Patents by Inventor Soo-Chang Song

Soo-Chang Song has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210009763
    Abstract: Provided is a hydrogel composition including thermosensitive poly(phosphazene) to which a plurality of hydrophobic amino acids, hydrophilic polymers, and host molecules are substituted; and a physiologically active material linked to a guest molecule, wherein the poly(phosphazene) and the physiologically active material form a conjugate by inclusion of the guest molecule in the host molecule via a host-guest interaction.
    Type: Application
    Filed: June 19, 2020
    Publication date: January 14, 2021
    Inventors: Soo Chang SONG, Ki Hyun HONG
  • Publication number: 20200377977
    Abstract: Provided is a method for producing steel including: preparing a first molten steel and a manganese-containing melt; supplying a nitrogen gas into a storage to blow nitrogen into the melt received in the storage and thereby adjusting a nitrogen content (wt %) in the melt to a required nitrogen content (wt %); and mixing the melt and the first molten steel to produce a second molten steel containing manganese and nitrogen. Since nitrogen is not blown while melting large amounts of solid materials, the oxidation of manganese due to a high temperature may be minimized or prevented. In addition, a large amount of solid material is not added, and a small amount of manganese-containing nonferrous metal or a FeMn ferroalloy is added, if necessary, into a produced melt in a molten state, and thus, a problem of temperature drop due to the input of the solid material may be minimized or prevented.
    Type: Application
    Filed: September 4, 2017
    Publication date: December 3, 2020
    Inventors: Soo Chang KANG, Chong Tae AHN, Woong Hee HAN, Jun Jeong BEAK, Min Ho SONG
  • Patent number: 10799529
    Abstract: The present disclosure relates to a pharmaceutical composition for preventing or treating spinal cord injury comprising an imidazole-poly(organophosphazene) hydrogel or a pharmaceutically acceptable salt thereof, a method for preventing or treating spinal cord injury, and a food composition for preventing or ameliorating spinal cord injury. The imidazole-poly(organophosphazene) hydrogel of the present disclosure has the effect of regenerating the extracellular matrix (ECM) by filling cystic cavities and can thus be effectively used for the prevention and treatment of spinal cord injury by a simple injection method.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: October 13, 2020
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Soo Chang Song, Young-min Kim
  • Patent number: 10603404
    Abstract: The present invention relates to a phosphazene-based polymer comprising an amino acid ester, polyethylene glycol, a group comprising a functional group, and a catechol group linked directly or by a linker to a part of or an entire functional group, in a predetermined ratio. In addition, the present invention relates to a preparation method thereof, and a tissue-adhesive composition comprising the same as an active ingredient.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: March 31, 2020
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Soo Chang Song, Young-Min Kim, ChangHo Kim
  • Publication number: 20200085860
    Abstract: The present disclosure relates to a pharmaceutical composition for preventing or treating spinal cord injury comprising an imidazole-poly(organophosphazene) hydrogel or a pharmaceutically acceptable salt thereof, a method for preventing or treating spinal cord injury, and a food composition for preventing or ameliorating spinal cord injury. The imidazole-poly(organophosphazene) hydrogel of the present disclosure has the effect of regenerating the extracellular matrix (ECM) by filling cystic cavities and can thus be effectively used for the prevention and treatment of spinal cord injury by a simple injection method.
    Type: Application
    Filed: September 11, 2019
    Publication date: March 19, 2020
    Inventors: Soo Chang SONG, Young-min KIM
  • Publication number: 20200048377
    Abstract: Provided is a thermosensitive phosphazene-based polymer including an amino acid ester moiety, a polyethyleneglycol moiety, and a moiety including a sulfate group linked directly or by a linker in a predetermined ratio, a method of preparing the same, and a hydrogel-formable composition including the same. For example, a hydrogel formed from the composition may be used for tissue regeneration or drug delivery or used as a storage, a body tissue regeneration inducer, or a filler in a body.
    Type: Application
    Filed: August 9, 2019
    Publication date: February 13, 2020
    Inventors: Soo Chang Song, Bo Bae Seo
  • Publication number: 20190309381
    Abstract: Provided is a dephosphorizing flux configured to adjust a phosphorous component contained in molten steel, the dephosphorizing flux includes a main material including BaCO3 and a supplementary material, wherein the supplementary material includes a first material containing either of NaHCO3 or Na2CO3 and a second material containing CaF2. Thus, in accordance with a dephosphorizing flux and a method for preparing the same of the present disclosure, the plugging of a lower blowing nozzle that blows a carrier gas during dephosphorization may be prevented while improving a dephosphorization ratio. In addition, since environment polluting substances are not used as in conventional arts, environment pollution risk may be reduced, and the cost burden due to the facility for pollution prevention and harmful substance management may be alleviated.
    Type: Application
    Filed: December 11, 2017
    Publication date: October 10, 2019
    Inventors: Woong Hee HAN, Chong Tae AHN, Jun Jeong BEAK, Min Ho SONG, Soo Chang KANG
  • Publication number: 20190211425
    Abstract: Provided is a method for producing alloy steel, the method comprising producing first alloy steel in a temperature holding furnace; maintaining the first alloy steel at a temperature of no lower than a melting point in the temperature holding furnace; and producing second alloy steel having an alloy content lower than the alloy content in the first alloy steel by melt mixing of the first alloy steel and molten steel. In the producing of the alloy steel, melting and storing of the ferroalloy are continuously performed, and thus, the temperature drop of the ferroalloy may be suppressed or prevented.
    Type: Application
    Filed: December 16, 2016
    Publication date: July 11, 2019
    Inventors: Woong Hee HAN, Chong Tae AHN, Soo Chang KANG, Jun Jeong BEAK, Min Ho SONG
  • Publication number: 20180133362
    Abstract: The present invention relates to a phosphazene-based polymer comprising an amino acid ester, polyethylene glycol, a group comprising a functional group, and a catechol group linked directly or by a linker to a part of or an entire functional group, in a predetermined ratio. In addition, the present invention relates to a preparation method thereof, and a tissue-adhesive composition comprising the same as an active ingredient.
    Type: Application
    Filed: November 10, 2017
    Publication date: May 17, 2018
    Inventors: Soo Chang SONG, Young-Min KIM, ChangHo KIM
  • Patent number: 9526699
    Abstract: The present invention relates to a biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances. According to the present invention, poly(organophosphazene) is a phosphagen-based polymer showing biodegradability, thermosensitivity, and sol-gel phase transition depending on temperature change, whereby when administered into a living body with bioactive substances such as drugs, the poly(organophosphazene) forms a gel-phase at body temperature to be capable of controlled release of the bioactive substances. Further, the poly(organophosphazene) has functional groups to chemically bind with bioactive substances through an ionic bond, covalent bond, or coordinate covalent bond to be capable of a sustained release of the bioactive substances due to its good binding property. Therefore, the poly(organophosphazene) is useful as a delivery material for bioactive substances.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: December 27, 2016
    Assignee: KIST
    Inventors: Soo-Chang Song, Sun-Mi Lee, Chang-Won Kim, Mi-Ran Park
  • Patent number: 9017726
    Abstract: The present invention relates to a poly(organophosphazene)-superparamagnetic nanoparticle complex including a biodegradable and thermosensitive poly(organophosphazene) and a iron oxide (Fe3O4, Magnetite)-series ferrite superparamagnetic nanoparticle, a preparation method, and uses of carrying a physiologically-active material, a bio-material and a biomaterial for cancer hyperthermia. The iron oxide is used as a MRI contrast agent for T?2 and T2* weighted image, and the poly(organophosphazene) shows a sol-to-gel behavior depending upon the temperature change. The complex is a bound-type where the superparamagnetic ferrite nanoparticle is bonded to phosphazene-based polymer via hydrophobic binding, and a mixed-type where the superparamagnetic ferrite nanoparticle is physically mixed with the phosphazene-based polymer.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: April 28, 2015
    Assignee: Korea Institute of Science and Technology
    Inventors: Soo-Chang Song, Jang Il Kim
  • Publication number: 20140031289
    Abstract: The present invention relates to a thermosensitive phosphazene-based polymer having a degradation controllable ionic group, a use thereof, and a use thereof as a material for delivering bioactive substances. The phosphazene-based polymer according to the present invention has the thermosensitivity of showing the temperature-dependent sol-gel phase transition. Thus, it forms a gel phase at the body temperature when it is injected into the body to make it easy to control the release of bioactive substances such as drugs, and has the functional groups capable of making chemical bonds such as ionic bond, covalent bond, coordinate bond, etc. with drugs and thus is excellent in bearing the drugs. Since it can control the degradation rate depending on the kind of ionic group, it can selectively control the release time depending on the characteristics of drugs. Furthermore, it has an excellent biocompatibility and thus is very useful as a material for delivery of bioactive substances such as drugs, etc.
    Type: Application
    Filed: August 8, 2012
    Publication date: January 30, 2014
    Applicant: Korea Institute of Science and Technology
    Inventors: Soo-Chang SONG, Young-Min Kim
  • Patent number: 8586020
    Abstract: Provided are a use of chemically-crosslinkable, poly(organophosphazene)s for biomaterials, chemically-crosslinkable poly(organophosphazene)s with a physiologically active substance covalently-bonded thereto, a use thereof for biomaterials, and a process for preparing the same. The chemical crosslinkings can be made by UV irradiation, and/or a crosslinker, and/or an additive, and/or an enzyme, and/or a mixing of at least one polymer.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: November 19, 2013
    Assignee: Korea Institute of Science and Technology
    Inventors: Soo-Chang Song, Thrimoorthy Potta, Mi-Ran Park
  • Publication number: 20130004455
    Abstract: Provided are a use of chemically-crosslinkable, poly(organophosphazene)s for biomaterials, chemically-crosslinkable poly(organophosphazene)s with a physiologically active substance covalently-bonded thereto, a use thereof for biomaterials, and a process for preparing the same. The chemical crosslinkings can be made by UV irradiation, and/or a crosslinker, and/or an additive, and/or an enzyme, and/or a mixing of at least one polymer.
    Type: Application
    Filed: June 30, 2011
    Publication date: January 3, 2013
    Applicant: Korea Institute of Science and Technology
    Inventors: Soo-Chang SONG, Thrimoorthy Potta, Mi-Ran Park
  • Patent number: 8313771
    Abstract: A phosphazene-based polymer hydrogel with a chemical cross-linkings formed by radiating ultraviolet (UV) and/or mixing with cross-linking agent and/or enzyme, and a method of preparing the same are provided. The hydrogel shows a sol-gel behavior and has an excellent solidity by containing the phosphazene-based polymer that is capable of cross-linking at a certain concentration.
    Type: Grant
    Filed: May 23, 2008
    Date of Patent: November 20, 2012
    Assignee: Korea Institute of Science and Technology
    Inventors: Soo-Chang Song, Thrimoorthy Potta, Sun-Mi Lee
  • Patent number: 8287888
    Abstract: The present invention relates to a poly(organophosphazene)-bioactive molecule conjugates in which biodegradable and thermosensitive poly(organophosphazene) with a functional group showing the sol-gel phase transition with change of temperature is combined with various bioactive molecules, such as drugs, a preparation method thereof, and a use thereof for delivery of bioactive molecules.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: October 16, 2012
    Assignee: Korea Institute of Science and Technology
    Inventors: Soo-Chang Song, Sun-Mi Lee, Chang-Won Kim
  • Publication number: 20120121517
    Abstract: The present invention relates to a poly(organophosphazene)-superparamagnetic nanoparticle complex including a biodegradable and thermosensitive poly(organophosphazene) and a iron oxide (Fe3O4, Magnetite)-series ferrite superparamagnetic nanoparticle, a preparation method, and uses of carrying a physiologically-active material, a bio-material and a biomaterial for cancer hyperthermia. The iron oxide is used as a MRI contrast agent for T-2 and T2* weighted image, and the poly(organophosphazene) shows a sol-to-gel behavior depending upon the temperature change. The complex is a bound-type where the superparamagnetic ferrite nanoparticle is bonded to phosphazene-based polymer via hydrophobic binding, and a mixed-type where the superparamagnetic ferrite nanoparticle is physically mixed with the phosphazene-based polymer.
    Type: Application
    Filed: June 30, 2011
    Publication date: May 17, 2012
    Inventors: Soo-Chang SONG, Jang Il KIM
  • Patent number: 8075916
    Abstract: A biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances are provided.
    Type: Grant
    Filed: May 17, 2008
    Date of Patent: December 13, 2011
    Assignee: Korea Institute of Science and Technology
    Inventors: Soo-Chang Song, Mi-Ran Park, Sun-Mi Lee
  • Publication number: 20100297155
    Abstract: A phosphazene-based polymer hydrogel with a chemical cross-linkings formed by radiating ultraviolet (UV) and/or mixing with cross-linking agent and/or enzyme, a method of preparing the same, and a hydrogel forming a chemical cross-linking by radiating ultraviolet and/or mixing with a cross-linking agent and/or an enzyme; where the hydrigel shows a sol-gel behavior and has an excellent solidity by containing the phosphazene-based polymer that is capable of cross-linking at a certain concentration, are provided.
    Type: Application
    Filed: May 23, 2008
    Publication date: November 25, 2010
    Inventors: Soo-Chang Song, Thrimoorthy Potta, Sun-Mi Lee
  • Publication number: 20090181088
    Abstract: The present invention relates to a poly(organophosphazene)-bioactive molecule conjugates in which biodegradable and thermosensitive poly(organophosphazene) with a functional group showing the sol-gel phase transition with change of temperature is combined with various bioactive molecules, such as drugs, a preparation method thereof, and a use thereof for delivery of bioactive molecules.
    Type: Application
    Filed: November 3, 2006
    Publication date: July 16, 2009
    Applicant: Korea Institute of Science and Technology
    Inventors: Soo-Chang Song, Sun-Mi Lee, Chang-Won Kim