a risk of cardiovascular disease (CVD) from one or more fundus images are disclosed. Fundus images associated with an individual are processed to determine whether fundus images are of sufficient quality. The fundus images of sufficient quality are processed to identify fundus images belonging to a single eye. A plurality of risk contributing factor sets of CNNs (RCF CNN) are configured to output an indicator of probability of the presence of a different risk contributing factor in each of the one or more fundus images. At least one of the RCF CNNs is configured in a jury system model having a plurality of jury member CNNs, each being configured to output a probability of a different feature in the one or more fundus images. The outputs of the jury member CNNs are processed to determine the indicator of probability of the presence of the risk contributing factor output by the RCF CNN.

Abstract: The invention provides novel imidazole pyrazole derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1-R7 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.