Abstract: The present invention relates to a method for preparing an antibody-containing solution free of viral contaminants starting from cultured cells are described. The method include a step of subjecting the antibody containing solution to a mix of solvent and detergent or to high pH.

Abstract: The present invention relates to a selected bacterial strain of Cutibacterium acnes and/or a cell wall therefrom or a post-biotic of the strain and to medical or nutritional uses thereof. The invention also concerns with pharmaceutical or nutritional compositions containing the strain, cell wall or postbiotic therefrom for the prevention or treatment of inflammatory diseases such as dermatitis or psoriasis or infections, especially skin or mucosal fungal or bacterial infections.

Abstract: Biomarkers tests which can be used to predict a positive or negative risk of preeclampsia are described. More specifically, a panel of biomarkers including MMP-7 and gpIIbIIIa, described. The test is useful to predict preeclampsia when a biological sample is obtained between the 16th and 22nd week of pregnancy. Prediction later in pregnancy can be achieved by a combination of Siglec-6, Activin A, ALCAM, and/or FCN2.

Abstract: Embodiments of the present invention relate to systems and model-free methods for perturbing neural network hardware parameters and measure the neural network response that are implemented natively within the neural network hardware and without requiring a knowledge of the internal structure of the network. Embodiments of the present invention also relate to systems and methods for configuring neural network hardware such that the network automatically performs parameter multiplexed gradient descent, which include adding a time-varying perturbation to each hardware parameter base value to modulate the cost, broadcasting the modulated cost signal to all hardware parameters, and filtering out modulations so as to extract gradient information.

Abstract: Disclosed herein is a micro-electro-mechanical mirror device having a fixed structure defining an external frame delimiting a cavity, a tiltable structure extending into the cavity, a reflecting surface carried by the tiltable structure and having a main extension in a horizontal plane, and an actuation structure coupled between the tiltable structure and the fixed structure. The actuation structure is formed by a first pair of actuation arms causing rotation of the tiltable structure around a first axis parallel to the horizontal plane. The actuation arms are elastically coupled to the tiltable structure through elastic coupling elements and are each formed by a bearing structure and a piezoelectric structure. The bearing structure of each actuation arm is formed by a soft region of a first material and the elastic coupling elements are formed by a bearing layer of a second material, the second material having greater stiffness than the first material.

Abstract: Methods and apparatus for forming a patterned layer of carbon are disclosed. In one arrangement, a selected portion of a surface of a solid structure is irradiated with extreme ultraviolet radiation in the presence of a carbon-containing precursor. The radiation interacts with the solid structure in the selected portion to cause formation of a layer of carbon in the selected portion from the carbon-containing precursor. The layer of carbon is formed in a pattern defined by the selected portion.

Abstract: The present application is directed to a method for preparing an amino-functional polyester, said method comprising: providing a mixture comprising at least one lactone monomer, a catalyst and a polyamine having at least one primary and at least one secondary amine group; and, subjecting said mixture to ring-opening polymerization conditions.

Abstract: A computer-implemented method for analyzing a vehicle trip is presented. The method may include obtaining a wireless communication address of a vehicle of an insured driver. One or more processors may determine whether the wireless communication address corresponds to one of one or more known vehicles associated with an insured driver. Responsive to determining that the wireless communication address corresponds to one of the one or more known vehicles associated with the insured driver, the one or more processors may collect a plurality of vehicle telematics data during the vehicle trip. The one or more processors may also analyze the plurality of vehicle telematics data to determine at least one driving behavior of the insured driver.

Abstract: The present invention relates to a method for preparing an antibody-containing solution free of viral contaminants starting from cultured cells are described. The method include a step of subjecting the antibody containing solution to a mix of solvent and detergent or to high pH.

Abstract: Methods and apparatus are provided for high resolution intravital imaging and for chronic optical imaging of tissues such as lung.

Abstract: A method implemented in an electronic device, the electronic device and a corresponding computer program product and medium. The method includes: at least partial playback, on a user interface of the electronic device, of items obtained from computing applications and associated with at least a first class of a plurality of item classes; acquiring at least a first command to be executed, wherein the first command relates to at least one of the items that has been at least partially played back.

Abstract: The present disclosure is directed to antibodies or antigen-binding portions thereof that specifically bind human CCR8, polynucleotides and vectors encoding the same, and pharmaceutical compositions comprising the same. Some aspects of the disclosure are directed to methods of treating a disease or condition comprising administering the anti-CCR8 antibody to a subject in need thereof.

Abstract: Embodiments relate to a composition comprising nanohydroxyapatite (NHAP) in an amount about 0.5 wt. % to about 50 wt. % of the composition having a particle size in a range of about 20-100 nm, an abrasive, a sweetener, and a natural oil, wherein the composition does not contain glycerin and fluoride, wherein the composition is alkaline and a dental product, and wherein the natural oil is a plant product.

Abstract: A multi-material structure includes a refractory portion with a metal or metal alloy of at least one of niobium (Nb), molybdenum (Mo), tantalum (Ta), tungsten (W), rhenium (Re), iridium (Ir), vanadium (V), and ruthenium (Ru). A structural portion is metallurgically joined with the refractory portion. The structural portion includes a titanium (Ti) alloy. At least one of the refractory and structural portions is additively manufactured.

Abstract: The present methods use gene therapy to confer inducible nitric oxide synthase (iNOS) expression solely in the tumor space, using focused ultrasound targeting. NOS catalyzes the reaction that generates nitric oxide (NO), a potent endogenous vasodilator. Microbubble-mediated non-viral delivery overcomes major barriers associated with non-viral NO gene therapy. The methods increase tumor perfusion and compound the efficacy of a vast array of chemotherapy, radiotherapy, and immune-based treatments.

Abstract: The present invention relates to form B of lurbinectedin of the formula: