Abstract: The present invention relates to a multifunctional wood preservative composition containing a compound prepared by reaction of hydrazine hydrate and boric acid and to a method for wood preservation treatment using the same. The wood preservative composition of the present invention can not only impart flame retardant, insect-repellent, rot-resistant, insect-repellent, and rust-proof effects to wood, such as various wooden structures including wooden cultural assets, but also causes no whitening and makes relatively fewer color changes for dancheong. Furthermore, the wood preservative composition of the present invention is provided as a one-component type liquid and thus can save time and costs for wood treatment and is convenient to use.

Abstract: Provided is a thermosensitive phosphazene-based polymer including an amino acid ester moiety, a polyethyleneglycol moiety, and a moiety including a sulfate group linked directly or by a linker in a predetermined ratio, a method of preparing the same, and a hydrogel-formable composition including the same. For example, a hydrogel formed from the composition may be used for tissue regeneration or drug delivery or used as a storage, a body tissue regeneration inducer, or a filler in a body.

Abstract: The present invention relates to a thermosensitive hydrogel composition, which while comprising an amino acid ester, polyethylene glycol, and a functional group for the introduction of a functional moiety at an end thereof at a predetermined ratio, comprises a polyphosphazene-based polymer having a controlled length and a content of polyethylene glycol contained therein, in which a reversible sol-gel transition character is altered; a medical polymer hydrogel comprising the polyphosphazene-based polymer; or an ink composition for 3D printing.

Abstract: Provided is a hydrogel composition including thermosensitive poly(phosphazene) to which a plurality of hydrophobic amino acids, hydrophilic polymers, and host molecules are substituted; and a physiologically active material linked to a guest molecule, wherein the poly(phosphazene) and the physiologically active material form a conjugate by inclusion of the guest molecule in the host molecule via a host-guest interaction.

Abstract: The present disclosure relates to a pharmaceutical composition for preventing or treating spinal cord injury comprising an imidazole-poly(organophosphazene) hydrogel or a pharmaceutically acceptable salt thereof, a method for preventing or treating spinal cord injury, and a food composition for preventing or ameliorating spinal cord injury. The imidazole-poly(organophosphazene) hydrogel of the present disclosure has the effect of regenerating the extracellular matrix (ECM) by filling cystic cavities and can thus be effectively used for the prevention and treatment of spinal cord injury by a simple injection method.

Abstract: The present invention relates to a phosphazene-based polymer comprising an amino acid ester, polyethylene glycol, a group comprising a functional group, and a catechol group linked directly or by a linker to a part of or an entire functional group, in a predetermined ratio. In addition, the present invention relates to a preparation method thereof, and a tissue-adhesive composition comprising the same as an active ingredient.

Abstract: The present disclosure relates to a pharmaceutical composition for preventing or treating spinal cord injury comprising an imidazole-poly(organophosphazene) hydrogel or a pharmaceutically acceptable salt thereof, a method for preventing or treating spinal cord injury, and a food composition for preventing or ameliorating spinal cord injury. The imidazole-poly(organophosphazene) hydrogel of the present disclosure has the effect of regenerating the extracellular matrix (ECM) by filling cystic cavities and can thus be effectively used for the prevention and treatment of spinal cord injury by a simple injection method.

Abstract: Provided is a thermosensitive phosphazene-based polymer including an amino acid ester moiety, a polyethyleneglycol moiety, and a moiety including a sulfate group linked directly or by a linker in a predetermined ratio, a method of preparing the same, and a hydrogel-formable composition including the same. For example, a hydrogel formed from the composition may be used for tissue regeneration or drug delivery or used as a storage, a body tissue regeneration inducer, or a filler in a body.

Abstract: The present invention relates to a phosphazene-based polymer comprising an amino acid ester, polyethylene glycol, a group comprising a functional group, and a catechol group linked directly or by a linker to a part of or an entire functional group, in a predetermined ratio. In addition, the present invention relates to a preparation method thereof, and a tissue-adhesive composition comprising the same as an active ingredient.

Abstract: The present invention relates to a biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances. According to the present invention, poly(organophosphazene) is a phosphagen-based polymer showing biodegradability, thermosensitivity, and sol-gel phase transition depending on temperature change, whereby when administered into a living body with bioactive substances such as drugs, the poly(organophosphazene) forms a gel-phase at body temperature to be capable of controlled release of the bioactive substances. Further, the poly(organophosphazene) has functional groups to chemically bind with bioactive substances through an ionic bond, covalent bond, or coordinate covalent bond to be capable of a sustained release of the bioactive substances due to its good binding property. Therefore, the poly(organophosphazene) is useful as a delivery material for bioactive substances.

Abstract: The present invention relates to a poly(organophosphazene)-superparamagnetic nanoparticle complex including a biodegradable and thermosensitive poly(organophosphazene) and a iron oxide (Fe3O4, Magnetite)-series ferrite superparamagnetic nanoparticle, a preparation method, and uses of carrying a physiologically-active material, a bio-material and a biomaterial for cancer hyperthermia. The iron oxide is used as a MRI contrast agent for T?2 and T2* weighted image, and the poly(organophosphazene) shows a sol-to-gel behavior depending upon the temperature change. The complex is a bound-type where the superparamagnetic ferrite nanoparticle is bonded to phosphazene-based polymer via hydrophobic binding, and a mixed-type where the superparamagnetic ferrite nanoparticle is physically mixed with the phosphazene-based polymer.

Abstract: The present invention relates to a thermosensitive phosphazene-based polymer having a degradation controllable ionic group, a use thereof, and a use thereof as a material for delivering bioactive substances. The phosphazene-based polymer according to the present invention has the thermosensitivity of showing the temperature-dependent sol-gel phase transition. Thus, it forms a gel phase at the body temperature when it is injected into the body to make it easy to control the release of bioactive substances such as drugs, and has the functional groups capable of making chemical bonds such as ionic bond, covalent bond, coordinate bond, etc. with drugs and thus is excellent in bearing the drugs. Since it can control the degradation rate depending on the kind of ionic group, it can selectively control the release time depending on the characteristics of drugs. Furthermore, it has an excellent biocompatibility and thus is very useful as a material for delivery of bioactive substances such as drugs, etc.

Abstract: Provided are a use of chemically-crosslinkable, poly(organophosphazene)s for biomaterials, chemically-crosslinkable poly(organophosphazene)s with a physiologically active substance covalently-bonded thereto, a use thereof for biomaterials, and a process for preparing the same. The chemical crosslinkings can be made by UV irradiation, and/or a crosslinker, and/or an additive, and/or an enzyme, and/or a mixing of at least one polymer.

Abstract: Provided are a use of chemically-crosslinkable, poly(organophosphazene)s for biomaterials, chemically-crosslinkable poly(organophosphazene)s with a physiologically active substance covalently-bonded thereto, a use thereof for biomaterials, and a process for preparing the same. The chemical crosslinkings can be made by UV irradiation, and/or a crosslinker, and/or an additive, and/or an enzyme, and/or a mixing of at least one polymer.

Abstract: A phosphazene-based polymer hydrogel with a chemical cross-linkings formed by radiating ultraviolet (UV) and/or mixing with cross-linking agent and/or enzyme, and a method of preparing the same are provided. The hydrogel shows a sol-gel behavior and has an excellent solidity by containing the phosphazene-based polymer that is capable of cross-linking at a certain concentration.

Abstract: The present invention relates to a poly(organophosphazene)-bioactive molecule conjugates in which biodegradable and thermosensitive poly(organophosphazene) with a functional group showing the sol-gel phase transition with change of temperature is combined with various bioactive molecules, such as drugs, a preparation method thereof, and a use thereof for delivery of bioactive molecules.

Abstract: The present invention relates to a poly(organophosphazene)-superparamagnetic nanoparticle complex including a biodegradable and thermosensitive poly(organophosphazene) and a iron oxide (Fe3O4, Magnetite)-series ferrite superparamagnetic nanoparticle, a preparation method, and uses of carrying a physiologically-active material, a bio-material and a biomaterial for cancer hyperthermia. The iron oxide is used as a MRI contrast agent for T-2 and T2* weighted image, and the poly(organophosphazene) shows a sol-to-gel behavior depending upon the temperature change. The complex is a bound-type where the superparamagnetic ferrite nanoparticle is bonded to phosphazene-based polymer via hydrophobic binding, and a mixed-type where the superparamagnetic ferrite nanoparticle is physically mixed with the phosphazene-based polymer.

Abstract: A biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances are provided.

Abstract: A phosphazene-based polymer hydrogel with a chemical cross-linkings formed by radiating ultraviolet (UV) and/or mixing with cross-linking agent and/or enzyme, a method of preparing the same, and a hydrogel forming a chemical cross-linking by radiating ultraviolet and/or mixing with a cross-linking agent and/or an enzyme; where the hydrigel shows a sol-gel behavior and has an excellent solidity by containing the phosphazene-based polymer that is capable of cross-linking at a certain concentration, are provided.

Abstract: The present invention relates to a poly(organophosphazene)-bioactive molecule conjugates in which biodegradable and thermosensitive poly(organophosphazene) with a functional group showing the sol-gel phase transition with change of temperature is combined with various bioactive molecules, such as drugs, a preparation method thereof, and a use thereof for delivery of bioactive molecules.