Abstract: Disclosed is an oligonucleotide-modified nucleic acid containing at least one 1-?-D-arabinofuranosylcytosine as a modified nucleic acid having therapeutic efficacies and guanosine. More particularly, a novel oligonucleotide-modified nucleic acid containing at least one modified nucleic acid (N) having therapeutic efficacies and being rich in guanosine (G) is synthesized and the fact that the novel oligonucleotide-modified nucleic acid has excellent apoptotic activities on blood cancer cells and drug-resistant blood cancer cells is identified. Based on this, provided is a composition for preventing, ameliorating or treating blood cancer, containing the novel oligonucleotide-modified nucleic acid, and the novel oligonucleotide-modified nucleic acid or a pharmaceutically acceptable salt thereof as an active ingredient.

Abstract: The present disclosure provides adenosine receptor (e.g., A2A and/or A1 receptor) antagonist compounds and compositions including said compounds. The present disclosure also provides methods of using said compounds and compositions for modulating (e.g., inhibiting or antagonizing) A2A and/or A1 receptor in a biological system. The compounds and compositions find use in various therapeutic applications including the treatment of cancer and in immuno-oncology. The compounds and compositions find use in various therapeutic applications including the treatment of central nervous system or neurodegenerative diseases, such as Parkinson’s disease.

Abstract: A method of preparing super absorbent polymer includes carrying out a crosslinking polymerization of a monomer mixture comprising a water-soluble ethylenically unsaturated monomer having at least partially neutralized acidic groups, a forming agent, a foam-promoting agent and a silicone-based surfactant in the presence of an internal crosslinking agent to form a hydrogel polymer; drying, pulverizing and classifying the hydrogel polymer to form a base polymer powder; and further crosslinking a surface of the base polymer powder in the presence of a surface crosslinking agent to form a surface crosslinked layer. The method produces super absorbent polymer having not only an excellent absorbent capacity and an absorbency under load but also the rewetting phenomenon can be effectively prevented.

Abstract: A pharmaceutical composition or an antiviral agent for the treatment of pulmonary fibrosis is disclosed. The composition or the antiviral agent contains a compound of Formula 1, which is a pyrazole derivative, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to a method for preparing a superabsorbent polymer, and a superabsorbent polymer prepared thereby. A superabsorbent polymer prepared by the preparation method exhibits minimized deterioration of physical properties after being pulverized, and thus basic absorbance performance is excellent and an excellent liquid permeability and absorbance rate can be exhibited.

Abstract: The present invention provides a novel pyrazole derivative compound represented by Chemical formula I or a salt thereof, and a pharmaceutical composition comprising the same.

Abstract: The present invention relates to an ophthalmic preparation containing an active ingredient selected from 3-phenyl-4-propyl-1-(pyridin-2-yl)-1H-pyrazol-5-ol compound or a pharmaceutically acceptable salt thereof. The eye drop according to the present invention is excellent in stability and safety and shows an excellent effect on prevention or treatment of eye diseases in such a way that an active ingredient thereof reaches a posterior segment of an eyeball simply through instillation rather than a direct injection into an eyeball.

Abstract: The present disclosure provides phosphodiesterase 5 (PDE-5) and/or phosphodiesterase 6 (PDE-6) inhibitor compounds and compositions including said compounds. In some embodiments, said compounds are nitrogen oxide (NO) donating PDE-5 and/or -6 inhibitor compounds that include a nitrogen oxide-containing donor substituent attached to a benzenesulfonamide group. The compounds can provide dual functionality for increasing protein kinase G (PKG) activity by inhibiting PDE-5 and PDE-6, and/or stimulating guanylate cyclase (sGC) via donation of nitrogen oxide (NO) from the donor substituent of the compound. The present disclosure also provides methods of using said compounds and compositions for inhibiting PDE-5 and/or -6 and increasing activity of protein kinase G (PKG). The compounds and compositions find use in therapeutic applications including in the treatment of a variety of eye diseases.

Abstract: The present invention relates to a method for preparing spherical cured polymer particles from a curable composition. The method comprises the steps of: dropping a curable composition onto a substrate having a water contact angle of 150° to 170° at 25° C. to form droplets of the curable composition; and curing the droplets to form the polymer particles.

Abstract: The present invention relates to a composition for treating eye diseases, wherein the composition comprises a pyrazole-based compound, which is a pharmacologically active substance, and a biodegradable polymer, so that a drug effectively reaches a posterior segment of an eyeball, while prolonging an action time of the drug administered into the eyeball.

Abstract: A super absorbent polymer according to the present invention has an excellent discoloration resistance property even under high temperature/high humidity conditions, while maintaining excellent absorption performance, and is preferably used for hygienic materials such as diapers, and thus can exhibit excellent performance.

Abstract: The present disclosure provides androgen receptor (AR) and phosphodiesterase 5 (PDE-5) inhibitor compounds and compositions including said compounds. The compounds can provide dual functionality for inhibiting AR and inhibiting PDE-5. The present disclosure also provides methods of using said compounds and compositions for inhibiting AR and PDE-5 in a biological system or sample. Also provided are methods of preparing said compounds and compositions, and synthetic precursors of said compounds.

Abstract: The present invention relates to a super absorbent polymer having not only excellent absorption rate and absorbency under load but also excellent rewetting properties, and a method for preparing the same.

Abstract: The present disclosure provides autotaxin (ATX) inhibitor compounds and compositions including said compounds. The present disclosure also provides methods of using said compounds and compositions for inhibiting ATX. Also provided are methods of preparing said compounds and compositions, and synthetic precursors of said compounds.

Abstract: The present disclosure provides a method of displaying frequently used applications and an apparatus using the same. The method of displaying frequently used applications includes: collecting application usage information in at least any one of a time period of a day or a user activity; determining an application usage pattern based on the collected application usage information; and determining frequently used applications in the time period of a day or the user activity based on the determined application usage pattern, and displaying the determined frequently used applications.

Abstract: The present invention relates to a novel crystalline 3-phenyl-4-propyl-1-(pyridin-2-yl)-1H-pyrazol-5-ol hydrochloride, a method for preparing the compound, and a pharmaceutical composition containing the compound as an active ingredient.

Abstract: The present invention relates to a super absorbent polymer which not only has excellent basic absorption performance but also can improve rewet characteristics and leakage suppression characteristics of hygienic materials such as diapers, and a method for preparing the same. The super absorbent polymer includes: a base polymer powder including a first cross-linked polymer of a water-soluble ethylenically unsaturated monomer having an acidic group of which at least a part is neutralized; and a surface crosslinked layer that is formed on the base polymer powder and includes a second cross-linked polymer in which the first crosslinked polymer is further crosslinked via a surface crosslinking agent, wherein the surface crosslinking agent includes a mixture of plural kinds of cyclic alkylene carbonates, and where the mixture has a Hansen solubility parameter by hydrogen bonding component of 13 or more.

Abstract: The present invention relates to a method for preparing superabsorbent polymer that has not only excellent permeability and absorption speed, but also minimized absorbency under pressure decrease rate, and superabsorbent polymer prepared thereby.

Abstract: The present invention relates to a super absorbent resin, and the super absorbent resin can exhibit a fast absorption rate and high gel strength even in a partially swollen state through the size optimization of partially swollen gel particles. Therefore, the use of the super absorbent resin can effectively prevent a rewetting phenomenon.

Abstract: The present invention relates to a novel crystalline 3-phenyl-4-propyl-1-(pyridin-2-yl)-1H-pyrazol-5-ol hydrochloride, a method for preparing the compound, and a pharmaceutical composition containing the compound as an active ingredient.