Abstract: A purpose of the present invention is to provide a peptide composition having immunomodulating effects for immunotherapy, the peptide content of which does not vary according to cellular origin, and a production method. For this purpose, a peptide composition with immunomodulating effects has been invented, which comprises a complete human ubiquitin (Ub) monomer and a human ubiquitin monomer variant lacking two terminal glycines (Ub(?GG)). The peptide composition for immunotherapy may also comprise at least one fragment of the following human proteins: ankyrin-1, protein 4.1, haemoglobin subunit alpha, haemoglobin subunit beta, haemoglobin subunit delta, complement protein C3, calpastatin, alpha-synuclein, fibrinogen alpha chain, cytoplasmic actin 1, thymosin beta-4, thymosin beta-10 or zyxin.

Abstract: A method includes identifying an image captured by an image capture device set at a first angle about an axis, the image corresponding to a time at which the image was captured, identifying within the image, a region of interest including an object to be used for calibration, determining, an image coordinate at which the object is displayed within the image, determining a camera angle corresponding to a position of the image capture system relative to the axis when the image was captured, identifying a bearing of the object relative to the reference direction, the bearing of the object determined using a geolocation of the image capture system and the time at which the image was captured, and determining, using the image coordinate, the camera angle, and the bearing of the object, an angular offset between the first angle and the reference direction to determine a second angle.

Abstract: The present disclosure provides a mobile device comprising: a motion sensor configured to determine a motion of the mobile device; a radiofrequency transceiver configured to receive an advertisement of at least one node; a controller configured to receive the motion of the mobile device; a user interface. The controller is configured to (i) obtain and parse the advertisement of the at least one node, when the mobile device is in a first motion, and (ii) display a list comprising the parsed advertisement of the at least one node on the user interface, when the mobile device is in a second motion. The first motion is the mobile device moving along a path and the second motion is the mobile device not moving away from a location on the path.

Abstract: Systems and methods are configured to manage streaming video content. A first time length specification for a content pod is accessed. If a determination is made that a response to a request for ancillary content of a duration corresponding to the first time length of the content pod includes ancillary content of insufficient duration to populate the first time length of the content pod, the content pod time length is reduced. Ancillary content items associated with the response to the request are streamed to a user device as part of a streaming channel comprising primary content having scheduled start times. A primary content item, having a scheduled start time, is streamed to the user device after the items of ancillary content, and earlier than the scheduled start time of the item of primary content.

Abstract: This invention relates to a synthetic method for the preparation of Compound 1 and precursors thereof. Compound 1 is prepared via reaction of isoxazole 2 with phenylether (R)-3-ONa.

Abstract: A cell for the electrochemical storage of electrical energy includes: a first sub-cell and a second sub-cell, which are each designed for the electrochemical storage of electrical energy; and a first electrolyte-stable insulation body for thermally insulating the first sub-cell and the second sub-cell from each other. The insulation body is arranged in an interstice between the first and second sub-cells, which is delimited by a side face of the first sub-cell and a side face of the second sub-cell, wherein the first insulation body has a first thermally insulating material having a thermal conductivity of at most 1 W/(m K) and a first heating structure designed to heat the first sub-cell and the second sub-cell, and wherein the first insulation body is electrically insulated from both the first sub-cell and the second sub-cell. A battery with such a cell and a vehicle with such a battery are also disclosed.

Abstract: Methods for diagnosis and treatment of cancers by use of exosomes comprising miRNAs and precursors thereof. For example, in some aspects, a cancer may be diagnosed or evaluated by determining the miRNA content of exosomes in a sample from a subject or by detecting miRNA processing in exosomes.

Abstract: A system, method, and computer program product are provided for consent management. A method may include receiving a first data request for user data associated with a user, the user data stored in a user data database; communicating a consent request to the requester system; receiving a consent response from the requester system; storing consent data associated with the consent response for the user data requested in the first data request in an immutable ledger; receiving a consent verification request from the user data database, the consent verification request based on a second data request for the user data from the requester system to the user data database; verifying the consent verification request based on the consent data; and communicating a consent verification response to the user data database, the consent verification response indicating consent from the user to share the user data with the requester system.

Abstract: Disclosed herein an anti-pT217 Tau antibody or a pT217 Tau-binding fragment thereof.

Abstract: Provided herein are methods and composition for immune repertoire sequencing and single cell barcoding. The methods and compositions can be used to pair any two sequences originating from a single cell, such as heavy and light chain antibody sequences, alpha and beta chain T-cell receptor sequences, or gamma and delta chain T-cell receptor sequences, for antibody and T-cell receptor discovery, disease and immune diagnostics, and low error sequencing.

Abstract: The invention discloses a soybean plant, or a part of said plant comprising the transgenic event CIGBDt-Def1 or the transgenic event CIGBIs-Def5, as well as a method for the detection of those events in soybean samples. It also provides a seed from a soybean plant comprising said transgenic events, and products obtained from a plant, or from soybean seeds, comprising one of said events. In addition, the invention is related to a method for the production of soybean plants resistant to glyphosate, and to diseases caused by fungi or oomycetes, comprising the introduction of one of the mentioned transgenic events in the genome of said plants. The increase in the yield of a soybean crop in the field can be achieved with the transgenic events of the invention.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for using machine learning to detect and correct satellite terminal performance limitations. In some implementations, a system retrieves data indicating labels for clusters of network performance anomalies. The system generates a set of training data to train a machine learning model, the set of training data being generated by assigning the labels for the clusters to sets of performance indicators used to generate the clusters. The system trains a machine learning model to predict classifications for communication devices based on input of performance indicators for the communication devices. The system determines a classification for the communication device based on output that the trained machine learning model generates.

Abstract: Kits and methods to distinguish between false and true labor are provided. The kits and methods can utilize differences in abundance and/or differences in the rate of change in abundance of B7-H2, SORC2, TF, C1-Esterase Inhibitor, Ran, IMDH1 and/or PGAM1, as markers of true labor.

Abstract: The invention is directed to a fall-classification device (100) with a receiver unit (102) configured to receive wireless communication signals (W) from wireless transmitters (101, 103) and a subject-activity data determination unit (106) configured to determine and provide, using signal-quality values determined by a quality signal determination unit, respective subject-activity data indicative of at least two subject-activity metrics of a subject (S) within a sensing volume (V1). A fall-event detection unit (108) is configured to determine, based on a time variation of the subject-activity data of at least one subject-activity metric, whether a fall-event has occurred.

Abstract: The present invention provides compounds of the formula: wherein A, B, D1, X, Y, Z, G, R1, R2, and R3a are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and pharmaceutically acceptable salts thereof for treating patients for cancer.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for managing display devices using machine learning. In some implementations, a system receives image data representing an image provided for presentation by a display device. The system processes the image data using a machine learning model that has been trained to evaluate status of display devices based on input of image data corresponding to the display devices. The system selects a classification for a status of the display device based on the output that the machine learning model generated based on the image data. The system provides an output indicating the selected classification over the communication network in response to receiving the image data.

Abstract: A method, implemented by a computing machine, for constructing a knowledge base. The method includes, while using a terminal, at least one update to the knowledge base based on information extracted from useful application areas of a digital image of a screenshot of at least part of the rendering from a screen of the terminal.

Abstract: A method for diagnosing lithium plating in lithium ion batteries includes performing electrochemical impedance spectroscopy analysis on complete or undisassembled lithium-ion batteries under different temperatures.